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The map label for this gene is tpiA

Identifier: 188526999

GI number: 188526999

Start: 185868

End: 186572

Strand: Direct

Name: tpiA

Synonym: HPSH_00995

Alternate gene names: 188526999

Gene position: 185868-186572 (Clockwise)

Preceding gene: 188526994

Following gene: 188527000

Centisome position: 11.56

GC content: 34.33

Gene sequence:

>705_bases
ATGACAAAAATTGCTATGGCTAATTTTAAATCCGCTATGCCTATTTTTAAAAGCCATGCGTATTTAGAAGAATTAGAAAA
GACTTTAAAACCGCAGCATTTTGATAGGGTGTTTGTATTCCCTGATTTTTTGGGGTTATTGCCTAATTCGTTTTTGCATT
TCACTTTAGGAGCGCAAAACGCTTACCCTAAAGATTGTGGGGCTTTTACCGGTGAAATCACTTCACAGCATTTAGAAGAA
CTCAAAATCAACACGCTTTTAATAGGGCATAGCGAGAGGAGATTGCTTTTAAAGGAAAGCCCTAGCTTTTTGAAAGAAAA
GTTTGATTTTTTTAAAAGTAAAAATTTTAAAATTGTCTATTGCATTGGCGAAGAATTAACGACCAGAGAAAAGGGTTTTA
AGGCTGTAAAGGAATTTTTAAACGAGCAATTAGAAAATATTGATCTTAATTATCCTAATTTAGTGGTGGCGTATGAGCCT
ATTTGGGCGATTGGCACAAAAAAGAGTGCTTCTTTAGAAGATATTTATCTCACGCATGGTTTTTTAAAGCAAATTTTAAA
TCAAAAAACGCCCTTGTTGTATGGGGGGAGCGTGAATGCGCAAAACGCTAAAGAAATTTTAGGGATTGATAGCGTGGATG
GCTTGTTGATTGGGAGTGCGTCTTTGGAATTAGAAAATTTTAAAACAATCATTTCATTTTTATAA

Upstream 100 bases:

>100_bases
AAAAATGCAATTCAAGGGGGCTATTGTTTAAAATTTACATTTTTTAACGCTATTAGATATAATAAGAGATAGTTACCACC
TATGAAATAAGGATCATTCA

Downstream 100 bases:

>100_bases
AGGAAAATCATGGGATTTTTAAAAGGTAAAAAAGGGCTTATTGTAGGGGTGGCAAACAATAAATCCATCGCTTATGGGAT
CGCTCAATCTTGTTTCAATC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTKIAMANFKSAMPIFKSHAYLEELEKTLKPQHFDRVFVFPDFLGLLPNSFLHFTLGAQNAYPKDCGAFTGEITSQHLEE
LKINTLLIGHSERRLLLKESPSFLKEKFDFFKSKNFKIVYCIGEELTTREKGFKAVKEFLNEQLENIDLNYPNLVVAYEP
IWAIGTKKSASLEDIYLTHGFLKQILNQKTPLLYGGSVNAQNAKEILGIDSVDGLLIGSASLELENFKTIISFL

Sequences:

>Translated_234_residues
MTKIAMANFKSAMPIFKSHAYLEELEKTLKPQHFDRVFVFPDFLGLLPNSFLHFTLGAQNAYPKDCGAFTGEITSQHLEE
LKINTLLIGHSERRLLLKESPSFLKEKFDFFKSKNFKIVYCIGEELTTREKGFKAVKEFLNEQLENIDLNYPNLVVAYEP
IWAIGTKKSASLEDIYLTHGFLKQILNQKTPLLYGGSVNAQNAKEILGIDSVDGLLIGSASLELENFKTIISFL
>Mature_233_residues
TKIAMANFKSAMPIFKSHAYLEELEKTLKPQHFDRVFVFPDFLGLLPNSFLHFTLGAQNAYPKDCGAFTGEITSQHLEEL
KINTLLIGHSERRLLLKESPSFLKEKFDFFKSKNFKIVYCIGEELTTREKGFKAVKEFLNEQLENIDLNYPNLVVAYEPI
WAIGTKKSASLEDIYLTHGFLKQILNQKTPLLYGGSVNAQNAKEILGIDSVDGLLIGSASLELENFKTIISFL

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=197, Percent_Identity=34.5177664974619, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI226529917, Length=197, Percent_Identity=34.5177664974619, Blast_Score=114, Evalue=6e-26,
Organism=Escherichia coli, GI1790353, Length=191, Percent_Identity=36.1256544502618, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17536593, Length=186, Percent_Identity=39.247311827957, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320255, Length=183, Percent_Identity=38.2513661202186, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28572008, Length=222, Percent_Identity=36.036036036036, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28572006, Length=222, Percent_Identity=36.036036036036, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28572004, Length=229, Percent_Identity=36.2445414847162, Blast_Score=128, Evalue=3e-30,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26532; Mature: 26401

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIAMANFKSAMPIFKSHAYLEELEKTLKPQHFDRVFVFPDFLGLLPNSFLHFTLGAQN
CCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHCCCCCEEEEECCCC
AYPKDCGAFTGEITSQHLEELKINTLLIGHSERRLLLKESPSFLKEKFDFFKSKNFKIVY
CCCCHHCCCCHHHHHHHHHHHHHEEEEEECCCCEEEECCCHHHHHHHHHHHHCCCCEEEE
CIGEELTTREKGFKAVKEFLNEQLENIDLNYPNLVVAYEPIWAIGTKKSASLEDIYLTHG
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECCCCCCCHHHHHHHHH
FLKQILNQKTPLLYGGSVNAQNAKEILGIDSVDGLLIGSASLELENFKTIISFL
HHHHHHCCCCCEEECCCCCCCCHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TKIAMANFKSAMPIFKSHAYLEELEKTLKPQHFDRVFVFPDFLGLLPNSFLHFTLGAQN
CCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHCCCCCEEEEECCCC
AYPKDCGAFTGEITSQHLEELKINTLLIGHSERRLLLKESPSFLKEKFDFFKSKNFKIVY
CCCCHHCCCCHHHHHHHHHHHHHEEEEEECCCCEEEECCCHHHHHHHHHHHHCCCCEEEE
CIGEELTTREKGFKAVKEFLNEQLENIDLNYPNLVVAYEPIWAIGTKKSASLEDIYLTHG
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECCCCCCCHHHHHHHHH
FLKQILNQKTPLLYGGSVNAQNAKEILGIDSVDGLLIGSASLELENFKTIISFL
HHHHHHCCCCCEEECCCCCCCCHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA