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The map label for this gene is serA [H]

Identifier: 188527838

GI number: 188527838

Start: 1069839

End: 1071413

Strand: Direct

Name: serA [H]

Synonym: HPSH_05420

Alternate gene names: 188527838

Gene position: 1069839-1071413 (Clockwise)

Preceding gene: 188527837

Following gene: 188527839

Centisome position: 66.51

GC content: 41.78

Gene sequence:

>1575_bases
ATGTATCAAGTAGCCATTTGCGACCCCATCCATGCTAAAGGCATTCAAATTTTAGAAGCTCAAAAAGACATTGTCTTGCA
TGATTATTCCAAATGCCCCAAAAATGAACTTTTAGGAAAACTCACCCTTATGGATGCGCTCATCACGCGCAGCATGACTC
CTATCACCAGCGATTTTTTAAAGCCCTTAACCCACTTAAAATCCATCGTGAGAGCGGGCGTGGGAGTGGATAATATTGAT
TTAGAAAGCTGTTCTCAAAAAGGGATTGTAGTGATGAATATCCCTACCGCTAACACGATTGCCGCTGTGGAATTAACGAT
GGCGCATTTGATCAATGCGGTGCGCTCGTTCCCTTGCGCGAACGATCAAATCAAACACCAAAGGTTATGGAAAAGAGAAG
ATTGGTATGGCACGGAATTGAAAAATAAAAAGCTGGGCATCATTGGTTTTGGGAATATTGGCTCTAGGGTGGGCATTAGG
GCTAAAGCTTTTGAAATGGAAGTCCTAGCCTATGATCCTTATATCCCTTCTTCAAAAGCCACTGATTTAGGGGTCATTTA
CACAAAAAATTTTGAAGATATTTTGCGGTGCGATGTGATCACTATCCACACCCCTAAAAATAAAGAAACCATTAACATGA
TAGGCGCTAAAGAGATCGAACGCATGAAAAAAGGGGTTATTTTGATCAATTGCGCTAGGGGTGGGCTTTATAATGAAGAC
GCTCTTTATGAAGCTTTAGAAACCAAAAAAGTGCGTTGGCTTGGTATCGATGTCTTTTCTAAAGAGCCTGGCATTCATAA
CAAGCTTTTAGACTTGCCTAATGTTTATGCGACCCCCCATATTGGCGCGAACACTTTAGAATCCCAAGAAGAAATTTCCA
AACAAGCCGCTCAAGGGGTTATGGAATCTTTAAGGGGTTCAAGCCACCCGCATGCTTTGAATTTACCCATGCAAGCTTTT
GACGCGAGCGCAAAAGCCTACTTGAATTTAGCGCAAAAATTGGGTTATTTTTCCAGTCAAATCCATAAGGGCGTGTGCCA
AAAAATTGAGCTCAGTCTTTGTGGGGAGATCAACCAATTTAAAGACGCCCTTGTAGCCTTTGCGCTAGTGGGGGTGTTAA
AACCTGTTGTAGGGGATAAAATCAATTACATTAACGCCCCCTTTGTGGCTAAAGAAAGAGGCATTGAGATTAAGGTTAGC
CTTAAAGAAAGCGCTTCGCCCTATAAAAACATGCTCTCTTTAACTCTAAATGCGGCTAATGGTTCAATCAGCGTGAGCGG
CACGGTGTTTGAAGAAGATATTTTAAAACTCACTGAGATTGATGGGTTTCATATTGATATAGAGCCAAAGGGCAAGATGC
TTTTATTCAGGAATACGGATATTCCAGGCGTTATTGGGAGTGTGGGGAATGCGTTCGCTAGGCATGGCATTAACATCGCT
GATTTTCGTTTGGGGCGTAACACGCAAAAAGAAGCCCTAGCGCTCATTATTGTAGATGAAGAAGTTTCTTTGGAAGTTTT
AGAAGAGCTTAAAAACATTCCTGCGTGCTTAAGCGTTCATTATGTGGTTATTTAA

Upstream 100 bases:

>100_bases
CATCATCTATTTAGACAAAAACAAAAAAGAACGCTTTTTAGCTGATTTAGACTATTATAAAATACGCTATCATGCCGTTT
TTTAAATTCAAAGGATAAAA

Downstream 100 bases:

>100_bases
GGTAGTTGGATGCGAGATTTTTTAAAGCTTTTAAAAGAGCATGATGAATTAGAAGTCATTGACACCCCCCTTGAAGTGGA
TTTAGAAATCGCTCATCTGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKNELLGKLTLMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILRCDVITIHTPKNKETINMIGAKEIERMKKGVILINCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQFKDALVAFALVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI

Sequences:

>Translated_524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKNELLGKLTLMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILRCDVITIHTPKNKETINMIGAKEIERMKKGVILINCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQFKDALVAFALVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
>Mature_524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKNELLGKLTLMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILRCDVITIHTPKNKETINMIGAKEIERMKKGVILINCARGGLYNED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQFKDALVAFALVGVLKPVVGDKINYINAPFVAKERGIEIKVS
LKESASPYKNMLSLTLNAANGSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=398, Percent_Identity=33.6683417085427, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4557497, Length=270, Percent_Identity=32.2222222222222, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=270, Percent_Identity=32.2222222222222, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI145580578, Length=270, Percent_Identity=31.8518518518519, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557499, Length=270, Percent_Identity=31.8518518518519, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI145580575, Length=281, Percent_Identity=31.6725978647687, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=30.1960784313725, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=33.6448598130841, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87082289, Length=266, Percent_Identity=28.9473684210526, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=28.6259541984733, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788660, Length=264, Percent_Identity=29.9242424242424, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081824, Length=246, Percent_Identity=26.4227642276423, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=307, Percent_Identity=37.785016286645, Blast_Score=195, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=29.5275590551181, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=337, Percent_Identity=28.486646884273, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=28.1345565749235, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=31.2757201646091, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=298, Percent_Identity=28.1879194630872, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=33.1428571428571, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=285, Percent_Identity=23.1578947368421, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=313, Percent_Identity=36.4217252396166, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24646446, Length=262, Percent_Identity=30.9160305343511, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646448, Length=262, Percent_Identity=30.9160305343511, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646452, Length=262, Percent_Identity=30.9160305343511, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646450, Length=262, Percent_Identity=30.9160305343511, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=30.9160305343511, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574286, Length=306, Percent_Identity=30.3921568627451, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=30.8917197452229, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=28.7539936102236, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=28.7539936102236, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=28.7539936102236, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=28.7539936102236, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=28.7539936102236, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=25.5591054313099, Blast_Score=112, Evalue=9e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57758; Mature: 57758

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKNELLGKLTLMDALITRSMTPITSDFL
CEEEEECCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
KPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCA
HHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
NDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCC
TDLGVIYTKNFEDILRCDVITIHTPKNKETINMIGAKEIERMKKGVILINCARGGLYNED
CCEEEEEECCHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHCCEEEEEECCCCCCCHH
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGV
HHHHHHHHCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MESLRGSSHPHALNLPMQAFDASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQF
HHHHCCCCCCCEEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KDALVAFALVGVLKPVVGDKINYINAPFVAKERGIEIKVSLKESASPYKNMLSLTLNAAN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHEEEEEEEECC
GSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
CEEEEEEEEHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKNELLGKLTLMDALITRSMTPITSDFL
CEEEEECCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
KPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCA
HHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
NDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCC
TDLGVIYTKNFEDILRCDVITIHTPKNKETINMIGAKEIERMKKGVILINCARGGLYNED
CCEEEEEECCHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHCCEEEEEECCCCCCCHH
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGV
HHHHHHHHCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MESLRGSSHPHALNLPMQAFDASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQF
HHHHCCCCCCCEEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KDALVAFALVGVLKPVVGDKINYINAPFVAKERGIEIKVSLKESASPYKNMLSLTLNAAN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHEEEEEEEECC
GSISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIA
CEEEEEEEEHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]