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The map label for this gene is clpP

Identifier: 188527362

GI number: 188527362

Start: 543121

End: 543708

Strand: Direct

Name: clpP

Synonym: HPSH_02845

Alternate gene names: 188527362

Gene position: 543121-543708 (Clockwise)

Preceding gene: 188527361

Following gene: 188527363

Centisome position: 33.76

GC content: 44.56

Gene sequence:

>588_bases
ATGGGATACATTCCTTATGTAATAGAGAATACCGATCGTGGGGAGCGCAGCTATGATATTTACTCGCGCCTTTTAAAGGA
TCGCATTGTTTTATTGAGCGGTGAGATCAATGATAGCGTGGCGTCTTCTATCGTGGCCCAACTCTTGTTTTTGGAAGCTG
AAGACCCTGAAAAAGACATTGGCTTGTATATCAATTCTCCCGGTGGGGTGATAACAAGCGGTCTTAGCATTTATGACACC
ATGAATTTTATCCGCCCTGATGTTTCCACGATTTGCATCGGTCAAGCGGCTTCTATGGGGGCGTTTTTACTGAGCTGTGG
GGCTAAGGGCAAGCGCTTTTCACTACCCCATTCAAGGATTATGATCCACCAGCCTTTAGGGGGGGCCCAAGGGCAAGCGA
GCGATATTGAAATCATTTCTAATGAGATTCTCAGGCTTAAGGGTTTGATGAATTCTATTCTGGCTCAAAACTCAGGGCAG
AGTTTGGAGCAAATCGCTAAAGACACGGACAGGGATTTTTACATGAGCGCTAAAGAAGCTAAAGAGTATGGCTTGATTGA
TAAAGTGTTAGAGAAAAATGTGAAGTGA

Upstream 100 bases:

>100_bases
TGGATAAAAACCTGCCTAAAGAGCAACAAGAAATTTTAGAGAAAATGAGGCCCAACGCTCAAAAAACTCAGGTGGGTTAA
ACGGCTAAAAAGGAGAGATG

Downstream 100 bases:

>100_bases
TTGCATGGCGTTATTAGAGATTATCCATTACCCTTCTAAAATCTTAAGAACGATTTCTAAAGAGATCGTTTCTTTTGATT
CAAAACTCCACCAACAGCTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYDT
MNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSGQ
SLEQIAKDTDRDFYMSAKEAKEYGLIDKVLEKNVK

Sequences:

>Translated_195_residues
MGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYDT
MNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSGQ
SLEQIAKDTDRDFYMSAKEAKEYGLIDKVLEKNVK
>Mature_194_residues
GYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYDTM
NFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSGQS
LEQIAKDTDRDFYMSAKEAKEYGLIDKVLEKNVK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=58.8235294117647, Blast_Score=231, Evalue=3e-61,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=70, Blast_Score=290, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=55.2631578947368, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=54.7872340425532, Blast_Score=229, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21396; Mature: 21265

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDI
CCCCCEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
GLYINSPGGVITSGLSIYDTMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRI
CEEECCCCCCCCCCHHHHHHHHHHCCCHHHEECCCHHHHHHHHHHCCCCCCEECCCCCEE
MIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSGQSLEQIAKDTDRDFYMSAKEA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCHHHH
KEYGLIDKVLEKNVK
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
GYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDI
CCCCEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
GLYINSPGGVITSGLSIYDTMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRI
CEEECCCCCCCCCCHHHHHHHHHHCCCHHHEECCCHHHHHHHHHHCCCCCCEECCCCCEE
MIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSGQSLEQIAKDTDRDFYMSAKEA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCHHHH
KEYGLIDKVLEKNVK
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]