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The map label for this gene is dnaX [H]

Identifier: 187933489

GI number: 187933489

Start: 3643538

End: 3645178

Strand: Reverse

Name: dnaX [H]

Synonym: CLL_A3447

Alternate gene names: 187933489

Gene position: 3645178-3643538 (Counterclockwise)

Preceding gene: 187933477

Following gene: 187932720

Centisome position: 95.92

GC content: 28.28

Gene sequence:

>1641_bases
TTGGGATATACAGCTTTATATAGAGAGTGGAGACCAAGGACATTTAATGATGTAGTAGGTCAGGAACATATAACAACAAC
GTTGAAAAATGAAATTTTAAATGACAGAATTGCACATGCATATCTTTTCTGTGGAACAAGAGGAACAGGTAAAACATCAA
CAGCTAAAGTTATGGCTAAAGCATTAAATTGTTTTAATATTCAAGATGGAGAGCCTTGCAATGAATGTGAGATGTGTAAA
AAGATAAATGAAGGCTTATCAATGGATGTTACAGAATTAGATGCAGCATCTAACAATGGAATAGATAGAATAAGAGATAT
AATTGATGATACAAAATATCCTCCACAAGAGGGTAAGTATAAGATTTATATATTAGATGAAGTTCATATGTTATCAGGGG
GAGCGGTAAATGCATTTTTAAAAACATTAGAAGAACCGCCAAGTAATGTTATATTTATATTAGCAACTACTGACCCTCAA
AAATTGCCTATAACTATTTTATCTAGATGTCAAAGATTCGATTTTAAAAGAATAAATCAAAAGGATATTTCAGATAGATT
AAGAAAAATAACTGAATCACAAAATGTTAGTGTTGATGAAAAGAGCTTAGATTTAATTGCTAGAGTGGCTGACGGTGCTA
TGAGAGACTCTTTAAGTATATTAGATCAAGCAATAGCTATGGGTGATAACAATATAAAATATGATGACTTAATAAGCATA
TTAGGATTGGTTACAAATGAATATTTATTTGACATAACTAATTCAATAGTAGAAAGAAATATAGAAAAAGCTATGGTGAT
AATTGATAAATTAGTTTTTTCAGGCAAGGATATTCATTTATTTATAAAAGATTTAATAGGACATTTTAGAAATTTACTTA
TGGTTAAGGTTTCTAATACTCCAGAAGAGATTTTGGATATGTCTCTTGAAAATATTGAACTTATAAAAGAGCAAGGTAAA
AAAATACGTATTGAAGAAATAATGAGAGGGATTAGAATTCTTCAAGAAGGGGAAGCTAATTCTAAAGTAAGCAAACAAAG
CAGATTATATTTAGAGCTTAGTATAATAAAGATGTGTAAAATAGAATATGATACATCAAGTGAAGTCATGCTTGCTAGGA
TAAATAAGTTAGAAGAAAGCATAAAAAGTGGTAAGATACAAGTAGTATCAAATTCACAAATAAATGAAAAAGCACCTTTA
ACTGACGTAGTGCCAAATAATCAAATTAAATCTAAAGAAAAACAAGTTAAAAAAGAACAACCTAATTTATCAGAAGAACA
TAATGTTAATGTTGAGTCTTCTTTAACAATAGATAATATAAAAAGAGCGTGGTCAGAAATATTAGAGGCATTTAAAGCAA
AAAGAGCAATGGTTATATATGCATCTATAGTAACTGCAAGACCATATAAATTTGAAAATGGTGTAGCCACGTTATTATAT
GAGGCATCATATGCTTTTAATAAAAATAGATTAGAAAAATTAGAATATAAAAAAATTGTTAATGAAGTATTTTCCGAAGT
ATTGAAAGATAAAATAATAGTAAGGTATGAAGTTGAAAATAATAAAGATGGCGAATCAAGTAAAGAAGAATTGCTAAAAC
AAAGGTTAGATGGAATGCCTTTTGAAATATTAGACGAATAG

Upstream 100 bases:

>100_bases
ACAAATATTAAGTTTAATATTATATAAAATTTATCATTTGATAGTTATTAGTGTATAATAAATATATGATTTAAGGGAAA
TAGAAAGGTGGAGGAAACCT

Downstream 100 bases:

>100_bases
AATCAATATTTTAATGTAGTAAACAATAAGAAAATGTTTTATAATAGAGAGTAGAAATTTATTAAGAGGAGGATTTGTAT
GGCAAAAGGAGGATTCCCTG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MGYTALYREWRPRTFNDVVGQEHITTTLKNEILNDRIAHAYLFCGTRGTGKTSTAKVMAKALNCFNIQDGEPCNECEMCK
KINEGLSMDVTELDAASNNGIDRIRDIIDDTKYPPQEGKYKIYILDEVHMLSGGAVNAFLKTLEEPPSNVIFILATTDPQ
KLPITILSRCQRFDFKRINQKDISDRLRKITESQNVSVDEKSLDLIARVADGAMRDSLSILDQAIAMGDNNIKYDDLISI
LGLVTNEYLFDITNSIVERNIEKAMVIIDKLVFSGKDIHLFIKDLIGHFRNLLMVKVSNTPEEILDMSLENIELIKEQGK
KIRIEEIMRGIRILQEGEANSKVSKQSRLYLELSIIKMCKIEYDTSSEVMLARINKLEESIKSGKIQVVSNSQINEKAPL
TDVVPNNQIKSKEKQVKKEQPNLSEEHNVNVESSLTIDNIKRAWSEILEAFKAKRAMVIYASIVTARPYKFENGVATLLY
EASYAFNKNRLEKLEYKKIVNEVFSEVLKDKIIVRYEVENNKDGESSKEELLKQRLDGMPFEILDE

Sequences:

>Translated_546_residues
MGYTALYREWRPRTFNDVVGQEHITTTLKNEILNDRIAHAYLFCGTRGTGKTSTAKVMAKALNCFNIQDGEPCNECEMCK
KINEGLSMDVTELDAASNNGIDRIRDIIDDTKYPPQEGKYKIYILDEVHMLSGGAVNAFLKTLEEPPSNVIFILATTDPQ
KLPITILSRCQRFDFKRINQKDISDRLRKITESQNVSVDEKSLDLIARVADGAMRDSLSILDQAIAMGDNNIKYDDLISI
LGLVTNEYLFDITNSIVERNIEKAMVIIDKLVFSGKDIHLFIKDLIGHFRNLLMVKVSNTPEEILDMSLENIELIKEQGK
KIRIEEIMRGIRILQEGEANSKVSKQSRLYLELSIIKMCKIEYDTSSEVMLARINKLEESIKSGKIQVVSNSQINEKAPL
TDVVPNNQIKSKEKQVKKEQPNLSEEHNVNVESSLTIDNIKRAWSEILEAFKAKRAMVIYASIVTARPYKFENGVATLLY
EASYAFNKNRLEKLEYKKIVNEVFSEVLKDKIIVRYEVENNKDGESSKEELLKQRLDGMPFEILDE
>Mature_545_residues
GYTALYREWRPRTFNDVVGQEHITTTLKNEILNDRIAHAYLFCGTRGTGKTSTAKVMAKALNCFNIQDGEPCNECEMCKK
INEGLSMDVTELDAASNNGIDRIRDIIDDTKYPPQEGKYKIYILDEVHMLSGGAVNAFLKTLEEPPSNVIFILATTDPQK
LPITILSRCQRFDFKRINQKDISDRLRKITESQNVSVDEKSLDLIARVADGAMRDSLSILDQAIAMGDNNIKYDDLISIL
GLVTNEYLFDITNSIVERNIEKAMVIIDKLVFSGKDIHLFIKDLIGHFRNLLMVKVSNTPEEILDMSLENIELIKEQGKK
IRIEEIMRGIRILQEGEANSKVSKQSRLYLELSIIKMCKIEYDTSSEVMLARINKLEESIKSGKIQVVSNSQINEKAPLT
DVVPNNQIKSKEKQVKKEQPNLSEEHNVNVESSLTIDNIKRAWSEILEAFKAKRAMVIYASIVTARPYKFENGVATLLYE
ASYAFNKNRLEKLEYKKIVNEVFSEVLKDKIIVRYEVENNKDGESSKEELLKQRLDGMPFEILDE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=281, Percent_Identity=24.1992882562278, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI31881687, Length=281, Percent_Identity=24.1992882562278, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI31563534, Length=286, Percent_Identity=25.5244755244755, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786676, Length=358, Percent_Identity=39.3854748603352, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1787341, Length=164, Percent_Identity=28.6585365853659, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=300, Percent_Identity=26, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17541988, Length=284, Percent_Identity=26.7605633802817, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17554730, Length=283, Percent_Identity=26.1484098939929, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324039, Length=284, Percent_Identity=27.8169014084507, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322528, Length=286, Percent_Identity=25.8741258741259, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324478, Length=338, Percent_Identity=24.5562130177515, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI18859927, Length=299, Percent_Identity=24.7491638795987, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17647857, Length=276, Percent_Identity=25.7246376811594, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62283; Mature: 62152

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYTALYREWRPRTFNDVVGQEHITTTLKNEILNDRIAHAYLFCGTRGTGKTSTAKVMAK
CCCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHH
ALNCFNIQDGEPCNECEMCKKINEGLSMDVTELDAASNNGIDRIRDIIDDTKYPPQEGKY
HHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCE
KIYILDEVHMLSGGAVNAFLKTLEEPPSNVIFILATTDPQKLPITILSRCQRFDFKRINQ
EEEEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHCCH
KDISDRLRKITESQNVSVDEKSLDLIARVADGAMRDSLSILDQAIAMGDNNIKYDDLISI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LGLVTNEYLFDITNSIVERNIEKAMVIIDKLVFSGKDIHLFIKDLIGHFRNLLMVKVSNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECCC
PEEILDMSLENIELIKEQGKKIRIEEIMRGIRILQEGEANSKVSKQSRLYLELSIIKMCK
HHHHHHCCHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHEEEEEEEHHHHE
IEYDTSSEVMLARINKLEESIKSGKIQVVSNSQINEKAPLTDVVPNNQIKSKEKQVKKEQ
EECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
PNLSEEHNVNVESSLTIDNIKRAWSEILEAFKAKRAMVIYASIVTARPYKFENGVATLLY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEHHHCCCCEECCCCEEEHH
EASYAFNKNRLEKLEYKKIVNEVFSEVLKDKIIVRYEVENNKDGESSKEELLKQRLDGMP
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCC
FEILDE
HHHCCC
>Mature Secondary Structure 
GYTALYREWRPRTFNDVVGQEHITTTLKNEILNDRIAHAYLFCGTRGTGKTSTAKVMAK
CCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHH
ALNCFNIQDGEPCNECEMCKKINEGLSMDVTELDAASNNGIDRIRDIIDDTKYPPQEGKY
HHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCE
KIYILDEVHMLSGGAVNAFLKTLEEPPSNVIFILATTDPQKLPITILSRCQRFDFKRINQ
EEEEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHCCH
KDISDRLRKITESQNVSVDEKSLDLIARVADGAMRDSLSILDQAIAMGDNNIKYDDLISI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LGLVTNEYLFDITNSIVERNIEKAMVIIDKLVFSGKDIHLFIKDLIGHFRNLLMVKVSNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECCC
PEEILDMSLENIELIKEQGKKIRIEEIMRGIRILQEGEANSKVSKQSRLYLELSIIKMCK
HHHHHHCCHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHEEEEEEEHHHHE
IEYDTSSEVMLARINKLEESIKSGKIQVVSNSQINEKAPLTDVVPNNQIKSKEKQVKKEQ
EECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
PNLSEEHNVNVESSLTIDNIKRAWSEILEAFKAKRAMVIYASIVTARPYKFENGVATLLY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEHHHCCCCEECCCCEEEHH
EASYAFNKNRLEKLEYKKIVNEVFSEVLKDKIIVRYEVENNKDGESSKEELLKQRLDGMP
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCC
FEILDE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]