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The map label for this gene is thrC [H]

Identifier: 188526903

GI number: 188526903

Start: 89652

End: 91112

Strand: Reverse

Name: thrC [H]

Synonym: HPSH_00490

Alternate gene names: 188526903

Gene position: 91112-89652 (Counterclockwise)

Preceding gene: 188526907

Following gene: 188526902

Centisome position: 5.66

GC content: 40.18

Gene sequence:

>1461_bases
ATGCCTTTTGTCCCCACGCGTTCTTTGAAAGAAAAAAAGATTGATTTTATTGAAGCAATATTAAACCCCAACGCCCCAAA
AGGCGGGCTTTACACTTTAGAGCATTTTGAAACATTAGAATGGCAGGATTGTTTGAATCTGAGCTATAACGAGCTGGTAG
AATGCGTGTTTGAGCGGTTGGGATTAGAGATTCCTAAGGGTTTATTAACAAGCGCTTTAAAACGCTATGAAAATTTTGAT
AACCCTAAAAATCCAGCCCCTATTTTTGCGCTCAATGAAAGGCTTTTTGTCCAAGAGCTCTACCATGGGCCTAGTTTGGC
GTTTAAAGACATGGCGTTACAGCCTTTAGCGAGCTTGTTTTCTAATCTAGCGGTAGGAAAAAATGAAAAGTATTTAATGC
TTGTTTCTACCAGTGGCGATACCGGCCCTGCGACTTTAGAAAGTTTGGCGGGCATGCCTAATGTTTTTGTGGTGTGTTTA
TACCCCAAAGACGGCACAAGTTTGGTCCAAAAACTCCAAATGGTTACCCAAAGCGCTAGCAATTTAAAGGTCTTTGGGAT
CAGTGGGGATTTTGATGATGCGCAAAACGCGCTCAAAAACCTTTTAAAAGACGATGATTTTAACGGCGCTTTAAAAACGC
GCCAATTAAAATTAAGCGTGGCTAATTCCGTGAATTTTGGGCGCATCGCTTTTCAAATCGTCTATCATATTTGGGGCTTT
TTAGAATTGTATAAAAAAGGCGCGATCAATTCTAAAGAAAAAATCACCCTAGCCATACCTAGCGGTAATTTTGGGAACGC
GTTAGGGGCGTTTTATGCCAAAAAAATGGGTTTGAATATTGATAAAATCAAGGTTGTAACCAACAGCAATGATGTTTTAA
GGGAGTTTATAGAAACAGGGCGTTACGATTTAACCCATCGTTCTTTAAAGCAAACCTACTCGCCGGCTATGGATATTTTA
AAAAGCTCTAATGTGGAAAGAGCGCTTTTTGACCTCTTTGGGTTTGAACGCACACTAGAATTGATGCAAGCTTTAGAAGA
AGAGAAATTTTATGCATTAAAGCCTAAAGAATTAGCCCTTTTACAGGAGCATTTTTCTTGCGCGAGCTGCTCAGATGAAG
CTTGTTTGAAAACAATCCAAGAAGTTTATGCAAAGCACCAATACCTGATTGACCCTCACACCGCCACCGCTTTAAACGCC
AGCTTGAAAACCAATGAAAAAACCCTTGTTTCTGCCACCGCCTCTTATGAAAAATTCCCCAGCACCACCCTTTTAGCCCT
AAACGAACAAAAGAAAAACGATAACGACAAAACCGCCCTAGAAACGCTTAAAAACAGCTACAATACCCCAGATAGCCAAC
GCCTTGATGATTTATTTGAAAGAGGAATCAAGCACCAAGAGGTTTTAAAACTCAATGAGATCAAATCTTCTATCCTTTTG
TGGCTAGAAAACACGCATTAA

Upstream 100 bases:

>100_bases
AGACGATCAATCATCCTCATCAAAAACCATTTTAAGGTTGCATTCGCTCTTTTAGGGTATGCTACGACTTGAAATTATCC
AAATATAAGAAGGAATCACC

Downstream 100 bases:

