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The map label for this gene is clpA [H]

Identifier: 188526843

GI number: 188526843

Start: 30565

End: 32787

Strand: Direct

Name: clpA [H]

Synonym: HPSH_00165

Alternate gene names: 188526843

Gene position: 30565-32787 (Clockwise)

Preceding gene: 188526842

Following gene: 188526844

Centisome position: 1.9

GC content: 40.4

Gene sequence:

>2223_bases
ATGGCTAAATTCAATCAAGATCTCAATGAAGTCCTAAACCGAGCTTTAAATTTAGCCCTAGATCTTAACCATGCCCTTTG
CACCACAGAGCATGTGCTATTGGTTATTTTAGAGCATGAGAGCGGGGCAAAGATGATTGGTGCTTTAGAAAGAGATGACT
ATGATAGATTAAAACAAATCCTTAAAGACTATTTGTTGCAATATGTGCCTTTAAAGAGTGATCCAGCCAAAATGCCTGCT
AGGAGTTTTGTGCTATTAAGAATGCTTAAAAGAATGTATGCGAGTGGTTTTGAGAGCGTGGGCGTGGAAGAATTGCTTAT
TTTAATGCTGGATCACCCCGATTGTTACGCTTCAAAACTCATGGATAGTTTTGGCATCGCTCGTTTGTATTCTAATCCTG
CTTTATTGGATTTGGATAACCATGGCATTCCTAATGACACCAATAATGAAGAAGCGCCCAAAAACACTCCCCTAAAAAAA
TACGCTAAGAATTTGAGCGCTTTAGCCCAAGATAACGCTTTAGATCCAGTCATTGGCAGAGAAGAAGAGATTTTAAGAGT
GATAGAAATTTTAGGGCGCAGAAAAAAGAATAACCCGCTTTTAATTGGCGAAGCGGGCGTAGGGAAAACCTCCATCGCTG
AAGCTTTGGCTTTAAAAATCGCTCAAAAAGAAGTGCCGGAGTTTTTGCAAGAATATGAAGTCTATTCTTTGGATTTAGCT
TTAATGGTGGCTGGGGCAAAATACAGAGGGGATTTTGAAAAACGCTTGAAAAAAACGCTCAAAGAAATCCAAGAAAACGG
CCGCATCATTTTATTCATTGATGAAATCCACACCCTTTTAGGTGCAGGGAACACTAACGCTGGGAGCTTAGATGCGGCGA
ATATATTAAAACCGGTCCTAACGGATGGGAGCTTGAAATGTTTAGGAGCGACCACTTTTGAAGAATACCGCAGCGTGTTT
GAAAAAGACAAGGCTTTCAACAGGCGTTTTTCAGTCATAAAAGTTGAAGAGCCTTCTAAAGAGGCGTGTTATTTGATCTT
AAAAAAGATCGCTCCCCTTTATGAAGAACACCACCAGGTGCGTTATGATGAGAGCGTGTTTAAGGCATGCGTGGATTTAA
CGAGTTATTACATGCATGATAAATTCTTGCCGGATAAAGCGATTGAATTGCTAGATGAGGTGGGATCGAGGAAAAAAATC
AGCCCTAAAAAGGGCAAAAAAATCAGCGTTGATGATGTGAAAGAAGCGCTCGCCATAAAGCTTAAAATCCCTAAAATGCG
TTTGAGCAGCGATAAAAAAGCCCTTTTAAGGAATTTAGAAAAATCGCTTAGAAATAAGATTTTCGCCCAAGCAGAAGCGA
TCAATCTTGTCAGTAATGCGATTAAAATCCAGCATTGCGGGCTTTCTGCAAAAAATAAGCCTGTGGGGAGCTTTTTATTC
GTGGGGCCTAGTGGGGTGGGGAAAACAGAGTTGGCTAAAGAATTGGCCTTGAATTTGAATTTGCATTTTGAACGCTTTGA
CATGAGCGAATACAAAGAAGCCCATAGCGTGGCCAAGCTCATCGGGAGTCCTAGCGGTTATGTGGGGTTTGAGCAAGGGG
GGTTATTGGTGAATGCGATTAAAAAACACCCGCATTGCTTGCTACTTTTAGATGAAATAGAAAAAGCCCATTCTAATGTG
TATGACTTGTTGTTGCAAGTGATGGATAACGCCACTTTGAGCGATAATTTGGGCAATCAGGCGAGTTTTAAGCATGTGAT
TTTGATCATGACTTCAAATGTGGGGAGTAAGGATAAGGATGCGCTAGGGTTTTTTAGCGCTAAAAACACCAAGTATGATA
AGGCCGTTAGAGAGCTTTTGACCCCCGAATTACGATCTAGAATTGATGCGATCGTGCCGTTTAACACGCTTGGTTTGGAG
GATTTTGAACGCATTGTTTCTGTGGAATTAGACAAATTAAAAGCCCTAGCGCTAGAGCAAGACATAGCCTTAAAATTTCA
TAAAGAAGTTTTGAAATTCATCGCGCAAAAAAGCTACCAAACGACTTTAGGAGCGAGGGAAATTAAAAAAATCATTCACA
ATGAGATCAAAACCCCATTAAGCGATCTACTGCTCTTGCAATCGTTTAAAAAACCTTGTAAGATCGCTTGCTTGCTAGAA
AAAAACCAATTGGTTTTGAAAGAAATCAAGCGCGTGCAAAAGGTGAAAGAAAATGACTTTTGA

Upstream 100 bases:

>100_bases
TCTATCCTTATGATATTGCCAGGCATAGGGCAGCATGGGTTAGGGATAAAGCCAGAGAGCTAGATCTCCCTTTAAAATTA
TTGGTAGAAGAGATAAGATA

Downstream 100 bases:

>100_bases
AATGCTTTATAGTAAGATCCATAGGGTCACTATCACAGACGCTAACCTTAATTATGTAGGATCGATCACCATAGATGAGG
ATTTGGCCAAGCTTGCCAAG

Product: ATP-dependent C1p protease (clpA)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MAKFNQDLNEVLNRALNLALDLNHALCTTEHVLLVILEHESGAKMIGALERDDYDRLKQILKDYLLQYVPLKSDPAKMPA
RSFVLLRMLKRMYASGFESVGVEELLILMLDHPDCYASKLMDSFGIARLYSNPALLDLDNHGIPNDTNNEEAPKNTPLKK
YAKNLSALAQDNALDPVIGREEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDLA
LMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGNTNAGSLDAANILKPVLTDGSLKCLGATTFEEYRSVF
EKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSYYMHDKFLPDKAIELLDEVGSRKKI
SPKKGKKISVDDVKEALAIKLKIPKMRLSSDKKALLRNLEKSLRNKIFAQAEAINLVSNAIKIQHCGLSAKNKPVGSFLF
VGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHSNV
YDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDKDALGFFSAKNTKYDKAVRELLTPELRSRIDAIVPFNTLGLE
DFERIVSVELDKLKALALEQDIALKFHKEVLKFIAQKSYQTTLGAREIKKIIHNEIKTPLSDLLLLQSFKKPCKIACLLE
KNQLVLKEIKRVQKVKENDF

Sequences:

>Translated_740_residues
MAKFNQDLNEVLNRALNLALDLNHALCTTEHVLLVILEHESGAKMIGALERDDYDRLKQILKDYLLQYVPLKSDPAKMPA
RSFVLLRMLKRMYASGFESVGVEELLILMLDHPDCYASKLMDSFGIARLYSNPALLDLDNHGIPNDTNNEEAPKNTPLKK
YAKNLSALAQDNALDPVIGREEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDLA
LMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGNTNAGSLDAANILKPVLTDGSLKCLGATTFEEYRSVF
EKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSYYMHDKFLPDKAIELLDEVGSRKKI
SPKKGKKISVDDVKEALAIKLKIPKMRLSSDKKALLRNLEKSLRNKIFAQAEAINLVSNAIKIQHCGLSAKNKPVGSFLF
VGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHSNV
YDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDKDALGFFSAKNTKYDKAVRELLTPELRSRIDAIVPFNTLGLE
DFERIVSVELDKLKALALEQDIALKFHKEVLKFIAQKSYQTTLGAREIKKIIHNEIKTPLSDLLLLQSFKKPCKIACLLE
KNQLVLKEIKRVQKVKENDF
>Mature_739_residues
AKFNQDLNEVLNRALNLALDLNHALCTTEHVLLVILEHESGAKMIGALERDDYDRLKQILKDYLLQYVPLKSDPAKMPAR
SFVLLRMLKRMYASGFESVGVEELLILMLDHPDCYASKLMDSFGIARLYSNPALLDLDNHGIPNDTNNEEAPKNTPLKKY
AKNLSALAQDNALDPVIGREEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDLAL
MVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGNTNAGSLDAANILKPVLTDGSLKCLGATTFEEYRSVFE
KDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSYYMHDKFLPDKAIELLDEVGSRKKIS
PKKGKKISVDDVKEALAIKLKIPKMRLSSDKKALLRNLEKSLRNKIFAQAEAINLVSNAIKIQHCGLSAKNKPVGSFLFV
GPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHSNVY
DLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDKDALGFFSAKNTKYDKAVRELLTPELRSRIDAIVPFNTLGLED
FERIVSVELDKLKALALEQDIALKFHKEVLKFIAQKSYQTTLGAREIKKIIHNEIKTPLSDLLLLQSFKKPCKIACLLEK
NQLVLKEIKRVQKVKENDF

