Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 188526926

GI number: 188526926

Start: 120189

End: 122027

Strand: Direct

Name: thrS

Synonym: HPSH_00615

Alternate gene names: 188526926

Gene position: 120189-122027 (Clockwise)

Preceding gene: 188526925

Following gene: 188526927

Centisome position: 7.47

GC content: 41.22

Gene sequence:

>1839_bases
ATGAGTGCGGAACTGATTGCTGTTTATAAAGACGAGCAAATAATAGATTTAGAGAGTGCGAAAGTCTTAGGACTGAGCGA
TGGGGTTAAAGCGTTAAACGGGACAGAGCCGATATATTTTGATGATTCGCCTTTGGCTTTAGAAGTGATCAGGCATTCAT
GTGCGCATTTGCTCGCACAAAGCTTGAAAGCCCTTTATCCGGACGCGAAATTTTTTGTAGGTCCTGTGGTAGAAGAGGGG
TTTTATTACGATTTTAAAACCGCTTCAAAAATCAGCGAAGAGGATTTGCCTAAAATTGAAGCGAAAATGAAAGAATTTGC
GAAGTTAAAGCTCGCTATCACTAAAGAGGTTTTAACCAGAGAGCAAGCCTTGGAGCGTTTTAAGGGCGATGAATTAAAGC
ATGCGGTCATGAGTAAAATCAGTGGCGATAAATTTGGCGTGTACCAACAAGGCGAGTTTGAAGATTTGTGTAAGGGGCCG
CATCTCCCAAACACTCGTTTTTTAAACCATTTCAAGCTCACTAAACTGGCTGGGGCTTATTTGGGTGGCGATGAAAACAA
TGAAATGCTCATTAGAATCTATGGCATCGCTTTTGCCACCAAAGAGGGCTTAAAAGATTATCTTTTCCAAATAGAAGAAG
CGAAAAAACGAAATCACAGAAAGCTGGGCGTGGAGCTAGGGCTTTTTAGTTTTGATGATGAGATAGGGGCAGGCTTACCC
TTGTGGCTGCCTAAAGGGGCAAGACTCAGAAAACGCATTGAAGATTTATTGAGTAAGGCGTTACTTTTAAGAGGCTATGA
GCCGGTTAAAGGCCCTGAGATTTTAAAGAGCGATGTGTGGAAAATCAGCGGGCATTATGACAACTATAAAGAAAACATGT
ATTTCACCACGATTGATGAGCAAGAATACGGCATAAAGCCTATGAACTGCGTGGGGCATATTAAAGTCTATCAAAGCGCT
TTGCACAGCTACAGGGATTTGCCCTTAAGATTTTATGAATACGGCGTGGTGCATCGGCATGAAAAAAGCGGCGTGTTGCA
TGGGCTTTTAAGGGTGAGAGAATTTACCCAAGATGATGCACATATTTTTTGCTCTTTTGAACAGATCCAAAGCGAAGTGA
GCGCGATTTTAGATTTTACGCATAAGATCATGCAAGCGTTTGATTTTAGCTATGAAATGGAATTATCCACAAGGCCGGCT
AAATCCATAGGCGATGATAAAGTGTGGGAAAAGGCCACTAACGCTTTAAAAGAAGCCCTAAAAGAGCACCGCATTGATTA
CAAGATTGATGAAGGGGGAGGGGCTTTCTATGGGCCTAAGATTGACATTAAAATCACCGATGCTTTAAAGCGTAAATGGC
AGTGCGGCACGATTCAAGTGGATATGAATTTGCCTGAACGCTTCAAGCTCGCTTTCACTAATGAGCATAATCACGCTGAA
CAGCCGGTGATGATCCACAGAGCGATTTTAGGCTCGTTTGAAAGGTTTATTGCGATTTTGAGCGAACATTTTGGGGGGAA
TTTCCCTTTCTTTGTCGCACCCACTCAAATCGCTCTCATTCCTATTAATGAAGAGCATCATGTTTTTGCTTTGAAATTAA
AAGAGGCGCTAAAAAAGCGCGATATTTTTGTAGAAGTGTTGGATAAAAACGACAGCTTGAATAAAAAGGTGCGCTTAGCC
GAAAAGCAAAAAATCCCTATGATTTTAGTGTTAGGGAATGAAGAGGTGGAGACAGAAATTTTATCCATTAGAGACAGAGA
AAAACAAGCTCAATATAAAATGCCCTTAAAGGAGTTTTTAAACATGGTTGAATCTAAGATGCAAGAGGTTAGTTTTTGA

