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The map label for this gene is gmk

Identifier: 188527125

GI number: 188527125

Start: 320099

End: 320719

Strand: Reverse

Name: gmk

Synonym: HPSH_01660

Alternate gene names: 188527125

Gene position: 320719-320099 (Counterclockwise)

Preceding gene: 188527126

Following gene: 188527124

Centisome position: 19.94

GC content: 38.33

Gene sequence:

>621_bases
ATGCATAATGATTTTAATTTACTCATCCTTTCAGGCCCTAGCGGAGCGGGTAAAAGCACCCTTACAAAGTATTTGCAAGA
AAAAATCCCAAAAACCCATTTTTCCCTTTCCACCACCACACGAAAGCCCAGAGAGGGCGAAGTTGATGGCTTGCATTACA
ATTTTGTCAGCGAAGAAGAATTCAAACAAGGCATAGAAAAAGGGCAGTTTTTAGAATGGGCGATCGTGCATAACCACTAT
TATGGCACTTCTAAAATCCCTGTAGAAAAAGCCTTAAAAGAGGGCAAAATCGTCATTTTTGATATTGATGTGCAAGGGCA
TGAGATCCTTAAAAAGCATTACCCCAACGCATGCTCTGTGTTTATTAGCACCAAAAACCAAGAGATTTTAAAAGAGCGCT
TGCTTTTAAGAGGGACGGATTCTAAAGAGACGATAGAAAAGCGCTTGATCAACGCTTATAAGGAAATGCAGTGCTTGGAG
AGCTTTGATTATCTCATCATCAATGAAGATTTGGAAAAATCCAAAGAAATCATCTTAAGCATCGCAAAAACTTTAGTCCA
TCGCTTAAAAGCGTTTAATTTTGAAAAAATATGCAAGGCTTGGAAAAACGAATCCTTATAA

Upstream 100 bases:

>100_bases
TTGCAAGATTTATTAAAAAGCCTCAATCAAGAGTCCTTGAAAAACCTTTTAGAAAACAAGACCTTAAGCATTAAAATCAC
TTTAGAGGATAAAAAACCTG

Downstream 100 bases:

>100_bases
AACCTATCAATTATTTTTTAAAAAAGCTATAATTCAGAGAAAACCAACCAATAGTTTAAGGAGTAAAATATGGGTGGATT
CACAAGCATATGGCATTGGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MHNDFNLLILSGPSGAGKSTLTKYLQEKIPKTHFSLSTTTRKPREGEVDGLHYNFVSEEEFKQGIEKGQFLEWAIVHNHY
YGTSKIPVEKALKEGKIVIFDIDVQGHEILKKHYPNACSVFISTKNQEILKERLLLRGTDSKETIEKRLINAYKEMQCLE
SFDYLIINEDLEKSKEIILSIAKTLVHRLKAFNFEKICKAWKNESL

Sequences:

>Translated_206_residues
MHNDFNLLILSGPSGAGKSTLTKYLQEKIPKTHFSLSTTTRKPREGEVDGLHYNFVSEEEFKQGIEKGQFLEWAIVHNHY
YGTSKIPVEKALKEGKIVIFDIDVQGHEILKKHYPNACSVFISTKNQEILKERLLLRGTDSKETIEKRLINAYKEMQCLE
SFDYLIINEDLEKSKEIILSIAKTLVHRLKAFNFEKICKAWKNESL
>Mature_206_residues
MHNDFNLLILSGPSGAGKSTLTKYLQEKIPKTHFSLSTTTRKPREGEVDGLHYNFVSEEEFKQGIEKGQFLEWAIVHNHY
YGTSKIPVEKALKEGKIVIFDIDVQGHEILKKHYPNACSVFISTKNQEILKERLLLRGTDSKETIEKRLINAYKEMQCLE
SFDYLIINEDLEKSKEIILSIAKTLVHRLKAFNFEKICKAWKNESL

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=171, Percent_Identity=38.0116959064327, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI226874833, Length=171, Percent_Identity=38.0116959064327, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4504221, Length=171, Percent_Identity=38.0116959064327, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI38570142, Length=182, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI14780902, Length=190, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI21361598, Length=183, Percent_Identity=28.9617486338798, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI262118263, Length=136, Percent_Identity=33.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4505237, Length=136, Percent_Identity=33.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118255, Length=136, Percent_Identity=33.8235294117647, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118259, Length=136, Percent_Identity=33.8235294117647, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790080, Length=171, Percent_Identity=45.0292397660819, Blast_Score=143, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=40.6976744186046, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=40.6976744186046, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71988048, Length=187, Percent_Identity=28.3422459893048, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71988041, Length=187, Percent_Identity=28.3422459893048, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=28.021978021978, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=172, Percent_Identity=45.9302325581395, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21356141, Length=173, Percent_Identity=39.3063583815029, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_HELPH (Q1CUI1)

Other databases:

- EMBL:   CP000241
- RefSeq:   YP_627065.1
- ProteinModelPortal:   Q1CUI1
- SMR:   Q1CUI1
- STRING:   Q1CUI1
- GeneID:   4098523
- GenomeReviews:   CP000241_GR
- KEGG:   hpa:HPAG1_0324
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   HPYL357544:HPAG1_0324-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23817; Mature: 23817

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNDFNLLILSGPSGAGKSTLTKYLQEKIPKTHFSLSTTTRKPREGEVDGLHYNFVSEEE
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCEEECCCCHHH
FKQGIEKGQFLEWAIVHNHYYGTSKIPVEKALKEGKIVIFDIDVQGHEILKKHYPNACSV
HHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEEE
FISTKNQEILKERLLLRGTDSKETIEKRLINAYKEMQCLESFDYLIINEDLEKSKEIILS
EEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
IAKTLVHRLKAFNFEKICKAWKNESL
HHHHHHHHHHHCCHHHHHHHHCCCCC
>Mature Secondary Structure
MHNDFNLLILSGPSGAGKSTLTKYLQEKIPKTHFSLSTTTRKPREGEVDGLHYNFVSEEE
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCEEECCCCHHH
FKQGIEKGQFLEWAIVHNHYYGTSKIPVEKALKEGKIVIFDIDVQGHEILKKHYPNACSV
HHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEEE
FISTKNQEILKERLLLRGTDSKETIEKRLINAYKEMQCLESFDYLIINEDLEKSKEIILS
EEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
IAKTLVHRLKAFNFEKICKAWKNESL
HHHHHHHHHHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA