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The map label for this gene is sbcD [H]

Identifier: 187934876

GI number: 187934876

Start: 3085124

End: 3086344

Strand: Reverse

Name: sbcD [H]

Synonym: CLL_A2991

Alternate gene names: 187934876

Gene position: 3086344-3085124 (Counterclockwise)

Preceding gene: 187933030

Following gene: 187933859

Centisome position: 81.21

GC content: 30.96

Gene sequence:

>1221_bases
ATGAGGATATTGCATACTGGTGACTGGCATTTAGGTAAAAACCTAGAAGGAAAAAGCAGAATGGATGAGCAGGAATTATT
TTTAAATGATTTTGCTAAGTTAGTTAAAGAAAATAATATAGATTTAGTTATTATTGCAGGTGATGTGTATGATTCTAGTA
ATCCCCCAGCAAGAGCAGAAAAGATGTTTTATGATACATTGAAAAAAATATCTTCTGATGGAGAGAGAATTACATTAGTT
ATATCAGGGAATCATGATAGTCCAGAAAGGCTTATATCAGCAGGTCAACTTGCAAGAGATCATGGAATAATTATGGTTGG
CACTCCTAAAACAATAGTTCAATGTGGCGAATATGGAAATCATAAAGTTATAGAGTCGGGAGAAGGGTACATTGAATTAG
AAGTAAATGGAGAAAGAGCGGTAGTATTAACTGTACCATATCCTAGCGAAAAGAGATTGAATGAAGTTTTATATGGAGAA
ATGGATGAAGAAGAACAACGATTAAAATCTTATAGCGATAGAATACATTCATTATTTGATTCTCTTAAGGTACGTTATAG
AAAAGATACTATTAATTTAGTTGCATCACATTTATTTGCTATGGGGAGTGAAGAAGGTGGTTCAGAAAGAAGTATTCAGT
TAGGGGGAAGCTATATTGTAGATGGAGGATGCTTTCCAAGTGAAGCTCAATATGTAGCTTTAGGACATGTTCATAAACCA
CAAATTGTTCCTGGTACTAATAAAAGAGCAAGATATTGTGGATCACCTATTCATTATAATAGAAAAGAAATAAATTTTGA
TAAGAAGTGTTTTATTGTAGATGTAAAATGCAATGAAGAACCTAATATACAAGACATTAATTTAAAGGTATATAAGCCTA
TTGAAATATGGAAATGCGCTAATATTGATGAAGCAATAGTAAAATGTAAAGAGAACTCAGAAAGAGAATGCTGGGTTTAT
CTTGAAATAGAAACTGATAGATATGTAAGAGAAGATGAAATAAAGCAGATGAAAGATTTTAAGAAAGATATATTAGAGAT
AATTCCTAAGATAAAAATAAATGATGAGGAAGATGATATTAAGAATATATCAGAAAAGTCTTTTGATGAAATATTTAAGG
ATTTTTATAAGAAAGAAAGAGGCGTTGAAGCAGATACGGAAGTTATTGAGTTATTTTTAAATATAATGTCAGAGGTAGGT
GAAGAAGATGAGACCAATTGA

Upstream 100 bases:

>100_bases
TGAATCAATAGGATATAAAGTTGGAAAAGATAAATTAAAATATGGTGGACTAAGAAGATATGTTTTAATTAAATATTTAC
ATTAATTTTGGGAGGTAAAG

Downstream 100 bases:

>100_bases
ACTTAGGGTTAAAGGATTAAATAGCTTTATAGAAGAGCAAAAGATAGATTTTAATAAGTTGACTGAAAGGGGATTTTTTG
GGATCTTTGGACCTACAGGT

Product: DNA repair exonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRILHTGDWHLGKNLEGKSRMDEQELFLNDFAKLVKENNIDLVIIAGDVYDSSNPPARAEKMFYDTLKKISSDGERITLV
ISGNHDSPERLISAGQLARDHGIIMVGTPKTIVQCGEYGNHKVIESGEGYIELEVNGERAVVLTVPYPSEKRLNEVLYGE
MDEEEQRLKSYSDRIHSLFDSLKVRYRKDTINLVASHLFAMGSEEGGSERSIQLGGSYIVDGGCFPSEAQYVALGHVHKP
QIVPGTNKRARYCGSPIHYNRKEINFDKKCFIVDVKCNEEPNIQDINLKVYKPIEIWKCANIDEAIVKCKENSERECWVY
LEIETDRYVREDEIKQMKDFKKDILEIIPKIKINDEEDDIKNISEKSFDEIFKDFYKKERGVEADTEVIELFLNIMSEVG
EEDETN

Sequences:

>Translated_406_residues
MRILHTGDWHLGKNLEGKSRMDEQELFLNDFAKLVKENNIDLVIIAGDVYDSSNPPARAEKMFYDTLKKISSDGERITLV
ISGNHDSPERLISAGQLARDHGIIMVGTPKTIVQCGEYGNHKVIESGEGYIELEVNGERAVVLTVPYPSEKRLNEVLYGE
MDEEEQRLKSYSDRIHSLFDSLKVRYRKDTINLVASHLFAMGSEEGGSERSIQLGGSYIVDGGCFPSEAQYVALGHVHKP
QIVPGTNKRARYCGSPIHYNRKEINFDKKCFIVDVKCNEEPNIQDINLKVYKPIEIWKCANIDEAIVKCKENSERECWVY
LEIETDRYVREDEIKQMKDFKKDILEIIPKIKINDEEDDIKNISEKSFDEIFKDFYKKERGVEADTEVIELFLNIMSEVG
EEDETN
>Mature_406_residues
MRILHTGDWHLGKNLEGKSRMDEQELFLNDFAKLVKENNIDLVIIAGDVYDSSNPPARAEKMFYDTLKKISSDGERITLV
ISGNHDSPERLISAGQLARDHGIIMVGTPKTIVQCGEYGNHKVIESGEGYIELEVNGERAVVLTVPYPSEKRLNEVLYGE
MDEEEQRLKSYSDRIHSLFDSLKVRYRKDTINLVASHLFAMGSEEGGSERSIQLGGSYIVDGGCFPSEAQYVALGHVHKP
QIVPGTNKRARYCGSPIHYNRKEINFDKKCFIVDVKCNEEPNIQDINLKVYKPIEIWKCANIDEAIVKCKENSERECWVY
LEIETDRYVREDEIKQMKDFKKDILEIIPKIKINDEEDDIKNISEKSFDEIFKDFYKKERGVEADTEVIELFLNIMSEVG
EEDETN

Specific function: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sbcD family [H]

Homologues:

Organism=Escherichia coli, GI1786598, Length=418, Percent_Identity=25.3588516746411, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 46574; Mature: 46574

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILHTGDWHLGKNLEGKSRMDEQELFLNDFAKLVKENNIDLVIIAGDVYDSSNPPARAE
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
KMFYDTLKKISSDGERITLVISGNHDSPERLISAGQLARDHGIIMVGTPKTIVQCGEYGN
HHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCC
HKVIESGEGYIELEVNGERAVVLTVPYPSEKRLNEVLYGEMDEEEQRLKSYSDRIHSLFD
CEEEECCCCEEEEEECCCEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SLKVRYRKDTINLVASHLFAMGSEEGGSERSIQLGGSYIVDGGCFPSEAQYVALGHVHKP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCCCCCEEEECCCCCC
QIVPGTNKRARYCGSPIHYNRKEINFDKKCFIVDVKCNEEPNIQDINLKVYKPIEIWKCA
CCCCCCCCCHHHCCCCCCCCHHHCCCCCEEEEEEEEECCCCCCEEEEEEEECCEEEEECC
NIDEAIVKCKENSERECWVYLEIETDRYVREDEIKQMKDFKKDILEIIPKIKINDEEDDI
CHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHH
KNISEKSFDEIFKDFYKKERGVEADTEVIELFLNIMSEVGEEDETN
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRILHTGDWHLGKNLEGKSRMDEQELFLNDFAKLVKENNIDLVIIAGDVYDSSNPPARAE
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
KMFYDTLKKISSDGERITLVISGNHDSPERLISAGQLARDHGIIMVGTPKTIVQCGEYGN
HHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCC
HKVIESGEGYIELEVNGERAVVLTVPYPSEKRLNEVLYGEMDEEEQRLKSYSDRIHSLFD
CEEEECCCCEEEEEECCCEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SLKVRYRKDTINLVASHLFAMGSEEGGSERSIQLGGSYIVDGGCFPSEAQYVALGHVHKP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCCCCCCCEEEECCCCCC
QIVPGTNKRARYCGSPIHYNRKEINFDKKCFIVDVKCNEEPNIQDINLKVYKPIEIWKCA
CCCCCCCCCHHHCCCCCCCCHHHCCCCCEEEEEEEEECCCCCCEEEEEEEECCEEEEECC
NIDEAIVKCKENSERECWVYLEIETDRYVREDEIKQMKDFKKDILEIIPKIKINDEEDDI
CHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHH
KNISEKSFDEIFKDFYKKERGVEADTEVIELFLNIMSEVGEEDETN
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377; 10568751; 1646786; 8493111 [H]