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The map label for this gene is tkt [H]

Identifier: 188527167

GI number: 188527167

Start: 358052

End: 359977

Strand: Reverse

Name: tkt [H]

Synonym: HPSH_01870

Alternate gene names: 188527167

Gene position: 359977-358052 (Counterclockwise)

Preceding gene: 188527168

Following gene: 188527166

Centisome position: 22.38

GC content: 44.76

Gene sequence:

>1926_bases
ATGCGATTGAGTAACGCTGACTTAGAACGATTAAAAAGCATGGCCAACACGCTACGCTTTTTGTGTGCGGACATGATAGA
TAAGGCTAATAGCGGGCATCCGGGCGTGTGCTTGGGATTAGCCGATGTGATGGTGGTTTTAAGCTTGCACTTAAACCTAA
ACCCCACCAACCCTAAATGGCTCAACAGGGACAGGCTGGTTTTTAGCGGAGGGCATGCGAGCGCGTTAGCGTATAGTTTG
TTGCATTTGTGGGGCTTTGATTTGAGCCTAGAAGATTTAAAGCGTTTCAGGCAATTACACTCTAAAACCCCAGGACACCC
CGAATTGCACCACACCGAAGGCATTGAGATTACGACCGGGCCTTTGGGGCAAGGTTTTGCTAACGCTGTGGGCTTTAGCA
TGGCGAGTCAATACGCTCAAAACCTTTTAGACAAAGAAGCCATTTCTCATAAAGTCTATTGCTTGTGTGGGGATGGGGAT
TTGCAAGAAGGCATTAGTTATGAGAGCGCTTCTTTAGCCGGGCACCTCAACCTGAACAACCTCATTGTGATTTATGACAG
CAACCAGATCAGCATTGAAGGCGCTATCAATATTAGTTTTAGCGAACAGGTTAAGATGCGTTTTTTAGCGCAAAATTGGG
AAGTGCTAGAATGCGATGGGCATGACTATCAAGCGATTCATAACGCTTTAGAAGAAGCCAAAAAATCCACCAAACCCACG
CTTTTAATCGCCCATACGATTATTGGTAAGGGGGCTATTGGTTTAGAGGGGAGTGAAAAAACGCATGGCTCACCCCTAAA
TAAAGAAGTGTTAAAACAATCCAAAGAAAACGCTCAAATCAATCCTGATGAAAGCTTTGTCATTAGCCCAAAAAACAAAA
TGCATTTTGAAGAAGTGAAAGTTAGGGGCGTTAGTTTAGAAGCCTTATGGGAAAAATCCTTAAGCCCTAAAGCAAAAGAA
AAGATCCATGCGTTGAAGGATTTTGATTTTAACGCCATCAATTACCCCGTTTTCAAAAAAGGCGAATCTTTAGCCACGAG
AGTGAGTAACGGCATGATTTTAAACGCTATCGCTAAAGAATGCGAGGGCTTTTTGGGGGGGAGCGCGGATTTAGCCCCGT
CTAATAACACGCAATTAAAACACTCTAGCGATTTCCCTTTAGGGCAAAACTTGCATTTTGGGATCAGAGAGCATGCCATG
GGGGCTATCACTAACGCTTTAGCGGCGTATGGCTTGTTTGTGCCTTTTTGCGCGACCTTTTTTGTGTTTAGCGATTACTT
GATGCCTAGCATTCGTTTGAGCGCTTTAATGAAACTAAAAGCCCTTTTTATCTTTACGCATGACAGCATTGGCGTGGGCG
AAGACGGGGCGACGCACCAGCCCATAGAACAACTGAGCCATTTACGCGCTTTGCCCAATTTCTACGCTTTCAGACCCAGC
GACGCTTTTGAAAATACCGCTTGCATGCAAGTGGCGTTAAGTTTGAGCGCTCCTAGCGGGCTTATTTTATCGCGCCAGAA
TTTACCCGTGCTTGATGAGGTTTCTAAAGAGCGGGTTTTAAAAGGCGCGTATGTTAAACACCACTCTAAAAATCCCATTA
TCACGCTGGTTGCGAGCGGGAGCGAAGTCTCTTTGGCTTTAGAGAGCGCTAAAATGTTAGAGCGAGAAAATATCCCCACT
CAAGTGGTGAGCGCGCCATGCTTTGATTTATTGGTGGAACAAGATGAAAGCTATCTTAAAGAGCTTTTTAAGGGTAAAGT
TTTAGTGATTGAAGCGAGTCGCGCGATAGAGTGGTATCGTTTTGCGGATAAAATCATTGGCATGGATTCTTTTGGGAGCT
CAGCAAAGGGCGATAAACTCTTTGAAAAATTTGGCTTCAGCGTTGAAAACATCACCGCTCAAGCTAAAAGGTTACTCCAC
GCATGA

Upstream 100 bases:

>100_bases
CTTAAAAATCAGATCCAACAAGACATCTTAAGAGCCAAAGAGATTTTGAGATAATTTGTGTTAAAATGGCTTTTAAAAAC
CTTAAAAATGGAAAAATTTG

Downstream 100 bases:

>100_bases
ACTTAGAAAAACTTTTTTCACAAAAAACCCCCCTATTTGTTTTTAGCTCCACCAGGCGTTTAAAACATTTCTATTTAGAG
CAAGGCGAAGGGTTTTTGCC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MRLSNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYSL
LHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASQYAQNLLDKEAISHKVYCLCGDGD
LQEGISYESASLAGHLNLNNLIVIYDSNQISIEGAINISFSEQVKMRFLAQNWEVLECDGHDYQAIHNALEEAKKSTKPT
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFVISPKNKMHFEEVKVRGVSLEALWEKSLSPKAKE
KIHALKDFDFNAINYPVFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTQLKHSSDFPLGQNLHFGIREHAM
GAITNALAAYGLFVPFCATFFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
DAFENTACMQVALSLSAPSGLILSRQNLPVLDEVSKERVLKGAYVKHHSKNPIITLVASGSEVSLALESAKMLERENIPT
QVVSAPCFDLLVEQDESYLKELFKGKVLVIEASRAIEWYRFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLH
A

Sequences:

>Translated_641_residues
MRLSNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYSL
LHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASQYAQNLLDKEAISHKVYCLCGDGD
LQEGISYESASLAGHLNLNNLIVIYDSNQISIEGAINISFSEQVKMRFLAQNWEVLECDGHDYQAIHNALEEAKKSTKPT
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFVISPKNKMHFEEVKVRGVSLEALWEKSLSPKAKE
KIHALKDFDFNAINYPVFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTQLKHSSDFPLGQNLHFGIREHAM
GAITNALAAYGLFVPFCATFFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
DAFENTACMQVALSLSAPSGLILSRQNLPVLDEVSKERVLKGAYVKHHSKNPIITLVASGSEVSLALESAKMLERENIPT
QVVSAPCFDLLVEQDESYLKELFKGKVLVIEASRAIEWYRFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLH
A
>Mature_641_residues
MRLSNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYSL
LHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASQYAQNLLDKEAISHKVYCLCGDGD
LQEGISYESASLAGHLNLNNLIVIYDSNQISIEGAINISFSEQVKMRFLAQNWEVLECDGHDYQAIHNALEEAKKSTKPT
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFVISPKNKMHFEEVKVRGVSLEALWEKSLSPKAKE
KIHALKDFDFNAINYPVFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTQLKHSSDFPLGQNLHFGIREHAM
GAITNALAAYGLFVPFCATFFVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
DAFENTACMQVALSLSAPSGLILSRQNLPVLDEVSKERVLKGAYVKHHSKNPIITLVASGSEVSLALESAKMLERENIPT
QVVSAPCFDLLVEQDESYLKELFKGKVLVIEASRAIEWYRFADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLH
A

