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The map label for this gene is ffh [H]

Identifier: 188527936

GI number: 188527936

Start: 1165712

End: 1167058

Strand: Reverse

Name: ffh [H]

Synonym: HPSH_05945

Alternate gene names: 188527936

Gene position: 1167058-1165712 (Counterclockwise)

Preceding gene: 188527937

Following gene: 188527935

Centisome position: 72.55

GC content: 41.13

Gene sequence:

>1347_bases
ATGTTTCAAGCATTAAGCGATGGGTTTAAAAACGCGCTCAATAAAATCCGCTTTCAAGATGATGGAAAAGCGCTAGATCG
GGCGTTAGATGAATTGAAAAAAACGCTCTTAAAAAATGATGTGCATCATAAAGTGGCTAGGGAATTGCTCAAAAAAGTGG
AAAGTCAAACGAAACTTAATGGCATTGGTAAGCAGCAATTTTTAGACGCTTTGGAAAAGAGTTTGTTAGAAATTTTAAGC
GCTAAAGGGAGCAGTGGTTTTACTTTCGCTCAAACGCCCCCTACCGTGGTTTTAATGGCAGGTTTGCAAGGGAGCGGTAA
GACAACCACCACCGCTAAACTCGCTCATTATCTAAAAACCAAAAATAAAAAAGTGCTTTTATGCGCATGCGATTTGCAAC
GCCTAGCGGCAGTAGAGCAATTAAAGGTTTTGGGCGAACAGGTGGGCGTGGAAGTTTTTTATGAAGAAAATAAAAGCGTG
AAAGAAATCGCTAACAACGCTTTAAAAAGGGCTAAAGAAGCGCAATTTGATGTTTTGCTCGTGGATAGCGCGGGGCGTTT
AGCCATTGATAAAGAGCTTATGCAAGAATTAAAAGAAGTTAAAGAAGTCTTAAACCCCCATGAAGTGCTGTATGTCGCAG
ACGCCTTGAGCGGGCAAGATGGGGTCAAAAGCGCGAGCGCATTTAATGAAGAAATAGGCGTGAGTGGGGTGGTGTTAAGC
AAATTTGATAGCGATTCTAAAGGGGGTATCGCCTTAGGCATCACTTACCAATTAGGCTTACCCTTGCGTTTTATTGGGAG
CGGGGAAAAAATCCCTGATTTAGATGTGTTTGTGCCTGAAAGGATTGTGGGGCGTTTGATGGGGGCTGGAGATATTATCT
CGCTCGCTGAAAAAACCGCCAGCGTTTTAAACCCTAATGAAGCCAAAGATTTAAGCAAAAAACTCAAAAAAGGGCAATTC
ACATTCAATGACTTTTTAAACCAGATTGAAAAAGTGAAAAAATTAGGCTCTATGAGTTCTCTAATCTCTATGATTCCAGG
TTTAGGGAATATGGCAAACGCGCTAAAAGACACGGATTTAGAAAGCTCTTTAGAAGTGAAAAAAATCAAGGCTATGGTCA
ATTCCATGACTAAAAAAGAGCAAGAAAACCCTGAGATTTTAAACGGCAGCCGAAGAAAAAGGATCGCTTTAGGGAGCGGC
TTAGAAGTGTCTGAAATCAATCGCATCATCAAACGCTTTGATCAAGCGAGCAAAATGGCGAAACGCTTAACGAATAAAAA
GGGTATTAGCGATTTGATGAATCTAATGAGTCAGGCTAAAAATCAAACGCCCCCTAAAATGCGCTGA

Upstream 100 bases:

>100_bases
TAGAAAAAGCTAAAGAGAGTTTAAAAACGCTTTTAGAAAAAGAAAGTAAAATTAAGCAAGAATTGGATTTGTTAGAACAA
CCATAATAAAAGGATAGAAA

Downstream 100 bases:

>100_bases
CTTTTAAGCATGTTTTAGGCGCTTTTGTTGTATAATCCTAAATTTAATATGAATATTTTAGGAGATTTTTGTAATGACAG
TCATCAGACTCACGCGCATT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFQALSDGFKNALNKIRFQDDGKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLNGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIANNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSASAFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Sequences:

>Translated_448_residues
MFQALSDGFKNALNKIRFQDDGKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLNGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIANNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSASAFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR
>Mature_448_residues
MFQALSDGFKNALNKIRFQDDGKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLNGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIANNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSASAFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=445, Percent_Identity=31.2359550561798, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI226371618, Length=379, Percent_Identity=31.6622691292876, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI23308697, Length=301, Percent_Identity=29.5681063122924, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI295424842, Length=301, Percent_Identity=29.5681063122924, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI89061728, Length=157, Percent_Identity=35.031847133758, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1788963, Length=431, Percent_Identity=41.0672853828306, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1789874, Length=231, Percent_Identity=38.0952380952381, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=434, Percent_Identity=31.3364055299539, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=200, Percent_Identity=36.5, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=426, Percent_Identity=31.6901408450704, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6320498, Length=273, Percent_Identity=30.7692307692308, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17647949, Length=438, Percent_Identity=29.9086757990868, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24641198, Length=299, Percent_Identity=30.4347826086957, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49101; Mature: 49101

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQALSDGFKNALNKIRFQDDGKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLN
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKT
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
KNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVKEIANNALKRAKEAQFDVLL
CCCEEEEEECCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
VDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSASAFNEEIGVSGVVLS
ECCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCHHHHHHHHHHCCCCCEEEE
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTA
CCCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
SVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDL
HHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
ESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMA
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KRLTNKKGISDLMNLMSQAKNQTPPKMR
HHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFQALSDGFKNALNKIRFQDDGKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKLN
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKT
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
KNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVKEIANNALKRAKEAQFDVLL
CCCEEEEEECCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
VDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSASAFNEEIGVSGVVLS
ECCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCHHHHHHHHHHCCCCCEEEE
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTA
CCCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
SVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDL
HHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
ESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMA
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KRLTNKKGISDLMNLMSQAKNQTPPKMR
HHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]