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The map label for this gene is bioB [H]

Identifier: 187933033

GI number: 187933033

Start: 362999

End: 364045

Strand: Reverse

Name: bioB [H]

Synonym: CLL_A0358

Alternate gene names: 187933033

Gene position: 364045-362999 (Counterclockwise)

Preceding gene: 187933339

Following gene: 187933622

Centisome position: 9.58

GC content: 28.46

Gene sequence:

>1047_bases
ATGAAAAATTTAATTGAAAAAGCAAGCATTACACATGAACTAAATAAAAATGAGATATTACAATTACTATCATGCGACGA
TATAAATGATGATTTATTTAAAGCTGCTGATAAAGTTCGTGAAAGATCTTTAGGCAATATTGTTCATTTAAGAGGATTAA
TAGAATTTACTAATATATGTAAGCGAAATTGTTTATATTGTGGATTAAGAAGAGATAATGAAAATATAAAAAGATATAGA
TTAAGTAAAGAGGAAATTATAGATTTTGCAAAGAAAGCTGTATCTTATGGTTATAAAACTATAGTTCTTCAAGGTGGAGA
AGATGACTTTTTTACTAAAGAAAAAATGGTGGAAATAATAAAAGAAATTAAAAATTTAAATGTAGCTTTAACATTAAGTC
TAGGTGAAAAGACTTATGAAGAATATAAAGCTTTTAAAGAAGCTGGTGCTGATAGATATTTACTTCGCATTGAAACAACT
GACAAAAAACTTTATAAGGAAATGGACCCTATGATGAGTTATGATGAAAGATTAAATTGTCTAAAAAATTTAGGTCATTT
AGGTTATGAAGTTGGAACAGGTGTATTAGTGGGATTACCAAATCAGACATTAGATTCTTTAGCAGACGACATTTTATTTT
TCAAAAAATTAAATGCTGATATGATTGGTATTGGTCCTTTTATTCCTAATGAAGATACCCCACTAAAATACTCTAAAGGT
GGAAATTTAAATTTAGCTTTAAAAGTAATGGCTATAACTAGATTATTACTTCCTGACATAAATATTCCTGCTACTACTGC
AATGGAATCATTACATAAAAATGGACGTATCTTAGCACTTCAAAGCGGTGCTAATGTAGTTATGCCAAATGTAACTGAAG
GTGAGTATAGAAAGCTGTATGCATTATATCCTGGTAAAATTTGTACAGGAGATACGCCTTCTCATTGTAGAGGATGTATA
ACAGGAAAAATAGCCTCAATTAACAGAGAGGTTTCTGATGGATATGGTTTTAGAGGAAATCAAAACAAAAATTCTCATAA
TAAATAA

Upstream 100 bases:

>100_bases
CATTAAGAGTTAAATGGCAAAGTCTTGTCCTTTAACTCTTATTTTTTATATAGTATACTAAGTTTAAAGTATTACGATAA
ATTAAACTTATGGAGGATAC

Downstream 100 bases:

>100_bases
TTAGATTTATAGAACTATTTAAAAATACTATTGATATTTTAGTATAATTTCTAAGTCCAATTGTGATTTGTTTTTTAGAA
TTCTTAGAGTAATTGTTCTT

Product: biotin synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKNLIEKASITHELNKNEILQLLSCDDINDDLFKAADKVRERSLGNIVHLRGLIEFTNICKRNCLYCGLRRDNENIKRYR
LSKEEIIDFAKKAVSYGYKTIVLQGGEDDFFTKEKMVEIIKEIKNLNVALTLSLGEKTYEEYKAFKEAGADRYLLRIETT
DKKLYKEMDPMMSYDERLNCLKNLGHLGYEVGTGVLVGLPNQTLDSLADDILFFKKLNADMIGIGPFIPNEDTPLKYSKG
GNLNLALKVMAITRLLLPDINIPATTAMESLHKNGRILALQSGANVVMPNVTEGEYRKLYALYPGKICTGDTPSHCRGCI
TGKIASINREVSDGYGFRGNQNKNSHNK

