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The map label for this gene is hemC

Identifier: 188527044

GI number: 188527044

Start: 231380

End: 232300

Strand: Reverse

Name: hemC

Synonym: HPSH_01235

Alternate gene names: 188527044

Gene position: 232300-231380 (Counterclockwise)

Preceding gene: 188527045

Following gene: 188527043

Centisome position: 14.44

GC content: 44.63

Gene sequence:

>921_bases
GTGGGAAATTTAGTGATTGGCTCTAGGGGGAGCGAATTAGCCTTATGGCAAGCGAATCACATTAAAGAACGCCTGAAAAA
AGAATGCTCTATAGAAAGCGAGATTCAAATCGTTAAGACTAAGGGCGATAAGATCTTAGACACCCCTTTAAATAAGATTG
GCGGTAAGGGGCTATTCACTAAGGAATTAGAAGAATTGCTTTTAAAAGGCGAAATTGATCTGGCGGTGCATTCTTTAAAA
GATGTGCCGGTCGTGTTTGAAAAGGGGTTAGACTTGGCATGCATCACTAAAAGGGCTGATGTGAGGGACACTTTTTTAAG
CGTGAAATTCCCTGATTTGATGAGCTTGCCTAAAGGGGCAAAGGTTGGCACGACTTCCTTAAGGCGCTCCATGCAACTCA
AACTAAAACGCCAGGATTTGGACACAGAAAGCTTGAGAGGGAATGTCCAAACCCGTTTGAAAAAGCTTGAATGCGGAGAA
TTTGACGCTATCATTTTGGCTGAAGCCGGGTTGTGCCGCCTAGAAATTCAAGGAGCGAAATACCGCAAGGCTTTTAGCGT
GGAAGAAATGATTCCTAGCATGGGTCAGGGGGCTTTAGGGGTAGAAATGCTCAAAAGCCACAAGCATTTTGCCACGCTTC
AAAAACTCAACGATGAAGAGAGCGCGTTTTGCTGCCATTTGGAAAGGGCGTTTGTTAAGGGGCTTAATGGAGGGTGTCAG
ATCCCTATTGGCGTGCATGCGAGTTTAATGGGTGATAGGGTTAAAATCCGGGCGGTTTTAGGCTTGCCTAACGGGAAAGA
AGTCATCGCTAAAGAAAGGCAAGGGGATAAAACTAAGGCGTTTGATCTGGTTCAAGAGCTTTTAGAAGCGTTTTTGCAAA
GCGGGGCTAAAGAGATTTTAGAAAAGGCGCAGTTGTTTTAA

Upstream 100 bases:

>100_bases
GAATGCATCAAACGCGCTAATTTAGAAAAACAAACGCTTAAAGACACAGAATTAGAAGAAAAAATTTTAGAAATGTTAAA
AAGCGAATAAGGGGGAAAGA

Downstream 100 bases:

>100_bases
TGCGTTTGTTTATCGCGCCGGTTTTGTTCTTGTGGTTAAGCTTGAATGCTAAAGAAGCGAATTTTATTTCTGATTTGGAA
TACGGGATGGCTCTTTATAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MGNLVIGSRGSELALWQANHIKERLKKECSIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGEIDLAVHSLK
DVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQLKLKRQDLDTESLRGNVQTRLKKLECGE
FDAIILAEAGLCRLEIQGAKYRKAFSVEEMIPSMGQGALGVEMLKSHKHFATLQKLNDEESAFCCHLERAFVKGLNGGCQ
IPIGVHASLMGDRVKIRAVLGLPNGKEVIAKERQGDKTKAFDLVQELLEAFLQSGAKEILEKAQLF

Sequences:

>Translated_306_residues
MGNLVIGSRGSELALWQANHIKERLKKECSIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGEIDLAVHSLK
DVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQLKLKRQDLDTESLRGNVQTRLKKLECGE
FDAIILAEAGLCRLEIQGAKYRKAFSVEEMIPSMGQGALGVEMLKSHKHFATLQKLNDEESAFCCHLERAFVKGLNGGCQ
IPIGVHASLMGDRVKIRAVLGLPNGKEVIAKERQGDKTKAFDLVQELLEAFLQSGAKEILEKAQLF
>Mature_305_residues
GNLVIGSRGSELALWQANHIKERLKKECSIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGEIDLAVHSLKD
VPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQLKLKRQDLDTESLRGNVQTRLKKLECGEF
DAIILAEAGLCRLEIQGAKYRKAFSVEEMIPSMGQGALGVEMLKSHKHFATLQKLNDEESAFCCHLERAFVKGLNGGCQI
PIGVHASLMGDRVKIRAVLGLPNGKEVIAKERQGDKTKAFDLVQELLEAFLQSGAKEILEKAQLF

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=250, Percent_Identity=44.4, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI66933009, Length=250, Percent_Identity=44.4, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI48994974, Length=299, Percent_Identity=47.8260869565217, Blast_Score=254, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=37.6947040498442, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20130425, Length=254, Percent_Identity=38.9763779527559, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33823; Mature: 33692

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLVIGSRGSELALWQANHIKERLKKECSIESEIQIVKTKGDKILDTPLNKIGGKGLFT
CCCEEECCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEECCCCEEHHCCHHHHCCCCCCH
KELEELLLKGEIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGA
HHHHHHHHCCCHHHHHHHHCCCCHHHHCCCCEEEEECCCCHHHHHEEEECCHHHCCCCCC
KVGTTSLRRSMQLKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAK
CCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCH
YRKAFSVEEMIPSMGQGALGVEMLKSHKHFATLQKLNDEESAFCCHLERAFVKGLNGGCQ
HHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCE
IPIGVHASLMGDRVKIRAVLGLPNGKEVIAKERQGDKTKAFDLVQELLEAFLQSGAKEIL
EEECCHHHHCCCCEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKAQLF
HHHCCC
>Mature Secondary Structure 
GNLVIGSRGSELALWQANHIKERLKKECSIESEIQIVKTKGDKILDTPLNKIGGKGLFT
CCEEECCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEECCCCEEHHCCHHHHCCCCCCH
KELEELLLKGEIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGA
HHHHHHHHCCCHHHHHHHHCCCCHHHHCCCCEEEEECCCCHHHHHEEEECCHHHCCCCCC
KVGTTSLRRSMQLKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAK
CCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCH
YRKAFSVEEMIPSMGQGALGVEMLKSHKHFATLQKLNDEESAFCCHLERAFVKGLNGGCQ
HHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCE
IPIGVHASLMGDRVKIRAVLGLPNGKEVIAKERQGDKTKAFDLVQELLEAFLQSGAKEIL
EEECCHHHHCCCCEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKAQLF
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA