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The map label for this gene is cobM [H]

Identifier: 187933497

GI number: 187933497

Start: 3014056

End: 3014814

Strand: Reverse

Name: cobM [H]

Synonym: CLL_A2932

Alternate gene names: 187933497

Gene position: 3014814-3014056 (Counterclockwise)

Preceding gene: 187933784

Following gene: 187935212

Centisome position: 79.33

GC content: 30.57

Gene sequence:

>759_bases
ATGGTTTATTTTATAGGAGCAGGTCCAGGCGCAGTAGATTTAATCACAGTTAGAGGAAGAGATATATTAGAAAAAGCAGA
TGTTGTTATATATGCGGGATCTTTAGTATCAAAGGAACATTTGAAATACTGTAAAAAGAATGCTAAATTTTATAATTCAG
CATCTATGACTTTAGATGATGTTATTAAAGTAGTTAAAACAGAATGTAGTGAAGATAGTGTAATAGTTAGATTACATACT
GGTGATCCATCAATATATGGTGCTATAAGGGAACAAATGGTTGAACTTGATAAAGAAAATATAAATTATGAAGTTGTTCC
AGGGGTAAGCTCATTTACAGCAGCTGCATCAGCAATAAAAAGAGAATTTACACTTCCAAGTATTACACAAACTGTTATTT
TAACAAGAGTTGAAGGAAGAACTCCAGTACCTGAAACAGAAGATCTTGAAGCTTTAGCATCAATAGGAGCATCTATGGCT
ATATTTTTATCAGTTTCTATGATTGATAAAGTTGTTAGGAAGTTAAGAAAAGGATATGGCAAAAATGTTCCAATAGCAGT
TATTGAAAGAGCAACTTGGGAAGATGAAAGAGTATTAATGGGAACACTAGATGACATAGTTGAAAAGGTAAAGGAAAATA
ATATAACTAAATGTGCTCAAATTTTAGTTGGAGATTTTATTGGTAATGAATTTGAAAAAAGTTTATTATATGATAAGAAT
TTTTCACATATGTTTAGAGACGCAGAGGATAAAAAATGA

Upstream 100 bases:

>100_bases
AAAAGACAGAGAAAAAATACTAAAACTTCGTGATTATATGTCATTAATTATAGCAAGCAGAGAATAAGGCACATTCAAAT
ATTAAGAAAAGAGGTAAAAT

Downstream 100 bases:

>100_bases
TAAGCATAATATGTCCATCACCTAAGGGGAAGGACATTGCTTATACTCTTAAAGAAGAGTTAGGATGTAATTTATATATA
AAAGAAGAAAGTTTAGAATG

Product: precorrin-4 C11-methyltransferase

Products: S-adenosyl-L-homocysteine; Precorrin 5

Alternate protein names: Cobalt-precorrin-3 methylase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MVYFIGAGPGAVDLITVRGRDILEKADVVIYAGSLVSKEHLKYCKKNAKFYNSASMTLDDVIKVVKTECSEDSVIVRLHT
GDPSIYGAIREQMVELDKENINYEVVPGVSSFTAAASAIKREFTLPSITQTVILTRVEGRTPVPETEDLEALASIGASMA
IFLSVSMIDKVVRKLRKGYGKNVPIAVIERATWEDERVLMGTLDDIVEKVKENNITKCAQILVGDFIGNEFEKSLLYDKN
FSHMFRDAEDKK

Sequences:

>Translated_252_residues
MVYFIGAGPGAVDLITVRGRDILEKADVVIYAGSLVSKEHLKYCKKNAKFYNSASMTLDDVIKVVKTECSEDSVIVRLHT
GDPSIYGAIREQMVELDKENINYEVVPGVSSFTAAASAIKREFTLPSITQTVILTRVEGRTPVPETEDLEALASIGASMA
IFLSVSMIDKVVRKLRKGYGKNVPIAVIERATWEDERVLMGTLDDIVEKVKENNITKCAQILVGDFIGNEFEKSLLYDKN
FSHMFRDAEDKK
>Mature_252_residues
MVYFIGAGPGAVDLITVRGRDILEKADVVIYAGSLVSKEHLKYCKKNAKFYNSASMTLDDVIKVVKTECSEDSVIVRLHT
GDPSIYGAIREQMVELDKENINYEVVPGVSSFTAAASAIKREFTLPSITQTVILTRVEGRTPVPETEDLEALASIGASMA
IFLSVSMIDKVVRKLRKGYGKNVPIAVIERATWEDERVLMGTLDDIVEKVKENNITKCAQILVGDFIGNEFEKSLLYDKN
FSHMFRDAEDKK

Specific function: Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5 [H]

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=234, Percent_Identity=26.0683760683761, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: 2.1.1.133

Molecular weight: Translated: 27991; Mature: 27991

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYFIGAGPGAVDLITVRGRDILEKADVVIYAGSLVSKEHLKYCKKNAKFYNSASMTLDD
CEEEEECCCCCEEEEEECCCHHHHHCCEEEEECCHHCHHHHHHHHHCCCCCCCCCCCHHH
VIKVVKTECSEDSVIVRLHTGDPSIYGAIREQMVELDKENINYEVVPGVSSFTAAASAIK
HHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHH
REFTLPSITQTVILTRVEGRTPVPETEDLEALASIGASMAIFLSVSMIDKVVRKLRKGYG
HHCCCCHHHHHHHEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
KNVPIAVIERATWEDERVLMGTLDDIVEKVKENNITKCAQILVGDFIGNEFEKSLLYDKN
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCC
FSHMFRDAEDKK
HHHHHCCCCCCC
>Mature Secondary Structure
MVYFIGAGPGAVDLITVRGRDILEKADVVIYAGSLVSKEHLKYCKKNAKFYNSASMTLDD
CEEEEECCCCCEEEEEECCCHHHHHCCEEEEECCHHCHHHHHHHHHCCCCCCCCCCCHHH
VIKVVKTECSEDSVIVRLHTGDPSIYGAIREQMVELDKENINYEVVPGVSSFTAAASAIK
HHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHH
REFTLPSITQTVILTRVEGRTPVPETEDLEALASIGASMAIFLSVSMIDKVVRKLRKGYG
HHCCCCHHHHHHHEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
KNVPIAVIERATWEDERVLMGTLDDIVEKVKENNITKCAQILVGDFIGNEFEKSLLYDKN
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCC
FSHMFRDAEDKK
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; Precorrin 4

Specific reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]