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The map label for this gene is rfbF [H]

Identifier: 187935021

GI number: 187935021

Start: 2417199

End: 2417978

Strand: Reverse

Name: rfbF [H]

Synonym: CLL_A2338

Alternate gene names: 187935021

Gene position: 2417978-2417199 (Counterclockwise)

Preceding gene: 187932727

Following gene: 187932731

Centisome position: 63.63

GC content: 29.49

Gene sequence:

>780_bases
ATGAAAGTAGTGATACTTGCAGGTGGATATGGGACTAGAATATCAGAAGAATCCCATTTAAGACCAAAACCTATGATTGA
AATTGGAGGTAATCCAATATTATGGCACATAATGAAAGGTTATTCCTATTATGGATTTAATGAATTCATAATTTGTTGTG
GATATAAAGGGCATATGATAAAAGAATATTTTGCAAATTATTATATATATAGTTCAGATATTACTTTTGAATTTCCTAAA
AATAATAAAATCTCAATTCATTCAAACATTGCAGAGCCATGGAAAGTGACATTAGTTGATACTGGCATTGATACTATGAC
TGGAGGAAGACTTAAAAGAGTTCAAAAGTATGTAGGAGATGAAACTTTTATGCTGACATATGGAGATGGAGTCAGTGATA
TTAATATTAATAATTTATTAGAATTTCATAAACAAAATAACAAAATAGCAACATTAACAGCAATTCAACCAGAGGCAAGA
TTTGGAATAATTAATATAGATGAGGATAACAGAACTGTAACATCATTTGATGAAAAGTCTAAGGAAAATGGAAGCTGGAT
TAATGGGGGTTATATGGTTTTAGAACCTAAAATTTTTGAGTATATTAAGGGGGATAATACGTTTTTAGAAAAGGAACCTA
TGGAGAATCTTGCAAAAGATAAAATGTTAAATGCGTATAAGCATAGTGGATTTTGGAAATGTATGGATACTCAAAGAGAT
AAAGAATTACTTGAAAAACTATGGAGAGAAAATAATGCTAAATGGAAGGTATGGGATTAA

Upstream 100 bases:

>100_bases
AAAAATATATTGTATGCTCATATTAAAAAAAATCATAGCATAAAGTAGTATTAGATATAATAAAAAATAATATTAATGTA
AATTGAGGGGAATAAGAATT

Downstream 100 bases:

>100_bases
TGCTTGAGTTTTATAATCAAAAAAGGGTTTTTATAACAGGACATACTGGATTTAAAGGAAGTTGGCTTACCAAGATTTTA
ATTATGGCAGGAGCTAAAGT

Product: glucose-1-phosphate cytidylyltransferase

Products: NA

Alternate protein names: CDP-glucose pyrophosphorylase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKVVILAGGYGTRISEESHLRPKPMIEIGGNPILWHIMKGYSYYGFNEFIICCGYKGHMIKEYFANYYIYSSDITFEFPK
NNKISIHSNIAEPWKVTLVDTGIDTMTGGRLKRVQKYVGDETFMLTYGDGVSDININNLLEFHKQNNKIATLTAIQPEAR
FGIINIDEDNRTVTSFDEKSKENGSWINGGYMVLEPKIFEYIKGDNTFLEKEPMENLAKDKMLNAYKHSGFWKCMDTQRD
KELLEKLWRENNAKWKVWD

Sequences:

>Translated_259_residues
MKVVILAGGYGTRISEESHLRPKPMIEIGGNPILWHIMKGYSYYGFNEFIICCGYKGHMIKEYFANYYIYSSDITFEFPK
NNKISIHSNIAEPWKVTLVDTGIDTMTGGRLKRVQKYVGDETFMLTYGDGVSDININNLLEFHKQNNKIATLTAIQPEAR
FGIINIDEDNRTVTSFDEKSKENGSWINGGYMVLEPKIFEYIKGDNTFLEKEPMENLAKDKMLNAYKHSGFWKCMDTQRD
KELLEKLWRENNAKWKVWD
>Mature_259_residues
MKVVILAGGYGTRISEESHLRPKPMIEIGGNPILWHIMKGYSYYGFNEFIICCGYKGHMIKEYFANYYIYSSDITFEFPK
NNKISIHSNIAEPWKVTLVDTGIDTMTGGRLKRVQKYVGDETFMLTYGDGVSDININNLLEFHKQNNKIATLTAIQPEAR
FGIINIDEDNRTVTSFDEKSKENGSWINGGYMVLEPKIFEYIKGDNTFLEKEPMENLAKDKMLNAYKHSGFWKCMDTQRD
KELLEKLWRENNAKWKVWD

Specific function: Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate. This enzyme can utilize either CTP or UTP as the nucle

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate cytidylyltransferase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI133931050, Length=251, Percent_Identity=27.0916334661355, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6320148, Length=251, Percent_Identity=27.4900398406374, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21355443, Length=246, Percent_Identity=26.0162601626016, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24644084, Length=246, Percent_Identity=26.0162601626016, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013446
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.33 [H]

Molecular weight: Translated: 30094; Mature: 30094

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVILAGGYGTRISEESHLRPKPMIEIGGNPILWHIMKGYSYYGFNEFIICCGYKGHMI
CEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCEECCCCEEEEEECCCCCHH
KEYFANYYIYSSDITFEFPKNNKISIHSNIAEPWKVTLVDTGIDTMTGGRLKRVQKYVGD
HHHHCCEEEEECCEEEECCCCCEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCC
ETFMLTYGDGVSDININNLLEFHKQNNKIATLTAIQPEARFGIINIDEDNRTVTSFDEKS
CEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCCEEECCHHCC
KENGSWINGGYMVLEPKIFEYIKGDNTFLEKEPMENLAKDKMLNAYKHSGFWKCMDTQRD
CCCCCEECCCEEEECHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHCCCEEEECCCHHH
KELLEKLWRENNAKWKVWD
HHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MKVVILAGGYGTRISEESHLRPKPMIEIGGNPILWHIMKGYSYYGFNEFIICCGYKGHMI
CEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCEECCCCEEEEEECCCCCHH
KEYFANYYIYSSDITFEFPKNNKISIHSNIAEPWKVTLVDTGIDTMTGGRLKRVQKYVGD
HHHHCCEEEEECCEEEECCCCCEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCC
ETFMLTYGDGVSDININNLLEFHKQNNKIATLTAIQPEARFGIINIDEDNRTVTSFDEKS
CEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCCEEECCHHCC
KENGSWINGGYMVLEPKIFEYIKGDNTFLEKEPMENLAKDKMLNAYKHSGFWKCMDTQRD
CCCCCEECCCEEEECHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHCCCEEEECCCHHH
KELLEKLWRENNAKWKVWD
HHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]