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=300, Percent_Identity=33.6666666666667, Blast_Score=137, Evalue=5e-32,
Organism=Escherichia coli, GI1787109, Length=747, Percent_Identity=39.3574297188755, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1788943, Length=262, Percent_Identity=49.618320610687, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6320464, Length=265, Percent_Identity=48.6792452830189, Blast_Score=248, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6323002, Length=245, Percent_Identity=51.4285714285714, Blast_Score=234, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83162; Mature: 83031

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFNQDLNEVLNRALNLALDLNHALCTTEHVLLVILEHESGAKMIGALERDDYDRLKQI
CCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEECCCCCHHHHHHCCCCHHHHHHH
LKDYLLQYVPLKSDPAKMPARSFVLLRMLKRMYASGFESVGVEELLILMLDHPDCYASKL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHH
MDSFGIARLYSNPALLDLDNHGIPNDTNNEEAPKNTPLKKYAKNLSALAQDNALDPVIGR
HHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
EEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDLA
HHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHH
LMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGNTNAGSLDAANILKPVL
HHHCCCHHCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHH
TDGSLKCLGATTFEEYRSVFEKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQV
CCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
RYDESVFKACVDLTSYYMHDKFLPDKAIELLDEVGSRKKISPKKGKKISVDDVKEALAIK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHEEE
LKIPKMRLSSDKKALLRNLEKSLRNKIFAQAEAINLVSNAIKIQHCGLSAKNKPVGSFLF
EECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEE
VGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAI
ECCCCCCHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHH
KKHPHCLLLLDEIEKAHSNVYDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDKD
HCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCH
ALGFFSAKNTKYDKAVRELLTPELRSRIDAIVPFNTLGLEDFERIVSVELDKLKALALEQ
HHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DIALKFHKEVLKFIAQKSYQTTLGAREIKKIIHNEIKTPLSDLLLLQSFKKPCKIACLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEC
KNQLVLKEIKRVQKVKENDF
CCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKFNQDLNEVLNRALNLALDLNHALCTTEHVLLVILEHESGAKMIGALERDDYDRLKQI
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEECCCCCHHHHHHCCCCHHHHHHH
LKDYLLQYVPLKSDPAKMPARSFVLLRMLKRMYASGFESVGVEELLILMLDHPDCYASKL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHH
MDSFGIARLYSNPALLDLDNHGIPNDTNNEEAPKNTPLKKYAKNLSALAQDNALDPVIGR
HHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
EEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDLA
HHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHH
LMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGNTNAGSLDAANILKPVL
HHHCCCHHCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHH
TDGSLKCLGATTFEEYRSVFEKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQV
CCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
RYDESVFKACVDLTSYYMHDKFLPDKAIELLDEVGSRKKISPKKGKKISVDDVKEALAIK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHEEE
LKIPKMRLSSDKKALLRNLEKSLRNKIFAQAEAINLVSNAIKIQHCGLSAKNKPVGSFLF
EECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEE
VGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAI
ECCCCCCHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHH
KKHPHCLLLLDEIEKAHSNVYDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDKD
HCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCH
ALGFFSAKNTKYDKAVRELLTPELRSRIDAIVPFNTLGLEDFERIVSVELDKLKALALEQ
HHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DIALKFHKEVLKFIAQKSYQTTLGAREIKKIIHNEIKTPLSDLLLLQSFKKPCKIACLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEC
KNQLVLKEIKRVQKVKENDF
CCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]