Sequences:

>Translated_348_residues
MKNLIEKASITHELNKNEILQLLSCDDINDDLFKAADKVRERSLGNIVHLRGLIEFTNICKRNCLYCGLRRDNENIKRYR
LSKEEIIDFAKKAVSYGYKTIVLQGGEDDFFTKEKMVEIIKEIKNLNVALTLSLGEKTYEEYKAFKEAGADRYLLRIETT
DKKLYKEMDPMMSYDERLNCLKNLGHLGYEVGTGVLVGLPNQTLDSLADDILFFKKLNADMIGIGPFIPNEDTPLKYSKG
GNLNLALKVMAITRLLLPDINIPATTAMESLHKNGRILALQSGANVVMPNVTEGEYRKLYALYPGKICTGDTPSHCRGCI
TGKIASINREVSDGYGFRGNQNKNSHNK
>Mature_348_residues
MKNLIEKASITHELNKNEILQLLSCDDINDDLFKAADKVRERSLGNIVHLRGLIEFTNICKRNCLYCGLRRDNENIKRYR
LSKEEIIDFAKKAVSYGYKTIVLQGGEDDFFTKEKMVEIIKEIKNLNVALTLSLGEKTYEEYKAFKEAGADRYLLRIETT
DKKLYKEMDPMMSYDERLNCLKNLGHLGYEVGTGVLVGLPNQTLDSLADDILFFKKLNADMIGIGPFIPNEDTPLKYSKG
GNLNLALKVMAITRLLLPDINIPATTAMESLHKNGRILALQSGANVVMPNVTEGEYRKLYALYPGKICTGDTPSHCRGCI
TGKIASINREVSDGYGFRGNQNKNSHNK

Specific function: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism [H]

COG id: COG0502

COG function: function code H; Biotin synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. Biotin synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR010722
- InterPro:   IPR002684
- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06968 BATS; PF04055 Radical_SAM [H]

EC number: =2.8.1.6 [H]

Molecular weight: Translated: 39202; Mature: 39202

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLIEKASITHELNKNEILQLLSCDDINDDLFKAADKVRERSLGNIVHLRGLIEFTNIC
CCHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
KRNCLYCGLRRDNENIKRYRLSKEEIIDFAKKAVSYGYKTIVLQGGEDDFFTKEKMVEII
HHCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
KEIKNLNVALTLSLGEKTYEEYKAFKEAGADRYLLRIETTDKKLYKEMDPMMSYDERLNC
HHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
LKNLGHLGYEVGTGVLVGLPNQTLDSLADDILFFKKLNADMIGIGPFIPNEDTPLKYSKG
HHHHHHCCHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCC
GNLNLALKVMAITRLLLPDINIPATTAMESLHKNGRILALQSGANVVMPNVTEGEYRKLY
CCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCEEEE
ALYPGKICTGDTPSHCRGCITGKIASINREVSDGYGFRGNQNKNSHNK
EECCCEEECCCCHHHHHHHHCCHHHHCCCHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKNLIEKASITHELNKNEILQLLSCDDINDDLFKAADKVRERSLGNIVHLRGLIEFTNIC
CCHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
KRNCLYCGLRRDNENIKRYRLSKEEIIDFAKKAVSYGYKTIVLQGGEDDFFTKEKMVEII
HHCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
KEIKNLNVALTLSLGEKTYEEYKAFKEAGADRYLLRIETTDKKLYKEMDPMMSYDERLNC
HHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
LKNLGHLGYEVGTGVLVGLPNQTLDSLADDILFFKKLNADMIGIGPFIPNEDTPLKYSKG
HHHHHHCCHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCC
GNLNLALKVMAITRLLLPDINIPATTAMESLHKNGRILALQSGANVVMPNVTEGEYRKLY
CCCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCEEEE
ALYPGKICTGDTPSHCRGCITGKIASINREVSDGYGFRGNQNKNSHNK
EECCCEEECCCCHHHHHHHHCCHHHHCCCHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA