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The map label for this gene is yisQ [H]

Identifier: 187934324

GI number: 187934324

Start: 2370795

End: 2372153

Strand: Reverse

Name: yisQ [H]

Synonym: CLL_A2301

Alternate gene names: 187934324

Gene position: 2372153-2370795 (Counterclockwise)

Preceding gene: 187935280

Following gene: 187935455

Centisome position: 62.42

GC content: 28.77

Gene sequence:

>1359_bases
ATGAGTAGTATAAACACATTAGAGAGGACAACTGAAAGAACAACATCGTTATTTAAATTGACATGGCCTATTTTTATAGA
ACTTATTTTACAAATGCTTGTAAGCAATGTGGATCAACTTATGTTAAGCAGGGTATCGGAAAATTCTGTTGCTGCTGTAG
GAAATGTAAATCAAATCATGAATTTCTTACTTATTACTTTTAGTATTATTACTATGGCAACAACAATACTTGTATCTCAA
TACTTAGGTGCAAAAAATTATGGAAAGGTTTCCGAAATATATTCTGTAGCTGTATTTTCTAACTTAGTATTTAGTATTTT
AATAAGCATATTGTTATTATGTTTCAATGGTATATTTTTTAAATGGCTAAGAATGCCAAGTGAACTGCTTAGAGATGCTA
AAACATATATAAGTATAATTGGTGGAGGAATATTTCTACAAGCTATATTTATGACTTATTCAGCCATATTAAGAAGTAAT
AGTTTAATGAAACAAGGAATGTATGTTTCTGCAATAGTAAATATCGTTAATATATTAGGAAACTTTCTTTTTATAAGTGG
TGCATTTGGGATACCGAAGCTTGGAGTAGAAGGAGTTGCTATATCAAGTGTATTAAGTAGGCTTATAGGAGTTATAGTTA
TAATATACATATTTAAACAAAATATAAAACAAAAAGTATCATTAAAGTACTTAAATCCATTTCCTAAAGAAATATTTAAA
AAGTTAATGATGATTGGTCTTCCATCTGGAGGTGAATCAGTATCATATAATTTTTCACAAATGGTGATATTAACATTTAT
AAACATGATGGGTACAAGCTCTGTTGCAACAAAAGCATATGTCGGAATATTGGTTTGGTTTTCATTCATATATGGTTCAG
CAGTATCGCAAGCAAATCAAATAAGAGTTGGGTATCTTATTGGTGCTAATAATGAAGATGAGGCATATAAGAAAGTTTTA
GAAACATTAAGACCAGCAGCATTTATTTCAGTAGGGGTTTCGATAATATTATTTATATTTAGTGATAATTTGCTTGGTAT
ATTTACATCTAACCCTGAAATTTTAAAATTAGGAAAACAAGTTTTATTTATAGATGTATTATTGGAGTTTGGAAGATCGT
TTAATCTTGTAATAATAAGAGGTATGCAAGCAGCAGGTGATATTAAATATCCTATATTTATAGGAGTTTTATCAATGTGG
ATTGTAGCAACAGGACTTTCATATATTTTTGGAATAGTATTAGGATTAGGACTTAGTGGGATATGGATTGCAATGATGTG
CGATGAATGTTTAAGAGGATTAATTTTCTATATAAGATGGAGAAGAGGTACTTGGAGATCTAAAAGAATAGTAAATTAA

Upstream 100 bases:

>100_bases
ATGTTTTGTGTTGTATAAATATTGTATTTTAAAATAATATTTATGCAAGAGAAATAAGTGAAACAACAAGAAGGATTTTT
GTGAAGGGAAAGGAGAAAAA

Downstream 100 bases:

>100_bases
TTTTAGTGTTAATTATTATGAATATATCAGTCTAATTTTAAAGAATAACATGATATGAAAATAATAAATAACTATTATAT
TATAAATCTCATACAATAAA

Product: mate efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSSINTLERTTERTTSLFKLTWPIFIELILQMLVSNVDQLMLSRVSENSVAAVGNVNQIMNFLLITFSIITMATTILVSQ
YLGAKNYGKVSEIYSVAVFSNLVFSILISILLLCFNGIFFKWLRMPSELLRDAKTYISIIGGGIFLQAIFMTYSAILRSN
SLMKQGMYVSAIVNIVNILGNFLFISGAFGIPKLGVEGVAISSVLSRLIGVIVIIYIFKQNIKQKVSLKYLNPFPKEIFK
KLMMIGLPSGGESVSYNFSQMVILTFINMMGTSSVATKAYVGILVWFSFIYGSAVSQANQIRVGYLIGANNEDEAYKKVL
ETLRPAAFISVGVSIILFIFSDNLLGIFTSNPEILKLGKQVLFIDVLLEFGRSFNLVIIRGMQAAGDIKYPIFIGVLSMW
IVATGLSYIFGIVLGLGLSGIWIAMMCDECLRGLIFYIRWRRGTWRSKRIVN

Sequences:

>Translated_452_residues
MSSINTLERTTERTTSLFKLTWPIFIELILQMLVSNVDQLMLSRVSENSVAAVGNVNQIMNFLLITFSIITMATTILVSQ
YLGAKNYGKVSEIYSVAVFSNLVFSILISILLLCFNGIFFKWLRMPSELLRDAKTYISIIGGGIFLQAIFMTYSAILRSN
SLMKQGMYVSAIVNIVNILGNFLFISGAFGIPKLGVEGVAISSVLSRLIGVIVIIYIFKQNIKQKVSLKYLNPFPKEIFK
KLMMIGLPSGGESVSYNFSQMVILTFINMMGTSSVATKAYVGILVWFSFIYGSAVSQANQIRVGYLIGANNEDEAYKKVL
ETLRPAAFISVGVSIILFIFSDNLLGIFTSNPEILKLGKQVLFIDVLLEFGRSFNLVIIRGMQAAGDIKYPIFIGVLSMW
IVATGLSYIFGIVLGLGLSGIWIAMMCDECLRGLIFYIRWRRGTWRSKRIVN
>Mature_451_residues
SSINTLERTTERTTSLFKLTWPIFIELILQMLVSNVDQLMLSRVSENSVAAVGNVNQIMNFLLITFSIITMATTILVSQY
LGAKNYGKVSEIYSVAVFSNLVFSILISILLLCFNGIFFKWLRMPSELLRDAKTYISIIGGGIFLQAIFMTYSAILRSNS
LMKQGMYVSAIVNIVNILGNFLFISGAFGIPKLGVEGVAISSVLSRLIGVIVIIYIFKQNIKQKVSLKYLNPFPKEIFKK
LMMIGLPSGGESVSYNFSQMVILTFINMMGTSSVATKAYVGILVWFSFIYGSAVSQANQIRVGYLIGANNEDEAYKKVLE
TLRPAAFISVGVSIILFIFSDNLLGIFTSNPEILKLGKQVLFIDVLLEFGRSFNLVIIRGMQAAGDIKYPIFIGVLSMWI
VATGLSYIFGIVLGLGLSGIWIAMMCDECLRGLIFYIRWRRGTWRSKRIVN

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=436, Percent_Identity=25.2293577981651, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50343; Mature: 50212

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSINTLERTTERTTSLFKLTWPIFIELILQMLVSNVDQLMLSRVSENSVAAVGNVNQIM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHH
NFLLITFSIITMATTILVSQYLGAKNYGKVSEIYSVAVFSNLVFSILISILLLCFNGIFF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWLRMPSELLRDAKTYISIIGGGIFLQAIFMTYSAILRSNSLMKQGMYVSAIVNIVNILG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
NFLFISGAFGIPKLGVEGVAISSVLSRLIGVIVIIYIFKQNIKQKVSLKYLNPFPKEIFK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KLMMIGLPSGGESVSYNFSQMVILTFINMMGTSSVATKAYVGILVWFSFIYGSAVSQANQ
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
IRVGYLIGANNEDEAYKKVLETLRPAAFISVGVSIILFIFSDNLLGIFTSNPEILKLGKQ
EEEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
VLFIDVLLEFGRSFNLVIIRGMQAAGDIKYPIFIGVLSMWIVATGLSYIFGIVLGLGLSG
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
IWIAMMCDECLRGLIFYIRWRRGTWRSKRIVN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SSINTLERTTERTTSLFKLTWPIFIELILQMLVSNVDQLMLSRVSENSVAAVGNVNQIM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHH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HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]