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The map label for this gene is apt [H]

Identifier: 188527581

GI number: 188527581

Start: 783739

End: 784278

Strand: Direct

Name: apt [H]

Synonym: HPSH_04015

Alternate gene names: 188527581

Gene position: 783739-784278 (Clockwise)

Preceding gene: 188527580

Following gene: 188527582

Centisome position: 48.72

GC content: 43.15

Gene sequence:

>540_bases
ATGAATGAAACGCTTAAAGAAGAACTTTTACAAAGCATCAGAGAAGTGAAAGACTACCCTAAAAAAGGGATTTTATTCAA
AGACATTACCACACTACTAAACTACCCTAAACTCTTTAACAAACTCATTGACGCGCTCAAAAAACGCTATCTCGCTCTCA
ATATAGACTTTATCGTGGGCATTGAAGCGAGAGGGTTTATTTTAGGCTCTGCTCTCGCTTATGCGCTTGGGGTGGGTTTT
GTGCCTGTAAGGAAAAAGGGCAAACTCCCCGCGCACACCCTATCTCAAAGCTACAGCCTAGAATATGGGAGCGACAGCAT
AGAAATCCACTCCGACGCTTTTAGGGGGGTTAAGGGGGTAAGGGTGGTGTTAATTGACGATTTATTAGCCACTGGAGGCA
CAGCTTTAGCGAGCCTTGAGCTTATCAAAGCCCTACAAGCCGAATGCATAGAAGCATGCTTTTTGATAGGGTTAAAAGAA
TTACCGGGTATCCAACTTTTAGAAGAGCGAGTGAAAACCTTTTGTTTGTTAGAGTGCTAG

Upstream 100 bases:

>100_bases
TCGTATTAAAGAATTGGAGCAAAAAATAGAAGCTCTCCTTTAAAAACGCTATAATAAATCAAAATTCTACAACCAATCAG
TTATATTAAAGGATATTAAA

Downstream 100 bases:

>100_bases
AATAAGGGTGAATTTTGGAAGAATACATCATTAACTTATGGAATCAGCATGCAGCGACTTGGGGGTATCTCATTTTGTTT
GGGTGGAGCATTTTAGAAGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDALKKRYLALNIDFIVGIEARGFILGSALAYALGVGF
VPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGVKGVRVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKE
LPGIQLLEERVKTFCLLEC

Sequences:

>Translated_179_residues
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDALKKRYLALNIDFIVGIEARGFILGSALAYALGVGF
VPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGVKGVRVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKE
LPGIQLLEERVKTFCLLEC
>Mature_179_residues
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDALKKRYLALNIDFIVGIEARGFILGSALAYALGVGF
VPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGVKGVRVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKE
LPGIQLLEERVKTFCLLEC

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=45.6140350877193, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=47.2, Blast_Score=111, Evalue=3e-25,
Organism=Escherichia coli, GI1786675, Length=172, Percent_Identity=50, Blast_Score=166, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17509087, Length=163, Percent_Identity=46.6257668711656, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=174, Percent_Identity=43.1034482758621, Blast_Score=124, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=167, Percent_Identity=37.125748502994, Blast_Score=98, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17136334, Length=166, Percent_Identity=38.5542168674699, Blast_Score=106, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19802; Mature: 19802

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDALKKRYLALNIDFIVG
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEE
IEARGFILGSALAYALGVGFVPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGVKGV
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECHHHHCCCCCE
RVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKELPGIQLLEERVKTFCLLEC
EEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNETLKEELLQSIREVKDYPKKGILFKDITTLLNYPKLFNKLIDALKKRYLALNIDFIVG
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEEEEEE
IEARGFILGSALAYALGVGFVPVRKKGKLPAHTLSQSYSLEYGSDSIEIHSDAFRGVKGV
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECHHHHCCCCCE
RVVLIDDLLATGGTALASLELIKALQAECIEACFLIGLKELPGIQLLEERVKTFCLLEC
EEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA