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The map label for this gene is guaA

Identifier: 188527826

GI number: 188527826

Start: 1055071

End: 1056597

Strand: Reverse

Name: guaA

Synonym: HPSH_05360

Alternate gene names: 188527826

Gene position: 1056597-1055071 (Counterclockwise)

Preceding gene: 188527827

Following gene: 188527825

Centisome position: 65.69

GC content: 41.19

Gene sequence:

>1527_bases
ATGATTTTAGTATTAGATTTTGGGAGCCAATACACACAGCTGATTGCTAGAAGATTGAGAGAGAGCGGGATTTATGCAGA
AATAGTCCCTTTTTTTGAAAGCATAGAAAACATTCAAAAAAAAGCCCCTAAAGGTTTGATTTTGAGTGGGGGGCCAGCGA
GCGTGTATGCTAAAGACGCTTACAAGCCTAGCAAGAAAATCTTTGATTTGGATTTGCCGATTTTAGGGATTTGCTACGGC
ATGCAGTATTTAGTGGATTTTTTTGGGGGGGTAGTGGCTTGCACGAATGAGCAAGAATTTGGTAAGGCTATCTTAGAAAT
CACTCAAGATTCTGTGATTTTTGAAGGCGTGAAAATTAAAAGCCTTGTGTGGATGAGTCATATGGATAAAGTCATAGAAT
TGCCTAAAGGCTTCACTACCCTTGCAAAAAGCCCTAATTCCCCCCATTGCGCGATTGAAAACGCTAAGATTTTTGGCTTG
CAATTCCACCCAGAAGTCATTCAAAGCGAAGAAGGGGGTAAGATTTTAGAAAATTTTGCCCTTTTGGTTTGCGGCTGTGA
AAAAACTTGGGGGATGCAGCATTTCGCTCAAAAAGAAATGGCACGATTGAAAGAAAAAATTGCTAACGCTAAGGTTTTGT
GCGCGGTGAGTGGGGGCGTGGATTCTACGGTGGTCGCTACGCTATTGCACAGAGCCATTAAGGATAATTTGATCGCTGTT
TTTGTAGATCATGGCTTGTTGCGTAAAAATGAAAAAGAAAAAGTTCAAGCGATGTTTAAAGACTTGCAAATCCCTTTAAA
CACGATAGACGCTAAAGAAATCTTTTTGTCTAAATTAAAGGGCGTGAGCGAGCCTGAATTGAAGCGAAAAATCATCGGCG
AAACCTTTATTGAAGCGTTTGAAAAAGAAGCCAAGAAGCACCATTTGAAAGGCAAAATTGAGTTTTTAGCCCAAGGCACT
TTATACCCTGATGTGATTGAATCCGTGAGCGTTAAAGGGCCTTCAAAAGTGATCAAAACCCACCATAATGTGGGCGGATT
GCCTGAATGGATGGACTTTAAACTCATAGAGCCTTTAAGGGAATTGTTTAAAGATGAGGTCCGTTTGTTGGGTAAGGAAT
TGGGCATTAGCCAGGATTTTTTAATGCGCCACCCCTTTCCAGGGCCTGGACTTGCGATAAGGATTTTAGGCGAAGTCAGC
GAGAGTAAGATCAGATGCTTGCAAGAAGCGGATTTTATTTTTATAGAAGAGCTTAAAAAAGCCAATTTGTATGACAAGGT
TTGGCAGGCTTTTTGCGTGCTGTTGAATGTCAATTCTGTGGGGGTTATGGGGGATAATCGCACTTATGAAAACGCTATTT
GTTTAAGGGCGGTGAATGCGAGCGATGGCATGACAGCGAGCTTTTCATTTTTGGAGCATTCTTTTTTAGAAAAGGTTTCT
AATCGCATCACTAATGAAGTGAGCGGTATCAATAGGGTGGTGTATGATATTACCTCTAAACCACCAGGAACGATTGAATG
GGAATGA

Upstream 100 bases:

>100_bases
TGGTTTGTGCAAAAAGCGCCCGCGTTGGCTGAAAGCTATAGGGTGAATTATAAGAATCAATACAATAAAACACAGACCCC
ACAAAAATAAAGAATGAGCG

Downstream 100 bases:

>100_bases
TTATCCGTAAAAATAGAGATAAAAAGTGGGATTTTTTGGGTAAGATTAGAAATTGATTTTAAAGAAAAAGAAAGAAAGGA
ATTTAATGAAAAAAGGTAGT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDAYKPSKKIFDLDLPILGICYG
MQYLVDFFGGVVACTNEQEFGKAILEITQDSVIFEGVKIKSLVWMSHMDKVIELPKGFTTLAKSPNSPHCAIENAKIFGL
QFHPEVIQSEEGGKILENFALLVCGCEKTWGMQHFAQKEMARLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAV
FVDHGLLRKNEKEKVQAMFKDLQIPLNTIDAKEIFLSKLKGVSEPELKRKIIGETFIEAFEKEAKKHHLKGKIEFLAQGT
LYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEVRLLGKELGISQDFLMRHPFPGPGLAIRILGEVS
ESKIRCLQEADFIFIEELKKANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
NRITNEVSGINRVVYDITSKPPGTIEWE

