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The map label for this gene is dcuA [H]

Identifier: 188527431

GI number: 188527431

Start: 615029

End: 616360

Strand: Reverse

Name: dcuA [H]

Synonym: HPSH_03245

Alternate gene names: 188527431

Gene position: 616360-615029 (Counterclockwise)

Preceding gene: 188527433

Following gene: 188527420

Centisome position: 38.32

GC content: 44.52

Gene sequence:

>1332_bases
ATGGTGGATGCCTTTTTTCAAATTGCAGTGTTACTTTTTTCGCTTTTTTTAGGGGCAAGGCTAGGGGGTTTGGGAGTGGG
CTATGCGGGGGGTTTGGGCGTGCTTGTTTTATGCTTATTTTTGGGGCTAAATCCGGGTAAAATCCCTTTTGATGTGATTT
TAATCATCATGGCAGTCATTAGCGCTATTAGCGCGATGCAAAAAGCGGGGGGCTTGGATTACTTAGTCAAAATCGCTGAA
AAAATTTTAAGAAAACACCCCAAGCAAATCAACTATCTCGCGCCAAGCGTGGCGTATTGTTTAACGATACTAGCCGGCAC
TGGGCATACGGTTTTTTCCTTGATCCCGGTGATTGTGGAAGTGAGCCAGAGCCAAAACATCAAACCCAAAGCGCCTTTAA
GCTTAGCGGTAGTCTCTAGTCAAGTCGCTATTACTGCAAGCCCGGTGAGCGCGGCGGTGGTGTTTATGAGCGGTATTTTA
GAGCCTTTAGGGGCGGATTACTTGACCCTTTTAATGGTTTGGATCCCTACGACTTTTTTAGCATGCATGATCACGGCGTT
TGTTATGGGTTTTACTGATTTGAAATTAGACAGCGATCCAAATTATTTAGAGCGTTTGAAAGCAAGAAAAATTTCGCCCC
CTACCATCAAAGAAGAAAAAGAAACCTCAAAAAGCGCGAAATTATCGTTATGGATTTTTATCGGTGGGGTTGTAGCGATC
GTTTTTTACGCGAGCGCGATTTCTAAAAATATCGCTTTGATTAGCCCGGTGGTTTTAGGCAGAGATCATGCGATTGTGTC
TTTCATGTTGAGCGTGGCAACTTTAATTGTGCTTTTTTGCAAAATTAACGCTAATGAAATCGCTCATTCAAGCGTGTTTA
AATCCGGCATGCAAGCGTGCGTGTGCGTGTTAGGCGTGGCGTGGTTGGGCGATACTTTTGTGAGCAATCATTTAGATGAA
ATCAAGCGATACGCTTCTTTTTTGATTGCAGATTACCCGTTTTTATTAGCCGTAGCGCTCTTTTTGGCTTCCATGCTTTT
GTATTCGCAAGCTGCCACCTCTAAAGCGCTCATCCCAAGCGTGATCACAGCCTTAGGCATTAGCGCTAACCACACGGAGC
ATTTGTATATTATCGTGGCTTCTTTTGCGAGCGTTTCGGCGTTGTTTGTGTTACCCACTTACCCCACTTTATTAGGAGCG
ATCGCTATGGATAACACCGGCACCACTAAAATGGGCCGTTATGTGTTTGATCATGCGTTTTTGATTCCTGGGGTTTTAAT
CGTGTTTTTGAGCGTGGCGTTAGGGTTTGTTGTCGCACCGTTGGTTTTGTAG

Upstream 100 bases:

>100_bases
GTAAATTTTGAGCCATAACTTCCCCTTCAAACAAAATAAAAGGATTTAAAGATTTTTGTAGTATAGTGAATCGTTGTTAA
AATAAATTTAAAAAGGGTTA

Downstream 100 bases:

>100_bases
ATTTTATCATTAATGATAAAAAGCTTGATGTTGCGGTTTTTCTAAACCCCCTCTAAAAAAGAGGGTTTGGATCACTCAGT
AAGCAAACACATAATTGAGA

Product: anaerobic C4-dicarboxylate transporter

Products: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MVDAFFQIAVLLFSLFLGARLGGLGVGYAGGLGVLVLCLFLGLNPGKIPFDVILIIMAVISAISAMQKAGGLDYLVKIAE
KILRKHPKQINYLAPSVAYCLTILAGTGHTVFSLIPVIVEVSQSQNIKPKAPLSLAVVSSQVAITASPVSAAVVFMSGIL
EPLGADYLTLLMVWIPTTFLACMITAFVMGFTDLKLDSDPNYLERLKARKISPPTIKEEKETSKSAKLSLWIFIGGVVAI
VFYASAISKNIALISPVVLGRDHAIVSFMLSVATLIVLFCKINANEIAHSSVFKSGMQACVCVLGVAWLGDTFVSNHLDE
IKRYASFLIADYPFLLAVALFLASMLLYSQAATSKALIPSVITALGISANHTEHLYIIVASFASVSALFVLPTYPTLLGA
IAMDNTGTTKMGRYVFDHAFLIPGVLIVFLSVALGFVVAPLVL

Sequences:

