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The map label for this gene is ycgO [H]

Identifier: 188526864

GI number: 188526864

Start: 49833

End: 51332

Strand: Reverse

Name: ycgO [H]

Synonym: HPSH_00270

Alternate gene names: 188526864

Gene position: 51332-49833 (Counterclockwise)

Preceding gene: 188526865

Following gene: 188526863

Centisome position: 3.19

GC content: 42.67

Gene sequence:

>1500_bases
ATGGGACATGTTGTTTTAAGCACCCCTATTGTTACGATGTTTGTCGCTTATTCGCTGTTAATGCTCTATATTGGTTTTTA
TTTTTACAAACAAAATGAAACGACTGAAGATTATTTCTTAGGCGATCGTTCCATGGGCCCTATCATTAGCGCTTTGAGCG
CAGGAGCGAGCGATATGAGCGGGTGGCTTTTAATGGGACTGCCTGGAGCTTTATACGTGGGGGGCTTAATCAACTCACAC
ATCGCCATAGGGTTGAGTTTGGGCGCGCTCATTAACTGGGTTTTTGTGGCTAAACGCTTACGCATTTATACGAGCGTGAT
CGCTAATTCCATCACCATTTCAGATTATTTTGAAACGCGCTTTAGCGATGATAAACACATCTTGCGCTTGATTTCAGCTT
TTGTGATTTTGATCTTTTTTATTTTTTACATTTCTTCAGGGCTGGTGAGTGGGGCTAAACTCTTTGAAGCGACCTTTGGC
ATTCAATACACCTACGCTTTAAGCATTGGCACGCTAATTATTGTCTCTTACACCTTTTTAGGGGGGTATAGGGCGGTGTG
CTGGACGGATTTGATTCAAGGGCTTTTGATGATGAGCGCTTTAATCGTGGTTCCAGTCGTTATGATAATCCATCTTGGAG
GGATTGGAGAAGGGATTAAGATCATTAGAGAAATCAAGCCTGAAAACCTTTCTTTCTTGCAAGGCTCTAGCATAGTCGCC
ATTATTTCAAGCCTTGCTTGGGGGTTAGGCTATTTTGGGCAACCCCATATTTTAGTGCGTTTCATGTCTATCCGCTCCAT
TAAAGATGTCCCTAAAGCGACCACTATTGGGATTTCTTGGATGGTTATTTCTTTGATTGGGGCATGCACTATGGGGCTTT
TAGGCGTTGCGTATGTGCATAAATTTGACTTGAGCTTAGAAGACCCTGAAAAGATTTTCATTGTGATGAGTCAATTGCTC
TTTAACCCTTGGATCACAGGCATTTTATTGAGCGCGATTTTAGCGGCGGTAATGAGCACGGCCAGTTCGCAACTGCTTGT
AAGCTCTTCTACCATTGCTGAAGACTTCTATGCGACGATTTTCAATAAAGACGCTCCGCAAAAATTAGTGATGGTTATTT
CTAGGCTCTCGGTTTTAGGGGTGGCTTGCATCGCTTTTTTCATTTCAACGGATAGAAACGCCAGCATTCTCAGCATCGTG
AGCTACGCATGGGCTGGCTTTGGCGCGAGTTTTGGCTCTGTGATTTTGTTTTCACTTTTTTGGTCAAGAATGACGCGCGT
TGGCGCGATTGCTGGCATGCTCTTTGGGGCTAGCACGGTGATTTTATACGATAAATTTGGCAAAAGCTTTTTGGATATTT
ATGAAATCGTTCCGGGCTTTATTGCAGCGAGCATCGCTATTGTTGTATCCAGTTTGTTTTCTAGCGTGCGAGCAGGCACT
AAAGAGGCTTTTGAAACCATGCTTAAAAAAATTAAAGAAATTGAAAGCTTTAAATATTAA

Upstream 100 bases:

>100_bases
ATCGTTACGGGAATTTAGGCTCAAGGGTTTTAAGGCGACCAACTTGCCACAAATCATGTTGTGCTGAAAAATAAATATTG
TATTAAATAAGGAGATCAAA

Downstream 100 bases:

>100_bases
TGCTTCAAATGAGTTTGGTTTAATCTTTAATCCCCCTATGCTCTTTAATCAAACCTTAACCTATATTTCTTTATTTTCTT
GGGCAGGAGTGGGGCGCTAT

Product: proline permease (putP)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MGHVVLSTPIVTMFVAYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPIISALSAGASDMSGWLLMGLPGALYVGGLINSH
IAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFG
IQYTYALSIGTLIIVSYTFLGGYRAVCWTDLIQGLLMMSALIVVPVVMIIHLGGIGEGIKIIREIKPENLSFLQGSSIVA
IISSLAWGLGYFGQPHILVRFMSIRSIKDVPKATTIGISWMVISLIGACTMGLLGVAYVHKFDLSLEDPEKIFIVMSQLL
FNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKDAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIV
SYAWAGFGASFGSVILFSLFWSRMTRVGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIAASIAIVVSSLFSSVRAGT
KEAFETMLKKIKEIESFKY

Sequences:

>Translated_499_residues
MGHVVLSTPIVTMFVAYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPIISALSAGASDMSGWLLMGLPGALYVGGLINSH
IAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFG
IQYTYALSIGTLIIVSYTFLGGYRAVCWTDLIQGLLMMSALIVVPVVMIIHLGGIGEGIKIIREIKPENLSFLQGSSIVA
IISSLAWGLGYFGQPHILVRFMSIRSIKDVPKATTIGISWMVISLIGACTMGLLGVAYVHKFDLSLEDPEKIFIVMSQLL
FNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKDAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIV
SYAWAGFGASFGSVILFSLFWSRMTRVGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIAASIAIVVSSLFSSVRAGT
KEAFETMLKKIKEIESFKY
>Mature_498_residues
GHVVLSTPIVTMFVAYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPIISALSAGASDMSGWLLMGLPGALYVGGLINSHI
AIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGI
QYTYALSIGTLIIVSYTFLGGYRAVCWTDLIQGLLMMSALIVVPVVMIIHLGGIGEGIKIIREIKPENLSFLQGSSIVAI
ISSLAWGLGYFGQPHILVRFMSIRSIKDVPKATTIGISWMVISLIGACTMGLLGVAYVHKFDLSLEDPEKIFIVMSQLLF
NPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKDAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIVS
YAWAGFGASFGSVILFSLFWSRMTRVGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIAASIAIVVSSLFSSVRAGTK
EAFETMLKKIKEIESFKY

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=493, Percent_Identity=46.4503042596349, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI256985183, Length=428, Percent_Identity=22.196261682243, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4507035, Length=386, Percent_Identity=24.0932642487047, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787251, Length=497, Percent_Identity=50.3018108651911, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI87082237, Length=487, Percent_Identity=27.9260780287474, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1790503, Length=451, Percent_Identity=22.1729490022173, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17539284, Length=369, Percent_Identity=26.0162601626016, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645928, Length=373, Percent_Identity=28.4182305630027, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI221459588, Length=433, Percent_Identity=25.635103926097, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24651741, Length=461, Percent_Identity=25.8134490238612, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221459586, Length=385, Percent_Identity=25.1948051948052, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573698, Length=408, Percent_Identity=26.2254901960784, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221459584, Length=349, Percent_Identity=23.7822349570201, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221459582, Length=359, Percent_Identity=27.5766016713092, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281362918, Length=465, Percent_Identity=26.0215053763441, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651739, Length=466, Percent_Identity=23.3905579399142, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54455; Mature: 54324

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHVVLSTPIVTMFVAYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPIISALSAGASDMS
CCCEEEHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCHHHHHHHHCCCCCCC
GWLLMGLPGALYVGGLINSHIAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGIQYTYALSIGTLIIVSYTFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHH
GGYRAVCWTDLIQGLLMMSALIVVPVVMIIHLGGIGEGIKIIREIKPENLSFLQGSSIVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHH
IISSLAWGLGYFGQPHILVRFMSIRSIKDVPKATTIGISWMVISLIGACTMGLLGVAYVH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFDLSLEDPEKIFIVMSQLLFNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHH
FNKDAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIVSYAWAGFGASFGSVILFSLF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
WSRMTRVGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIAASIAIVVSSLFSSVRAGT
HHHHHHHHHHHHHHHCCHHEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KEAFETMLKKIKEIESFKY
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GHVVLSTPIVTMFVAYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPIISALSAGASDMS
CCEEEHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCHHHHHHHHCCCCCCC
GWLLMGLPGALYVGGLINSHIAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGIQYTYALSIGTLIIVSYTFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHH
GGYRAVCWTDLIQGLLMMSALIVVPVVMIIHLGGIGEGIKIIREIKPENLSFLQGSSIVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHH
IISSLAWGLGYFGQPHILVRFMSIRSIKDVPKATTIGISWMVISLIGACTMGLLGVAYVH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFDLSLEDPEKIFIVMSQLLFNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHH
FNKDAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIVSYAWAGFGASFGSVILFSLF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
WSRMTRVGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIAASIAIVVSSLFSSVRAGT
HHHHHHHHHHHHHHHCCHHEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KEAFETMLKKIKEIESFKY
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]