Definition Helicobacter pylori Shi470, complete genome.
Accession NC_010698
Length 1,608,548

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The map label for this gene is gyrB

Identifier: 188527660

GI number: 188527660

Start: 860900

End: 863221

Strand: Reverse

Name: gyrB

Synonym: HPSH_04410

Alternate gene names: 188527660

Gene position: 863221-860900 (Counterclockwise)

Preceding gene: 188527661

Following gene: 188527659

Centisome position: 53.66

GC content: 40.53

Gene sequence:

>2322_bases
ATGCAAAATTACCAGAGCCATAGTATCAAGGTTTTAAAAGGCTTAGAGGGGGTTAGGAAACGCCCTGGAATGTATATTGG
CGATACCAATGTGGGTGGGTTGCACCACATGGTGTATGAAGTCGTGGATAACGCTGTAGATGAGAGCATGGCGGGTTTTT
GCGATACGATTAATATCACTTTGACTGATGAGGGTTCATGCATTGTAGAAGATAACGGGCGAGGCATTCCTGTAGATATT
CACCCCACGGAAAAAATCCCCGCTTGCACCGTGGTTTTAACGATTTTGCATGCGGGAGGCAAGTTTGATAATGATACTTA
TAAAGTTTCAGGCGGTTTGCATGGCGTGGGCGTTTCGGTTGTGAACGCTTTAAGCAAACGCTTGATTATGACCATTAAAA
AAGAGGGTCAAATCTATCGCCAGGAGTTTGAAAAGGGTATCCCCATTAGCGAGCTTGAAATCATTGGCAAAACCAAAAGC
GCTAAAGAAAGCGGCACAACTATTGAATTTTTCCCTGATGAGAGCGTGATGGAAGTCGTTGAATTTCAAGCGGATATTTT
ACAAAAACGCTTCAAAGAAATGGCGTATCTTAACGACGGCTTAAAAATTTCTTTCAAAGAAGAAAAAACCCAGTTGCAAG
AGACTTATTTCTATGAAGACGGCTTGAAACAATTCGTTAAAGACAGCGCTAAAAAGGAATTGCTCACCCCCATTATTTCG
TTTAAAAGCATGGATGAAGAAACGCGCACTTCTATAGAAGTCGCTCTAGCGTATGCTGATGATTACAATGAAAACACTTT
AAGCTTTGTGAATAACATTAAAACTTCTGAGGGCGGCACGCATGAAGCGGGCTTTAAAATGGGCTTGTCTAAGGCGATTT
TACAATATATTGATGGAAACATTAAGACAAGAGAATCCCGCCCCATCTCTGAAGACATTAAAGAGGGCTTGATTGCGGTC
GTGAGCTTGAAAATGAGCGAGCCTTTATTTGAAGGGCAGACTAAATCCAAACTCGGTAGTTCGTATGCGCGCGCGTTGGT
TTCAAAATTAGTCTATGATAAAATCCATCAATTTTTAGAAGAAAACCCTAACGAAGCCAAAATCATTGCCAATAAAGCCC
TTTTAGCCGCAAAAGCCAGAGAAGCCAGTAAGAAAGCCAGAGAGCTTACAAGGAAAAAAGATAATTTGAGTGTCGGCACT
TTGCCTGGAAAATTAGCCGATTGCCAGAGTAAAGATCCTTTAGAGAGTGAAATTTTTTTAGTGGAGGGCGATAGTGCAGG
CGGTAGCGCTAAACAAGGGCGCGATAGGGTTTTCCAAGCGATCTTGCCTTTAAAAGGTAAGATTTTAAATGTGGAAAAAA
GCCATTTGTCAAAAATCCTAAAATCAGAAGAGATTAAAAACATGATCACGGCTTTTGGGTGTGGCATTCAAGAGAGTTTT
GATATAGAAAGATTGCGCTATCATAAAATCATTATCATGACCGATGCTGATGTGGATGGGAGCCATATCCAAACCTTGCT
GATGACTTTTTTCTATCGTTATTTGCGCCCGCTGATTGAACAAGGGCATGTTTATATCGCTCAAGCCCCTCTTTACAAAT
ACAAGAAAGGCAAGACAGAAATCTATCTTAAAGACAGCGTGGCTTTGGATCATTTCTTAATTGAGCATGGCATCAATTCG
GTGGATATTGAAGGGATTGGCAAGAACGATTTGATGAATTTGTTAAAAGTGGCGCGCCATTACCGCTACGCGCTTTTGGA
ATTAGAAAAACGCTACAATTTGCTAGAAATTTTACGCTTTTTGATTGAAACTAAGGACGCCTTAAGCTTTGATATGAAAA
TTTTAGAAAAAAGCATTTTGGAAAAATTAGAGGGCTTGAATTATCAGATCTTACGCTCTTTTGCTACTGAAGAGAGCTTG
CATTTGCACGCGCAAACCCCTAAAGGCTTGGTGGAATTTAACCTAGATGACAACCTCTTTAAAGAGGTGTTGTTTGAAGA
AGCGAATTACACTTACCAAAAGCTTATGGAGTATAATTTAGACTTCTTAGAAAATAAGGATATTTTGGCGTTTTTAGAAG
AAGTGGAAAATCATGCTAAAAAGGGAGCGAATATCCAGCGCTATAAGGGGCTAGGCGAGATGAACCCCAATGATTTGTGG
GAAACGACCATGCATAAAGAAAACCGCAGCTTAATCAAACTCAAAATTGAAGATTTAGAAAAAACCGATGCAGTCTTTTC
GCTTTGCATGGGCGATGAGGTAGAGCCTAGAAGAGCCTTTATCCAAGCGCATGCTAAAGATGTGAAGCAGCTAGATGTGT
AA

Upstream 100 bases:

>100_bases
CGCCTTTTTTGATCCAAGAGTCTCTTGATGAAAAGCAAAGCCATTTGAACGCTAAAATTTCCACTTTGATGATGCCAATC
ACACTATAAAGGCTGATTGA

Downstream 100 bases:

>100_bases
GGGATTTTGATTAGAACCCCTAAACATTTAAATAAGCGAGAGAGCGTGAATTTAGGGGCTTATTACACGCCTTGTTATTG
AGCGTGGGGAAACGCTAGGC

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINITLTDEGSCIVEDNGRGIPVDI
HPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKS
AKESGTTIEFFPDESVMEVVEFQADILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIIS
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDGNIKTRESRPISEDIKEGLIAV
VSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGT
LPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINS
VDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSFDMKILEKSILEKLEGLNYQILRSFATEESL
HLHAQTPKGLVEFNLDDNLFKEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV

Sequences:

>Translated_773_residues
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINITLTDEGSCIVEDNGRGIPVDI
HPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKS
AKESGTTIEFFPDESVMEVVEFQADILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIIS
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDGNIKTRESRPISEDIKEGLIAV
VSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGT
LPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINS
VDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSFDMKILEKSILEKLEGLNYQILRSFATEESL
HLHAQTPKGLVEFNLDDNLFKEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV
>Mature_773_residues
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINITLTDEGSCIVEDNGRGIPVDI
HPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKS
AKESGTTIEFFPDESVMEVVEFQADILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIIS
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDGNIKTRESRPISEDIKEGLIAV
VSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGT
LPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINS
VDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSFDMKILEKSILEKLEGLNYQILRSFATEESL
HLHAQTPKGLVEFNLDDNLFKEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=576, Percent_Identity=27.0833333333333, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI19913406, Length=583, Percent_Identity=25.3859348198971, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI48994957, Length=816, Percent_Identity=43.75, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=544, Percent_Identity=42.0955882352941, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI212645845, Length=501, Percent_Identity=27.5449101796407, Blast_Score=139, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17535065, Length=560, Percent_Identity=26.7857142857143, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI212645657, Length=144, Percent_Identity=31.25, Blast_Score=73, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=568, Percent_Identity=28.169014084507, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17136538, Length=504, Percent_Identity=26.7857142857143, Blast_Score=124, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 87486; Mature: 87486

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINIT
CCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LTDEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSV
EECCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
VNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKSAKESGTTIEFFPDESVMEVV
HHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHEECCCCCCCCCCCEEEECCCHHHHHHH
EFQADILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIIS
HHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDGN
HHCCCHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
IKTRESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFL
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEE
VEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
EECCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTE
CHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCEE
IYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRF
EEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LIETKDALSFDMKILEKSILEKLEGLNYQILRSFATEESLHLHAQTPKGLVEFNLDDNLF
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCEEECCCHHHH
KEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
HHHHHHHCCHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHH
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINIT
CCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LTDEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSV
EECCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
VNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKSAKESGTTIEFFPDESVMEVV
HHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHEECCCCCCCCCCCEEEECCCHHHHHHH
EFQADILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIIS
HHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDGN
HHCCCHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
IKTRESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFL
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEE
VEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
EECCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTE
CHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCEE
IYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRF
EEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LIETKDALSFDMKILEKSILEKLEGLNYQILRSFATEESLHLHAQTPKGLVEFNLDDNLF
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCEEECCCHHHH
KEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
HHHHHHHCCHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHH
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]