>100_bases
AGCTTTTTTGAGCTTTTAGCCTTAACAAGAGTTACATTTTAAGTTAAAACACACTATAATAAATAAACTCTAAACAAAAA
TTAAACTGAATGAAAGGGAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLEHFETLEWQDCLNLSYNELVECVFERLGLEIPKGLLTSALKRYENFD
NPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCL
YPKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNGALKTRQLKLSVANSVNFGRIAFQIVYHIWGF
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDIL
KSSNVERALFDLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAKHQYLIDPHTATALNA
SLKTNEKTLVSATASYEKFPSTTLLALNEQKKNDNDKTALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
WLENTH

Sequences:

>Translated_486_residues
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLEHFETLEWQDCLNLSYNELVECVFERLGLEIPKGLLTSALKRYENFD
NPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCL
YPKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNGALKTRQLKLSVANSVNFGRIAFQIVYHIWGF
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDIL
KSSNVERALFDLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAKHQYLIDPHTATALNA
SLKTNEKTLVSATASYEKFPSTTLLALNEQKKNDNDKTALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
WLENTH
>Mature_485_residues
PFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLEHFETLEWQDCLNLSYNELVECVFERLGLEIPKGLLTSALKRYENFDN
PKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLY
PKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNGALKTRQLKLSVANSVNFGRIAFQIVYHIWGFL
ELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDILK
SSNVERALFDLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAKHQYLIDPHTATALNAS
LKTNEKTLVSATASYEKFPSTTLLALNEQKKNDNDKTALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILLW
LENTH

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=472, Percent_Identity=36.0169491525424, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI149193323, Length=445, Percent_Identity=31.0112359550562, Blast_Score=181, Evalue=2e-45,
Organism=Escherichia coli, GI1786185, Length=334, Percent_Identity=29.6407185628743, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319901, Length=445, Percent_Identity=33.0337078651685, Blast_Score=206, Evalue=6e-54,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54655; Mature: 54524

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLEHFETLEWQDCLNLSYNELVECVFERL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCHHHHHCCCHHHHHHHHHHHH
GLEIPKGLLTSALKRYENFDNPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLF
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLYPKDGTSLVQKLQMVTQSAS
HHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
NLKVFGISGDFDDAQNALKNLLKDDDFNGALKTRQLKLSVANSVNFGRIAFQIVYHIWGF
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHEEEEEHHCCCCHHHHHHHHHHHHHHH
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETG
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCC
RYDLTHRSLKQTYSPAMDILKSSNVERALFDLFGFERTLELMQALEEEKFYALKPKELAL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
LQEHFSCASCSDEACLKTIQEVYAKHQYLIDPHTATALNASLKTNEKTLVSATASYEKFP
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCCCCCCCEEEEHHHHHHCC
STTLLALNEQKKNDNDKTALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHEEE
WLENTH
EEECCC
>Mature Secondary Structure 
PFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLEHFETLEWQDCLNLSYNELVECVFERL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCHHHHHCCCHHHHHHHHHHHH
GLEIPKGLLTSALKRYENFDNPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLF
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLYPKDGTSLVQKLQMVTQSAS
HHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
NLKVFGISGDFDDAQNALKNLLKDDDFNGALKTRQLKLSVANSVNFGRIAFQIVYHIWGF
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHEEEEEHHCCCCHHHHHHHHHHHHHHH
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIDKIKVVTNSNDVLREFIETG
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCC
RYDLTHRSLKQTYSPAMDILKSSNVERALFDLFGFERTLELMQALEEEKFYALKPKELAL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
LQEHFSCASCSDEACLKTIQEVYAKHQYLIDPHTATALNASLKTNEKTLVSATASYEKFP
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCCCCCCCEEEEHHHHHHCC
STTLLALNEQKKNDNDKTALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHEEE
WLENTH
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]