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The map label for this gene is folP-A [H]

Identifier: 188528019

GI number: 188528019

Start: 1255819

End: 1256961

Strand: Direct

Name: folP-A [H]

Synonym: HPSH_06370

Alternate gene names: 188528019

Gene position: 1255819-1256961 (Clockwise)

Preceding gene: 188528018

Following gene: 188528021

Centisome position: 78.07

GC content: 38.93

Gene sequence:

>1143_bases
ATGATTTTAAAACGCCTTAACCCTGATGCGCTCAAAAACGCCCTTTTAAAAACCGGATCAGAAAAACCCGCTCAAACCCA
TATGCATAAAAAAGGCGTTAGCTTTGTTTTTGAAATCCAGCATCTGCCCTTAAGCGCAACGCTCATTTTAAAACAAGAGG
CCATCAGCGTTGGGGGCGATTTCGCCACGCCAAGAGATTGTATTTTAGCTAAAGAGCCTTTTTATGATGGGGTGTTGATT
GTGAGCGCTAGCCAGTTAGAACGCCTTATTGTCAAGTGCCACTCCCAACCCTTTGGGCTTAAAAATTTAGCGCAAGAATT
AAAAAGCCACCTTAAAGCCAAAAAACCTAACAACCCACAGATCATGGCAATTTTGAATCTCACGCCGGATAGTTTTTATG
AAAAAAGCCGGTTTGATAGCAAAAAAGCGCTTGAAGAAATCTATCAATTATTAAAAAAGGGTATCACGCTCATTGATATA
GGCGCAGCCAGTTCAAGACCACAGAGTGAAACCATTGATCCAAAAATAGAGCAAGATCGCTTAAAAGAAATTTTATTAGA
AATCAAATCCCAAAAACTCTACCAATGCGCTAAATTCAGCATAGACACCTACCATGCTAAAACCGCCCAAATGGCTTTGG
AGCATTATTTTTCCATCCTTAATGATGTGAGCGGTTTTAGTAGTATTAAAATGCTAGAAGTCGCAAAAGATTACAAGCCC
ACTTGCATTTTAATGCACACTCAAAAAACCCCCAAAGACATGCAAGAAAATGTTTTTTACCACAATCTGTTTGATGAAAT
GGATCGCTTCTTTAAGGAAAAACTAGAGGTTTTAGAAAAATACGCGCTTCAAGATATTATTTTAGATATAGGGTTTGGAT
TCGCTAAATTAAAAGAGCATAATTTAGCCTTAATCAAGCATTTAAGCCACTTCCTCAAATTCAAAAAACCCTTATTGGTG
GGAGCAAGTCGTAAAAACACGATCGGGCTTATCACCGGGCGTGAAGTTCAAAACCGGCTCGCTGGCACTTTAAGCTTGCA
TTTAATGGCACTGCAAAATGGAGCGAGTATTTTAAGAGCGCATGACATTGATGAGCATATAGACCTCATCAAGGTGTTTA
AGAGTTTAGAAGAAACAAATTGA

Upstream 100 bases:

>100_bases
AAGCCTTTGATTTAGCGATCAAAGCTAACAGCTCTTATTACAAGCTCAGCTATAATCTTTTACCCCTACTTTTAAGCCTT
TTATCTAAAAAGAAAACGCC

Downstream 100 bases:

>100_bases
AAAGCGCTTCACCCTAACCCCATTTTAAAGGGTAACATCCATAGAAGAAGGGTTGTTATAAGCGTTCTGGTAGCGTTGCA
AAAAAGCGTTATGGTTGGTA

Product: dihydropteroate synthase (folP)

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MILKRLNPDALKNALLKTGSEKPAQTHMHKKGVSFVFEIQHLPLSATLILKQEAISVGGDFATPRDCILAKEPFYDGVLI
VSASQLERLIVKCHSQPFGLKNLAQELKSHLKAKKPNNPQIMAILNLTPDSFYEKSRFDSKKALEEIYQLLKKGITLIDI
GAASSRPQSETIDPKIEQDRLKEILLEIKSQKLYQCAKFSIDTYHAKTAQMALEHYFSILNDVSGFSSIKMLEVAKDYKP
TCILMHTQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLV
GASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRAHDIDEHIDLIKVFKSLEETN

Sequences:

>Translated_380_residues
MILKRLNPDALKNALLKTGSEKPAQTHMHKKGVSFVFEIQHLPLSATLILKQEAISVGGDFATPRDCILAKEPFYDGVLI
VSASQLERLIVKCHSQPFGLKNLAQELKSHLKAKKPNNPQIMAILNLTPDSFYEKSRFDSKKALEEIYQLLKKGITLIDI
GAASSRPQSETIDPKIEQDRLKEILLEIKSQKLYQCAKFSIDTYHAKTAQMALEHYFSILNDVSGFSSIKMLEVAKDYKP
TCILMHTQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLV
GASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRAHDIDEHIDLIKVFKSLEETN
>Mature_380_residues
MILKRLNPDALKNALLKTGSEKPAQTHMHKKGVSFVFEIQHLPLSATLILKQEAISVGGDFATPRDCILAKEPFYDGVLI
VSASQLERLIVKCHSQPFGLKNLAQELKSHLKAKKPNNPQIMAILNLTPDSFYEKSRFDSKKALEEIYQLLKKGITLIDI
GAASSRPQSETIDPKIEQDRLKEILLEIKSQKLYQCAKFSIDTYHAKTAQMALEHYFSILNDVSGFSSIKMLEVAKDYKP
TCILMHTQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLV
GASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRAHDIDEHIDLIKVFKSLEETN

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=263, Percent_Identity=33.4600760456274, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=28.8401253918495, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 43136; Mature: 43136

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKRLNPDALKNALLKTGSEKPAQTHMHKKGVSFVFEIQHLPLSATLILKQEAISVGGD
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCCEEEEEEHHHHHHCCCC
FATPRDCILAKEPFYDGVLIVSASQLERLIVKCHSQPFGLKNLAQELKSHLKAKKPNNPQ
CCCCHHHEEECCCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
IMAILNLTPDSFYEKSRFDSKKALEEIYQLLKKGITLIDIGAASSRPQSETIDPKIEQDR
EEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHH
LKEILLEIKSQKLYQCAKFSIDTYHAKTAQMALEHYFSILNDVSGFSSIKMLEVAKDYKP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
TCILMHTQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRA
HHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHH
HDIDEHIDLIKVFKSLEETN
CCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MILKRLNPDALKNALLKTGSEKPAQTHMHKKGVSFVFEIQHLPLSATLILKQEAISVGGD
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCCEEEEEEHHHHHHCCCC
FATPRDCILAKEPFYDGVLIVSASQLERLIVKCHSQPFGLKNLAQELKSHLKAKKPNNPQ
CCCCHHHEEECCCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
IMAILNLTPDSFYEKSRFDSKKALEEIYQLLKKGITLIDIGAASSRPQSETIDPKIEQDR
EEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHH
LKEILLEIKSQKLYQCAKFSIDTYHAKTAQMALEHYFSILNDVSGFSSIKMLEVAKDYKP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
TCILMHTQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYALQDIILDIGFGFAKLKEH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRA
HHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHH
HDIDEHIDLIKVFKSLEETN
CCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]