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The map label for this gene is icd [H]

Identifier: 188526837

GI number: 188526837

Start: 26857

End: 28134

Strand: Direct

Name: icd [H]

Synonym: HPSH_00135

Alternate gene names: 188526837

Gene position: 26857-28134 (Clockwise)

Preceding gene: 188526835

Following gene: 188526838

Centisome position: 1.67

GC content: 42.96

Gene sequence:

>1278_bases
ATGGCTTACAACCCTAAAATCTTACAAAAGCCTAAAGAGGGCGAAGAAATTACGATTAAAGACAACAAATTGCATGTGCC
AAACCACCCCATTATCCCTTTCATTGAGGGCGATGGCATTGGATCTGATATTACCCCGGCGATGGTTAAAGTCGTGGATA
GCGCGGTTCAAAAGGCTTATAAAGGCGAGAAAAAAATCGCATGGTATGAGGTGTTTGTGGGCGAAAAATGCTATCAAAAA
TTTAAAGATCATAAAGAATTAAGCCCTGAAGAGCAATGGCTGTTACCGGACACTATTGAAGCGATTAACCACTATAAAGT
TTCTATTAAAGGGCCTTTGACCACGCCTATTGGTGAAGGGTTTAGATCTTTGAATGTAGCGTTACGCCAAAAAATGGATC
TGTATGTGTGCTTGAGACCGGTAAGGTGGTATGGTAGCCCAAGCCCGGTTAAAGAACCACAGAAAGTGGATATGGTGATT
TTTAGAGAAAATTCTGAAGACATTTATGCGGGCATTGAATGGCAAGAAGGCAGTGCGGAAGCGAAAAAACTCATCCATTT
TTTACAAAATGAACTAAAGGTTAAAAAAATCCGCTTCCCTGAAAGCAGCGGTATAGGGGTGAAACCCATTAGTAAGGAAG
GCACAGAGAGACTGGTTAGGAAAGCGATTGAATACGCTATTGATAACGACAAGCCAAGCGTAACTTTTGTGCATAAAGGT
AACATCATGAAATACACTGAGGGGGCGTTCATGAAATGGGGCTATGCACTCGCTCAAAAAGAATTTAACGCTCAAGTCAT
TGATAAAGGCCCATGGTGTTCTTTGAAAAACCCTAAAACCGGTAAGGAAATCATCATTAAAGACATGATCGCTGACGCGT
TTTTGCAACAAATCCTCTTACGCCCTAGCGAATACAGCGTTATTGCGACCATGAATTTGAACGGGGATTATATCTCTGAT
GCGTTAGCGGCGATGGTGGGGGGTATTGGTATCGCTCCTGGGGCTAATCTCAATGACACAGTGGGCATGTTTGAAGCCAC
CCATGGCACCGCTCCTAAATACACCGGGCTAGATAAAGTCAATCCGGGGTCTATTATTTTGAGCGCGGAAATGATGTTAA
GGCATATGGGCTGGGTGGAAGCGGCTGATTTGATCGTTTCTGCGATGGAAAAAGCGATTAAGGGCAAGAAAGTCACTTAT
GATTTCGCTCGTTTAATGGATGGGGCTAAAGAAGTGAAATGCTCTGAATTTGCTAGCGTGATGATTGAAAACATGTGA

Upstream 100 bases:

>100_bases
CAATCGCTACTTTTAAACACGCATTCAAAAAAGATTTTTAGGGGTTATATAGTATTTTTGCGCTAGTATAGTTACTTGAA
TTTTATAAAAAGGATGAGAG

Downstream 100 bases:

>100_bases
AAGAGCGTTTTTTAAGCTCTTAAATGGTGTTTGGATGCGAAAAAAGGCTAATACTATCATAAGGAATGAAGTTGATAAAA
TTTGTGCGTAATGTGGTTTT

Product: isocitrate dehydrogenase (icd)

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMVKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQK
FKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVI
FRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKG
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISD
ALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYTGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKGKKVTY
DFARLMDGAKEVKCSEFASVMIENM

Sequences:

>Translated_425_residues
MAYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMVKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQK
FKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVI
FRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKG
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISD
ALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYTGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKGKKVTY
DFARLMDGAKEVKCSEFASVMIENM
>Mature_424_residues
AYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMVKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKF
KDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIF
RENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGN
IMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDA
LAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYTGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKGKKVTYD
FARLMDGAKEVKCSEFASVMIENM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=390, Percent_Identity=32.3076923076923, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI28178821, Length=404, Percent_Identity=24.5049504950495, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI28178816, Length=367, Percent_Identity=25.0681198910082, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI28178838, Length=372, Percent_Identity=24.7311827956989, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4758582, Length=348, Percent_Identity=25.2873563218391, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI28178819, Length=221, Percent_Identity=26.6968325791855, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1787381, Length=416, Percent_Identity=69.7115384615385, Blast_Score=609, Evalue=1e-176,
Organism=Escherichia coli, GI1788101, Length=386, Percent_Identity=25.3886010362694, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87081683, Length=406, Percent_Identity=24.8768472906404, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=31.7948717948718, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25144293, Length=306, Percent_Identity=27.7777777777778, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=302, Percent_Identity=29.4701986754967, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=398, Percent_Identity=23.6180904522613, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324709, Length=398, Percent_Identity=29.8994974874372, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324291, Length=381, Percent_Identity=28.0839895013123, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322097, Length=374, Percent_Identity=27.0053475935829, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24643270, Length=392, Percent_Identity=32.3979591836735, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24643268, Length=392, Percent_Identity=32.3979591836735, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24661184, Length=402, Percent_Identity=30.3482587064677, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI161078637, Length=301, Percent_Identity=27.2425249169435, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161078635, Length=301, Percent_Identity=27.2425249169435, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161078633, Length=301, Percent_Identity=27.2425249169435, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24650122, Length=301, Percent_Identity=27.2425249169435, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI161078639, Length=301, Percent_Identity=27.2425249169435, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI20130355, Length=396, Percent_Identity=23.989898989899, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI281362242, Length=406, Percent_Identity=25.615763546798, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24648872, Length=406, Percent_Identity=25.615763546798, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 47479; Mature: 47347

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMVKVVDSAVQKAY
CCCCCCHHCCCCCCCEEEEECCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
KGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEG
CCCCCEEEEEEHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCHHHH
FRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAE
HHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHH
AKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKG
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECC
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILL
CEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
RPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYTGLDKV
CCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCC
NPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKGKKVTYDFARLMDGAKEVKCSEFASV
CCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHH
MIENM
HHCCC
>Mature Secondary Structure 
AYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMVKVVDSAVQKAY
CCCCCHHCCCCCCCEEEEECCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
KGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEG
CCCCCEEEEEEHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCHHHH
FRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAE
HHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHH
AKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKG
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECC
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILL
CEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
RPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYTGLDKV
CCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCC
NPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKGKKVTYDFARLMDGAKEVKCSEFASV
CCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHH
MIENM
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]