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The map label for this gene is hslU

Identifier: 188527647

GI number: 188527647

Start: 847886

End: 849217

Strand: Reverse

Name: hslU

Synonym: HPSH_04345

Alternate gene names: 188527647

Gene position: 849217-847886 (Counterclockwise)

Preceding gene: 188527648

Following gene: 188527646

Centisome position: 52.79

GC content: 38.81

Gene sequence:

>1332_bases
ATGTCTGAATTGAATATGACCCCAAGAGAAATTGTCGCTTATTTAGATGAATACATCATTGGGCAAAAGGAAGCTAAAAA
GTCTATCGCTATCGCTTTTAGGAATCGTTACAGGCGTTTGCAGCTGGAAAAATCCTTACAAGAAGAAATCACGCCTAAAA
ACATTTTAATGATTGGATCTACTGGCGTGGGTAAAACTGAAATCGCAAGAAGAATAGCAAAAATCATGAAACTCCCCTTT
GTGAAAGTGGAAGCGAGCAAATACACAGAAGTGGGTTTTGTGGGGCGCGATGTGGAGTCTATGGTAAGGGATTTAGTCAA
TAACAGCGTGCTTTTAGTGGAAAATGAGCATAAAGAAAAACTAAAAGACAAGATTGAAGAAGCGGTTATAGAAAAAATCG
CTAAAAAACTCCTACCCCCCTTGCCTAATGGGGTGAGCGAAGAAAAAAAACAAGAATACGCTAACAGCCTTTTAAAAATG
CAACAAAGAATCGTGCAAGGCGAGTTGGATAGCCGAGAAATTGAAATTGAAGTGCGTAAAAAAAGCATAGAGATTGATTC
TAATGTGCCGCCTGAAATTTTAAGGGTTCAAGAAAATGTGATTAAGTTTTTCCATAAAGAACAGGATAAAGTCAAAAAAA
CTTTAAGCGTTAAAGAGGCTAAAGAAGCCCTAAAGGCAGAAATTAGCGACACGCTTTTAGATGGCGAAGCCATTAAAATG
GAAGGCTTGAAGCGCGCGGAAAGTTCAGGGGTGATTTTTATTGATGAAATTGATAAGATCGCTGTAAGCTCTAAAGAAGG
AGGCCGTCAAGATCCCAGTAAAGAGGGGGTTCAAAGGGATTTATTGCCGATTGTAGAGGGGAGTGTGGTGAATACGAAGT
ATGGTCCTATTAAAACAGAGCATATTTTATTCATTGCAGCGGGGGCTTTTCATCTTTCTAAGCCAAGCGATCTCATCCCT
GAATTGCAGGGGCGTTTCCCTTTAAGGGTGGAGTTAGAGAGTTTAACCGAAGAAATCATGTATATGATTTTAACCCAAAC
TAAAACTTCTATCATCAAGCAATACCAAGCCCTTTTAAAAGTGGAAGGCGTAGGAATTGCGTTTGAAGACAATGCGATCA
AAGAGTTAGCCAAACTTTCTTATAACGCCAATCAAAAAAGCGAAGATATAGGCGCTAGAAGGTTGCACACCACCATTGAA
AAAGTGCTAGAAGACATTAGTTTTGAAGCGGAGAATTATTCTGGGCAAAATGTTACTATCACTAAAGAGTTGGTCCAATC
AAAGCTAGAGGATTTAGTGGCTGATGAAAATTTAGTGAAGTATATTTTATAA

Upstream 100 bases:

>100_bases
TCGCTCATTTAGAGCCTAGAAAACTTGTAGAAGAGTCCTTAAAAATCGCAGGAGATCTTTGCATTTACACCAACACGAAT
ATTAAAATTTTGGAGCTTTA

Downstream 100 bases:

>100_bases
TGAAAACTAAGGCGGGCTTTGTAGCTCTTATAGGCAAACCAAACGCTGGAAAAAGCACTCTTTTAAACACTTTATTAAAC
GCTCATTTAGCCCTCGTTTC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSELNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGSTGVGKTEIARRIAKIMKLPF
VKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEKLKDKIEEAVIEKIAKKLLPPLPNGVSEEKKQEYANSLLKM
QQRIVQGELDSREIEIEVRKKSIEIDSNVPPEILRVQENVIKFFHKEQDKVKKTLSVKEAKEALKAEISDTLLDGEAIKM
EGLKRAESSGVIFIDEIDKIAVSSKEGGRQDPSKEGVQRDLLPIVEGSVVNTKYGPIKTEHILFIAAGAFHLSKPSDLIP
ELQGRFPLRVELESLTEEIMYMILTQTKTSIIKQYQALLKVEGVGIAFEDNAIKELAKLSYNANQKSEDIGARRLHTTIE
KVLEDISFEAENYSGQNVTITKELVQSKLEDLVADENLVKYIL

Sequences:

>Translated_443_residues
MSELNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGSTGVGKTEIARRIAKIMKLPF
VKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEKLKDKIEEAVIEKIAKKLLPPLPNGVSEEKKQEYANSLLKM
QQRIVQGELDSREIEIEVRKKSIEIDSNVPPEILRVQENVIKFFHKEQDKVKKTLSVKEAKEALKAEISDTLLDGEAIKM
EGLKRAESSGVIFIDEIDKIAVSSKEGGRQDPSKEGVQRDLLPIVEGSVVNTKYGPIKTEHILFIAAGAFHLSKPSDLIP
ELQGRFPLRVELESLTEEIMYMILTQTKTSIIKQYQALLKVEGVGIAFEDNAIKELAKLSYNANQKSEDIGARRLHTTIE
KVLEDISFEAENYSGQNVTITKELVQSKLEDLVADENLVKYIL
>Mature_442_residues
SELNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGSTGVGKTEIARRIAKIMKLPFV
KVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEKLKDKIEEAVIEKIAKKLLPPLPNGVSEEKKQEYANSLLKMQ
QRIVQGELDSREIEIEVRKKSIEIDSNVPPEILRVQENVIKFFHKEQDKVKKTLSVKEAKEALKAEISDTLLDGEAIKME
GLKRAESSGVIFIDEIDKIAVSSKEGGRQDPSKEGVQRDLLPIVEGSVVNTKYGPIKTEHILFIAAGAFHLSKPSDLIPE
LQGRFPLRVELESLTEEIMYMILTQTKTSIIKQYQALLKVEGVGIAFEDNAIKELAKLSYNANQKSEDIGARRLHTTIEK
VLEDISFEAENYSGQNVTITKELVQSKLEDLVADENLVKYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=113, Percent_Identity=35.3982300884956, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790366, Length=446, Percent_Identity=47.7578475336323, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1786642, Length=156, Percent_Identity=38.4615384615385, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 50103; Mature: 49971

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGS
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
TGVGKTEIARRIAKIMKLPFVKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEK
CCCCHHHHHHHHHHHHHCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCCEEEEECCHHHH
LKDKIEEAVIEKIAKKLLPPLPNGVSEEKKQEYANSLLKMQQRIVQGELDSREIEIEVRK
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
KSIEIDSNVPPEILRVQENVIKFFHKEQDKVKKTLSVKEAKEALKAEISDTLLDGEAIKM
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
EGLKRAESSGVIFIDEIDKIAVSSKEGGRQDPSKEGVQRDLLPIVEGSVVNTKYGPIKTE
HHHHHCCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCC
HILFIAAGAFHLSKPSDLIPELQGRFPLRVELESLTEEIMYMILTQTKTSIIKQYQALLK
EEEEEEECCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEGVGIAFEDNAIKELAKLSYNANQKSEDIGARRLHTTIEKVLEDISFEAENYSGQNVTI
HCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
TKELVQSKLEDLVADENLVKYIL
HHHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
SELNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGS
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
TGVGKTEIARRIAKIMKLPFVKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEK
CCCCHHHHHHHHHHHHHCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCCEEEEECCHHHH
LKDKIEEAVIEKIAKKLLPPLPNGVSEEKKQEYANSLLKMQQRIVQGELDSREIEIEVRK
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
KSIEIDSNVPPEILRVQENVIKFFHKEQDKVKKTLSVKEAKEALKAEISDTLLDGEAIKM
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
EGLKRAESSGVIFIDEIDKIAVSSKEGGRQDPSKEGVQRDLLPIVEGSVVNTKYGPIKTE
HHHHHCCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCC
HILFIAAGAFHLSKPSDLIPELQGRFPLRVELESLTEEIMYMILTQTKTSIIKQYQALLK
EEEEEEECCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEGVGIAFEDNAIKELAKLSYNANQKSEDIGARRLHTTIEKVLEDISFEAENYSGQNVTI
HCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
TKELVQSKLEDLVADENLVKYIL
HHHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA