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The map label for this gene is uvrB [H]

Identifier: 188527894

GI number: 188527894

Start: 1129925

End: 1131901

Strand: Reverse

Name: uvrB [H]

Synonym: HPSH_05725

Alternate gene names: 188527894

Gene position: 1131901-1129925 (Counterclockwise)

Preceding gene: 188527895

Following gene: 188527887

Centisome position: 70.37

GC content: 40.21

Gene sequence:

>1977_bases
ATGCCTTTATTTGATTTAAAAAGCCCTTACCCACCAGCAGGCGATCAGCCCCAAGCCATAGAAGCCTTAACGAAGAGCTT
GAAAAATAACAACCATTATCAAACTTTAGTGGGGGTTACAGGGAGCGGTAAAACTTATACGATGGCCAATATCATCGCCA
ATACCAACAAACCCACTCTGATCATGAGCCATAATAAGACCTTATGCGCGCAGCTCTATAGCGAGTTTAAGGCGTTTTTC
CCGCATAATAGGGTGGAGTATTTTATCTCCCACTTTGACTACTACCAGCCTGAAAGCTATATCCCTAGAAGGGATTTATT
CATTGAAAAAGACAGCTCTATTAATGATGATTTAGAGCGTTTGAGGTTGAGTGCAGCCACCTCACTTTTAGGTTATGATG
ATGTGATCGTGATAGCGAGCGTTTCGGCTAATTATGGTTTGGGTAACCCTGAAGAATATTTAAAAGTCATGGAAAAAATC
AAAGTGGGCGAGAAGCGCGCTTATAAGAGCTTTTTGTTAAAGCTAGTGGAAATGGGTTATAGCCGTAATGAAGTGGTGTT
TGATAGGGGGAGCTTTAGGGCGACCGGAGAATGCGTGGATATTTTCCCCGCTTATAATGACGCTGAATTTATCAGGATTG
AATTTTTTGGCGATGAGATAGAAAGGATTGCTGTCTTTGACGCTTTAGAAAAAAATGAAATCAAGTGCTTGGATTCTGTC
ATGCTTTATGCGGCCAGTCAGTTTGCTGTAGGGAGTGAGAGGTTGAATTTAGCCATTAAAAGCATTGAAGATGAACTCGC
TTTAAGATTGAAATTTTTTAAAGAGCAAGATAAAATGCTTGAATACAACCGCCTCAAACAACGCACTGAGCATGATTTAG
AAATGATTAGTGCAACCGGTGTGTGTAAGGGCATTGAAAATTACGCGCGCCATTTTACAGGCAAAGCCCCTAATGAAACG
CCTTTTTGTTTGTTTGATTATTTAGGGATATTTGAGCGGGAGTTTTTAGTCATTGTGGATGAAAGCCATGTGAGCTTGCC
GCAGTTTGGGGGGATGTACACAGGGGATATGAGCAGGAAAAGCGTTTTAGTGGAATATGGTTTTAGATTGCCTAGCGCTT
TAGACAACCGCCCTTTAAAATTTGATGAATTTATCCATAAAAATTGCCAGTTCCTTTTTGTGTCCGCTACGCCCAATAAG
CTAGAATTAGAGCTTTCTCAAAAGAATGTCGCTGAGCAAATCATTCGCCCTACAGGGCTTTTAGACCCTAAATTTGAAGT
GCGAGACAGCGATAAGCAAGTCCAGGATTTATTTGATGAAATCAAGTTAGTGGTGGCTAGAGATGAAAGGGTGCTCATCA
CCACGCTCACTAAAAAAATGGCAGAAGAATTGTGCAAATATTATGCTGAATGGGGCTTGAAGGCGCGTTACATGCATAGT
GAAATTGATGCGATTGAAAGAAATCACATCATCCGCTCTTTAAGGCTTAAAGAATTTGACATTTTAATAGGGATCAATCT
TTTAAGAGAAGGGTTGGATTTGCCTGAAGTTTCTTTAGTAGCGATCATGGATGCGGATAAAGAAGGGTTTTTAAGGAGTG
AAACAAGTCTCATTCAAACCATGGGGCGAGCTGCTAGAAACGCTAATGGCAAGGTTTTATTATACGCCAAAAAAATCACT
CAAAGCATGCAAAAAGCCTTTGAAATTACGAGCTACAGGCGCGCTAAGCAAGAAGAATTTAATAAGCTTCATCATATCAC
CCCCAAAACCGTTACTCGCGCCTTAGAAGAGGAGTTGAAATTAAGAGACGATGAGGTTAAAATTGCTAAAGCCTTAAAAA
AGGACAAAATCCCTAAAAGCGAAAGGGAAAAGATCATTAAAGAACTGGATAAAAAAATGCGAGAATGCGCGAAAAATTTG
GATTTTGAAGAAGCGATGCATTTGAGAGACGAAATCGCTAAATTAAGAACGCTTTAA

Upstream 100 bases:

>100_bases
GCGAAAAAACCGATCATTATCAAAACATTGATTTTTTTGAGATTGAATAAAGCGTGTTAAAAAACCACTATAATACCCCT
AAAAAATGCGAGTTTTAAAG

Downstream 100 bases:

>100_bases
AAACTATAAGCGTAGTTGAAATAAACCGAGTAATTGCGCCTGAAATCAACCCGATACAACACGCTGTTGATCCCGTATTC
TAAAAATCGTAAAACCTTTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MPLFDLKSPYPPAGDQPQAIEALTKSLKNNNHYQTLVGVTGSGKTYTMANIIANTNKPTLIMSHNKTLCAQLYSEFKAFF
PHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSAATSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKI
KVGEKRAYKSFLLKLVEMGYSRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKCLDSV
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNET
PFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYTGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNK
LELELSQKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKARYMHS
EIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKIT
QSMQKAFEITSYRRAKQEEFNKLHHITPKTVTRALEEELKLRDDEVKIAKALKKDKIPKSEREKIIKELDKKMRECAKNL
DFEEAMHLRDEIAKLRTL

Sequences:

>Translated_658_residues
MPLFDLKSPYPPAGDQPQAIEALTKSLKNNNHYQTLVGVTGSGKTYTMANIIANTNKPTLIMSHNKTLCAQLYSEFKAFF
PHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSAATSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKI
KVGEKRAYKSFLLKLVEMGYSRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKCLDSV
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNET
PFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYTGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNK
LELELSQKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKARYMHS
EIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKIT
QSMQKAFEITSYRRAKQEEFNKLHHITPKTVTRALEEELKLRDDEVKIAKALKKDKIPKSEREKIIKELDKKMRECAKNL
DFEEAMHLRDEIAKLRTL
>Mature_657_residues
PLFDLKSPYPPAGDQPQAIEALTKSLKNNNHYQTLVGVTGSGKTYTMANIIANTNKPTLIMSHNKTLCAQLYSEFKAFFP
HNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSAATSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIK
VGEKRAYKSFLLKLVEMGYSRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKCLDSVM
LYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNETP
FCLFDYLGIFEREFLVIVDESHVSLPQFGGMYTGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKL
ELELSQKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKARYMHSE
IDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKITQ
SMQKAFEITSYRRAKQEEFNKLHHITPKTVTRALEEELKLRDDEVKIAKALKKDKIPKSEREKIIKELDKKMRECAKNLD
FEEAMHLRDEIAKLRTL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=52.0958083832335, Blast_Score=675, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75852; Mature: 75721

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFDLKSPYPPAGDQPQAIEALTKSLKNNNHYQTLVGVTGSGKTYTMANIIANTNKPTL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEHHEECCCCCEE
IMSHNKTLCAQLYSEFKAFFPHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLER
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHH
LRLSAATSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIKVGEKRAYKSFLLKLVEMGY
HHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
SRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKCLDSV
CCCCEEEECCCCCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHH
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCKGIENYARHFTGKAPNETPFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYTGDMSRK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHH
SVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKLELELSQKNVAEQIIRPTGL
HHHHHHCCCCCHHHCCCCCCHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHCCCCC
LDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKARYMHS
CCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQT
HHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
MGRAARNANGKVLLYAKKITQSMQKAFEITSYRRAKQEEFNKLHHITPKTVTRALEEELK
HHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRDDEVKIAKALKKDKIPKSEREKIIKELDKKMRECAKNLDFEEAMHLRDEIAKLRTL
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLFDLKSPYPPAGDQPQAIEALTKSLKNNNHYQTLVGVTGSGKTYTMANIIANTNKPTL
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEHHEECCCCCEE
IMSHNKTLCAQLYSEFKAFFPHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLER
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHH
LRLSAATSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIKVGEKRAYKSFLLKLVEMGY
HHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
SRNEVVFDRGSFRATGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALEKNEIKCLDSV
CCCCEEEECCCCCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHH
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKMLEYNRLKQRTEHDLEMISATG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCKGIENYARHFTGKAPNETPFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYTGDMSRK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCHH
SVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKLELELSQKNVAEQIIRPTGL
HHHHHHCCCCCHHHCCCCCCHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHCCCCC
LDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKARYMHS
CCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EIDAIERNHIIRSLRLKEFDILIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQT
HHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
MGRAARNANGKVLLYAKKITQSMQKAFEITSYRRAKQEEFNKLHHITPKTVTRALEEELK
HHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRDDEVKIAKALKKDKIPKSEREKIIKELDKKMRECAKNLDFEEAMHLRDEIAKLRTL
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA