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The map label for this gene is glmU

Identifier: 188527472

GI number: 188527472

Start: 659800

End: 661059

Strand: Direct

Name: glmU

Synonym: HPSH_03450

Alternate gene names: 188527472

Gene position: 659800-661059 (Clockwise)

Preceding gene: 188527469

Following gene: 188527473

Centisome position: 41.02

GC content: 42.3

Gene sequence:

>1260_bases
ATGCATTCTAGCCTGCCTAAAACTTTACACACGATTTGCGGGGAGCCTATGTTGTTTTACATTTTAGAAACGGCTTTTTC
AATCAGCGATGATGTGCATCTTATCTTGCACCACCAACAAGAACGCATTAAAGAAGCGGTGTTGAAGCGTTTTAAGGGCG
TGATTTTCCACACTCAAATCGTGGAAAAATATTCAGGGACAGGTGGGGCCATCATGCAAGAAGATAAAACGCCTATCCCC
ACTCAACATGAGCGGGTTTTGATTTTGAATGCGGACATGCCTTTGATCACTAAAGACGCTCTCACCCCCTTATTAGAAAG
CCACAATAACGCTATAGGCTTCCTCCATTTGGCTGACCCTAAAGGTTATGGGCGCGTTGTTTTAGAAAACCATCAGGTTA
AAAAGATTGTAGAAGAAAAGGACGCTAATACCAAAGAAAAAGAAATTAAAAGCGTGAATGCTGGCGTGTATGGGTTTGAA
AGGGAGTTTTTAGAAAAATACTTACCCAAGCTCCATGATCAAAACGCCCAAAAAGAATACTACCTCACGGATTTAATCGC
TCTAGGAATCAACGAAAACGAAACAATTGACGCTATTTTTTTAGAAGAAGAGTGCTTTTTAGGGGTGAATAGCCAAACAG
AAAGGGCGAAGGCTGAAGAAATCATGCTAGAAAGACTGCGAAAAAACGCCATGGACTTGGGGGTAGTGATGCAATTGCCT
AGTAGCGTTTATTTAGAAAAAGGCGTGAGTTTTAAGGGGGAGTGCGTTTTAGAGCAAGGGGTGCGTTTGAGTGGGAATTG
TTTGATAGAAAATGCACATATTAAGGCTTATAGCGTGATAGAAGAGAGCCAAATTGTTAATAGCAGTGTGGGGCCGTTTG
CCCATGTGCGCCCTAAAAGCGTGATTTGTAATAGCCATGTGGGGAATTTTGTAGAAACTAAAAACGCCAAACTTCAAGGC
GCTAAAGCAGGGCATTTGAGCTATTTAGGGGATTGTGAGATAGGGAAAAACACCAATGTAGGGGCTGGCGTGATCACTTG
CAATTATGATGGCAAAAACAAACACCAAACAATCATCGGTGAAAATGTCTTTATAGGGAGCGATAGCCAGCTAGTCGCCC
CAATCAATATCGGCTCTAATGTCTTAATCGGCAGCGGCACCACCATCACTAAAGACATTCCTAGCGGTTCGTTGAGCCTT
TCACGCGCCCCTCAAACTAACATTGAAAACGGGTATTTTAAGTTTTTTAAGAAATCTTAA

Upstream 100 bases:

>100_bases
AAGCCAAATTATAAGATAAGGCATGTTAAAATTCCCTAAAATAAGTTTAAGGATTTTAATGTTTTCTGTCATCATACTAG
CAGCTGGTAAAGGCACTCGC

Downstream 100 bases:

>100_bases
AGAGTTTGAAAAATCGCTTTTACAGAAAAAATTGCAATGTTTTAAAACTTTATTGAGCGTATTTTTAATGGATTAAAAAG
TCCTCTTTTTATTCTCAATC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MHSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEAVLKRFKGVIFHTQIVEKYSGTGGAIMQEDKTPIP
TQHERVLILNADMPLITKDALTPLLESHNNAIGFLHLADPKGYGRVVLENHQVKKIVEEKDANTKEKEIKSVNAGVYGFE
REFLEKYLPKLHDQNAQKEYYLTDLIALGINENETIDAIFLEEECFLGVNSQTERAKAEEIMLERLRKNAMDLGVVMQLP
SSVYLEKGVSFKGECVLEQGVRLSGNCLIENAHIKAYSVIEESQIVNSSVGPFAHVRPKSVICNSHVGNFVETKNAKLQG
AKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKNKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSL
SRAPQTNIENGYFKFFKKS

Sequences:

>Translated_419_residues
MHSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEAVLKRFKGVIFHTQIVEKYSGTGGAIMQEDKTPIP
TQHERVLILNADMPLITKDALTPLLESHNNAIGFLHLADPKGYGRVVLENHQVKKIVEEKDANTKEKEIKSVNAGVYGFE
REFLEKYLPKLHDQNAQKEYYLTDLIALGINENETIDAIFLEEECFLGVNSQTERAKAEEIMLERLRKNAMDLGVVMQLP
SSVYLEKGVSFKGECVLEQGVRLSGNCLIENAHIKAYSVIEESQIVNSSVGPFAHVRPKSVICNSHVGNFVETKNAKLQG
AKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKNKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSL
SRAPQTNIENGYFKFFKKS
>Mature_419_residues
MHSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEAVLKRFKGVIFHTQIVEKYSGTGGAIMQEDKTPIP
TQHERVLILNADMPLITKDALTPLLESHNNAIGFLHLADPKGYGRVVLENHQVKKIVEEKDANTKEKEIKSVNAGVYGFE
REFLEKYLPKLHDQNAQKEYYLTDLIALGINENETIDAIFLEEECFLGVNSQTERAKAEEIMLERLRKNAMDLGVVMQLP
SSVYLEKGVSFKGECVLEQGVRLSGNCLIENAHIKAYSVIEESQIVNSSVGPFAHVRPKSVICNSHVGNFVETKNAKLQG
AKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKNKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSL
SRAPQTNIENGYFKFFKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=444, Percent_Identity=36.7117117117117, Blast_Score=283, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 46363; Mature: 46363

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEAVLKRFKGVIFHTQI
CCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
VEKYSGTGGAIMQEDKTPIPTQHERVLILNADMPLITKDALTPLLESHNNAIGFLHLADP
HHHHCCCCCCEEECCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHCCCCEEEEEEEECC
KGYGRVVLENHQVKKIVEEKDANTKEKEIKSVNAGVYGFEREFLEKYLPKLHDQNAQKEY
CCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHH
YLTDLIALGINENETIDAIFLEEECFLGVNSQTERAKAEEIMLERLRKNAMDLGVVMQLP
EEEEEEEECCCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCC
SSVYLEKGVSFKGECVLEQGVRLSGNCLIENAHIKAYSVIEESQIVNSSVGPFAHVRPKS
CHHHHHCCCCCCCCEEEECCCEECCCEEEEECCEEEEEHHHHHHHHCCCCCCCCCCCCHH
VICNSHVGNFVETKNAKLQGAKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKNKHQTIIG
EEECCCCCCCEECCCCEECCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEEC
ENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSLSRAPQTNIENGYFKFFKKS
CEEEECCCCCEEEEEECCCEEEEECCCEEEECCCCCCCEECCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MHSSLPKTLHTICGEPMLFYILETAFSISDDVHLILHHQQERIKEAVLKRFKGVIFHTQI
CCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
VEKYSGTGGAIMQEDKTPIPTQHERVLILNADMPLITKDALTPLLESHNNAIGFLHLADP
HHHHCCCCCCEEECCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHCCCCEEEEEEEECC
KGYGRVVLENHQVKKIVEEKDANTKEKEIKSVNAGVYGFEREFLEKYLPKLHDQNAQKEY
CCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHH
YLTDLIALGINENETIDAIFLEEECFLGVNSQTERAKAEEIMLERLRKNAMDLGVVMQLP
EEEEEEEECCCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCC
SSVYLEKGVSFKGECVLEQGVRLSGNCLIENAHIKAYSVIEESQIVNSSVGPFAHVRPKS
CHHHHHCCCCCCCCEEEECCCEECCCEEEEECCEEEEEHHHHHHHHCCCCCCCCCCCCHH
VICNSHVGNFVETKNAKLQGAKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKNKHQTIIG
EEECCCCCCCEECCCCEECCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEEC
ENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSLSRAPQTNIENGYFKFFKKS
CEEEECCCCCEEEEEECCCEEEEECCCEEEECCCCCCCEECCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA