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The map label for this gene is 187935688

Identifier: 187935688

GI number: 187935688

Start: 2929571

End: 2930257

Strand: Reverse

Name: 187935688

Synonym: CLL_A2854

Alternate gene names: NA

Gene position: 2930257-2929571 (Counterclockwise)

Preceding gene: 187933093

Following gene: 187934679

Centisome position: 77.11

GC content: 28.82

Gene sequence:

>687_bases
ATGTATAATATTAAACAACTTAAAATACCTAAGGATGAAGTCCTTAGGTATTTAGGTTATAAAAAGCAAGAATTAACAGT
ATCAATGGATGTATTAATAGATGAAACTATAGATGAGTGTAAGAAATTAATAATACCTAAGTATGTTTGTGCTAAGTATA
AAAATCATACTGAAAATGATGGAGTATATGTAGATGGAACAAATTTAATATTAAAAGGAGAAGACATTAAAAATCATCTT
CTTTATGCACAGGAAGTATTTGTTATAGCAGGTACTGTAGGAAGCAAAGTAGAGAAAAAAATCAAGTTATATGAAACAAT
AGAATTAACAAAAGCTTTAATTTTAGATGCTTGCGCGACAGTAGCAATAGAAGAGTTTTTAGATGAAATAGAAGAAAAGA
TAAGATTAGATGTAAGAAAAGAAAACAGTGCGATAACATTTAGATATAGTCCGGGATATGGTGATTTGTCATTAGATATT
CAAAGGGATATAGTGAATACATTAAAAGCAGATAAAGCAATAGGTCTTACGGTATCGTCACATTATTTATTATTTCCTAG
GAAATCAGTAACTGCAATAATAGGTGTTATTCCAAAGGAAAAAGAGGAAAAACAAAGAGGATGTGAAGTTTGTAAGAACT
ATAATAATTGTAGTTTTAGAAGAGAGGGGAATAATTGTGGGGCTTAA

Upstream 100 bases:

>100_bases
CAATGTGGAAATTATAGAGATTTATCTTTATTTGGTGCAAAAGAATATGCTAAGGAAGCATTAGAAAGAGGATTTTCTCT
TAATATATACGGAGAATAAA

Downstream 100 bases:

>100_bases
AGAATTTATAAAAGATAATATACTTGTATTTGATGGGGCAATGGGAACAATGCTTCAAAAAGAGGGACTAAAACTTGGAG
AAAATCCTGAAATATTTAAT

Product: vitamin B12 dependent methionine synthase, activation domain protein

Products: tetrahydrofolate; L-methionine

Alternate protein names: 5-Methyltetrahydrofolate-Homocysteine Methyltransferase; Cobalamin-Dependent Methionine Synthase

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MYNIKQLKIPKDEVLRYLGYKKQELTVSMDVLIDETIDECKKLIIPKYVCAKYKNHTENDGVYVDGTNLILKGEDIKNHL
LYAQEVFVIAGTVGSKVEKKIKLYETIELTKALILDACATVAIEEFLDEIEEKIRLDVRKENSAITFRYSPGYGDLSLDI
QRDIVNTLKADKAIGLTVSSHYLLFPRKSVTAIIGVIPKEKEEKQRGCEVCKNYNNCSFRREGNNCGA

Sequences:

>Translated_228_residues
MYNIKQLKIPKDEVLRYLGYKKQELTVSMDVLIDETIDECKKLIIPKYVCAKYKNHTENDGVYVDGTNLILKGEDIKNHL
LYAQEVFVIAGTVGSKVEKKIKLYETIELTKALILDACATVAIEEFLDEIEEKIRLDVRKENSAITFRYSPGYGDLSLDI
QRDIVNTLKADKAIGLTVSSHYLLFPRKSVTAIIGVIPKEKEEKQRGCEVCKNYNNCSFRREGNNCGA
>Mature_228_residues
MYNIKQLKIPKDEVLRYLGYKKQELTVSMDVLIDETIDECKKLIIPKYVCAKYKNHTENDGVYVDGTNLILKGEDIKNHL
LYAQEVFVIAGTVGSKVEKKIKLYETIELTKALILDACATVAIEEFLDEIEEKIRLDVRKENSAITFRYSPGYGDLSLDI
QRDIVNTLKADKAIGLTVSSHYLLFPRKSVTAIIGVIPKEKEEKQRGCEVCKNYNNCSFRREGNNCGA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.13

Molecular weight: Translated: 25920; Mature: 25920

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNIKQLKIPKDEVLRYLGYKKQELTVSMDVLIDETIDECKKLIIPKYVCAKYKNHTEND
CCCCCCCCCCHHHHHHHHCCCCHHEEEEHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCC
GVYVDGTNLILKGEDIKNHLLYAQEVFVIAGTVGSKVEKKIKLYETIELTKALILDACAT
CEEECCCEEEEECCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VAIEEFLDEIEEKIRLDVRKENSAITFRYSPGYGDLSLDIQRDIVNTLKADKAIGLTVSS
HHHHHHHHHHHHHHEEEEEECCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCEEEEEEEC
HYLLFPRKSVTAIIGVIPKEKEEKQRGCEVCKNYNNCSFRREGNNCGA
CEEEECCHHHHHHEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MYNIKQLKIPKDEVLRYLGYKKQELTVSMDVLIDETIDECKKLIIPKYVCAKYKNHTEND
CCCCCCCCCCHHHHHHHHCCCCHHEEEEHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCC
GVYVDGTNLILKGEDIKNHLLYAQEVFVIAGTVGSKVEKKIKLYETIELTKALILDACAT
CEEECCCEEEEECCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VAIEEFLDEIEEKIRLDVRKENSAITFRYSPGYGDLSLDIQRDIVNTLKADKAIGLTVSS
HHHHHHHHHHHHHHEEEEEECCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCEEEEEEEC
HYLLFPRKSVTAIIGVIPKEKEEKQRGCEVCKNYNNCSFRREGNNCGA
CEEEECCHHHHHHEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-methyltetrahydrofolate; L-homocysteine

Specific reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA