Click here to switch to the map view.

The map label for this gene is adhA [H]

Identifier: 188527883

GI number: 188527883

Start: 1118434

End: 1119486

Strand: Direct

Name: adhA [H]

Synonym: HPSH_05670

Alternate gene names: 188527883

Gene position: 1118434-1119486 (Clockwise)

Preceding gene: 188527882

Following gene: 188527886

Centisome position: 69.53

GC content: 40.84

Gene sequence:

>1053_bases
ATGAGAGTTCAATCTAAAGGTTTTGCTATTTTTTCTAAAGACGGGCATTTCAAACCCCATGATTTTAGCCGCCATGCTGT
AGGTCCTAAAGATGTGTTGATTGACATTCTTTATGCAGGGATTTGCCATAGCGATATTCATAGCGCTTATAGCGAATGGA
AAGAAGGCATTTATCCTATGATTCCTGGGCATGAAATTGCTGGGGTCATCAAAGAAGTGGGCAAGGAAGTTAAGAAATTT
AAAATTGGCGATGTGGTGGGCGTGGGCTGTTTTGTCAATTCATGCAGGACATGTAAGCCTTGTAAAGAACACCAAGAGCA
ATTTTGCGCCAACCATAAAACGGTATTCACTTACGATTGTTTGGATTATTTCCATGACAACGAACCCCACATGGGCGGAT
ACTCTAACAATATTGTCGTGGATGAAAACTATGTGATTAGCGTGGATAAAAACGCTCCTTTAGAAAAAGTAGCCCCCTTG
CTTTGTGCGGGCATCACCACTTATTCGCCCTTAAAATTTTCTAAGGTTACTAAAGGCACAAAAGTTGGTGTCGCTGGGTT
TGGCGGGCTAGGAAGCATGGCGGTTAAATACGCTGTGGCTATGGGGGCTGAAGTGAGTGTTTTTGCAAGAAATGAACACA
AAAAACAAAACGCTTTAAGCATGGGGGTTAAACATTTCTACACTGACCCTAAACAATGCAAAGAAGAATTGGATTTTATC
ATTTCAACCATTCCTACCCATTATGATTTAAAAGACTACCTCAAGCTCTTAACTTATAATGGCGATCTAGCCCTTGTGGG
GCTCCCCCCTGCAGAAGTCGCTCCAGTGCTTAGCGTTTTTGATTTTATCTTTTTAGGCAATCGCAAGGTTTATGGCTCAT
TGATTGGGGGCATTAAAGAAACCCAAGAGATGATGGATTTTTCTGTCAAACACAATATTTACCCTGAAATAGATTTGATT
TTAGGCAAGGATATTGACACCGCCTATCACAACCTAACCCATGGGAAAGCGAAATTCCGCTATGTGATTGATATGAAAAA
ATCGTTTGATTAA

Upstream 100 bases:

>100_bases
CCATGTAACCAACAATTATAAAATTAGTTAAACCTATAAAAACATAAGCAAACCATAAAAACGATACAATAGCGGTATTT
TAATCAAACAAGGAGTTTTA

Downstream 100 bases:

>100_bases
AGGCTTTGGCTCTAGCTCTTTTTTAAGAGCTTGAGTAGGATTTTTTTAACAATCCCATGAAGCCCTAGGATTTTAAGGGT
TTTACTAATAAGACTCTTAA

Product: NADP-dependent alcohol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRVQSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDIHSAYSEWKEGIYPMIPGHEIAGVIKEVGKEVKKF
KIGDVVGVGCFVNSCRTCKPCKEHQEQFCANHKTVFTYDCLDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPL
LCAGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQNALSMGVKHFYTDPKQCKEELDFI
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPAEVAPVLSVFDFIFLGNRKVYGSLIGGIKETQEMMDFSVKHNIYPEIDLI
LGKDIDTAYHNLTHGKAKFRYVIDMKKSFD

Sequences:

>Translated_350_residues
MRVQSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDIHSAYSEWKEGIYPMIPGHEIAGVIKEVGKEVKKF
KIGDVVGVGCFVNSCRTCKPCKEHQEQFCANHKTVFTYDCLDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPL
LCAGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQNALSMGVKHFYTDPKQCKEELDFI
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPAEVAPVLSVFDFIFLGNRKVYGSLIGGIKETQEMMDFSVKHNIYPEIDLI
LGKDIDTAYHNLTHGKAKFRYVIDMKKSFD
>Mature_350_residues
MRVQSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDIHSAYSEWKEGIYPMIPGHEIAGVIKEVGKEVKKF
KIGDVVGVGCFVNSCRTCKPCKEHQEQFCANHKTVFTYDCLDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPL
LCAGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQNALSMGVKHFYTDPKQCKEELDFI
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPAEVAPVLSVFDFIFLGNRKVYGSLIGGIKETQEMMDFSVKHNIYPEIDLI
LGKDIDTAYHNLTHGKAKFRYVIDMKKSFD

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=320, Percent_Identity=27.8125, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI34577061, Length=313, Percent_Identity=28.1150159744409, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501939, Length=366, Percent_Identity=27.3224043715847, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=27.3224043715847, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4501929, Length=313, Percent_Identity=26.8370607028754, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI262073058, Length=331, Percent_Identity=24.4712990936556, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71743840, Length=319, Percent_Identity=25.705329153605, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71565154, Length=211, Percent_Identity=30.3317535545024, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI71565152, Length=302, Percent_Identity=25.8278145695364, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786518, Length=354, Percent_Identity=40.9604519774011, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI87082401, Length=346, Percent_Identity=31.7919075144509, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87081918, Length=350, Percent_Identity=26.5714285714286, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1790045, Length=281, Percent_Identity=26.6903914590747, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788075, Length=286, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788073, Length=281, Percent_Identity=24.5551601423488, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=316, Percent_Identity=28.7974683544304, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=326, Percent_Identity=27.6073619631902, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=328, Percent_Identity=26.8292682926829, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17565904, Length=204, Percent_Identity=32.3529411764706, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=189, Percent_Identity=32.2751322751323, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=188, Percent_Identity=32.4468085106383, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=182, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=183, Percent_Identity=28.9617486338798, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=367, Percent_Identity=28.6103542234332, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=356, Percent_Identity=28.0898876404494, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323961, Length=354, Percent_Identity=28.5310734463277, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324486, Length=354, Percent_Identity=28.5310734463277, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323980, Length=342, Percent_Identity=30.1169590643275, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6319949, Length=345, Percent_Identity=29.2753623188406, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320033, Length=304, Percent_Identity=28.9473684210526, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=389, Percent_Identity=25.706940874036, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=328, Percent_Identity=25, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17137530, Length=217, Percent_Identity=27.1889400921659, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 38994; Mature: 38994

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVQSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDIHSAYSEWKEGIYPM
CCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IPGHEIAGVIKEVGKEVKKFKIGDVVGVGCFVNSCRTCKPCKEHQEQFCANHKTVFTYDC
CCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEHH
LDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLCAGITTYSPLKFSKVTKGT
HHHHCCCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCC
KVGVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQNALSMGVKHFYTDPKQCKEELDFI
EECCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPAEVAPVLSVFDFIFLGNRKVYGSLIGGIKE
HHHCCCCCCHHHHHHHHEECCCEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHH
TQEMMDFSVKHNIYPEIDLILGKDIDTAYHNLTHGKAKFRYVIDMKKSFD
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCEEEEEEEEECCCCC
>Mature Secondary Structure
MRVQSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDIHSAYSEWKEGIYPM
CCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IPGHEIAGVIKEVGKEVKKFKIGDVVGVGCFVNSCRTCKPCKEHQEQFCANHKTVFTYDC
CCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEHH
LDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLCAGITTYSPLKFSKVTKGT
HHHHCCCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCC
KVGVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQNALSMGVKHFYTDPKQCKEELDFI
EECCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPAEVAPVLSVFDFIFLGNRKVYGSLIGGIKE
HHHCCCCCCHHHHHHHHEECCCEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHH
TQEMMDFSVKHNIYPEIDLILGKDIDTAYHNLTHGKAKFRYVIDMKKSFD
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]