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The map label for this gene is hcpE [H]

Identifier: 188527042

GI number: 188527042

Start: 229851

End: 230918

Strand: Reverse

Name: hcpE [H]

Synonym: HPSH_01225

Alternate gene names: 188527042

Gene position: 230918-229851 (Counterclockwise)

Preceding gene: 188527043

Following gene: 188527036

Centisome position: 14.36

GC content: 41.1

Gene sequence:

>1068_bases
ATGAGTGTCAAAATTTTAAAAATATTAGTTTGTGGGTTATTTTTTTGGAGCTTGCAAGCCCATTTATGGGGGAAAAAAGA
CAAGAGCTTTTTAGGGGTTGCTGAAAGGGCCTATAAAAGCGGGAATTATTCTAAAGCTGCATCTTATTTTAAAAAAGCAT
GCAACGATGGGGTGAGTGAAGGTTGCACGCAATTAGGAATCATTTATGAAAACGGGCAAGGCACTAAAATAGATTATAAA
AAAGCCCTAGAATATTACCAAAGCGCATGCCAGGGTGATGATAGGGAAGGGTGTTTTGGTTTAGGGGGGCTTTATGATGA
GGGGTTAGGCACGACTCAAAATTATCAAGAGGCCATTGACGCTTATGCTAATGCGTGCGTTTTAAAACACCCTGAGAGTT
GCTACAATTTAGGCATTATTTATGACCGAAAAATCAAAGGCAATGCCGCTCAAGCGGTTACCTACTATCAAAAAAGCTGC
AATTTTGATATGGCTAAGGGGTGTTATGTTTTGGGCGTGGCTTATGAAAAAGGCTTTTTAGAAGTCAAACAAAGCAACCA
TAAAGCCGTGATTTATTATTTGAAAGCGTGCCGATTGAATGATGGGCAGGCTTGTCGCGCGTTAGGGAGTTTGTTTGAAA
ATGGCGATGCAGGGCTTGATGAAGATTTTGAAGTGGCGTTTGATTATTTGCAAAAAGCTTGCGGATTAAATAATTCTGGT
GGTTGCGCGAGTTTAGGCTCTATGTATATGTTAGGCAGGTATGTCAAAAAAGATCCCCAAAAGGCTTTTAATTTTTTCAA
ACAAGCATGCGATATGGGGAGTGCGGTGAGTTGCTCTAGGATGGGCTTTATGTATTCCCAAGGGGACGCTGTTCCAAAAG
ACTTGAGGAAAGCCCTTGATAATTATGAAAGGGGTTGCGATATGGGCGATGAAGTGGGTTGCTTCGCTCTAGCGGGCATG
TATTACAACATGAAAGATAAAGAAAACGCCATAATGATTTATGACAAGGGCTGTAAGCTGGGCATGAAACAAGCATGCGA
AAACCTCACTAAACTTAGGGGGTATTGA

Upstream 100 bases:

>100_bases
GCCTTAATCAAAGCGCTTGATTTATGTTAAAATGGGGTGTTGCATTTTTTGTTTTGATTGAAGAGGGTTCTAAAAATCAG
AATTTATAAAGAAGGTAAGA

Downstream 100 bases:

>100_bases
AAAATTTAAAACCACCCAAGCAGAAAACCCAAACGCCTTTAGCGTTTGTGATGAATGCTACTAGTCTATAATATTGCGTT
CGTATCTAGGACAAAGGAGT

Product: cysteine-rich protein E

Products: NA

Alternate protein names: Cysteine-rich protein E [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSVKILKILVCGLFFWSLQAHLWGKKDKSFLGVAERAYKSGNYSKAASYFKKACNDGVSEGCTQLGIIYENGQGTKIDYK
KALEYYQSACQGDDREGCFGLGGLYDEGLGTTQNYQEAIDAYANACVLKHPESCYNLGIIYDRKIKGNAAQAVTYYQKSC
NFDMAKGCYVLGVAYEKGFLEVKQSNHKAVIYYLKACRLNDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSG
GCASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALDNYERGCDMGDEVGCFALAGM
YYNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY

Sequences:

>Translated_355_residues
MSVKILKILVCGLFFWSLQAHLWGKKDKSFLGVAERAYKSGNYSKAASYFKKACNDGVSEGCTQLGIIYENGQGTKIDYK
KALEYYQSACQGDDREGCFGLGGLYDEGLGTTQNYQEAIDAYANACVLKHPESCYNLGIIYDRKIKGNAAQAVTYYQKSC
NFDMAKGCYVLGVAYEKGFLEVKQSNHKAVIYYLKACRLNDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSG
GCASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALDNYERGCDMGDEVGCFALAGM
YYNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY
>Mature_354_residues
SVKILKILVCGLFFWSLQAHLWGKKDKSFLGVAERAYKSGNYSKAASYFKKACNDGVSEGCTQLGIIYENGQGTKIDYKK
ALEYYQSACQGDDREGCFGLGGLYDEGLGTTQNYQEAIDAYANACVLKHPESCYNLGIIYDRKIKGNAAQAVTYYQKSCN
FDMAKGCYVLGVAYEKGFLEVKQSNHKAVIYYLKACRLNDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSGG
CASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALDNYERGCDMGDEVGCFALAGMY
YNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY

Specific function: May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives [H]

COG id: COG0790

COG function: function code R; FOG: TPR repeat, SEL1 subfamily

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 8 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI19923669, Length=321, Percent_Identity=28.0373831775701, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI151301150, Length=323, Percent_Identity=23.5294117647059, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI87081769, Length=260, Percent_Identity=26.1538461538462, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17563256, Length=329, Percent_Identity=24.3161094224924, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537799, Length=191, Percent_Identity=30.3664921465969, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319410, Length=274, Percent_Identity=25.1824817518248, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355295, Length=288, Percent_Identity=25.6944444444444, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI116007256, Length=221, Percent_Identity=28.9592760180996, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006597
- InterPro:   IPR011990 [H]

Pfam domain/function: PF08238 Sel1 [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 39306; Mature: 39175

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKILKILVCGLFFWSLQAHLWGKKDKSFLGVAERAYKSGNYSKAASYFKKACNDGVSE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
GCTQLGIIYENGQGTKIDYKKALEYYQSACQGDDREGCFGLGGLYDEGLGTTQNYQEAID
HHHEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCCEECCCCHHCCCCCCHHHHHHHH
AYANACVLKHPESCYNLGIIYDRKIKGNAAQAVTYYQKSCNFDMAKGCYVLGVAYEKGFL
HHHHHEEECCCHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCHH
EVKQSNHKAVIYYLKACRLNDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSG
EECCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCC
GCASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALD
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHCCEECCCCCCHHHHHHHHH
NYERGCDMGDEVGCFALAGMYYNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY
HHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVKILKILVCGLFFWSLQAHLWGKKDKSFLGVAERAYKSGNYSKAASYFKKACNDGVSE
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHH
GCTQLGIIYENGQGTKIDYKKALEYYQSACQGDDREGCFGLGGLYDEGLGTTQNYQEAID
HHHEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCCEECCCCHHCCCCCCHHHHHHHH
AYANACVLKHPESCYNLGIIYDRKIKGNAAQAVTYYQKSCNFDMAKGCYVLGVAYEKGFL
HHHHHEEECCCHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCHH
EVKQSNHKAVIYYLKACRLNDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSG
EECCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCC
GCASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALD
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHCCEECCCCCCHHHHHHHHH
NYERGCDMGDEVGCFALAGMYYNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY
HHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]