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The map label for this gene is mutS2 [H]

Identifier: 187935216

GI number: 187935216

Start: 2549929

End: 2552286

Strand: Reverse

Name: mutS2 [H]

Synonym: CLL_A2463

Alternate gene names: 187935216

Gene position: 2552286-2549929 (Counterclockwise)

Preceding gene: 187932705

Following gene: 187935547

Centisome position: 67.16

GC content: 29.73

Gene sequence:

>2358_bases
ATGAACAAGAGATCTTTAAGAGTTTTAGAATTTAATAAAGTAAAGGAAATACTTAAAAAGTATGCATATAGCAGTTCTGC
TAAGAAATTAGTAGATGAACTTGTACCTTATGACAATACATATGAAATAAATAATAGCTTAGAAGAATCTAATGAGGCAC
TTGAAATATTGATGAAAAAGGGTAATCCTCCAATAGAAGGGCTTTGTGATATAGGAGATATACTTCAAAGAGCGAAAAAA
GGAGGTACATTAACTCCAGAACAACTATTAAAGGTATTAGGAATGCTTACAGCAACTAGAAGAATGCAGGAATTTTTTAA
AAGAGAAGAACAAGAAGTATCTTTTCCTAAGTTAGAAGATTTAGCGTATATATTAGCGCCAATTAATGACTTAGAAAAAG
AAATTGAGAGGTCTATTTTATCAGAAGATGAAGTTAGTGATAATGCTAGTACTACTTTATATAATATAAGAAGAAGTTTA
AAAGAAAAGAATTCTTCAGTAAGAGAAAAAATAAATTCAATAGTTAGAAGTAATTCAAAGTATTTACAAGACTCTTTATA
TACAATAAGAGGAGATAGATATGTAATTCCAGTAAAGGCTGAATATAAGAGTTCAGTTCCAGGACTTGTACATGATCAGA
GTTCAACAGGAGCCACTCTTTTTATAGAACCTATGGGGTTAGTTAATTTAAATAATGAAATAAAAGAACTTATGCTAAAA
GAAAAGGCTGAAATAGATAGGGTACTTTCTGCATTGTCATTAAAAGTAAAAATGAATGCAGAACACTGTGAGAGTAATTT
AAAAATACTTACTAATTTAGATTTTATTTTTTCAAAGGGTAAATATGCATGTGAATTAAATGCAATAAAACCTATGGTAA
GAGATGACGGAATATTTAACATAATGTCTGGTAGACATCCTTTAATTGAAAAAGATAAAGTTGTGCCTTTAGATGTTGTT
TTAGGTGATGAATTTGATACTTTAATGATAACTGGACCTAATACAGGTGGTAAAACTGTTACATTAAAAACAGTGGGATT
GCTTCATATAATGGCATTGAGTGGACTGCTTATACCTGCAAGTTCTAATTCATCGGTATCATTTTTTAAGGAAGTATTCG
CTGATATAGGAGATGAACAAAGTATTGAACAAAGTTTATCAACTTTTTCATCTCATTTAACTAATATAGTAAATATCATG
GAATATGATAATAGACAATCACTTATTTTATTTGATGAATTAGGTGGAGGAACTGACCCAGCAGAAGGTGCAGCCCTTGC
AATAGCTATTATAGAAAATTTAAGTAGTAAAGGTGCAAAACTAATAGCAACAACTCACTATAGTGAATTAAAAGCATATG
CATTAAATAAAGATCGAGTTGAAAATGCATCTGTAGAGTTTGATATTAATACATTAAGACCTACATATAGGTTATTAATT
GGAGTTCCAGGAAAATCTAATGCATTTGAGATTTCTAAAAGAATAGGACTTGGAAAAGAAGTTATAGATTGTGCAAAAAA
TTATATGTCTAAAGAAAATTTAGAGTTTGAAGGCTTAATAAGAAATCTTCAAGAAAAAAGCATTATTGCTAAAAAAGATG
CGAGAGATGCTAAAGTTATTAAGGATGAGGCAGATAACTTAAAGAAAAAATATGAACAAAAACTTGAAAGACTTGAAAAA
GTTAAAGATAAAGCTTATATGGAGGCTAGAGAAGAAGCTAAAAAGATAGTAGCTAATGCAAAAGATGAAGCTGATGAAAT
ATTAAAAGCTATGAGAGAACTTGAAAAACTTGGTATTGGAAGTGGCGGAAGACAAAGATTAGAAGAAGAACGTAAAAAAC
TTAAAGATAGTTTAGAAGAAAAAGAAAAGAATCTATATAAGATGAAAGAAAATGATGGTGAAGTACTTGAAAAGGTAGCT
TTAGGAATGGAAGCATTTTTACCATCTTTAAATCAAACTGTTGTAGTAATTTCTATGCCTGATAATAGAGGGGAAGTACA
AGTTGAAGCTGGAATTATGAAAATTTCAGTTAAGTTAAAGGATCTTAGAAAAACTAAACAATCTAAAGTTGAAAAGGTAA
AGAAAAAGAGAGAATTAAAATTACATTTTAGTAAAGTTGAAAATCGTATAGATTTAAGAGGTTTAGATGCAGAAGAAGCT
TGCTATAGAGTAGATAAGTATTTAGATGACGCTTACATGGGTAACCTAGGGGAAGTAACTATAGTACATGGAAAAGGTAC
TGGAATTCTTAGAAAAGCTATAAATGATATGCTTAAGAGACATGTACATGTTAAGAATTATAGATTAGGCGGATATGGTG
AAGGCGGAGATGGTGCAACAATAGTTGAACTAAAATAA

Upstream 100 bases:

>100_bases
AAAGTGATATTAGAAGAAGTAAAAAAACTTAAAAAAAGTGAAAATAGAATCTATACTAAAGGTCATTATAAACGTGGTGT
AGAGTAGAGGGGAACTATAA

Downstream 100 bases:

>100_bases
GATGATGTTTTGAAATATTAATCTTTTGTATAAAGCTCGTGGACAGAGAAATTTGCTTTAAGAACTCTAAAATAAAGATT
AGTCCAATTAATGCATGCTC

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MNKRSLRVLEFNKVKEILKKYAYSSSAKKLVDELVPYDNTYEINNSLEESNEALEILMKKGNPPIEGLCDIGDILQRAKK
GGTLTPEQLLKVLGMLTATRRMQEFFKREEQEVSFPKLEDLAYILAPINDLEKEIERSILSEDEVSDNASTTLYNIRRSL
KEKNSSVREKINSIVRSNSKYLQDSLYTIRGDRYVIPVKAEYKSSVPGLVHDQSSTGATLFIEPMGLVNLNNEIKELMLK
EKAEIDRVLSALSLKVKMNAEHCESNLKILTNLDFIFSKGKYACELNAIKPMVRDDGIFNIMSGRHPLIEKDKVVPLDVV
LGDEFDTLMITGPNTGGKTVTLKTVGLLHIMALSGLLIPASSNSSVSFFKEVFADIGDEQSIEQSLSTFSSHLTNIVNIM
EYDNRQSLILFDELGGGTDPAEGAALAIAIIENLSSKGAKLIATTHYSELKAYALNKDRVENASVEFDINTLRPTYRLLI
GVPGKSNAFEISKRIGLGKEVIDCAKNYMSKENLEFEGLIRNLQEKSIIAKKDARDAKVIKDEADNLKKKYEQKLERLEK
VKDKAYMEAREEAKKIVANAKDEADEILKAMRELEKLGIGSGGRQRLEEERKKLKDSLEEKEKNLYKMKENDGEVLEKVA
LGMEAFLPSLNQTVVVISMPDNRGEVQVEAGIMKISVKLKDLRKTKQSKVEKVKKKRELKLHFSKVENRIDLRGLDAEEA
CYRVDKYLDDAYMGNLGEVTIVHGKGTGILRKAINDMLKRHVHVKNYRLGGYGEGGDGATIVELK

Sequences:

>Translated_785_residues
MNKRSLRVLEFNKVKEILKKYAYSSSAKKLVDELVPYDNTYEINNSLEESNEALEILMKKGNPPIEGLCDIGDILQRAKK
GGTLTPEQLLKVLGMLTATRRMQEFFKREEQEVSFPKLEDLAYILAPINDLEKEIERSILSEDEVSDNASTTLYNIRRSL
KEKNSSVREKINSIVRSNSKYLQDSLYTIRGDRYVIPVKAEYKSSVPGLVHDQSSTGATLFIEPMGLVNLNNEIKELMLK
EKAEIDRVLSALSLKVKMNAEHCESNLKILTNLDFIFSKGKYACELNAIKPMVRDDGIFNIMSGRHPLIEKDKVVPLDVV
LGDEFDTLMITGPNTGGKTVTLKTVGLLHIMALSGLLIPASSNSSVSFFKEVFADIGDEQSIEQSLSTFSSHLTNIVNIM
EYDNRQSLILFDELGGGTDPAEGAALAIAIIENLSSKGAKLIATTHYSELKAYALNKDRVENASVEFDINTLRPTYRLLI
GVPGKSNAFEISKRIGLGKEVIDCAKNYMSKENLEFEGLIRNLQEKSIIAKKDARDAKVIKDEADNLKKKYEQKLERLEK
VKDKAYMEAREEAKKIVANAKDEADEILKAMRELEKLGIGSGGRQRLEEERKKLKDSLEEKEKNLYKMKENDGEVLEKVA
LGMEAFLPSLNQTVVVISMPDNRGEVQVEAGIMKISVKLKDLRKTKQSKVEKVKKKRELKLHFSKVENRIDLRGLDAEEA
CYRVDKYLDDAYMGNLGEVTIVHGKGTGILRKAINDMLKRHVHVKNYRLGGYGEGGDGATIVELK
>Mature_785_residues
MNKRSLRVLEFNKVKEILKKYAYSSSAKKLVDELVPYDNTYEINNSLEESNEALEILMKKGNPPIEGLCDIGDILQRAKK
GGTLTPEQLLKVLGMLTATRRMQEFFKREEQEVSFPKLEDLAYILAPINDLEKEIERSILSEDEVSDNASTTLYNIRRSL
KEKNSSVREKINSIVRSNSKYLQDSLYTIRGDRYVIPVKAEYKSSVPGLVHDQSSTGATLFIEPMGLVNLNNEIKELMLK
EKAEIDRVLSALSLKVKMNAEHCESNLKILTNLDFIFSKGKYACELNAIKPMVRDDGIFNIMSGRHPLIEKDKVVPLDVV
LGDEFDTLMITGPNTGGKTVTLKTVGLLHIMALSGLLIPASSNSSVSFFKEVFADIGDEQSIEQSLSTFSSHLTNIVNIM
EYDNRQSLILFDELGGGTDPAEGAALAIAIIENLSSKGAKLIATTHYSELKAYALNKDRVENASVEFDINTLRPTYRLLI
GVPGKSNAFEISKRIGLGKEVIDCAKNYMSKENLEFEGLIRNLQEKSIIAKKDARDAKVIKDEADNLKKKYEQKLERLEK
VKDKAYMEAREEAKKIVANAKDEADEILKAMRELEKLGIGSGGRQRLEEERKKLKDSLEEKEKNLYKMKENDGEVLEKVA
LGMEAFLPSLNQTVVVISMPDNRGEVQVEAGIMKISVKLKDLRKTKQSKVEKVKKKRELKLHFSKVENRIDLRGLDAEEA
CYRVDKYLDDAYMGNLGEVTIVHGKGTGILRKAINDMLKRHVHVKNYRLGGYGEGGDGATIVELK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=364, Percent_Identity=29.1208791208791, Blast_Score=112, Evalue=2e-24,
Organism=Homo sapiens, GI36949366, Length=331, Percent_Identity=31.4199395770393, Blast_Score=108, Evalue=3e-23,
Organism=Homo sapiens, GI4557761, Length=317, Percent_Identity=28.7066246056782, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI4504191, Length=315, Percent_Identity=27.3015873015873, Blast_Score=98, Evalue=4e-20,
Organism=Homo sapiens, GI26638666, Length=251, Percent_Identity=30.2788844621514, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4505253, Length=251, Percent_Identity=30.2788844621514, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI26638664, Length=252, Percent_Identity=30.1587301587302, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI262231786, Length=170, Percent_Identity=32.3529411764706, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1789089, Length=325, Percent_Identity=28.6153846153846, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508445, Length=320, Percent_Identity=26.875, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17534743, Length=244, Percent_Identity=29.0983606557377, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508447, Length=283, Percent_Identity=26.5017667844523, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=251, Percent_Identity=23.5059760956175, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319935, Length=264, Percent_Identity=32.1969696969697, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=259, Percent_Identity=26.2548262548263, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320302, Length=273, Percent_Identity=26.3736263736264, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=184, Percent_Identity=30.9782608695652, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=329, Percent_Identity=23.7082066869301, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320047, Length=188, Percent_Identity=29.2553191489362, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664545, Length=288, Percent_Identity=29.1666666666667, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24584320, Length=210, Percent_Identity=29.0476190476191, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 88204; Mature: 88204