Upstream 100 bases:

>100_bases
CCTAAAGCTGAGAAAGTGGATTCGCAAGTGCAATGCGGGTTTGGCTCAAAAGATTGCTAAATTTTAAGGTTTATAAGAAA
GGAAATATAAGTTTTAAAGA

Downstream 100 bases:

>100_bases
GCAGAAACGAAATGTTGTTAAACGGAGATATTAATTTTAAAGAAGTGCGTTGCGTGGGCGATAATGGCGAAGTGTATGGG
ATCATTTCTTCCAAAGAAGC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MSAELIAVYKDEQIIDLESAKVLGLSDGVKALNGTEPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEG
FYYDFKTASKISEEDLPKIEAKMKEFAKLKLAITKEVLTREQALERFKGDELKHAVMSKISGDKFGVYQQGEFEDLCKGP
HLPNTRFLNHFKLTKLAGAYLGGDENNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRNHRKLGVELGLFSFDDEIGAGLP
LWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSA
LHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMQAFDFSYEMELSTRPA
KSIGDDKVWEKATNALKEALKEHRIDYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNHAE
QPVMIHRAILGSFERFIAILSEHFGGNFPFFVAPTQIALIPINEEHHVFALKLKEALKKRDIFVEVLDKNDSLNKKVRLA
EKQKIPMILVLGNEEVETEILSIRDREKQAQYKMPLKEFLNMVESKMQEVSF

Sequences:

>Translated_612_residues
MSAELIAVYKDEQIIDLESAKVLGLSDGVKALNGTEPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEG
FYYDFKTASKISEEDLPKIEAKMKEFAKLKLAITKEVLTREQALERFKGDELKHAVMSKISGDKFGVYQQGEFEDLCKGP
HLPNTRFLNHFKLTKLAGAYLGGDENNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRNHRKLGVELGLFSFDDEIGAGLP
LWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSA
LHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMQAFDFSYEMELSTRPA
KSIGDDKVWEKATNALKEALKEHRIDYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNHAE
QPVMIHRAILGSFERFIAILSEHFGGNFPFFVAPTQIALIPINEEHHVFALKLKEALKKRDIFVEVLDKNDSLNKKVRLA
EKQKIPMILVLGNEEVETEILSIRDREKQAQYKMPLKEFLNMVESKMQEVSF
>Mature_611_residues
SAELIAVYKDEQIIDLESAKVLGLSDGVKALNGTEPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEGF
YYDFKTASKISEEDLPKIEAKMKEFAKLKLAITKEVLTREQALERFKGDELKHAVMSKISGDKFGVYQQGEFEDLCKGPH
LPNTRFLNHFKLTKLAGAYLGGDENNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRNHRKLGVELGLFSFDDEIGAGLPL
WLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSAL
HSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMQAFDFSYEMELSTRPAK
SIGDDKVWEKATNALKEALKEHRIDYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNHAEQ
PVMIHRAILGSFERFIAILSEHFGGNFPFFVAPTQIALIPINEEHHVFALKLKEALKKRDIFVEVLDKNDSLNKKVRLAE
KQKIPMILVLGNEEVETEILSIRDREKQAQYKMPLKEFLNMVESKMQEVSF