>Translated_443_residues
MVDAFFQIAVLLFSLFLGARLGGLGVGYAGGLGVLVLCLFLGLNPGKIPFDVILIIMAVISAISAMQKAGGLDYLVKIAE
KILRKHPKQINYLAPSVAYCLTILAGTGHTVFSLIPVIVEVSQSQNIKPKAPLSLAVVSSQVAITASPVSAAVVFMSGIL
EPLGADYLTLLMVWIPTTFLACMITAFVMGFTDLKLDSDPNYLERLKARKISPPTIKEEKETSKSAKLSLWIFIGGVVAI
VFYASAISKNIALISPVVLGRDHAIVSFMLSVATLIVLFCKINANEIAHSSVFKSGMQACVCVLGVAWLGDTFVSNHLDE
IKRYASFLIADYPFLLAVALFLASMLLYSQAATSKALIPSVITALGISANHTEHLYIIVASFASVSALFVLPTYPTLLGA
IAMDNTGTTKMGRYVFDHAFLIPGVLIVFLSVALGFVVAPLVL
>Mature_443_residues
MVDAFFQIAVLLFSLFLGARLGGLGVGYAGGLGVLVLCLFLGLNPGKIPFDVILIIMAVISAISAMQKAGGLDYLVKIAE
KILRKHPKQINYLAPSVAYCLTILAGTGHTVFSLIPVIVEVSQSQNIKPKAPLSLAVVSSQVAITASPVSAAVVFMSGIL
EPLGADYLTLLMVWIPTTFLACMITAFVMGFTDLKLDSDPNYLERLKARKISPPTIKEEKETSKSAKLSLWIFIGGVVAI
VFYASAISKNIALISPVVLGRDHAIVSFMLSVATLIVLFCKINANEIAHSSVFKSGMQACVCVLGVAWLGDTFVSNHLDE
IKRYASFLIADYPFLLAVALFLASMLLYSQAATSKALIPSVITALGISANHTEHLYIIVASFASVSALFVLPTYPTLLGA
IAMDNTGTTKMGRYVFDHAFLIPGVLIVFLSVALGFVVAPLVL

Specific function: Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane [H]

COG id: COG2704

COG function: function code R; Anaerobic C4-dicarboxylate transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dcuA/dcuB transporter (TC 2.A.13.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790580, Length=440, Percent_Identity=53.4090909090909, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1790565, Length=418, Percent_Identity=35.8851674641148, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004668 [H]

Pfam domain/function: PF03605 DcuA_DcuB [H]

EC number: NA

Molecular weight: Translated: 47223; Mature: 47223

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDAFFQIAVLLFSLFLGARLGGLGVGYAGGLGVLVLCLFLGLNPGKIPFDVILIIMAVI
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SAISAMQKAGGLDYLVKIAEKILRKHPKQINYLAPSVAYCLTILAGTGHTVFSLIPVIVE
HHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VSQSQNIKPKAPLSLAVVSSQVAITASPVSAAVVFMSGILEPLGADYLTLLMVWIPTTFL
HCCCCCCCCCCCEEHEEECCCCEEEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
ACMITAFVMGFTDLKLDSDPNYLERLKARKISPPTIKEEKETSKSAKLSLWIFIGGVVAI
HHHHHHHHHCCHHEEECCCCCHHHHHHHCCCCCCCCCCHHHCCCHHHEEHHHHHHHHHHH
VFYASAISKNIALISPVVLGRDHAIVSFMLSVATLIVLFCKINANEIAHSSVFKSGMQAC
HHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VCVLGVAWLGDTFVSNHLDEIKRYASFLIADYPFLLAVALFLASMLLYSQAATSKALIPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VITALGISANHTEHLYIIVASFASVSALFVLPTYPTLLGAIAMDNTGTTKMGRYVFDHAF
HHHHHCCCCCCCCEEEEEEEHHHHHHHEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHH
LIPGVLIVFLSVALGFVVAPLVL
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDAFFQIAVLLFSLFLGARLGGLGVGYAGGLGVLVLCLFLGLNPGKIPFDVILIIMAVI
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SAISAMQKAGGLDYLVKIAEKILRKHPKQINYLAPSVAYCLTILAGTGHTVFSLIPVIVE
HHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VSQSQNIKPKAPLSLAVVSSQVAITASPVSAAVVFMSGILEPLGADYLTLLMVWIPTTFL
HCCCCCCCCCCCEEHEEECCCCEEEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
ACMITAFVMGFTDLKLDSDPNYLERLKARKISPPTIKEEKETSKSAKLSLWIFIGGVVAI
HHHHHHHHHCCHHEEECCCCCHHHHHHHCCCCCCCCCCHHHCCCHHHEEHHHHHHHHHHH
VFYASAISKNIALISPVVLGRDHAIVSFMLSVATLIVLFCKINANEIAHSSVFKSGMQAC
HHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VCVLGVAWLGDTFVSNHLDEIKRYASFLIADYPFLLAVALFLASMLLYSQAATSKALIPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VITALGISANHTEHLYIIVASFASVSALFVLPTYPTLLGAIAMDNTGTTKMGRYVFDHAF
HHHHHCCCCCCCCEEEEEEEHHHHHHHEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHH
LIPGVLIVFLSVALGFVVAPLVL
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Specific reaction: C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] = C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]