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The map label for this gene is hpt [H]

Identifier: 187934669

GI number: 187934669

Start: 1014965

End: 1015486

Strand: Reverse

Name: hpt [H]

Synonym: CLL_A1003

Alternate gene names: 187934669

Gene position: 1015486-1014965 (Counterclockwise)

Preceding gene: 187933631

Following gene: 187935186

Centisome position: 26.72

GC content: 28.35

Gene sequence:

>522_bases
ATGGATAATAAAAAGCGTAATATACTTTTTTCTAAAGAAAAAATTGATGCTAGAATAGAAGAATTAGGTAAAGTTATCAC
TGAAGATTATAAAGATAAAAACCTTTATGTTTTATCTTTATTAAGAGGTAGCTTTATATATGCAGCTGATTTAGTTAGAG
CAATAGATACAAAAACCAAAATAGGCTTTATGACCACTTCAAGTTACGGTCATGATGAAGTATCTTCAGGAAAAGTTAAA
GTAATTAATGATATTCCTGATAATATTGAAGGATATGATGTTCTTATTGTTGATGATATCATCGACACTGGTATAACAAT
GAACTTTGTTGTTAATCACGTAAAAAGTTTAGGTGCTGCTTCAGTTAAAACTTGTGTTTTACTTGACAAACCATCAAGAA
GAACAGTTGAAATTGAACCTAATTATTGTTGTTTTACAATTGAAGATCTTTTTGTAGTTGGTTATGGTTTAAATTATGGA
GATCACTATAGAAACATCCCTTACGTATTTAACTGGCAATAA

Upstream 100 bases:

>100_bases
TACTATTAAACTACTTTAAAGAAACATAATGAGATATATTAGAGGAGGTGACCTGTTGTTAAATCTTTGTTATGATTTTA
GATTTTAACAACAGAATGGC

Downstream 100 bases:

>100_bases
ATTTTATAATCACTTTTACATATTAAAAGATTATAAGAAAAAGAAGGAGCTGTATCAGATTGATTTGAAAAACTCTAATC
TGGTACAGCCTCTTCTTTTT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MDNKKRNILFSKEKIDARIEELGKVITEDYKDKNLYVLSLLRGSFIYAADLVRAIDTKTKIGFMTTSSYGHDEVSSGKVK
VINDIPDNIEGYDVLIVDDIIDTGITMNFVVNHVKSLGAASVKTCVLLDKPSRRTVEIEPNYCCFTIEDLFVVGYGLNYG
DHYRNIPYVFNWQ

Sequences:

>Translated_173_residues
MDNKKRNILFSKEKIDARIEELGKVITEDYKDKNLYVLSLLRGSFIYAADLVRAIDTKTKIGFMTTSSYGHDEVSSGKVK
VINDIPDNIEGYDVLIVDDIIDTGITMNFVVNHVKSLGAASVKTCVLLDKPSRRTVEIEPNYCCFTIEDLFVVGYGLNYG
DHYRNIPYVFNWQ
>Mature_173_residues
MDNKKRNILFSKEKIDARIEELGKVITEDYKDKNLYVLSLLRGSFIYAADLVRAIDTKTKIGFMTTSSYGHDEVSSGKVK
VINDIPDNIEGYDVLIVDDIIDTGITMNFVVNHVKSLGAASVKTCVLLDKPSRRTVEIEPNYCCFTIEDLFVVGYGLNYG
DHYRNIPYVFNWQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=162, Percent_Identity=32.0987654320988, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4504483, Length=162, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI87081689, Length=165, Percent_Identity=43.6363636363636, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17510817, Length=160, Percent_Identity=29.375, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19660; Mature: 19660

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNKKRNILFSKEKIDARIEELGKVITEDYKDKNLYVLSLLRGSFIYAADLVRAIDTKTK
CCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHHCCCCE
IGFMTTSSYGHDEVSSGKVKVINDIPDNIEGYDVLIVDDIIDTGITMNFVVNHVKSLGAA
EEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEEEECHHCCCCHHHHHHHHHHHCCCC
SVKTCVLLDKPSRRTVEIEPNYCCFTIEDLFVVGYGLNYGDHYRNIPYVFNWQ
CEEEEEEEECCCCCEEEECCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MDNKKRNILFSKEKIDARIEELGKVITEDYKDKNLYVLSLLRGSFIYAADLVRAIDTKTK
CCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHHCCCCE
IGFMTTSSYGHDEVSSGKVKVINDIPDNIEGYDVLIVDDIIDTGITMNFVVNHVKSLGAA
EEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEEEECHHCCCCHHHHHHHHHHHCCCC
SVKTCVLLDKPSRRTVEIEPNYCCFTIEDLFVVGYGLNYGDHYRNIPYVFNWQ
CEEEEEEEECCCCCEEEECCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]