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=591, Percent_Identity=26.5651438240271, Blast_Score=203, Evalue=5e-52,
Organism=Homo sapiens, GI4507521, Length=591, Percent_Identity=26.5651438240271, Blast_Score=203, Evalue=5e-52,
Organism=Homo sapiens, GI133778974, Length=648, Percent_Identity=25.9259259259259, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI225637459, Length=569, Percent_Identity=23.725834797891, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI225637463, Length=480, Percent_Identity=24.375, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI225637461, Length=480, Percent_Identity=24.375, Blast_Score=134, Evalue=4e-31,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=42.3831070889894, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=40.393343419062, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17539652, Length=568, Percent_Identity=27.4647887323944, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6325331, Length=664, Percent_Identity=42.7710843373494, Blast_Score=490, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=40.3903903903904, Blast_Score=469, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45551847, Length=563, Percent_Identity=27.708703374778, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45550715, Length=563, Percent_Identity=27.708703374778, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24666278, Length=659, Percent_Identity=26.5553869499241, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24645119, Length=525, Percent_Identity=27.2380952380952, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 70521; Mature: 70521

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCC
LNRDRLVFSGGHASALAYSLLHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTG
CCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECC
PLGQGFANAVGFSMASQYAQNLLDKEAISHKVYCLCGDGDLQEGISYESASLAGHLNLNN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCCCCCCEEEEECCCC
LIVIYDSNQISIEGAINISFSEQVKMRFLAQNWEVLECDGHDYQAIHNALEEAKKSTKPT
EEEEECCCEEEEEEEEEECHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCE
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFVISPKNKMHFEEVK
EEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCHHHHH
VRGVSLEALWEKSLSPKAKEKIHALKDFDFNAINYPVFKKGESLATRVSNGMILNAIAKE
EECCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHCCCHHHHHHHH
CEGFLGGSADLAPSNNTQLKHSSDFPLGQNLHFGIREHAMGAITNALAAYGLFVPFCATF
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCC
DAFENTACMQVALSLSAPSGLILSRQNLPVLDEVSKERVLKGAYVKHHSKNPIITLVASG
CCCCCHHHHHHEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
SEVSLALESAKMLERENIPTQVVSAPCFDLLVEQDESYLKELFKGKVLVIEASRAIEWYR
CCEEEHHHHHHHHHHCCCCHHHHHCHHHHHHHHCCHHHHHHHHCCCEEEEECCHHHHHHH
FADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLHA
HHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLSNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCC
LNRDRLVFSGGHASALAYSLLHLWGFDLSLEDLKRFRQLHSKTPGHPELHHTEGIEITTG
CCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECC
PLGQGFANAVGFSMASQYAQNLLDKEAISHKVYCLCGDGDLQEGISYESASLAGHLNLNN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCCCCCCEEEEECCCC
LIVIYDSNQISIEGAINISFSEQVKMRFLAQNWEVLECDGHDYQAIHNALEEAKKSTKPT
EEEEECCCEEEEEEEEEECHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCE
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENAQINPDESFVISPKNKMHFEEVK
EEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCHHHHH
VRGVSLEALWEKSLSPKAKEKIHALKDFDFNAINYPVFKKGESLATRVSNGMILNAIAKE
EECCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHCCCHHHHHHHH
CEGFLGGSADLAPSNNTQLKHSSDFPLGQNLHFGIREHAMGAITNALAAYGLFVPFCATF
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FVFSDYLMPSIRLSALMKLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCC
DAFENTACMQVALSLSAPSGLILSRQNLPVLDEVSKERVLKGAYVKHHSKNPIITLVASG
CCCCCHHHHHHEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
SEVSLALESAKMLERENIPTQVVSAPCFDLLVEQDESYLKELFKGKVLVIEASRAIEWYR
CCEEEHHHHHHHHHHCCCCHHHHHCHHHHHHHHCCHHHHHHHHCCCEEEEECCHHHHHHH
FADKIIGMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLHA
HHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]