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRSLRVLEFNKVKEILKKYAYSSSAKKLVDELVPYDNTYEINNSLEESNEALEILMKK
CCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHC
GNPPIEGLCDIGDILQRAKKGGTLTPEQLLKVLGMLTATRRMQEFFKREEQEVSFPKLED
CCCCCHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAYILAPINDLEKEIERSILSEDEVSDNASTTLYNIRRSLKEKNSSVREKINSIVRSNSK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLQDSLYTIRGDRYVIPVKAEYKSSVPGLVHDQSSTGATLFIEPMGLVNLNNEIKELMLK
HHHHHHEEEECCEEEEEEEHHHCCCCCCCEECCCCCCCEEEEECCCCCCCCHHHHHHHHH
EKAEIDRVLSALSLKVKMNAEHCESNLKILTNLDFIFSKGKYACELNAIKPMVRDDGIFN
HHHHHHHHHHHHHHEEEECHHHHCCCCEEEECHHHHHCCCCCEEEECCCCCHHHCCCCEE
IMSGRHPLIEKDKVVPLDVVLGDEFDTLMITGPNTGGKTVTLKTVGLLHIMALSGLLIPA
ECCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHCCEEEEC
SSNSSVSFFKEVFADIGDEQSIEQSLSTFSSHLTNIVNIMEYDNRQSLILFDELGGGTDP
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
AEGAALAIAIIENLSSKGAKLIATTHYSELKAYALNKDRVENASVEFDINTLRPTYRLLI
CCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHCCCCEEEEEECCCCCEEEEEE
GVPGKSNAFEISKRIGLGKEVIDCAKNYMSKENLEFEGLIRNLQEKSIIAKKDARDAKVI
ECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
KDEADNLKKKYEQKLERLEKVKDKAYMEAREEAKKIVANAKDEADEILKAMRELEKLGIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
SGGRQRLEEERKKLKDSLEEKEKNLYKMKENDGEVLEKVALGMEAFLPSLNQTVVVISMP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECC
DNRGEVQVEAGIMKISVKLKDLRKTKQSKVEKVKKKRELKLHFSKVENRIDLRGLDAEEA
CCCCCEEEEECEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
CYRVDKYLDDAYMGNLGEVTIVHGKGTGILRKAINDMLKRHVHVKNYRLGGYGEGGDGAT
HHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEE
IVELK
EEEEC
>Mature Secondary Structure
MNKRSLRVLEFNKVKEILKKYAYSSSAKKLVDELVPYDNTYEINNSLEESNEALEILMKK
CCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHC
GNPPIEGLCDIGDILQRAKKGGTLTPEQLLKVLGMLTATRRMQEFFKREEQEVSFPKLED
CCCCCHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAYILAPINDLEKEIERSILSEDEVSDNASTTLYNIRRSLKEKNSSVREKINSIVRSNSK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLQDSLYTIRGDRYVIPVKAEYKSSVPGLVHDQSSTGATLFIEPMGLVNLNNEIKELMLK
HHHHHHEEEECCEEEEEEEHHHCCCCCCCEECCCCCCCEEEEECCCCCCCCHHHHHHHHH
EKAEIDRVLSALSLKVKMNAEHCESNLKILTNLDFIFSKGKYACELNAIKPMVRDDGIFN
HHHHHHHHHHHHHHEEEECHHHHCCCCEEEECHHHHHCCCCCEEEECCCCCHHHCCCCEE
IMSGRHPLIEKDKVVPLDVVLGDEFDTLMITGPNTGGKTVTLKTVGLLHIMALSGLLIPA
ECCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHCCEEEEC
SSNSSVSFFKEVFADIGDEQSIEQSLSTFSSHLTNIVNIMEYDNRQSLILFDELGGGTDP
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
AEGAALAIAIIENLSSKGAKLIATTHYSELKAYALNKDRVENASVEFDINTLRPTYRLLI
CCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHCCCCEEEEEECCCCCEEEEEE
GVPGKSNAFEISKRIGLGKEVIDCAKNYMSKENLEFEGLIRNLQEKSIIAKKDARDAKVI
ECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
KDEADNLKKKYEQKLERLEKVKDKAYMEAREEAKKIVANAKDEADEILKAMRELEKLGIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
SGGRQRLEEERKKLKDSLEEKEKNLYKMKENDGEVLEKVALGMEAFLPSLNQTVVVISMP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECC
DNRGEVQVEAGIMKISVKLKDLRKTKQSKVEKVKKKRELKLHFSKVENRIDLRGLDAEEA
CCCCCEEEEECEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
CYRVDKYLDDAYMGNLGEVTIVHGKGTGILRKAINDMLKRHVHVKNYRLGGYGEGGDGAT
HHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEE
IVELK
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA