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The map label for this gene is 187933781

Identifier: 187933781

GI number: 187933781

Start: 2036028

End: 2037506

Strand: Reverse

Name: 187933781

Synonym: CLL_A1963

Alternate gene names: NA

Gene position: 2037506-2036028 (Counterclockwise)

Preceding gene: 187932842

Following gene: 187934334

Centisome position: 53.61

GC content: 28.4

Gene sequence:

>1479_bases
ATGATGGAGAACCAAGAAAATAATAGAAAAGATTATAGAGAAGCTGTAAATGCAATTGGTAAAAAGGAATTTACCCTTAT
AAAGATGCAGGAATATGGGTTTTGGCCACAGAATCTACCTACCCCTTATGAAAGACAAGAAAATGAAACAAGTGAACAGT
ATGAGAATAGAAAAAATCTATTAGAAAAATATGAAAAAGTAATTGATGAAATTGCTAATTTATATGAAGAAAAAGATAAA
ATAAATTCAAAGTTAATAGAACTTCAAAAAAAGTACGATGAAACATGGGATTATGAGAAAATAAGATTAGATGTATCTAA
GACTATTATGGAGGAATCTATTGCAAGGCGTGCCGAAAGAAAAAAACAAAGGGAACTTGAAAAAAGACAGCGCTCAGAGG
AATGGAAAAAAGAAAAAGAAGATAAAATTGTATTTATAGGAAAAGGATATTCTAGTTTACTTAAAGATAAAGAAACTCAT
AAAGAAAAGCTATTAGCACAAGATTTACCTATTATAAATGATGACAAAGAACTAGCTAGTTTTCTAGGGATAGAATATAA
GAAGTTGAGGTTTTTAGTTTATCATAGAGATGTAGTATCTGTTGATCATTATTATAGATACACTATTCCTAAAAAAAGAG
GAGGAGTTCGTAATATTGCAGCTCCAAAATCAGTATTAAAGAATTCACAAAGAAAAATTTTAGATGACATTTTATTGAAA
ATTCCTACTAGTGATGAGGCTCATGGATTTTTAAAGGGAAAATCTGTGGTTTCGGCTGCAGAAAGTCATTTTAAACAGCC
AGAATTGCTTATTAATATAGATCTTGAAGATTTCTTTCCAACAATTACATTTGAAAGGGTAAGAGGATTATTTAAATCCT
TTGGATATTCTGGATATATAGCATCTATGTTAGCAATGATTTGTACATATTGCGAACGTATGAAGATAGAAATTAGAGGA
GAAGAAAAATATATAAAGACATCAAATAGAATTCTCCCACAAGGTTCACCAGCAAGTCCGATGATTACAAATATAATTTG
TATAAAATTAGACAAAAGATTAAAAGGACTTTCTTCTAAATATAATTTTACTTATACAAGATATGCAGATGATATGAGTT
TTAGCTTTAATGGGGATGATTATGAATTAAACATTGGCAGATTTATAGGATTAGTTTCAAAGATTGTTAAAGAAGAGGGC
TTTAATATAAACAAGGATAAAACAAAATTCTTAAAAAAGAATAATTGTCAATGTATAACAGGTATTGTAATAAACAATGA
AGAAATTGGAGTGCCTAAAAAATGGGTTAAAAAATTAAGGGCTGCTATTTACAATGCTAATAAAGCTAGAAATAGTGGTG
AAGTATTATCTAGTAAAGTTATAAATGAAATATTAGGAATGACATCATGGATAAAAAGTGTTAATGAAAAAAGATACAAA
GCTATCATTGATTCTGCAATGGAGTTGATTAATAGTTAG

Upstream 100 bases:

>100_bases
CACACATTTTAGCTTTATATTTAACTTCTACAAAATTTTTAAAGCTAAAATTAGAACCAAATAAAGAATATAAAATTAAT
GATATTATGGAGACGGTACT

Downstream 100 bases:

>100_bases
TTATAAATTTGTATTAAAAAGAAGATCTATAATTAACTTATAATATATTATATTAATTATAGGTTTATATAAAAATAATA
TGAATAAGTGGTTTAGAGTG

Product: reverse transcriptase

Products: NA

Alternate protein names: Mx162-RT; Reverse transcriptase [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MMENQENNRKDYREAVNAIGKKEFTLIKMQEYGFWPQNLPTPYERQENETSEQYENRKNLLEKYEKVIDEIANLYEEKDK
INSKLIELQKKYDETWDYEKIRLDVSKTIMEESIARRAERKKQRELEKRQRSEEWKKEKEDKIVFIGKGYSSLLKDKETH
KEKLLAQDLPIINDDKELASFLGIEYKKLRFLVYHRDVVSVDHYYRYTIPKKRGGVRNIAAPKSVLKNSQRKILDDILLK
IPTSDEAHGFLKGKSVVSAAESHFKQPELLINIDLEDFFPTITFERVRGLFKSFGYSGYIASMLAMICTYCERMKIEIRG
EEKYIKTSNRILPQGSPASPMITNIICIKLDKRLKGLSSKYNFTYTRYADDMSFSFNGDDYELNIGRFIGLVSKIVKEEG
FNINKDKTKFLKKNNCQCITGIVINNEEIGVPKKWVKKLRAAIYNANKARNSGEVLSSKVINEILGMTSWIKSVNEKRYK
AIIDSAMELINS

Sequences:

>Translated_492_residues
MMENQENNRKDYREAVNAIGKKEFTLIKMQEYGFWPQNLPTPYERQENETSEQYENRKNLLEKYEKVIDEIANLYEEKDK
INSKLIELQKKYDETWDYEKIRLDVSKTIMEESIARRAERKKQRELEKRQRSEEWKKEKEDKIVFIGKGYSSLLKDKETH
KEKLLAQDLPIINDDKELASFLGIEYKKLRFLVYHRDVVSVDHYYRYTIPKKRGGVRNIAAPKSVLKNSQRKILDDILLK
IPTSDEAHGFLKGKSVVSAAESHFKQPELLINIDLEDFFPTITFERVRGLFKSFGYSGYIASMLAMICTYCERMKIEIRG
EEKYIKTSNRILPQGSPASPMITNIICIKLDKRLKGLSSKYNFTYTRYADDMSFSFNGDDYELNIGRFIGLVSKIVKEEG
FNINKDKTKFLKKNNCQCITGIVINNEEIGVPKKWVKKLRAAIYNANKARNSGEVLSSKVINEILGMTSWIKSVNEKRYK
AIIDSAMELINS
>Mature_492_residues
MMENQENNRKDYREAVNAIGKKEFTLIKMQEYGFWPQNLPTPYERQENETSEQYENRKNLLEKYEKVIDEIANLYEEKDK
INSKLIELQKKYDETWDYEKIRLDVSKTIMEESIARRAERKKQRELEKRQRSEEWKKEKEDKIVFIGKGYSSLLKDKETH
KEKLLAQDLPIINDDKELASFLGIEYKKLRFLVYHRDVVSVDHYYRYTIPKKRGGVRNIAAPKSVLKNSQRKILDDILLK
IPTSDEAHGFLKGKSVVSAAESHFKQPELLINIDLEDFFPTITFERVRGLFKSFGYSGYIASMLAMICTYCERMKIEIRG
EEKYIKTSNRILPQGSPASPMITNIICIKLDKRLKGLSSKYNFTYTRYADDMSFSFNGDDYELNIGRFIGLVSKIVKEEG
FNINKDKTKFLKKNNCQCITGIVINNEEIGVPKKWVKKLRAAIYNANKARNSGEVLSSKVINEILGMTSWIKSVNEKRYK
AIIDSAMELINS

Specific function: Participates in the synthesis of a msDNA (a branched RNA linked by a 2',5'-phosphodiester linkage to a single-stranded DNA) of unknown function. The retron transcript serves as primer and template to the reaction, and codes for the RT [H]

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000123
- InterPro:   IPR000477 [H]

Pfam domain/function: PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 57532; Mature: 57532

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMENQENNRKDYREAVNAIGKKEFTLIKMQEYGFWPQNLPTPYERQENETSEQYENRKNL
CCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCHHCCCCHHHHHHHHHHH
LEKYEKVIDEIANLYEEKDKINSKLIELQKKYDETWDYEKIRLDVSKTIMEESIARRAER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHHH
KKQRELEKRQRSEEWKKEKEDKIVFIGKGYSSLLKDKETHKEKLLAQDLPIINDDKELAS
HHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHH
FLGIEYKKLRFLVYHRDVVSVDHYYRYTIPKKRGGVRNIAAPKSVLKNSQRKILDDILLK
HHCCCHHHHEEHEEECCHHHHCCEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
IPTSDEAHGFLKGKSVVSAAESHFKQPELLINIDLEDFFPTITFERVRGLFKSFGYSGYI
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCHHHHHHHHHHHHHCCCCHHH
ASMLAMICTYCERMKIEIRGEEKYIKTSNRILPQGSPASPMITNIICIKLDKRLKGLSSK
HHHHHHHHHHHHHCEEEEECCHHHHHHCCCCCCCCCCCCCHHHHHEEEEECHHHHCCCCC
YNFTYTRYADDMSFSFNGDDYELNIGRFIGLVSKIVKEEGFNINKDKTKFLKKNNCQCIT
CCEEEEEECCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEE
GIVINNEEIGVPKKWVKKLRAAIYNANKARNSGEVLSSKVINEILGMTSWIKSVNEKRYK
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIDSAMELINS
HHHHHHHHHHCC
>Mature Secondary Structure
MMENQENNRKDYREAVNAIGKKEFTLIKMQEYGFWPQNLPTPYERQENETSEQYENRKNL
CCCCCCCCHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCHHCCCCHHHHHHHHHHH
LEKYEKVIDEIANLYEEKDKINSKLIELQKKYDETWDYEKIRLDVSKTIMEESIARRAER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHHH
KKQRELEKRQRSEEWKKEKEDKIVFIGKGYSSLLKDKETHKEKLLAQDLPIINDDKELAS
HHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHH
FLGIEYKKLRFLVYHRDVVSVDHYYRYTIPKKRGGVRNIAAPKSVLKNSQRKILDDILLK
HHCCCHHHHEEHEEECCHHHHCCEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
IPTSDEAHGFLKGKSVVSAAESHFKQPELLINIDLEDFFPTITFERVRGLFKSFGYSGYI
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCHHHHHHHHHHHHHCCCCHHH
ASMLAMICTYCERMKIEIRGEEKYIKTSNRILPQGSPASPMITNIICIKLDKRLKGLSSK
HHHHHHHHHHHHHCEEEEECCHHHHHHCCCCCCCCCCCCCHHHHHEEEEECHHHHCCCCC
YNFTYTRYADDMSFSFNGDDYELNIGRFIGLVSKIVKEEGFNINKDKTKFLKKNNCQCIT
CCEEEEEECCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEE
GIVINNEEIGVPKKWVKKLRAAIYNANKARNSGEVLSSKVINEILGMTSWIKSVNEKRYK
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIIDSAMELINS
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2465092; 2465091 [H]