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The map label for this gene is 188527416

Identifier: 188527416

GI number: 188527416

Start: 598150

End: 598635

Strand: Reverse

Name: 188527416

Synonym: HPSH_03135

Alternate gene names: NA

Gene position: 598635-598150 (Counterclockwise)

Preceding gene: 188527417

Following gene: 188527415

Centisome position: 37.22

GC content: 38.68

Gene sequence:

>486_bases
ATGCAACATTTATACGCTCCTTGGCGCGAAAGTTATTTGAAAGAGAAAGATAAGAGTTGTGTCTTTTGTGAAATTTCTCA
AAACCCTACAAAAGATTCAGAAAACAGAGTGCTTTATAGAAATAGCGATCTCTTTGTTGTGATGAACGCCTACCCTTATA
ACCCAGGGCATTTGTTGATCATTCCCCATGCTCACAAGGCGAGCGTTGAACTTTTAGAGCTGAATACTTGGCTGAATATG
AATATATTAGTGCCTAAAGCGTTAAAAGCGTTGTATGCTTATGGCGCTCAAGGGATCAATTTAGGTTTGAATTTGCACAG
AAACGCCGGAGCAGGAATCCCTGAGCATTTGCACATGCATTTAGTGCCTAGGTTTTTAGGCGATAGCAATTTTATAAGCG
TTATCGCTCAAACTAGGGTTTGTGGGATTGATTTAAATGAAACCTATCTTACCTTAAAAAACTTATTAGAAAAGGAGCTT
GGTTGA

Upstream 100 bases:

>100_bases
GGATAAAGCGCAATTGGAAAATATCTTACAAGCCACCACGATTCAAGGCGATTTGATTTTATTCGCCAATGACGCCCCTA
ATTACATTTAGGAAATGAAC

Downstream 100 bases:

>100_bases
AAACAAACGCTTTTAGTTTGGGTGTGCTACAATTGATTTTAATTCATTTTAGGGAGTGTAAGCGATGAAGGCGCGTGGGT
TTAAGACAAAGATGCGTGGG

Product: histidine triad (HIT) family protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MQHLYAPWRESYLKEKDKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHAHKASVELLELNTWLNM
NILVPKALKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFISVIAQTRVCGIDLNETYLTLKNLLEKEL
G

Sequences:

>Translated_161_residues
MQHLYAPWRESYLKEKDKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHAHKASVELLELNTWLNM
NILVPKALKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFISVIAQTRVCGIDLNETYLTLKNLLEKEL
G
>Mature_161_residues
MQHLYAPWRESYLKEKDKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHAHKASVELLELNTWLNM
NILVPKALKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFISVIAQTRVCGIDLNETYLTLKNLLEKEL
G

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 18297; Mature: 18297

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHLYAPWRESYLKEKDKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLI
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCEEEE
IPHAHKASVELLELNTWLNMNILVPKALKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH
EECCCCCCEEEEEEECEEEEEEECHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHH
LVPRFLGDSNFISVIAQTRVCGIDLNETYLTLKNLLEKELG
HHHHHHCCCHHEEHEEHHEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHLYAPWRESYLKEKDKSCVFCEISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLI
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCEEEE
IPHAHKASVELLELNTWLNMNILVPKALKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH
EECCCCCCEEEEEEECEEEEEEECHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHH
LVPRFLGDSNFISVIAQTRVCGIDLNETYLTLKNLLEKELG
HHHHHHCCCHHEEHEEHHEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]