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The map label for this gene is lpxD

Identifier: 188527001

GI number: 188527001

Start: 187419

End: 188429

Strand: Direct

Name: lpxD

Synonym: HPSH_01005

Alternate gene names: 188527001

Gene position: 187419-188429 (Clockwise)

Preceding gene: 188527000

Following gene: 188527002

Centisome position: 11.65

GC content: 41.35

Gene sequence:

>1011_bases
ATGAAATTAAGCGAATTGTTAAGCGCCTATTCTATTGAAACGGAATTTTCAAACGATTTTGAAGTGCATGCTTTAGCGGA
ATTGGATAAGGCCACGCCTAATGATATTAGCTATATTGACCAAGCGCGCTACCTTAAACTTTTAAAAGATTCAAAAGCCG
GGGCGGTGTTTATCCGTAAAAAAGAATCTTCTAAAGTGCCAAAACACATGCAAGCTTTAATCGTGGATAACCCGCATCTA
GTCTTTGCTAAAGCTTCGCATGCCTTTAAAATCCCTTTTTTTAAAAACCCAGAAAGCGTGAATGAGCCTAAACATTTTAA
AAAAGTAACGATCATGCCTAATGTTATAATTGGAGAGGGCGTAGAAATTGGCGAAAACTCTTTGATTTATCCGGGCGTGG
TGATCGCTGATGGGGTCAAAATCGGTAAAAATTGTATTTTGTATCCTCGTGTGATTTTGTATCAAAACACGATTTTAGAA
GACAATGTTACTATCCATGCAGGCAGTGTGATTGGAGGCGATGGCTTTGGTTATGCACACACCGCTTTAGGAGAGCATGT
CAAAATTGAGCATGTGGGGATTGTTAGGATTCAAAAAAATGTAGAAATTGGAGCTAACACGGCGATTGATAGGGCGGTGT
TTGGTGAGACTTTGATTAAAGAGGGCGTTAAGATTGATAACCTGGTTCAAATCGGGCATAATTGCGTTTTAGGCGAGCAC
AGCATTGTTGTTTCTCAAGTGGGCTTGAGCGGCTCTACAACCACTGGCCGTAATGTGGTTTTTGGCGGGCAAGTGGGCAT
TGGGGGGCATTTGCATGTGGGCGAATTCACTCAAATTGGAGGTAAAAGCGCGGTGGGTAAAGACTTGCCCCCTAACACTA
ATTTTGCCGGAGCGATCCCTGCTATGGAAATCCATGAATGGCACCATTTCTTGGCTCATTTACGAACGAATTTTAGAAAA
CAGCAAAAAACGAGTTTGTTGCAAAAAGCTAAAGGGTTTTTTAAGTCTTAA

Upstream 100 bases:

>100_bases
GGATGCTGGCTATCATGTTATGGGCATGGGGGCTGTGGAAGAAAAAGATAATAAAGCTACGCTATTGTGGGATTTGCATA
AAGAACAATAAGGGGTATTG

Downstream 100 bases:

>100_bases
AGAATGAAATAAGCTATAATAAGCCCATTTTGAATACGAATGATTATTTTAATAAGGACAATCAATGAAAGATAGTTTTC
TTTTCACTTCTGAATCAGTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKLSELLSAYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRKKESSKVPKHMQALIVDNPHL
VFAKASHAFKIPFFKNPESVNEPKHFKKVTIMPNVIIGEGVEIGENSLIYPGVVIADGVKIGKNCILYPRVILYQNTILE
DNVTIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS

Sequences:

>Translated_336_residues
MKLSELLSAYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRKKESSKVPKHMQALIVDNPHL
VFAKASHAFKIPFFKNPESVNEPKHFKKVTIMPNVIIGEGVEIGENSLIYPGVVIADGVKIGKNCILYPRVILYQNTILE
DNVTIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS
>Mature_336_residues
MKLSELLSAYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRKKESSKVPKHMQALIVDNPHL
VFAKASHAFKIPFFKNPESVNEPKHFKKVTIMPNVIIGEGVEIGENSLIYPGVVIADGVKIGKNCILYPRVILYQNTILE
DNVTIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=319, Percent_Identity=30.7210031347962, Blast_Score=141, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36641; Mature: 36641

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSELLSAYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRK
CCHHHHHHHHEEECCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
KESSKVPKHMQALIVDNPHLVFAKASHAFKIPFFKNPESVNEPKHFKKVTIMPNVIIGEG
CCCCCCCHHHEEEEECCCCEEEEECCCEEECCCCCCCCCCCCCCHHEEEEECCCEEEECC
VEIGENSLIYPGVVIADGVKIGKNCILYPRVILYQNTILEDNVTIHAGSVIGGDGFGYAH
CEECCCCEECCCEEEECCEEECCCEEECCEEEEEECEEECCCEEEEECCEECCCCCCHHH
TALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
HHCCCCEEEEEEEEEEEECCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEECCC
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIP
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCCHHHCCCCCCCCCCCCCCCCCCCCCC
AMEIHEWHHFLAHLRTNFRKQQKTSLLQKAKGFFKS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLSELLSAYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRK
CCHHHHHHHHEEECCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
KESSKVPKHMQALIVDNPHLVFAKASHAFKIPFFKNPESVNEPKHFKKVTIMPNVIIGEG
CCCCCCCHHHEEEEECCCCEEEEECCCEEECCCCCCCCCCCCCCHHEEEEECCCEEEECC
VEIGENSLIYPGVVIADGVKIGKNCILYPRVILYQNTILEDNVTIHAGSVIGGDGFGYAH
CEECCCCEECCCEEEECCEEECCCEEECCEEEEEECEEECCCEEEEECCEECCCCCCHHH
TALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
HHCCCCEEEEEEEEEEEECCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEECCC
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIP
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCCHHHCCCCCCCCCCCCCCCCCCCCCC
AMEIHEWHHFLAHLRTNFRKQQKTSLLQKAKGFFKS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA