Click here to switch to the map view.

The map label for this gene is guaD [H]

Identifier: 187935669

GI number: 187935669

Start: 636253

End: 636726

Strand: Reverse

Name: guaD [H]

Synonym: CLL_A0635

Alternate gene names: 187935669

Gene position: 636726-636253 (Counterclockwise)

Preceding gene: 187934023

Following gene: 187934121

Centisome position: 16.75

GC content: 32.07

Gene sequence:

>474_bases
ATGCAAAAAAAAGATATAATGGATTTATGTGTGGAAAAGTGTAAAGAAGGCATGTTGAATTTAGACGGTGGACCTTTTGG
TGCTGCAATTGTAAAAGATGGAGAGATAATAGCTCTCGCCAATAATACAGTTATTAGTACCAACGATCCCACAGCTCATG
GAGAAGTGAATGCAATAAGACAAGCCTGTAGCAAATTATCTACATTTGATTTAACCGGATGTGAATTATATACAACATCT
GAACCATGCCCAATGTGTATGTCAGCAATAATATGGGCTAACATATCAAAAGTTTATTATGGTTGCACTGTTAAAGATGC
TGCTGATATAGGATTTAGAGATGAGCATATATTAAACTTCTTAAAAGGTGATTGCACTAATAAAAAAGTTTTAGATTTAG
AACAAATCGATAAATCAAATTGCATGACTGCATTTAAAATGTGGATAAATAATCAAAATAAAACAAGCTATTAA

Upstream 100 bases:

>100_bases
CTATTTTATGGCACAAAAATTGCTATTAATGTTAATTAATTCTAGTTTATATCTAAAGAGAGTTTTAATAGAACTCAATC
ATATTATGGAGGATGTTCAA

Downstream 100 bases:

>100_bases
TACCTCTTAAATAAATTAATTAATTAAATAAAGCCATAAAAAAATAAATGCCTATTTAGAATAAGAGGTTGCCTCAAATA
TATTTTGAGACAACCTTTTA

Product: cytidine/deoxycytidylate deaminase family protein

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MQKKDIMDLCVEKCKEGMLNLDGGPFGAAIVKDGEIIALANNTVISTNDPTAHGEVNAIRQACSKLSTFDLTGCELYTTS
EPCPMCMSAIIWANISKVYYGCTVKDAADIGFRDEHILNFLKGDCTNKKVLDLEQIDKSNCMTAFKMWINNQNKTSY

Sequences:

>Translated_157_residues
MQKKDIMDLCVEKCKEGMLNLDGGPFGAAIVKDGEIIALANNTVISTNDPTAHGEVNAIRQACSKLSTFDLTGCELYTTS
EPCPMCMSAIIWANISKVYYGCTVKDAADIGFRDEHILNFLKGDCTNKKVLDLEQIDKSNCMTAFKMWINNQNKTSY
>Mature_157_residues
MQKKDIMDLCVEKCKEGMLNLDGGPFGAAIVKDGEIIALANNTVISTNDPTAHGEVNAIRQACSKLSTFDLTGCELYTTS
EPCPMCMSAIIWANISKVYYGCTVKDAADIGFRDEHILNFLKGDCTNKKVLDLEQIDKSNCMTAFKMWINNQNKTSY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=78, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17554608, Length=153, Percent_Identity=47.0588235294118, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17555996, Length=157, Percent_Identity=42.0382165605096, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17333; Mature: 17333

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
10.2 %Cys+Met (Translated Protein)
5.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
10.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKDIMDLCVEKCKEGMLNLDGGPFGAAIVKDGEIIALANNTVISTNDPTAHGEVNAIR
CCCHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCEEEEECCEEEECCCCCCCCHHHHHH
QACSKLSTFDLTGCELYTTSEPCPMCMSAIIWANISKVYYGCTVKDAADIGFRDEHILNF
HHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHH
LKGDCTNKKVLDLEQIDKSNCMTAFKMWINNQNKTSY
HHCCCCCCEEECHHHHCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQKKDIMDLCVEKCKEGMLNLDGGPFGAAIVKDGEIIALANNTVISTNDPTAHGEVNAIR
CCCHHHHHHHHHHHHCCCEECCCCCCCEEEEECCCEEEEECCEEEECCCCCCCCHHHHHH
QACSKLSTFDLTGCELYTTSEPCPMCMSAIIWANISKVYYGCTVKDAADIGFRDEHILNF
HHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHH
LKGDCTNKKVLDLEQIDKSNCMTAFKMWINNQNKTSY
HHCCCCCCEEECHHHHCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]