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The map label for this gene is comEC [H]

Identifier: 187934495

GI number: 187934495

Start: 1983630

End: 1984706

Strand: Reverse

Name: comEC [H]

Synonym: CLL_A1884

Alternate gene names: 187934495

Gene position: 1984706-1983630 (Counterclockwise)

Preceding gene: 187933263

Following gene: 187935403

Centisome position: 52.22

GC content: 30.27

Gene sequence:

>1077_bases
ATGAAAACTACTAAAAAATTACTTAGTTTATCTATGGCTGTATTATTGTCGACATTTAGTTTAGGATGTAAACAAGCTAA
TGCTATTAACAAAACTAATATTGAAACTACTAAAACACAAGAAACCTCAGTAGGAGATATGAAAGTCCACTATATTGATG
TAGGTCAGGGAGATTCAGAGTTAATTCAAGTAGATGGAAAGAACATTCTTATTGATGCAGGTAATAATGATAGCATGGCT
TATAATTACTTGAAGAAACTAGGTATTAAAAAGCTAGATTACGTTATGGTCACACATCCACATTCAGATCATATTGGTGG
AATGACACAAATAATTAATGAATTTGATATTGGAGAGTTCTATGCTCCAAAGGTTAATCATACAACAAAGACATTTGAAA
ATATGATAAAAGCACTACAAAGTAAAGGAATAAAACTTACAGCTCCAACACCAGGAGATACTTTAAATGTAGGTAATGCA
ACATTACAATTTTTAGCTCCTAATAGTACAAAATATGAGGATATGAATAATTACTCTATAGCCTGTAAGTTAAAGTATGG
AAATACTTCTTATGTATTTATGGGGGATGCAGAAGCATTAAGTGAAGGCGAAATATTAGCCAAGCAATTAGATATTAGTG
CAGACGTACTTAAGTTAGGTCATCATGGAAGTCATTCTTCAACTTCTCAAGCATTTTTAGACAAAGTAAATCCAAGATAT
GCTATTGTTTCTTGTGGTAAAGGAAATGATTATGGTCATCCTCATCAAGAAACAATTGATAAACTAAATGCAAAAAATAT
TAACATATTAAGAACAGATGTAAGTGGAACTATAATATCTAGTTCAGATGGAAATAATATAATTTTTAATGTTAATGCAA
GTGGAACTAATACAGGAAATACAACTAACAATAGCACTTCAGAGACTAAGACAAAAAGCAATAGTGTTTGGGTAGCTAAT
AAAACTTCTAAAGTATATCACAGCAGTAAGGATTGTAGTAATATGAAAAATCCAACTGAAATATCTTTAGAAGATGCTCA
AACAAAGGGATTAAAACCGTGTTCAAAATGTAATTAA

Upstream 100 bases:

>100_bases
ATGGACAGACTCAAATAAAGAAAATGAGATTAATAAAAGTAGTATTGAAGAAAGTAATAATATAATAAAATAATATTATA
AAATTAAAGGGAGTGAATAA

Downstream 100 bases:

>100_bases
TAAAAAAGCAGTAGGTAAAAATTACTTACTGCTTTATTTTTATTTAACTAAAGTTAATACACTGCTAGAATATACAATTA
TGATTCTAAATATTTAAAAG

Product: metallo beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKTTKKLLSLSMAVLLSTFSLGCKQANAINKTNIETTKTQETSVGDMKVHYIDVGQGDSELIQVDGKNILIDAGNNDSMA
YNYLKKLGIKKLDYVMVTHPHSDHIGGMTQIINEFDIGEFYAPKVNHTTKTFENMIKALQSKGIKLTAPTPGDTLNVGNA
TLQFLAPNSTKYEDMNNYSIACKLKYGNTSYVFMGDAEALSEGEILAKQLDISADVLKLGHHGSHSSTSQAFLDKVNPRY
AIVSCGKGNDYGHPHQETIDKLNAKNINILRTDVSGTIISSSDGNNIIFNVNASGTNTGNTTNNSTSETKTKSNSVWVAN
KTSKVYHSSKDCSNMKNPTEISLEDAQTKGLKPCSKCN

Sequences:

>Translated_358_residues
MKTTKKLLSLSMAVLLSTFSLGCKQANAINKTNIETTKTQETSVGDMKVHYIDVGQGDSELIQVDGKNILIDAGNNDSMA
YNYLKKLGIKKLDYVMVTHPHSDHIGGMTQIINEFDIGEFYAPKVNHTTKTFENMIKALQSKGIKLTAPTPGDTLNVGNA
TLQFLAPNSTKYEDMNNYSIACKLKYGNTSYVFMGDAEALSEGEILAKQLDISADVLKLGHHGSHSSTSQAFLDKVNPRY
AIVSCGKGNDYGHPHQETIDKLNAKNINILRTDVSGTIISSSDGNNIIFNVNASGTNTGNTTNNSTSETKTKSNSVWVAN
KTSKVYHSSKDCSNMKNPTEISLEDAQTKGLKPCSKCN
>Mature_358_residues
MKTTKKLLSLSMAVLLSTFSLGCKQANAINKTNIETTKTQETSVGDMKVHYIDVGQGDSELIQVDGKNILIDAGNNDSMA
YNYLKKLGIKKLDYVMVTHPHSDHIGGMTQIINEFDIGEFYAPKVNHTTKTFENMIKALQSKGIKLTAPTPGDTLNVGNA
TLQFLAPNSTKYEDMNNYSIACKLKYGNTSYVFMGDAEALSEGEILAKQLDISADVLKLGHHGSHSSTSQAFLDKVNPRY
AIVSCGKGNDYGHPHQETIDKLNAKNINILRTDVSGTIISSSDGNNIIFNVNASGTNTGNTTNNSTSETKTKSNSVWVAN
KTSKVYHSSKDCSNMKNPTEISLEDAQTKGLKPCSKCN

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=228, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 38907; Mature: 38907

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTKKLLSLSMAVLLSTFSLGCKQANAINKTNIETTKTQETSVGDMKVHYIDVGQGDSE
CCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCE
LIQVDGKNILIDAGNNDSMAYNYLKKLGIKKLDYVMVTHPHSDHIGGMTQIINEFDIGEF
EEEECCCEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCE
YAPKVNHTTKTFENMIKALQSKGIKLTAPTPGDTLNVGNATLQFLAPNSTKYEDMNNYSI
ECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCEEECCCEEEEEECCCCCCCCCCCCEEE
ACKLKYGNTSYVFMGDAEALSEGEILAKQLDISADVLKLGHHGSHSSTSQAFLDKVNPRY
EEEEEECCEEEEEECCHHHHCCCHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHCCCCCE
AIVSCGKGNDYGHPHQETIDKLNAKNINILRTDVSGTIISSSDGNNIIFNVNASGTNTGN
EEEECCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCEEEECCCCCEEEEEEECCCCCCCC
TTNNSTSETKTKSNSVWVANKTSKVYHSSKDCSNMKNPTEISLEDAQTKGLKPCSKCN
CCCCCCCCCCCCCCEEEEEECCHHHHCCCCHHHCCCCCCEEEECCCCCCCCCCHHCCC
>Mature Secondary Structure
MKTTKKLLSLSMAVLLSTFSLGCKQANAINKTNIETTKTQETSVGDMKVHYIDVGQGDSE
CCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCE
LIQVDGKNILIDAGNNDSMAYNYLKKLGIKKLDYVMVTHPHSDHIGGMTQIINEFDIGEF
EEEECCCEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCE
YAPKVNHTTKTFENMIKALQSKGIKLTAPTPGDTLNVGNATLQFLAPNSTKYEDMNNYSI
ECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCEEECCCEEEEEECCCCCCCCCCCCEEE
ACKLKYGNTSYVFMGDAEALSEGEILAKQLDISADVLKLGHHGSHSSTSQAFLDKVNPRY
EEEEEECCEEEEEECCHHHHCCCHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHCCCCCE
AIVSCGKGNDYGHPHQETIDKLNAKNINILRTDVSGTIISSSDGNNIIFNVNASGTNTGN
EEEECCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCEEEECCCCCEEEEEEECCCCCCCC
TTNNSTSETKTKSNSVWVANKTSKVYHSSKDCSNMKNPTEISLEDAQTKGLKPCSKCN
CCCCCCCCCCCCCCEEEEEECCHHHHCCCCHHHCCCCCCEEEECCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]