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The map label for this gene is mutY [H]

Identifier: 188526946

GI number: 188526946

Start: 138725

End: 139594

Strand: Reverse

Name: mutY [H]

Synonym: HPSH_00715

Alternate gene names: 188526946

Gene position: 139594-138725 (Counterclockwise)

Preceding gene: 188526947

Following gene: 188526943

Centisome position: 8.68

GC content: 37.82

Gene sequence:

>870_bases
ATGAGCCAACAAACCCAAATCAGCACGGTGGTTGAGCGTTTTTATTCCCCCTTTTTAGAAGCTTTCCCCACTTTAAAAGA
CTTAGCGAGCGCTCAATTAGAGGAGGTTTTATTGCTCTGGAGAGGGCTTGGCTACTATTCAAGGGCTAAAAATTTAAAAA
AAAGCGCTGAAATTTGCGTTAAAGAACACAACTCACAATTACCCAATGACTATCAAAGCCTGTTGAAACTCCCCGGGATT
GGTGCATACACGGCTAATGCGATTTTATGTTTTGGCTTTAGAGAAAAGAGCGCATGCGTGGATGCCAATATCAAACGAGT
GCTTTTAAGGCTTTTTGGTTTGGATCCTAATATCACGGCTAAAGATCTGCAAATTAAGGCGAATGACTTTCTCAATCTTA
ATGAAAGCTTTAATCATAACCAAGCCCTAATTGATCTCGGGGCTTTAATCTGCTCCCCTAAACCCAAATGCGCGATTTGC
CCTTTAAACCCTTATTGTTTGGGTAAAAACCACCCAGAAAAACACACGCTTAAGAAAAAACAAGAAATCATTCAAGAAGA
GCGTTACTTGGGCGTTGTGATCCAAAATAACCAAATCGCTTTAGAAAAAATAGAGCAAAAACTCTATTTTGGGATGCACC
ATTTCCCTAATCTCAAAGAAAACCTAGAATACAAACTCCCCTTTTTAGGCACAATCAAACACAGCCACACTAAATTCAAG
CTCAATTTAAACCTCTATCTCGCTGCGATAAAAGATTTAAAAAACCCTATTCGTTTTTATAGCCTTAAAGACTTAGAAAC
CTTACCCATAAGCTCTATGACGCTTAAAATTTTGAATTTTTTAAAACAAAAAAATTTATTTGGGGGTTAA

Upstream 100 bases:

>100_bases
CGCCCTTTTAAAATGGTATGAAAAATTTGGGCGAAAGGATTTACCTTTTAGGAACTTAAAGGGCATTAACGCTCCTTATG
AAGTCTATATCAGCGAAGTG

Downstream 100 bases:

>100_bases
ACCCTGCCAAATCTAAAATGGCTCTACTTTATCGCAGGCACCACTTCAGGGATCAAATACGCAATCGCGCTAATCACGAC
TCCCATGATCGCTACAAAAA

Product: DNA glycosylase MutY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSQQTQISTVVERFYSPFLEAFPTLKDLASAQLEEVLLLWRGLGYYSRAKNLKKSAEICVKEHNSQLPNDYQSLLKLPGI
GAYTANAILCFGFREKSACVDANIKRVLLRLFGLDPNITAKDLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCAIC
PLNPYCLGKNHPEKHTLKKKQEIIQEERYLGVVIQNNQIALEKIEQKLYFGMHHFPNLKENLEYKLPFLGTIKHSHTKFK
LNLNLYLAAIKDLKNPIRFYSLKDLETLPISSMTLKILNFLKQKNLFGG

Sequences:

>Translated_289_residues
MSQQTQISTVVERFYSPFLEAFPTLKDLASAQLEEVLLLWRGLGYYSRAKNLKKSAEICVKEHNSQLPNDYQSLLKLPGI
GAYTANAILCFGFREKSACVDANIKRVLLRLFGLDPNITAKDLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCAIC
PLNPYCLGKNHPEKHTLKKKQEIIQEERYLGVVIQNNQIALEKIEQKLYFGMHHFPNLKENLEYKLPFLGTIKHSHTKFK
LNLNLYLAAIKDLKNPIRFYSLKDLETLPISSMTLKILNFLKQKNLFGG
>Mature_288_residues
SQQTQISTVVERFYSPFLEAFPTLKDLASAQLEEVLLLWRGLGYYSRAKNLKKSAEICVKEHNSQLPNDYQSLLKLPGIG
AYTANAILCFGFREKSACVDANIKRVLLRLFGLDPNITAKDLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCAICP
LNPYCLGKNHPEKHTLKKKQEIIQEERYLGVVIQNNQIALEKIEQKLYFGMHHFPNLKENLEYKLPFLGTIKHSHTKFKL
NLNLYLAAIKDLKNPIRFYSLKDLETLPISSMTLKILNFLKQKNLFGG

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=183, Percent_Identity=39.8907103825137, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI6912520, Length=183, Percent_Identity=39.8907103825137, Blast_Score=141, Evalue=5e-34,
Organism=Homo sapiens, GI115298654, Length=183, Percent_Identity=39.8907103825137, Blast_Score=141, Evalue=5e-34,
Organism=Homo sapiens, GI115298652, Length=183, Percent_Identity=39.8907103825137, Blast_Score=141, Evalue=5e-34,
Organism=Homo sapiens, GI115298650, Length=183, Percent_Identity=39.8907103825137, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI190358497, Length=183, Percent_Identity=39.8907103825137, Blast_Score=141, Evalue=6e-34,
Organism=Escherichia coli, GI1789331, Length=270, Percent_Identity=32.962962962963, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 33009; Mature: 32878

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQTQISTVVERFYSPFLEAFPTLKDLASAQLEEVLLLWRGLGYYSRAKNLKKSAEICV
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHNSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANIKRVLLRLFGLDPNITA
HHHCCCCCHHHHHHHHCCCCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCH
KDLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCAICPLNPYCLGKNHPEKHTLKKK
HHEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCEECCCCCCHHHHHHHH
QEIIQEERYLGVVIQNNQIALEKIEQKLYFGMHHFPNLKENLEYKLPFLGTIKHSHTKFK
HHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHCCEECCCEEEEEECCCEEEE
LNLNLYLAAIKDLKNPIRFYSLKDLETLPISSMTLKILNFLKQKNLFGG
EEHHHHHHHHHHHCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQQTQISTVVERFYSPFLEAFPTLKDLASAQLEEVLLLWRGLGYYSRAKNLKKSAEICV
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHNSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANIKRVLLRLFGLDPNITA
HHHCCCCCHHHHHHHHCCCCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCH
KDLQIKANDFLNLNESFNHNQALIDLGALICSPKPKCAICPLNPYCLGKNHPEKHTLKKK
HHEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCEECCCCCCHHHHHHHH
QEIIQEERYLGVVIQNNQIALEKIEQKLYFGMHHFPNLKENLEYKLPFLGTIKHSHTKFK
HHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHCCEECCCEEEEEECCCEEEE
LNLNLYLAAIKDLKNPIRFYSLKDLETLPISSMTLKILNFLKQKNLFGG
EEHHHHHHHHHHHCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]