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The map label for this gene is rppH [H]

Identifier: 188528015

GI number: 188528015

Start: 1252946

End: 1253419

Strand: Direct

Name: rppH [H]

Synonym: HPSH_06350

Alternate gene names: 188528015

Gene position: 1252946-1253419 (Clockwise)

Preceding gene: 188528014

Following gene: 188528016

Centisome position: 77.89

GC content: 40.93

Gene sequence:

>474_bases
ATGCTACATAAAAAATATCGTCCTAATGTTGCGGCTATCATTATGTCGCCAGATTACCCTAATACATGCGAAATTTTTAT
CGCTGAGCGCATAGATATTGAGGGAGCGTGGCAGTTCCCCCAAGGGGGCATTGATGAGGGCGAAACCCCTTTAGAAGCGC
TCCATAGAGAATTATTAGAAGAAATTGGCACGAATGAAATAGAGATTTTAGCGCAATACCCCAGATGGATCGCCTATGAT
TTCCCAAGCAATATGGAGCACAAATTCTATTCGTTTGACGGGCAAAAGCAACGCTATTTTTTAGTGCGCCTAAAGCATGC
TAACAACATTGATTTGAACAAACACACGCCAGAATTTAGAGCTTACCAATTCATCCATCTTAAGGATTTGCTTAAAAAAA
TCGTTCCCTTTAAGCGTCAAGTGTATCGCCAAGTCATTGCTTATTTCAGAAGAGAGGGGTATTTAGGGTGTTAA

Upstream 100 bases:

>100_bases
TTTTAATTTTTGATTTTAATGGCATTCTTAACCCTACTTAAAGCCAGCATGCATTATAATACCATCTTAATCAAATAAGA
AAGAGCTAAAATAAAGACCT

Downstream 100 bases:

>100_bases
TCGTTCAAAAATACGGCGGCACGAGCATGGGCAGCGTAGAAAGGATCCACAATGTCGCTCAAAGGGTTTTAGAAAGCGTT
AAATTAGGGCATCAGGTGGT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MLHKKYRPNVAAIIMSPDYPNTCEIFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLEEIGTNEIEILAQYPRWIAYD
FPSNMEHKFYSFDGQKQRYFLVRLKHANNIDLNKHTPEFRAYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC

Sequences:

>Translated_157_residues
MLHKKYRPNVAAIIMSPDYPNTCEIFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLEEIGTNEIEILAQYPRWIAYD
FPSNMEHKFYSFDGQKQRYFLVRLKHANNIDLNKHTPEFRAYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC
>Mature_157_residues
MLHKKYRPNVAAIIMSPDYPNTCEIFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLEEIGTNEIEILAQYPRWIAYD
FPSNMEHKFYSFDGQKQRYFLVRLKHANNIDLNKHTPEFRAYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=154, Percent_Identity=34.4155844155844, Blast_Score=89, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18725; Mature: 18725

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHKKYRPNVAAIIMSPDYPNTCEIFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLE
CCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHH
EIGTNEIEILAQYPRWIAYDFPSNMEHKFYSFDGQKQRYFLVRLKHANNIDLNKHTPEFR
HHCCCCEEHEECCCCEEEECCCCCCCCEEECCCCCCCEEEEEEEECCCCCCCCCCCCCHH
AYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLHKKYRPNVAAIIMSPDYPNTCEIFIAERIDIEGAWQFPQGGIDEGETPLEALHRELLE
CCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHH
EIGTNEIEILAQYPRWIAYDFPSNMEHKFYSFDGQKQRYFLVRLKHANNIDLNKHTPEFR
HHCCCCEEHEECCCCEEEECCCCCCCCEEECCCCCCCEEEEEEEECCCCCCCCCCCCCHH
AYQFIHLKDLLKKIVPFKRQVYRQVIAYFRREGYLGC
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA