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The map label for this gene is lon [H]

Identifier: 187933930

GI number: 187933930

Start: 2965530

End: 2967863

Strand: Reverse

Name: lon [H]

Synonym: CLL_A2887

Alternate gene names: 187933930

Gene position: 2967863-2965530 (Counterclockwise)

Preceding gene: 187933551

Following gene: 187935182

Centisome position: 78.09

GC content: 29.69

Gene sequence:

>2334_bases
ATGACACAAAATTTATATACACTTCCGCTGATACCCTTAAGAGGGTTAACTATTTTTCCTAATATAGTAGCACATTTTGA
TGTTGGAAGAAAAAGATCAATAGCAGCAATTGAAGAAGCTATGTTAAATAATGAAGAAATTTTTCTTGTTACTCAAAAAG
ATCCTGAAATAGAGGATCCTGAGAGAGAAGATATATATGATATAGGAACACTTTGCAAAATAAAACAAATTCTTAAAATG
TCTGACAACACAATTAAAGTGCTTGTTGAAGGGGTAAAAAGAGGGAAAATAGTTGAATATATAGCGGATGATAATGAATA
TATTGAAGGTTCTATAGAATTTATAGAGCAAGAAATAGAAATAAATGAAGAACTAGAAGCTTATATAAAACTTTTAGATG
AAGATTTTATAGAATTATTGAAGATATCAGATGATAATTATGTAGATATTATAAGATCAACAGAACCTTTAGATGATCCT
AGTGGGTTTGTTGACATAATAGCATCTTACTCTGTTACAGAAGACGATATAAAGCAAGAAGTATTAGAAACAATAGATAT
TAAGAAAAGAATAGAGATAGTATTATCTAGAGTGAAAATTGAAACAGATATCTTGAAAATCCAAAATAAGCTTTCAAAAA
AAGTTAAAAAACATATTGATGAAGAACAAAAACAATTTTACCTTAGAGAGCAATTAAAAGCAATCCAAGAAGAACTAGGA
ATGGATGATGAAGAAAAGAAAGAAATAAATAAATACGAAACTTTACTTAATAAAACAAAACTTCCAAAGCAAGTAAAAGA
AAAGGTTCAGTATGAATTAAGTAGACTTAAAAGTACTTCTTCATCTTCTTCAGAAGGAAATTTAATAAAGTCATATTTAG
ATTGGGTATTTAACATACCTTGGAATAAGCAAACTAAGGAAAATATAGACATAATAAAAGCCAGAGAAGTATTAGACAAT
GAACATTATGGATTAGAAGATGTTAAAGATAGAATTGTAGAGTATCTAGCAGTAAAGCAAATAAGTAAAAATTCTAAAGG
ACCTATTTTATGTTTAGTTGGTCCTCCTGGAGTAGGAAAAACTTCAATAGCTAAGTCAATAGCACATTCTACTAATAGAA
AATATTCAAGAATATCCCTTGGTGGAATGAAAGATGAAGCTGAAATTAGAGGACATAGAAAAACATATGTTGGAGCTATA
CCAGGAAGAATAGCTTATGCATTAAAAGAAGCTAAAACTATGAATCCTTTGATATTATTTGATGAAATTGATAAAATTAG
TTCAAGTTATAAGGGAGAACCATCTGATGCACTTTTAGAAGTATTAGATAGTGAGCAGAATAAGACTTTTAGAGATAATT
ATTTAGAACTAGATATGGATTTATCAAAAGTAATGTTTATAGCCACAGCTAATTCTTTAGAGACTATACCAAGAGCATTA
TTAGATAGAATGGAAATAATAGAGGTATCTGGATATACTTATGAAGAAAAATTTAATATAGCTAAAAATCACTTAATACC
AAAAGTATTTGAGGAAATAGGCATTAAATTTGATAAGGTAGAGTTTGAAGAAGAAGCAATCAATGAAATAATAGAAGGAT
ATACTAGAGAATCAGGTGTTCGAGGGCTTACAAGAAATTTAAATTCTATTATAAGAAAAGCTTTGGCAGAAATGCTAAGT
GAAAATCTATCAAATATTATAATTGACAAAAGTAAGGTAGAAAAGCTTTTAGGCAAAAGGAAATATGAATTTGACAAGAT
AGACAAAGAAGATAAAATAGGTGTAGTTACAGGAATGGCATGGACGGCATATGGTGGAGACACATTACCGGTAGAAGTAA
TGGCAATGAAGGGAAGCGGAAAGCTAGAACTTACAGGAAAATTAGGTGATGTAATGAAAGAGTCTGCAAAAGCTGCTTAT
AGTTATGTTAGAGCTAATGCAGATAAATTCCAAATAGAAGAAAACTTCTATAAAAATAAAGATATTCATATACATGCACC
AGAAGGTGCAGTACCTAAAGATGGTCCATCTGCTGGAGTAACAATGGTTACAGCTCTAGTGTCAGCTTTATCTGGTAAGA
AAGTTAAGCATAATATTGCGATGACAGGGGAAGTAACTTTAACTGGTAGAGTGCTTCCGATAGGAGGACTAAAGGAAAAA
TCATTAGCAGCATTTAGAGCTGGTATAGATACTATAATAATTCCAAAAGAAAATGAGAAAGATATAGAAAAGATACCAAA
TTCAATAAAAAATAAATTAAATATCATTCCCGTAAGTCAAGTGAATGAGGTATTAAAAAATGCGCTAATTGGAGAGGATA
CTAATGAGAATTAA

Upstream 100 bases:

>100_bases
AGTTTATAATTTAGACTAATCCTAAATTATGTATATTTATTGAAATATACACTTAATATGTGTATACTAAATGAAGTAAT
TAAGATGGAGGGGCGTTTGA

Downstream 100 bases:

>100_bases
ACAATCAGAATTTATTATTTCAGCTGTAAAACCACATCAATACCCAATTGATCATAGAAATGAAGTTGCTTTTGTTGGAA
GATCTAATGTTGGAAAGAGT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MTQNLYTLPLIPLRGLTIFPNIVAHFDVGRKRSIAAIEEAMLNNEEIFLVTQKDPEIEDPEREDIYDIGTLCKIKQILKM
SDNTIKVLVEGVKRGKIVEYIADDNEYIEGSIEFIEQEIEINEELEAYIKLLDEDFIELLKISDDNYVDIIRSTEPLDDP
SGFVDIIASYSVTEDDIKQEVLETIDIKKRIEIVLSRVKIETDILKIQNKLSKKVKKHIDEEQKQFYLREQLKAIQEELG
MDDEEKKEINKYETLLNKTKLPKQVKEKVQYELSRLKSTSSSSSEGNLIKSYLDWVFNIPWNKQTKENIDIIKAREVLDN
EHYGLEDVKDRIVEYLAVKQISKNSKGPILCLVGPPGVGKTSIAKSIAHSTNRKYSRISLGGMKDEAEIRGHRKTYVGAI
PGRIAYALKEAKTMNPLILFDEIDKISSSYKGEPSDALLEVLDSEQNKTFRDNYLELDMDLSKVMFIATANSLETIPRAL
LDRMEIIEVSGYTYEEKFNIAKNHLIPKVFEEIGIKFDKVEFEEEAINEIIEGYTRESGVRGLTRNLNSIIRKALAEMLS
ENLSNIIIDKSKVEKLLGKRKYEFDKIDKEDKIGVVTGMAWTAYGGDTLPVEVMAMKGSGKLELTGKLGDVMKESAKAAY
SYVRANADKFQIEENFYKNKDIHIHAPEGAVPKDGPSAGVTMVTALVSALSGKKVKHNIAMTGEVTLTGRVLPIGGLKEK
SLAAFRAGIDTIIIPKENEKDIEKIPNSIKNKLNIIPVSQVNEVLKNALIGEDTNEN

Sequences:

>Translated_777_residues
MTQNLYTLPLIPLRGLTIFPNIVAHFDVGRKRSIAAIEEAMLNNEEIFLVTQKDPEIEDPEREDIYDIGTLCKIKQILKM
SDNTIKVLVEGVKRGKIVEYIADDNEYIEGSIEFIEQEIEINEELEAYIKLLDEDFIELLKISDDNYVDIIRSTEPLDDP
SGFVDIIASYSVTEDDIKQEVLETIDIKKRIEIVLSRVKIETDILKIQNKLSKKVKKHIDEEQKQFYLREQLKAIQEELG
MDDEEKKEINKYETLLNKTKLPKQVKEKVQYELSRLKSTSSSSSEGNLIKSYLDWVFNIPWNKQTKENIDIIKAREVLDN
EHYGLEDVKDRIVEYLAVKQISKNSKGPILCLVGPPGVGKTSIAKSIAHSTNRKYSRISLGGMKDEAEIRGHRKTYVGAI
PGRIAYALKEAKTMNPLILFDEIDKISSSYKGEPSDALLEVLDSEQNKTFRDNYLELDMDLSKVMFIATANSLETIPRAL
LDRMEIIEVSGYTYEEKFNIAKNHLIPKVFEEIGIKFDKVEFEEEAINEIIEGYTRESGVRGLTRNLNSIIRKALAEMLS
ENLSNIIIDKSKVEKLLGKRKYEFDKIDKEDKIGVVTGMAWTAYGGDTLPVEVMAMKGSGKLELTGKLGDVMKESAKAAY
SYVRANADKFQIEENFYKNKDIHIHAPEGAVPKDGPSAGVTMVTALVSALSGKKVKHNIAMTGEVTLTGRVLPIGGLKEK
SLAAFRAGIDTIIIPKENEKDIEKIPNSIKNKLNIIPVSQVNEVLKNALIGEDTNEN
>Mature_776_residues
TQNLYTLPLIPLRGLTIFPNIVAHFDVGRKRSIAAIEEAMLNNEEIFLVTQKDPEIEDPEREDIYDIGTLCKIKQILKMS
DNTIKVLVEGVKRGKIVEYIADDNEYIEGSIEFIEQEIEINEELEAYIKLLDEDFIELLKISDDNYVDIIRSTEPLDDPS
GFVDIIASYSVTEDDIKQEVLETIDIKKRIEIVLSRVKIETDILKIQNKLSKKVKKHIDEEQKQFYLREQLKAIQEELGM
DDEEKKEINKYETLLNKTKLPKQVKEKVQYELSRLKSTSSSSSEGNLIKSYLDWVFNIPWNKQTKENIDIIKAREVLDNE
HYGLEDVKDRIVEYLAVKQISKNSKGPILCLVGPPGVGKTSIAKSIAHSTNRKYSRISLGGMKDEAEIRGHRKTYVGAIP
GRIAYALKEAKTMNPLILFDEIDKISSSYKGEPSDALLEVLDSEQNKTFRDNYLELDMDLSKVMFIATANSLETIPRALL
DRMEIIEVSGYTYEEKFNIAKNHLIPKVFEEIGIKFDKVEFEEEAINEIIEGYTRESGVRGLTRNLNSIIRKALAEMLSE
NLSNIIIDKSKVEKLLGKRKYEFDKIDKEDKIGVVTGMAWTAYGGDTLPVEVMAMKGSGKLELTGKLGDVMKESAKAAYS
YVRANADKFQIEENFYKNKDIHIHAPEGAVPKDGPSAGVTMVTALVSALSGKKVKHNIAMTGEVTLTGRVLPIGGLKEKS
LAAFRAGIDTIIIPKENEKDIEKIPNSIKNKLNIIPVSQVNEVLKNALIGEDTNEN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=670, Percent_Identity=42.3880597014925, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI31377667, Length=833, Percent_Identity=36.8547418967587, Blast_Score=521, Evalue=1e-148,
Organism=Escherichia coli, GI1786643, Length=769, Percent_Identity=45.9037711313394, Blast_Score=716, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=657, Percent_Identity=39.2694063926941, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17556486, Length=535, Percent_Identity=43.5514018691589, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319449, Length=685, Percent_Identity=42.4817518248175, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221513036, Length=635, Percent_Identity=42.992125984252, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24666867, Length=635, Percent_Identity=42.992125984252, Blast_Score=542, Evalue=1e-154,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87820; Mature: 87689

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNLYTLPLIPLRGLTIFPNIVAHFDVGRKRSIAAIEEAMLNNEEIFLVTQKDPEIEDP
CCCCEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
EREDIYDIGTLCKIKQILKMSDNTIKVLVEGVKRGKIVEYIADDNEYIEGSIEFIEQEIE
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHC
INEELEAYIKLLDEDFIELLKISDDNYVDIIRSTEPLDDPSGFVDIIASYSVTEDDIKQE
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHH
VLETIDIKKRIEIVLSRVKIETDILKIQNKLSKKVKKHIDEEQKQFYLREQLKAIQEELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHC
MDDEEKKEINKYETLLNKTKLPKQVKEKVQYELSRLKSTSSSSSEGNLIKSYLDWVFNIP
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECC
WNKQTKENIDIIKAREVLDNEHYGLEDVKDRIVEYLAVKQISKNSKGPILCLVGPPGVGK
CCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
TSIAKSIAHSTNRKYSRISLGGMKDEAEIRGHRKTYVGAIPGRIAYALKEAKTMNPLILF
HHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHEEECCCHHHHHHHHHHCCCCCEEEE
DEIDKISSSYKGEPSDALLEVLDSEQNKTFRDNYLELDMDLSKVMFIATANSLETIPRAL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHCCCEEECCCHHHEEEEEECCHHHHHHHHH
LDRMEIIEVSGYTYEEKFNIAKNHLIPKVFEEIGIKFDKVEFEEEAINEIIEGYTRESGV
HHHHHEEEECCCEEHHHHHHHHHHCCHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHCH
RGLTRNLNSIIRKALAEMLSENLSNIIIDKSKVEKLLGKRKYEFDKIDKEDKIGVVTGMA
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHCCCCCCHHCCCCCCCCEEEECCE
WTAYGGDTLPVEVMAMKGSGKLELTGKLGDVMKESAKAAYSYVRANADKFQIEENFYKNK
EEECCCCCCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHCCCC
DIHIHAPEGAVPKDGPSAGVTMVTALVSALSGKKVKHNIAMTGEVTLTGRVLPIGGLKEK
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCEEEEEEEEEEEEEEECCCCCHH
SLAAFRAGIDTIIIPKENEKDIEKIPNSIKNKLNIIPVSQVNEVLKNALIGEDTNEN
HHHHHHCCCCEEEECCCCCHHHHHCCHHHHHCEEEEEHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQNLYTLPLIPLRGLTIFPNIVAHFDVGRKRSIAAIEEAMLNNEEIFLVTQKDPEIEDP
CCCEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
EREDIYDIGTLCKIKQILKMSDNTIKVLVEGVKRGKIVEYIADDNEYIEGSIEFIEQEIE
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHC
INEELEAYIKLLDEDFIELLKISDDNYVDIIRSTEPLDDPSGFVDIIASYSVTEDDIKQE
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHH
VLETIDIKKRIEIVLSRVKIETDILKIQNKLSKKVKKHIDEEQKQFYLREQLKAIQEELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHC
MDDEEKKEINKYETLLNKTKLPKQVKEKVQYELSRLKSTSSSSSEGNLIKSYLDWVFNIP
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECC
WNKQTKENIDIIKAREVLDNEHYGLEDVKDRIVEYLAVKQISKNSKGPILCLVGPPGVGK
CCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
TSIAKSIAHSTNRKYSRISLGGMKDEAEIRGHRKTYVGAIPGRIAYALKEAKTMNPLILF
HHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHEEECCCHHHHHHHHHHCCCCCEEEE
DEIDKISSSYKGEPSDALLEVLDSEQNKTFRDNYLELDMDLSKVMFIATANSLETIPRAL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHCCCEEECCCHHHEEEEEECCHHHHHHHHH
LDRMEIIEVSGYTYEEKFNIAKNHLIPKVFEEIGIKFDKVEFEEEAINEIIEGYTRESGV
HHHHHEEEECCCEEHHHHHHHHHHCCHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHCH
RGLTRNLNSIIRKALAEMLSENLSNIIIDKSKVEKLLGKRKYEFDKIDKEDKIGVVTGMA
HHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHCCCCCCHHCCCCCCCCEEEECCE
WTAYGGDTLPVEVMAMKGSGKLELTGKLGDVMKESAKAAYSYVRANADKFQIEENFYKNK
EEECCCCCCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHCCCC
DIHIHAPEGAVPKDGPSAGVTMVTALVSALSGKKVKHNIAMTGEVTLTGRVLPIGGLKEK
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCEEEEEEEEEEEEEEECCCCCHH
SLAAFRAGIDTIIIPKENEKDIEKIPNSIKNKLNIIPVSQVNEVLKNALIGEDTNEN
HHHHHHCCCCEEEECCCCCHHHHHCCHHHHHCEEEEEHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]