Sequences:

>Translated_508_residues
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDAYKPSKKIFDLDLPILGICYG
MQYLVDFFGGVVACTNEQEFGKAILEITQDSVIFEGVKIKSLVWMSHMDKVIELPKGFTTLAKSPNSPHCAIENAKIFGL
QFHPEVIQSEEGGKILENFALLVCGCEKTWGMQHFAQKEMARLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAV
FVDHGLLRKNEKEKVQAMFKDLQIPLNTIDAKEIFLSKLKGVSEPELKRKIIGETFIEAFEKEAKKHHLKGKIEFLAQGT
LYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEVRLLGKELGISQDFLMRHPFPGPGLAIRILGEVS
ESKIRCLQEADFIFIEELKKANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
NRITNEVSGINRVVYDITSKPPGTIEWE
>Mature_508_residues
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDAYKPSKKIFDLDLPILGICYG
MQYLVDFFGGVVACTNEQEFGKAILEITQDSVIFEGVKIKSLVWMSHMDKVIELPKGFTTLAKSPNSPHCAIENAKIFGL
QFHPEVIQSEEGGKILENFALLVCGCEKTWGMQHFAQKEMARLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAV
FVDHGLLRKNEKEKVQAMFKDLQIPLNTIDAKEIFLSKLKGVSEPELKRKIIGETFIEAFEKEAKKHHLKGKIEFLAQGT
LYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEVRLLGKELGISQDFLMRHPFPGPGLAIRILGEVS
ESKIRCLQEADFIFIEELKKANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
NRITNEVSGINRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=545, Percent_Identity=35.2293577981651, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1788854, Length=519, Percent_Identity=50.6743737957611, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1787517, Length=181, Percent_Identity=29.8342541436464, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992717, Length=566, Percent_Identity=33.5689045936396, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI133901714, Length=566, Percent_Identity=33.5689045936396, Blast_Score=272, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71992710, Length=566, Percent_Identity=33.5689045936396, Blast_Score=271, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6323873, Length=514, Percent_Identity=56.420233463035, Blast_Score=555, Evalue=1e-159,
Organism=Drosophila melanogaster, GI281365319, Length=546, Percent_Identity=35.1648351648352, Blast_Score=270, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56840; Mature: 56840

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDA
CEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCC
YKPSKKIFDLDLPILGICYGMQYLVDFFGGVVACTNEQEFGKAILEITQDSVIFEGVKIK
CCCCCCEEECCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCHHHCCCCHHH
SLVWMSHMDKVIELPKGFTTLAKSPNSPHCAIENAKIFGLQFHPEVIQSEEGGKILENFA
HHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCCEEEEEEECHHHHCCCCCCHHHHHHE
LLVCGCEKTWGMQHFAQKEMARLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAV
EEEECCCHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEE
FVDHGLLRKNEKEKVQAMFKDLQIPLNTIDAKEIFLSKLKGVSEPELKRKIIGETFIEAF
EECCHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EKEAKKHHLKGKIEFLAQGTLYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLR
HHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHH
ELFKDEVRLLGKELGISQDFLMRHPFPGPGLAIRILGEVSESKIRCLQEADFIFIEELKK
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHH
ANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
NRITNEVSGINRVVYDITSKPPGTIEWE
HHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESIENIQKKAPKGLILSGGPASVYAKDA
CEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCC
YKPSKKIFDLDLPILGICYGMQYLVDFFGGVVACTNEQEFGKAILEITQDSVIFEGVKIK
CCCCCCEEECCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCHHHCCCCHHH
SLVWMSHMDKVIELPKGFTTLAKSPNSPHCAIENAKIFGLQFHPEVIQSEEGGKILENFA
HHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCCEEEEEEECHHHHCCCCCCHHHHHHE
LLVCGCEKTWGMQHFAQKEMARLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAV
EEEECCCHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEE
FVDHGLLRKNEKEKVQAMFKDLQIPLNTIDAKEIFLSKLKGVSEPELKRKIIGETFIEAF
EECCHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EKEAKKHHLKGKIEFLAQGTLYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLR
HHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHH
ELFKDEVRLLGKELGISQDFLMRHPFPGPGLAIRILGEVSESKIRCLQEADFIFIEELKK
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHH
ANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVS
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
NRITNEVSGINRVVYDITSKPPGTIEWE
HHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA