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The map label for this gene is accC [H]

Identifier: 188527865

GI number: 188527865

Start: 1099221

End: 1100588

Strand: Direct

Name: accC [H]

Synonym: HPSH_05565

Alternate gene names: 188527865

Gene position: 1099221-1100588 (Clockwise)

Preceding gene: 188527864

Following gene: 188527866

Centisome position: 68.34

GC content: 43.93

Gene sequence:

>1368_bases
ATGAATAAAGAAAATAAAAAGGTAGAAAAAAAAGAGCTTTCGCGCATTTTGATCGCTAATAGAGGCGAGATCGCTTTAAG
AGCGATCCAAACCATTCAAGAAATGGGTAAAGAATCCATAGCCATTTATTCTATCGCTGACAAGGACGCCCACTACCTCA
ATACGGCTAACGCAAAAGTGTGTATAGGGGGGGCAAAATCCAGCGAGAGTTACTTGAATATCCCTGCAATCATTAGCGCG
GCAGAATTGTTTGAAGCGGATGCGATTTTCCCTGGGTATGGGTTTTTGAGCGAGAATCAGAATTTTGTAGAGATTTGCTC
GCACCATTCTTTAGAATTTATTGGCCCAAGCGCGAAAGTCATGGCTTTAATGAGCGACAAATCCAAAGCCAAAAGCGTGA
TGAAAGAAGCTGGCATGCCTGTGATTGAGGGCAGTGATGGGTTGCTTAAAAGCTATCAAGAAGCTGAAGAAATCGCTGAT
AAAATCGGCTACCCTGTCATCATTAAAGCGGCCGCTGGTGGGGGCGGGAGAGGCATGCGCGTCGTAGAAGATAAATCCAG
GCTCAAAAACCTTTATTTAGCCGCAGAAACGGAAGCTTTGAGCGCGTTTGGCGATGGGAGCGTGTATTTAGAAAAATTCA
TCAACAAGCCTAAGCACATTGAAGTCCAAATTCTAGCCGATAAGCATGGCAATGTCATTCATGTGGGCGAAAGGGATTGT
TCGGTGCAAAGACGCCAGCAAAAGCTCATTGAAGAAACCCCGGCAGTGGTTTTAGAAGAGGGCGTTCGTAAGCGTTTGCT
AGAAACAGCGATCAAGGCCGCTAAATATATCGGCTATGTGGGGGCTGGGACTTTTGAATTTTTGCTCGATTCTAACATGA
AAGATTTTTATTTCATGGAGATGAACACTCGTTTACAAGTGGAACACACCATTAGCGAAATGGTGAGCGGGTTAAACCTC
ATTGAATGGATGATTAAAATCGCTCAAGGCGAGGAATTGCCCAAGCAAGAAAGCTTTTCTCTCAAAGGGCATGCGATAGA
ATGCAGAATCACTGCAGAAGATCCTAAAAAATTCTACCCAAGCCCGGGTAAAATCACCGAATGGATCGCCCCTGGTGGGG
TGAATGTGCGCCTTGATTCGCACGCGCATGCTCATTATGTCGTGCCCACACACTATGATTCTATGATTGGCAAGCTCATT
GTGTGGGGTGAAAACAGAGAAAAAGCGATCGCTAAGATGAAAAGGGCTTTAAAGGAATTTAAGGTAGAAGGCATTAAAAC
AACCATTCCTTTCCACCTTGAAATGCTTGAAAATGCGGATTTCAGGCAAGCAAAAATCCACACGAAGTATTTAGAAGAAA
ATTTTTAA

Upstream 100 bases:

>100_bases
AAGTGGAATACCCTTGCAAGGTGGTTTCTGTTGAAGTGGGGGACGCCCAGCCGGTAGAATACGGCACGAAACTCATTAAA
GTTGAAAAGCTTTAAAATCC

Downstream 100 bases:

>100_bases
GTTTTAAGGATTTTCTTAAGCATGATTTAAGGATTTTAAACGATCAGAAAAAATCAGCATTAAATTTTATGATTTTATAG
TAGAGTTTTTTCATGCAAAC

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAIISA
AELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIAD
KIGYPVIIKAAAGGGGRGMRVVEDKSRLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
SVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSGLNL
IEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHAHYVVPTHYDSMIGKLI
VWGENREKAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF

Sequences:

>Translated_455_residues
MNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAIISA
AELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIAD
KIGYPVIIKAAAGGGGRGMRVVEDKSRLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
SVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSGLNL
IEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHAHYVVPTHYDSMIGKLI
VWGENREKAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
>Mature_455_residues
MNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAIISA
AELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIAD
KIGYPVIIKAAAGGGGRGMRVVEDKSRLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
SVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSGLNL
IEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHAHYVVPTHYDSMIGKLI
VWGENREKAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=43.6241610738255, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=456, Percent_Identity=43.640350877193, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=456, Percent_Identity=43.640350877193, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=456, Percent_Identity=43.640350877193, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=42.7616926503341, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI295821183, Length=450, Percent_Identity=42.6666666666667, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=42.6666666666667, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI38679977, Length=516, Percent_Identity=31.7829457364341, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679967, Length=516, Percent_Identity=31.7829457364341, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679974, Length=516, Percent_Identity=31.7829457364341, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679960, Length=516, Percent_Identity=31.7829457364341, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=31.5686274509804, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=30.0589390962672, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI18105007, Length=238, Percent_Identity=24.3697478991597, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI170295797, Length=305, Percent_Identity=23.9344262295082, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169790915, Length=305, Percent_Identity=23.9344262295082, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI21361331, Length=305, Percent_Identity=23.9344262295082, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=51.0112359550562, Blast_Score=435, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17562816, Length=460, Percent_Identity=44.1304347826087, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71987519, Length=447, Percent_Identity=43.4004474272931, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=41.7410714285714, Blast_Score=360, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=29.4949494949495, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71997168, Length=518, Percent_Identity=29.3436293436293, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=518, Percent_Identity=29.3436293436293, Blast_Score=217, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI193204318, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=40.3153153153153, Blast_Score=343, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=43.8053097345133, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=42.9203539823009, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6323863, Length=461, Percent_Identity=33.8394793926247, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=31.3953488372093, Blast_Score=243, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6322569, Length=323, Percent_Identity=23.2198142414861, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=44.4196428571429, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363050, Length=460, Percent_Identity=43.2608695652174, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=460, Percent_Identity=43.2608695652174, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=460, Percent_Identity=43.2608695652174, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=460, Percent_Identity=43.2608695652174, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=460, Percent_Identity=43.2608695652174, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=403, Percent_Identity=45.1612903225806, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.6163021868787, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.6163021868787, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.6163021868787, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.6163021868787, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50783; Mature: 50783

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKV
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEE
CIGGAKSSESYLNIPAIISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKV
EEECCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCHHE
MALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADKIGYPVIIKAAAGGGGRGMR
EEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCE
VVEDKSRLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
EEHHHHHHHHEEEEECHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCH
SVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFME
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCEEEEE
MNTRLQVEHTISEMVSGLNLIEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKKFYP
ECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHHHCC
SPGKITEWIAPGGVNVRLDSHAHAHYVVPTHYDSMIGKLIVWGENREKAIAKMKRALKEF
CCCCEEEEECCCCEEEEECCCCCEEEEECCCHHHHHCEEEEECCCHHHHHHHHHHHHHHH
KVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
HHCCCEEECCCHHEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKV
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEE
CIGGAKSSESYLNIPAIISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKV
EEECCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCHHE
MALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADKIGYPVIIKAAAGGGGRGMR
EEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCE
VVEDKSRLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGERDC
EEHHHHHHHHEEEEECHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCH
SVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFME
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCEEEEE
MNTRLQVEHTISEMVSGLNLIEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKKFYP
ECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHHHCC
SPGKITEWIAPGGVNVRLDSHAHAHYVVPTHYDSMIGKLIVWGENREKAIAKMKRALKEF
CCCCEEEEECCCCEEEEECCCCCEEEEECCCHHHHHCEEEEECCCHHHHHHHHHHHHHHH
KVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
HHCCCEEECCCHHEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]