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The map label for this gene is dapA [H]

Identifier: 187935775

GI number: 187935775

Start: 3676753

End: 3677625

Strand: Reverse

Name: dapA [H]

Synonym: CLL_A3477

Alternate gene names: 187935775

Gene position: 3677625-3676753 (Counterclockwise)

Preceding gene: 187933776

Following gene: 187934731

Centisome position: 96.77

GC content: 26.58

Gene sequence:

>873_bases
ATGAAGATTGAAGGAATAATAATACCACTTGTAACACCATTTAAAAATAATTGTATTGATTTTGTTTGCTATAAAAAGTT
GATAGATTATTATATTGAGCAAGGTGTAGATGGTATAATACCATTAGGAACTACTGGGGAAAGTCCAACAATAGAATCTT
TTGAATATAATGAAATACTATTAAAAACAATGGAATATAATAATGGTAGAACAAAAGTTTATGTAGGACTTGGCGGAAAT
AATACATCTGAAGTAATAAAAAGGTTAAAGATAGCAGAAGATAATAGTGTTGATGGAATATTATCAGTAGCACCATATTA
TTCTAGACCAAATCAAAGAGGGATTTATGAACATTTTAAGAGTATATCTGAATCTACAGATAGAGATATACTAATATATA
ATATTCCCTATAGAACTGGAGTTAATATAGAAAATGATACTATATATAAGTTGGCACAGCTAAAAAATATAGTTGGAATA
AAAGATTGCTCGGGAAATATAAGTCAAACTTCAGAACTATTATTAAACAGACCCAATGATGAATTTTCTATATTAACAGG
AGAAGATGCTCTTTTTTATACTACATTAGCACTTGGTGGTGATGGTGGGATTTTAGCATCTGCAAGTTTAAACACAAAAA
GTTTTATAAAAGTATATAATGATATGAAATCAAATGATTATAAAGAAGCATTAAAAACATGGAGAGATATTTCTAAGGTT
ATACCATTATTATTTAATGAACCTAATCCAACTCCATTAAAATATTGTTTGAAAAACATGGGATTAATTGATTCTGATGA
AGTTAGATTACCACTAACTAATATAACAGATGAACTTAAGTATAAATTAGATAATATGTTATTTTCTAAATAA

Upstream 100 bases:

>100_bases
AAATAATATTTTTATAAGCTTTAGCAATGAAACTCTACCCGTTATAGTAATACTATAACGGGTTTTCTTTATGACAATAT
TTTTTTGGGGGGCAATAATT

Downstream 100 bases:

>100_bases
CTATTTATATAAGGGGCTAGGACAATTAGCAATAAGTAATAAGTAAAAAATATGGGGATATTTTTAAATAAATAAAATTA
AAGGATTAAAAGTTCTTTAG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKIEGIIIPLVTPFKNNCIDFVCYKKLIDYYIEQGVDGIIPLGTTGESPTIESFEYNEILLKTMEYNNGRTKVYVGLGGN
NTSEVIKRLKIAEDNSVDGILSVAPYYSRPNQRGIYEHFKSISESTDRDILIYNIPYRTGVNIENDTIYKLAQLKNIVGI
KDCSGNISQTSELLLNRPNDEFSILTGEDALFYTTLALGGDGGILASASLNTKSFIKVYNDMKSNDYKEALKTWRDISKV
IPLLFNEPNPTPLKYCLKNMGLIDSDEVRLPLTNITDELKYKLDNMLFSK

Sequences:

>Translated_290_residues
MKIEGIIIPLVTPFKNNCIDFVCYKKLIDYYIEQGVDGIIPLGTTGESPTIESFEYNEILLKTMEYNNGRTKVYVGLGGN
NTSEVIKRLKIAEDNSVDGILSVAPYYSRPNQRGIYEHFKSISESTDRDILIYNIPYRTGVNIENDTIYKLAQLKNIVGI
KDCSGNISQTSELLLNRPNDEFSILTGEDALFYTTLALGGDGGILASASLNTKSFIKVYNDMKSNDYKEALKTWRDISKV
IPLLFNEPNPTPLKYCLKNMGLIDSDEVRLPLTNITDELKYKLDNMLFSK
>Mature_290_residues
MKIEGIIIPLVTPFKNNCIDFVCYKKLIDYYIEQGVDGIIPLGTTGESPTIESFEYNEILLKTMEYNNGRTKVYVGLGGN
NTSEVIKRLKIAEDNSVDGILSVAPYYSRPNQRGIYEHFKSISESTDRDILIYNIPYRTGVNIENDTIYKLAQLKNIVGI
KDCSGNISQTSELLLNRPNDEFSILTGEDALFYTTLALGGDGGILASASLNTKSFIKVYNDMKSNDYKEALKTWRDISKV
IPLLFNEPNPTPLKYCLKNMGLIDSDEVRLPLTNITDELKYKLDNMLFSK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=236, Percent_Identity=23.3050847457627, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1788823, Length=285, Percent_Identity=38.9473684210526, Blast_Score=204, Evalue=4e-54,
Organism=Escherichia coli, GI87082415, Length=295, Percent_Identity=27.1186440677966, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786463, Length=236, Percent_Identity=29.6610169491525, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789620, Length=278, Percent_Identity=25.8992805755396, Blast_Score=107, Evalue=8e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32693; Mature: 32693

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEGIIIPLVTPFKNNCIDFVCYKKLIDYYIEQGVDGIIPLGTTGESPTIESFEYNEIL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHE
LKTMEYNNGRTKVYVGLGGNNTSEVIKRLKIAEDNSVDGILSVAPYYSRPNQRGIYEHFK
EEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHH
SISESTDRDILIYNIPYRTGVNIENDTIYKLAQLKNIVGIKDCSGNISQTSELLLNRPND
HHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCEEECCCCCHHHHHHHHHCCCCC
EFSILTGEDALFYTTLALGGDGGILASASLNTKSFIKVYNDMKSNDYKEALKTWRDISKV
CEEEEECCCEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IPLLFNEPNPTPLKYCLKNMGLIDSDEVRLPLTNITDELKYKLDNMLFSK
HHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIEGIIIPLVTPFKNNCIDFVCYKKLIDYYIEQGVDGIIPLGTTGESPTIESFEYNEIL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHE
LKTMEYNNGRTKVYVGLGGNNTSEVIKRLKIAEDNSVDGILSVAPYYSRPNQRGIYEHFK
EEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHH
SISESTDRDILIYNIPYRTGVNIENDTIYKLAQLKNIVGIKDCSGNISQTSELLLNRPND
HHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCEEECCCCCHHHHHHHHHCCCCC
EFSILTGEDALFYTTLALGGDGGILASASLNTKSFIKVYNDMKSNDYKEALKTWRDISKV
CEEEEECCCEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IPLLFNEPNPTPLKYCLKNMGLIDSDEVRLPLTNITDELKYKLDNMLFSK
HHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]