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The map label for this gene is uvrD [H]

Identifier: 188527736

GI number: 188527736

Start: 944730

End: 946760

Strand: Direct

Name: uvrD [H]

Synonym: HPSH_04795

Alternate gene names: 188527736

Gene position: 944730-946760 (Clockwise)

Preceding gene: 188527735

Following gene: 188527737

Centisome position: 58.73

GC content: 40.13

Gene sequence:

>2031_bases
TTGTTAGAAACTTTGCAATTAAACCCTGAGCAATTAAAAGCGGCCAAGGCTTTGAAAGGGTATAATTTAGTGATTGCGAG
CGCTGGCACAGGAAAGACTTCTACGATTGTGGGGCGCATTTTATACCTGCTTGATAACGGCATCAAGCCTGAAGAAATCT
TGCTTTTGACTTTCACCAATAAAGCGAGTAATGAAATGATCGCTAGGGTGGCTAAATATTCCAAGTTAAGCTCCAAAATT
GAAGCGGGCACTTTCCATGCGGTGGCGTATCGCTATTTAAAAGAGCATTACCCCAATTTAAGCCTAAAGCAACCTAAAGA
ATTGAAAAAACTTTTAGAAAGCATTGTGGATACTAAAAACGCGCTAACAGATGACGATAAAAAGCCCTACACTTCGCAGC
ATCTCTACGCCCTCTATTCTCTTTATACCAACGCTCTAAAACAAGAAGATTTTAGTGCATGGCTTTCTAATAAAAACCCT
GAACACACGCCATACGCCGCCTTTTATGAAAACATTTTAGACGAATTTGAAAACACTAAAAAAAAGCATAATTATATTGA
CTATAACGACTTACTGCTGTTGTTTAAACAAGCGATGCTAGAAAGACCTAGCCCTTATAAAGAAGTGCTTTGCGATGAGT
TTCAAGACACTAACCCCTTACAAGAATCCATTTTAGACGCTATCAACCCTCCCAGTTTGTTTTGCGTGGGCGATTACGAT
CAGAGCATTTACGCTTTTAATGGGGCGGATATTTCTATCATTTCTAATTTCACTCAAAAATACAAAAACGCCCAGGTTTT
CACGCTCACCAAAAACTACCGCTCTTCTAAAGAGATTTTAGATCTCGCTAATCAAGTGATACAACACAACGAGCGCATTT
ACCCTAAAAATTTAGAAGTGGTGAAATCAGGGCATTTCAATAAGCCCGCGCTTTTAAATTACAACGACAATATCGCGCAA
TGCCAAGACATCGCTAAACGCATTGTCATGCGAAAGGATTTTAAAGAAGTGGCAGTGATTTTTAGGAATAACGCGAGCGC
GGATCAATTAGAAGCCGCTTTAAGATCCCACAATGTGCCAAGCAAAAGAAAAGGGAGCGCAAGCTTCTTTGAATCCAAAG
AAGTGGCGTTAGCGTTAGACATTTGCGCGCTCATCTTTAACCCTAAAGACATTATGGCAGCAATCCATGTTTTAAGCCAT
ATCAGCGATATTGGCTCTAACACCGCTAAAGACATTCATGAGGCCTTAATGCTTTTAGGCAATGGCGATCTCAAATTAGC
CCTAACCCACCCTAATAAAGAAGCCAAAATTTACACCAAGAAAAAAGAAATCACCTCTATGGGGCTTTTTGAAGAAATTT
TTGCCCTAGAAAACAGCTCAAGGTTTAATAGCGTGATAGATAAAGCGTTTCATTCGCACCCGGTGTTGATGCACCCTAAA
ATCTCACTCAATGGGGCTAAAATGCTTAGCGATTTTTTCATTCTTTATACCAAAGCCCCTACCCATTCCCCTAGCGCTTT
AATCAAACACATCCTAGAAAGCGTGTTTTTTCAAACCTTTAAAACACGCCTTTTAAAAGAGCGATCCAAGAATAAGGACG
GCTCTTATAACGAATTTAAAAAACTCCAAGCGCAAAAACGCTTCAATGAAAAAATGGATTTGCTGAGTTCTTTGGCGAAA
AATTACCAGAATTTAGGGCGTTTTTTAAACGGCACTTTAATAGGCTCTAGTGAAGCCACGCAAGGCGAGGGCGTGAATTT
ATTGAGCGTGCATGCTTCTAAAGGCTTGGAATTTAAAGATGTTTATATTATCGATTTAATGGAGGGCCGTTTCCCTAACC
ACAAGCTCATGAATACCGGTGGGGGCATTGAAGAAGAGCGGCGGCTTTTTTATGTCGCTATCACAAGGGCTAAGGAAAAT
TTATGGCTTTCTTATGCGAAAAACGAATTGAGAGAAAACGCCAAACCTAAAGAGCATAAGCCCTCGGTGTTTTTGTATGA
AGCGGGGCTTTTGAAACCCGATTTAAAATAA

Upstream 100 bases:

>100_bases
GGCAAGAATTAGGCTTTGTGTGCGATGGGCGTTTTTTGTTTTCGCAACGCTCTTTAGAAAACGCTCTTTTGCCTAAAGAT
TTTTTAAATGAGGATAAAAC

Downstream 100 bases:

>100_bases
AATTGGTTTTTGTGTTGTTTGTTTAAAACGCTAGCAATCATAGATTTTAGCTCTAGCTTGCGCTAGAGCCAAAATTTTAG
TATAATGGCGTTGTGAGGAC

Product: rep helicase, single-stranded DNA-dependent ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MLETLQLNPEQLKAAKALKGYNLVIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTNKASNEMIARVAKYSKLSSKI
EAGTFHAVAYRYLKEHYPNLSLKQPKELKKLLESIVDTKNALTDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNP
EHTPYAAFYENILDEFENTKKKHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYD
QSIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQHNERIYPKNLEVVKSGHFNKPALLNYNDNIAQ
CQDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSHNVPSKRKGSASFFESKEVALALDICALIFNPKDIMAAIHVLSH
ISDIGSNTAKDIHEALMLLGNGDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPK
ISLNGAKMLSDFFILYTKAPTHSPSALIKHILESVFFQTFKTRLLKERSKNKDGSYNEFKKLQAQKRFNEKMDLLSSLAK
NYQNLGRFLNGTLIGSSEATQGEGVNLLSVHASKGLEFKDVYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKEN
LWLSYAKNELRENAKPKEHKPSVFLYEAGLLKPDLK

Sequences:

>Translated_676_residues
MLETLQLNPEQLKAAKALKGYNLVIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTNKASNEMIARVAKYSKLSSKI
EAGTFHAVAYRYLKEHYPNLSLKQPKELKKLLESIVDTKNALTDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNP
EHTPYAAFYENILDEFENTKKKHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYD
QSIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQHNERIYPKNLEVVKSGHFNKPALLNYNDNIAQ
CQDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSHNVPSKRKGSASFFESKEVALALDICALIFNPKDIMAAIHVLSH
ISDIGSNTAKDIHEALMLLGNGDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPK
ISLNGAKMLSDFFILYTKAPTHSPSALIKHILESVFFQTFKTRLLKERSKNKDGSYNEFKKLQAQKRFNEKMDLLSSLAK
NYQNLGRFLNGTLIGSSEATQGEGVNLLSVHASKGLEFKDVYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKEN
LWLSYAKNELRENAKPKEHKPSVFLYEAGLLKPDLK
>Mature_676_residues
MLETLQLNPEQLKAAKALKGYNLVIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTNKASNEMIARVAKYSKLSSKI
EAGTFHAVAYRYLKEHYPNLSLKQPKELKKLLESIVDTKNALTDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNP
EHTPYAAFYENILDEFENTKKKHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYD
QSIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQHNERIYPKNLEVVKSGHFNKPALLNYNDNIAQ
CQDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSHNVPSKRKGSASFFESKEVALALDICALIFNPKDIMAAIHVLSH
ISDIGSNTAKDIHEALMLLGNGDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPK
ISLNGAKMLSDFFILYTKAPTHSPSALIKHILESVFFQTFKTRLLKERSKNKDGSYNEFKKLQAQKRFNEKMDLLSSLAK
NYQNLGRFLNGTLIGSSEATQGEGVNLLSVHASKGLEFKDVYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKEN
LWLSYAKNELRENAKPKEHKPSVFLYEAGLLKPDLK

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=695, Percent_Identity=28.0575539568345, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI48994965, Length=694, Percent_Identity=27.0893371757925, Blast_Score=169, Evalue=7e-43,
Organism=Escherichia coli, GI1787196, Length=371, Percent_Identity=25.0673854447439, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322369, Length=469, Percent_Identity=27.5053304904051, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324477, Length=490, Percent_Identity=24.4897959183673, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 76767; Mature: 76767

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETLQLNPEQLKAAKALKGYNLVIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTN
CCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECC
KASNEMIARVAKYSKLSSKIEAGTFHAVAYRYLKEHYPNLSLKQPKELKKLLESIVDTKN
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ALTDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNPEHTPYAAFYENILDEFENTK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KKHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYD
HHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCC
QSIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQHNERIYPKNLEV
CCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHH
VKSGHFNKPALLNYNDNIAQCQDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSHNVP
HCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
SKRKGSASFFESKEVALALDICALIFNPKDIMAAIHVLSHISDIGSNTAKDIHEALMLLG
CCCCCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
NGDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPK
CCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCC
ISLNGAKMLSDFFILYTKAPTHSPSALIKHILESVFFQTFKTRLLKERSKNKDGSYNEFK
CCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KLQAQKRFNEKMDLLSSLAKNYQNLGRFLNGTLIGSSEATQGEGVNLLSVHASKGLEFKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEEECCCCCCCCC
VYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKENLWLSYAKNELRENAKPKEHK
EEEEEEECCCCCCCCEECCCCCCCHHCEEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCC
PSVFLYEAGLLKPDLK
CCEEEEECCCCCCCCC
>Mature Secondary Structure
MLETLQLNPEQLKAAKALKGYNLVIASAGTGKTSTIVGRILYLLDNGIKPEEILLLTFTN
CCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECC
KASNEMIARVAKYSKLSSKIEAGTFHAVAYRYLKEHYPNLSLKQPKELKKLLESIVDTKN
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ALTDDDKKPYTSQHLYALYSLYTNALKQEDFSAWLSNKNPEHTPYAAFYENILDEFENTK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KKHNYIDYNDLLLLFKQAMLERPSPYKEVLCDEFQDTNPLQESILDAINPPSLFCVGDYD
HHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCC
QSIYAFNGADISIISNFTQKYKNAQVFTLTKNYRSSKEILDLANQVIQHNERIYPKNLEV
CCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHH
VKSGHFNKPALLNYNDNIAQCQDIAKRIVMRKDFKEVAVIFRNNASADQLEAALRSHNVP
HCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
SKRKGSASFFESKEVALALDICALIFNPKDIMAAIHVLSHISDIGSNTAKDIHEALMLLG
CCCCCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
NGDLKLALTHPNKEAKIYTKKKEITSMGLFEEIFALENSSRFNSVIDKAFHSHPVLMHPK
CCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCC
ISLNGAKMLSDFFILYTKAPTHSPSALIKHILESVFFQTFKTRLLKERSKNKDGSYNEFK
CCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KLQAQKRFNEKMDLLSSLAKNYQNLGRFLNGTLIGSSEATQGEGVNLLSVHASKGLEFKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEEECCCCCCCCC
VYIIDLMEGRFPNHKLMNTGGGIEEERRLFYVAITRAKENLWLSYAKNELRENAKPKEHK
EEEEEEECCCCCCCCEECCCCCCCHHCEEEEEEEEECHHHHHHHHHHHHHHHCCCCCCCC
PSVFLYEAGLLKPDLK
CCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]