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The map label for this gene is csd [H]

Identifier: 187933491

GI number: 187933491

Start: 2420099

End: 2421238

Strand: Reverse

Name: csd [H]

Synonym: CLL_A2340

Alternate gene names: 187933491

Gene position: 2421238-2420099 (Counterclockwise)

Preceding gene: 187934694

Following gene: 187932727

Centisome position: 63.71

GC content: 31.49

Gene sequence:

>1140_bases
ATGATTTATTTAGATAATGCAGCAACATCTTTTCCAAAACCATCACAAGTTTATGAAGAAGTACTAAATTGTATGAGAAA
CTATGCTGCCAATCCAGGAAGAGGTTCTTATGAGATATCTATAAAAGCAGCTTTAAAAATAATGGAAACAAGAGAAGAAA
TATGTCAATTATTTAATATTCCTAGCCCATTTAACTTGATTTTCACATGTAATGCAACAGAAGCCTTAAATATAGGTATT
AAAGGTGTTTTAAAAAGAGGGGATCATGTTATTAGTACAATGATTGAACATAATTCTGTTTTAAGGCCACTTCATTCATT
AAGTGAAGATGGAGTTGAAGTCACTTTGGTAAGTGTAGATAAAGCAGGATATGTTAATATCAAGGATATTAAGGAAGAGA
TTAAGGAAAGCACCAAGATGATTATTATCAATCATGCTTCTAATGTACTAGGAAGTATTCAGGATATTAAAAATATCGGA
AATCTCTCAAAGTCAAAAGGAATTATCTTTATGGTAGATGCATCTCAAAGTGCTGGAGTTATTCCTATTGACGTGGAACG
TGATAATATTGATTTATTAGCATTCTCAGGACATAAAGGATTATTGGGGCCACAAGGAACAGGGGGATTATTTATACGAA
ATGGTATAAAATTAAAGAATTTTAGGGAAGGTGGAACAGGAAGTAACTCCCATTTTATGATTCAACCAGATTTTATGCCA
GATCAATTTGAAAGTGGAACATTAAATATCCCAGGGATTGCAGGGTTATGTGAAGGGGTAAAATTTATTAAGAAGGTTGG
AATAAGAACTATAGAAAAACATGAAGAAGAATTAATGTCATATTTATTGAAGGAATTAAAAAAGCTATCTTATATAAAAA
TTTATGGAAGTAATTCTGTAAAACAAAGAAGCTCAGTAATTTCCTTTAATGTAGAGGGAGTTGATGCTTCAATTGTTGGT
GAACAATTGAATGAAGAGGGAATAGCTGTACGAACAGGGTATCATTGTGCACCTCTAATACATGATGTGATTGATACAGA
ATATGCGGGGACAGTTAGAGTTAGCCCAGGATATTTTAATACTTTAGATGATATAGATAAACTATTAGTGACAATAATGA
AGATTTATAAAGTAAGATAA

Upstream 100 bases:

>100_bases
TTTTACTTAATTTAATTATAACTTGGATTATTGAATTTTGTTGGAGTTTTTTTTGCAAAAATTAGCTAACACAACGTATA
AATTTAATAAGGAGTTTTAT

Downstream 100 bases:

>100_bases
GGCACATTCAAAAATAATAGACTAGTATGCCTGTCTATTATTTTTGAATGTGCCTAATTTAAGACAAAGGATGTAGTACA
TATATAACTATATATGTAAT

Product: cysteine desulfurase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MIYLDNAATSFPKPSQVYEEVLNCMRNYAANPGRGSYEISIKAALKIMETREEICQLFNIPSPFNLIFTCNATEALNIGI
KGVLKRGDHVISTMIEHNSVLRPLHSLSEDGVEVTLVSVDKAGYVNIKDIKEEIKESTKMIIINHASNVLGSIQDIKNIG
NLSKSKGIIFMVDASQSAGVIPIDVERDNIDLLAFSGHKGLLGPQGTGGLFIRNGIKLKNFREGGTGSNSHFMIQPDFMP
DQFESGTLNIPGIAGLCEGVKFIKKVGIRTIEKHEEELMSYLLKELKKLSYIKIYGSNSVKQRSSVISFNVEGVDASIVG
EQLNEEGIAVRTGYHCAPLIHDVIDTEYAGTVRVSPGYFNTLDDIDKLLVTIMKIYKVR

Sequences:

>Translated_379_residues
MIYLDNAATSFPKPSQVYEEVLNCMRNYAANPGRGSYEISIKAALKIMETREEICQLFNIPSPFNLIFTCNATEALNIGI
KGVLKRGDHVISTMIEHNSVLRPLHSLSEDGVEVTLVSVDKAGYVNIKDIKEEIKESTKMIIINHASNVLGSIQDIKNIG
NLSKSKGIIFMVDASQSAGVIPIDVERDNIDLLAFSGHKGLLGPQGTGGLFIRNGIKLKNFREGGTGSNSHFMIQPDFMP
DQFESGTLNIPGIAGLCEGVKFIKKVGIRTIEKHEEELMSYLLKELKKLSYIKIYGSNSVKQRSSVISFNVEGVDASIVG
EQLNEEGIAVRTGYHCAPLIHDVIDTEYAGTVRVSPGYFNTLDDIDKLLVTIMKIYKVR
>Mature_379_residues
MIYLDNAATSFPKPSQVYEEVLNCMRNYAANPGRGSYEISIKAALKIMETREEICQLFNIPSPFNLIFTCNATEALNIGI
KGVLKRGDHVISTMIEHNSVLRPLHSLSEDGVEVTLVSVDKAGYVNIKDIKEEIKESTKMIIINHASNVLGSIQDIKNIG
NLSKSKGIIFMVDASQSAGVIPIDVERDNIDLLAFSGHKGLLGPQGTGGLFIRNGIKLKNFREGGTGSNSHFMIQPDFMP
DQFESGTLNIPGIAGLCEGVKFIKKVGIRTIEKHEEELMSYLLKELKKLSYIKIYGSNSVKQRSSVISFNVEGVDASIVG
EQLNEEGIAVRTGYHCAPLIHDVIDTEYAGTVRVSPGYFNTLDDIDKLLVTIMKIYKVR

Specific function: Cysteine Desulfurases Mobilize The Sulfur From L- Cysteine To Yield L-Alanine, An Essential Step In Sulfur Metabolism For Biosynthesis Of A Variety Of Sulfur-Containing Biomolecules. Component Of The Suf Operon, Which Is Activated And Required Under Speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=294, Percent_Identity=30.6122448979592, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI156713448, Length=319, Percent_Identity=26.9592476489028, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787970, Length=389, Percent_Identity=29.305912596401, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1789175, Length=381, Percent_Identity=30.1837270341207, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI48994898, Length=270, Percent_Identity=32.2222222222222, Blast_Score=147, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI25143064, Length=269, Percent_Identity=33.8289962825279, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17533177, Length=330, Percent_Identity=26.969696969697, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25147498, Length=376, Percent_Identity=24.468085106383, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319831, Length=389, Percent_Identity=28.5347043701799, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI20129463, Length=230, Percent_Identity=33.0434782608696, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41759; Mature: 41759

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLDNAATSFPKPSQVYEEVLNCMRNYAANPGRGSYEISIKAALKIMETREEICQLFNI
CEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCC
PSPFNLIFTCNATEALNIGIKGVLKRGDHVISTMIEHNSVLRPLHSLSEDGVEVTLVSVD
CCCCEEEEEECCCCEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
KAGYVNIKDIKEEIKESTKMIIINHASNVLGSIQDIKNIGNLSKSKGIIFMVDASQSAGV
CCCCEEHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCE
IPIDVERDNIDLLAFSGHKGLLGPQGTGGLFIRNGIKLKNFREGGTGSNSHFMIQPDFMP
EEEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCEEEECCCCCCCCCCCEEEEECCCCC
DQFESGTLNIPGIAGLCEGVKFIKKVGIRTIEKHEEELMSYLLKELKKLSYIKIYGSNSV
CCCCCCCEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCH
KQRSSVISFNVEGVDASIVGEQLNEEGIAVRTGYHCAPLIHDVIDTEYAGTVRVSPGYFN
HHCCCEEEEEECCCCHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCC
TLDDIDKLLVTIMKIYKVR
CHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIYLDNAATSFPKPSQVYEEVLNCMRNYAANPGRGSYEISIKAALKIMETREEICQLFNI
CEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCC
PSPFNLIFTCNATEALNIGIKGVLKRGDHVISTMIEHNSVLRPLHSLSEDGVEVTLVSVD
CCCCEEEEEECCCCEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
KAGYVNIKDIKEEIKESTKMIIINHASNVLGSIQDIKNIGNLSKSKGIIFMVDASQSAGV
CCCCEEHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCE
IPIDVERDNIDLLAFSGHKGLLGPQGTGGLFIRNGIKLKNFREGGTGSNSHFMIQPDFMP
EEEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCEEEECCCCCCCCCCCEEEEECCCCC
DQFESGTLNIPGIAGLCEGVKFIKKVGIRTIEKHEEELMSYLLKELKKLSYIKIYGSNSV
CCCCCCCEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCH
KQRSSVISFNVEGVDASIVGEQLNEEGIAVRTGYHCAPLIHDVIDTEYAGTVRVSPGYFN
HHCCCEEEEEECCCCHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCC
TLDDIDKLLVTIMKIYKVR
CHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]