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The map label for this gene is cobB [H]

Identifier: 188528048

GI number: 188528048

Start: 1282608

End: 1283297

Strand: Direct

Name: cobB [H]

Synonym: HPSH_06525

Alternate gene names: 188528048

Gene position: 1282608-1283297 (Clockwise)

Preceding gene: 188528047

Following gene: 188528049

Centisome position: 79.74

GC content: 43.91

Gene sequence:

>690_bases
ATGAAAAATTTAGTGATCCTAAGCGGGGCTGGCATTTCAGCAGAAAGCGGGATTAAAACCTTTAGAGACGCTGATGGCTT
GTGGGAAGGGCATGACATCATGGAAGTTGCCTCGCCTTATGGCTGGAAAAAGAACCCGCAAAAGGTGTTGGATTTCTACA
ACCAAAGGCGCCGACAGCTTTTTGAGGTTTATCCTAACAAGGCTCATGAGGCTTTAGCGGAATTGGAAAAACACTATCAA
GTTAATATCATCACCCAAAATGTAGATGATTTGCATGAAAGGGCGGGTTCTTCTCGCATTTTGCACTTGCATGGGGAATT
ATTGAGCGTTCGCAGCGAAAAAGATCCTAATTTGGTTTATAGGTGGGAAAAGGACTTGAATTTAGGCGACTTGGCCAAAG
ACAAATCGCAATTACGCCCTGATATTGTGTGGTTTGGCGAAGCGGTGCCTTTGCTTGAAGAAGCGATTTCTTTAGTCAAA
CAAGCGCATCTTTTAATCATCATTGGCACTTCTTTGCAAGTCTATCCCGCTGCTAGCCTCTACACGCATGCACATAAAGA
CGCTCTCATTTATTACATTGACCCTAAGGCTAAAAACGCCCATTTGCCCCAGAATGTCCAATGCATTAATGATAGCGCGG
TGCATGCCATGCAAGATTTAATGCCCAAACTCATAGAAATGGCCTCTTAA

Upstream 100 bases:

>100_bases
GCATGGGGTTACTTATAGGGTTTGTTACGCCTTTTATTTTTAAGTTTTTTTTGCATGACAAACTCAGCGGCACTCATATT
GAAACCATCAAGGAGGAAAC

Downstream 100 bases:

>100_bases
GAGATGTTAAAATAATTTTTATTTTTTCAGCTAACGATTAGCAAAAACATGGTTTAATTGGCTTCATCATTTGCTAATAA
TTAAAGGAGTTTGAGAGTCT

Product: hypothetical protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHEALAELEKHYQ
VNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLLEEAISLVK
QAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINDSAVHAMQDLMPKLIEMAS

Sequences:

>Translated_229_residues
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHEALAELEKHYQ
VNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLLEEAISLVK
QAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINDSAVHAMQDLMPKLIEMAS
>Mature_229_residues
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHEALAELEKHYQ
VNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLLEEAISLVK
QAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINDSAVHAMQDLMPKLIEMAS

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=196, Percent_Identity=37.7551020408163, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI6912664, Length=208, Percent_Identity=35.5769230769231, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI13787215, Length=208, Percent_Identity=35.5769230769231, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI7657575, Length=206, Percent_Identity=28.1553398058252, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI308199517, Length=188, Percent_Identity=46.2765957446808, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17541892, Length=195, Percent_Identity=25.1282051282051, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25954; Mature: 25954

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQL
CCCEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
FEVYPNKAHEALAELEKHYQVNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVY
HHHCCCHHHHHHHHHHHCEEEEEEECCHHHHHHHCCCCEEEEECHHHHHHCCCCCCCEEE
RWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLLEEAISLVKQAHLLIIIGTSLQVYPAASL
EECCCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCEEEEECCCEEEEECHHH
YTHAHKDALIYYIDPKAKNAHLPQNVQCINDSAVHAMQDLMPKLIEMAS
HHHCCCCEEEEEECCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQL
CCCEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
FEVYPNKAHEALAELEKHYQVNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVY
HHHCCCHHHHHHHHHHHCEEEEEEECCHHHHHHHCCCCEEEEECHHHHHHCCCCCCCEEE
RWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLLEEAISLVKQAHLLIIIGTSLQVYPAASL
EECCCCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCEEEEECCCEEEEECHHH
YTHAHKDALIYYIDPKAKNAHLPQNVQCINDSAVHAMQDLMPKLIEMAS
HHHCCCCEEEEEECCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]