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=563, Percent_Identity=37.6554174067496, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI38570111, Length=593, Percent_Identity=37.0994940978078, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI20070344, Length=577, Percent_Identity=34.1421143847487, Blast_Score=355, Evalue=8e-98,
Organism=Escherichia coli, GI1788013, Length=572, Percent_Identity=41.958041958042, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1786392, Length=160, Percent_Identity=28.125, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984184, Length=570, Percent_Identity=38.9473684210526, Blast_Score=417, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71984192, Length=570, Percent_Identity=38.9473684210526, Blast_Score=417, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6322112, Length=560, Percent_Identity=40.1785714285714, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=36.6412213740458, Blast_Score=260, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24583842, Length=603, Percent_Identity=37.1475953565506, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI28574141, Length=603, Percent_Identity=37.1475953565506, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24583839, Length=603, Percent_Identity=37.1475953565506, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 70225; Mature: 70094

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELIAVYKDEQIIDLESAKVLGLSDGVKALNGTEPIYFDDSPLALEVIRHSCAHLLAQ
CCCCEEEEECCCEEEEECCCEEEECCCCCHHCCCCCCEEECCCCHHHHHHHHHHHHHHHH
SLKALYPDAKFFVGPVVEEGFYYDFKTASKISEEDLPKIEAKMKEFAKLKLAITKEVLTR
HHHHHCCCCHHEECHHHHCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EQALERFKGDELKHAVMSKISGDKFGVYQQGEFEDLCKGPHLPNTRFLNHFKLTKLAGAY
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LGGDENNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRNHRKLGVELGLFSFDDEIGAGLP
CCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEECEEEEEEECCCCCCCCCC
LWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDE
EECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEECCCCCCCCCEEEEEECC
QEYGIKPMNCVGHIKVYQSALHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCEECCHHHHHHHHHHHHHHCCCCC
HIFCSFEQIQSEVSAILDFTHKIMQAFDFSYEMELSTRPAKSIGDDKVWEKATNALKEAL
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
KEHRIDYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNHAE
HHCCCCEEEECCCCEEECCEEEEEEEHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCC
QPVMIHRAILGSFERFIAILSEHFGGNFPFFVAPTQIALIPINEEHHVFALKLKEALKKR
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCEEEHHHHHHHHHC
DIFVEVLDKNDSLNKKVRLAEKQKIPMILVLGNEEVETEILSIRDREKQAQYKMPLKEFL
CEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHH
NMVESKMQEVSF
HHHHHHHHHCCC
>Mature Secondary Structure 
SAELIAVYKDEQIIDLESAKVLGLSDGVKALNGTEPIYFDDSPLALEVIRHSCAHLLAQ
CCCEEEEECCCEEEEECCCEEEECCCCCHHCCCCCCEEECCCCHHHHHHHHHHHHHHHH
SLKALYPDAKFFVGPVVEEGFYYDFKTASKISEEDLPKIEAKMKEFAKLKLAITKEVLTR
HHHHHCCCCHHEECHHHHCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EQALERFKGDELKHAVMSKISGDKFGVYQQGEFEDLCKGPHLPNTRFLNHFKLTKLAGAY
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LGGDENNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRNHRKLGVELGLFSFDDEIGAGLP
CCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEECEEEEEEECCCCCCCCCC
LWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDE
EECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEECCCCCCCCCEEEEEECC
QEYGIKPMNCVGHIKVYQSALHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCEECCHHHHHHHHHHHHHHCCCCC
HIFCSFEQIQSEVSAILDFTHKIMQAFDFSYEMELSTRPAKSIGDDKVWEKATNALKEAL
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
KEHRIDYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNHAE
HHCCCCEEEECCCCEEECCEEEEEEEHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCC
QPVMIHRAILGSFERFIAILSEHFGGNFPFFVAPTQIALIPINEEHHVFALKLKEALKKR
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCEEEHHHHHHHHHC
DIFVEVLDKNDSLNKKVRLAEKQKIPMILVLGNEEVETEILSIRDREKQAQYKMPLKEFL
CEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHH
NMVESKMQEVSF
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA