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The map label for this gene is helD [H]

Identifier: 187932513

GI number: 187932513

Start: 2923853

End: 2926138

Strand: Reverse

Name: helD [H]

Synonym: CLL_A2851

Alternate gene names: 187932513

Gene position: 2926138-2923853 (Counterclockwise)

Preceding gene: 187935058

Following gene: 187933493

Centisome position: 77.0

GC content: 25.28

Gene sequence:

>2286_bases
ATGAAAAATGAATTATTATATGAAGAAGAAGTATTAGAAGAAAAGAGAAGTTTAATTTTAGAAGAATTAAATGAAAAAAG
AATTAATAGAGAAAAAGTAAATGAAAAGATTAGATATTTATCTAAAGAGTCCAAGGGAAGTTATAATGAAGAAAAGGAAA
CTACTGAGAAGATATATGGTGTACTACAAAAAGATATAGATGGATATGAAGAAGCACTTGAAATACCGTATTTTGGCAGG
GTTGATTTTACAGAAAAATTTGGATTTGAAGAAAATATATATATTGGAAAGAAAGGAATCACTAATAATATGAGAGGTGA
AGAAGTTGTAGTGGACTGGAGAGCTCCTATAGCTGACTTATATTATAGTGGAACTGGTGGAGAAGCATACTACAAAGCTC
CAGCAGGACTAATTGAAGGAAAACTGTTACTTAAAAGAAAGTTTTTATTTGATGATGGAAAAATTAAAGATATATTTGAT
GATTCATTAAATGAATTAATGATAAATGGAGAAGAAGGAACAGAATTAGTAGATGAATTTTTAAAAATTAATCTTGAAGA
GAGTAGAGGAAAAAAGTTAAAAGAAGTTGTTTCTACTATACAAAAAGAACAAAATGAAATCATAAGATGGCCTAAGAATT
TTCCAATAATAGTTCAGGGGTCAGCAGGATCTGGAAAAACCACAATAGCTCTTCATAGATTAGCATATCTTATTTACAGA
TATAAAGACAGTATGAAGGGCGACGATATATTAGTACTAGCACCAAATAAATTATTTTTAGACTATATATCTGAGACATT
GCCTAATTTAGGTGCGGAAGAAGTAAAACAAAATACATTTGAAGAACTTGTGAAATCTAAATTTAAGCTTAGAGGAAAAA
TCTATAGTAAGGATGATAAGCTTAGAGCAATAATGGAAGAAGATGATGATAATAAAAGAAATTTTATAATAAAATCTGCA
GGTTTTAAAGGTTCTATTGAATTTAAAAATATGATAGATAAATATATTGCATTAGTAGATAGTAGCACAAGAGAAATAGA
AGATATAACTATAGATGGATATATTATTTTTGAAAAAAAAGAAATAGTTAAATTATATCTAAAAGATTTAAAATCTTATG
CTATAAATAAAAGAAAAGATGAAATTAAAAGATATTTATCTTTAAAAATAAAAGAAAAAATAGAGGTTTTGCTGTATTCC
ATTGATTTTAGATGGGAAAGTAAAATAAAAAATATAAAAAATACTTGTGAAGATTTGATTGAAAGAAGAAAACTTTTAGT
AGAGGAATATGATAAGAGAGATGAAATTAAAAATCATATATTAAAAAACTATAAGAAACAATTTAATGAGTATTTTAAAA
GTTGGAAAGGTATAGGCGTTAGTGATATATATTATAGATTTTTTACTGACGATCTTTTTGATTTTATAGGGCCAGAAAAT
ATTTCTAGTGAATTATTGGATTTTATGAAAGAGGATTTTTTAATTAATTATGAAAATAAGATTATTGATGAAGATGATTT
AGCACCGCTTTTATATATAAGAAATTTATTAGAAGGAATTGAAGAAAAAGAAAAGTTTAAACATATAGTAGTAGATGAAG
CACAAGATTATAGTCCGTTTCAAATACATTTAATAAATTCATTTTCTAAAGGTAACTCATTGACTTTAGTTGGTGATTTA
GCTCAAGGAATTTATTATTATAAAGGATTAAAATGTTGGGAAGATATAACTAAAGACTTATTTAAAGACAAAGCTACTTA
TGTTCAATTGACTCAAAGTTATAGATCTACAGTAGAAATAATTGATTTTGCAAAGCATACTTTGAAGGCTCAAAAGTTAG
GTCTTAAAGATGCAAAAGCTGTATTAAGGCATGGAGAAGAGCCAAAAATAATTGAATTTGACGAAAGTGAAAAAAATATT
TACAAAATTATTGATAAAATAATTGAAAAAATCAGAGAATTAGGTAAAATTAGTATAGCTATAATAACTAAAGATTCTAA
ACAAGCACAGAAGGTAGAAAAGATTTTGAAAAATAACAGTGCATATAAATTTCAACGTATAAAAGGAAAAGAGGCTTGCT
TTTTAGAGGATAATGTTATAATACCATCTTATTTAACTAAGGGATTAGAATTTGATTGTACAATTATATATAATCCAAGT
AAGAAAAATTATCAGAATAATATATTAGATCAAAGACTATTATATGTGATGTTAACTAGAGCTTTACATTATGAATATAT
TTTAAAACTAGATTCATTAACTCATTTGATTGAGGAAAATAATTAA

Upstream 100 bases:

>100_bases
TTAGAGGAAATGTTTTTATAATTTACTAAATATACTATATTATTATGATTAATATTTGGATATAATTGATATGTTAAGTT
ATTTTTATAAGAGGTAAAGT

Downstream 100 bases:

>100_bases
AAAAATATATTCATTAAAAATAAAAAGTGCATATAATAATATCAACTATTGGAAGTTGAATTATTATATGTTCTATAAAA
AATTAAGAGGTGAACAAAAT

Product: ATP-dependent DNA helicase, UvrD/REP family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 761; Mature: 761

Protein sequence:

>761_residues
MKNELLYEEEVLEEKRSLILEELNEKRINREKVNEKIRYLSKESKGSYNEEKETTEKIYGVLQKDIDGYEEALEIPYFGR
VDFTEKFGFEENIYIGKKGITNNMRGEEVVVDWRAPIADLYYSGTGGEAYYKAPAGLIEGKLLLKRKFLFDDGKIKDIFD
DSLNELMINGEEGTELVDEFLKINLEESRGKKLKEVVSTIQKEQNEIIRWPKNFPIIVQGSAGSGKTTIALHRLAYLIYR
YKDSMKGDDILVLAPNKLFLDYISETLPNLGAEEVKQNTFEELVKSKFKLRGKIYSKDDKLRAIMEEDDDNKRNFIIKSA
GFKGSIEFKNMIDKYIALVDSSTREIEDITIDGYIIFEKKEIVKLYLKDLKSYAINKRKDEIKRYLSLKIKEKIEVLLYS
IDFRWESKIKNIKNTCEDLIERRKLLVEEYDKRDEIKNHILKNYKKQFNEYFKSWKGIGVSDIYYRFFTDDLFDFIGPEN
ISSELLDFMKEDFLINYENKIIDEDDLAPLLYIRNLLEGIEEKEKFKHIVVDEAQDYSPFQIHLINSFSKGNSLTLVGDL
AQGIYYYKGLKCWEDITKDLFKDKATYVQLTQSYRSTVEIIDFAKHTLKAQKLGLKDAKAVLRHGEEPKIIEFDESEKNI
YKIIDKIIEKIRELGKISIAIITKDSKQAQKVEKILKNNSAYKFQRIKGKEACFLEDNVIIPSYLTKGLEFDCTIIYNPS
KKNYQNNILDQRLLYVMLTRALHYEYILKLDSLTHLIEENN

Sequences:

>Translated_761_residues
MKNELLYEEEVLEEKRSLILEELNEKRINREKVNEKIRYLSKESKGSYNEEKETTEKIYGVLQKDIDGYEEALEIPYFGR
VDFTEKFGFEENIYIGKKGITNNMRGEEVVVDWRAPIADLYYSGTGGEAYYKAPAGLIEGKLLLKRKFLFDDGKIKDIFD
DSLNELMINGEEGTELVDEFLKINLEESRGKKLKEVVSTIQKEQNEIIRWPKNFPIIVQGSAGSGKTTIALHRLAYLIYR
YKDSMKGDDILVLAPNKLFLDYISETLPNLGAEEVKQNTFEELVKSKFKLRGKIYSKDDKLRAIMEEDDDNKRNFIIKSA
GFKGSIEFKNMIDKYIALVDSSTREIEDITIDGYIIFEKKEIVKLYLKDLKSYAINKRKDEIKRYLSLKIKEKIEVLLYS
IDFRWESKIKNIKNTCEDLIERRKLLVEEYDKRDEIKNHILKNYKKQFNEYFKSWKGIGVSDIYYRFFTDDLFDFIGPEN
ISSELLDFMKEDFLINYENKIIDEDDLAPLLYIRNLLEGIEEKEKFKHIVVDEAQDYSPFQIHLINSFSKGNSLTLVGDL
AQGIYYYKGLKCWEDITKDLFKDKATYVQLTQSYRSTVEIIDFAKHTLKAQKLGLKDAKAVLRHGEEPKIIEFDESEKNI
YKIIDKIIEKIRELGKISIAIITKDSKQAQKVEKILKNNSAYKFQRIKGKEACFLEDNVIIPSYLTKGLEFDCTIIYNPS
KKNYQNNILDQRLLYVMLTRALHYEYILKLDSLTHLIEENN
>Mature_761_residues
MKNELLYEEEVLEEKRSLILEELNEKRINREKVNEKIRYLSKESKGSYNEEKETTEKIYGVLQKDIDGYEEALEIPYFGR
VDFTEKFGFEENIYIGKKGITNNMRGEEVVVDWRAPIADLYYSGTGGEAYYKAPAGLIEGKLLLKRKFLFDDGKIKDIFD
DSLNELMINGEEGTELVDEFLKINLEESRGKKLKEVVSTIQKEQNEIIRWPKNFPIIVQGSAGSGKTTIALHRLAYLIYR
YKDSMKGDDILVLAPNKLFLDYISETLPNLGAEEVKQNTFEELVKSKFKLRGKIYSKDDKLRAIMEEDDDNKRNFIIKSA
GFKGSIEFKNMIDKYIALVDSSTREIEDITIDGYIIFEKKEIVKLYLKDLKSYAINKRKDEIKRYLSLKIKEKIEVLLYS
IDFRWESKIKNIKNTCEDLIERRKLLVEEYDKRDEIKNHILKNYKKQFNEYFKSWKGIGVSDIYYRFFTDDLFDFIGPEN
ISSELLDFMKEDFLINYENKIIDEDDLAPLLYIRNLLEGIEEKEKFKHIVVDEAQDYSPFQIHLINSFSKGNSLTLVGDL
AQGIYYYKGLKCWEDITKDLFKDKATYVQLTQSYRSTVEIIDFAKHTLKAQKLGLKDAKAVLRHGEEPKIIEFDESEKNI
YKIIDKIIEKIRELGKISIAIITKDSKQAQKVEKILKNNSAYKFQRIKGKEACFLEDNVIIPSYLTKGLEFDCTIIYNPS
KKNYQNNILDQRLLYVMLTRALHYEYILKLDSLTHLIEENN

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 89289; Mature: 89289

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNELLYEEEVLEEKRSLILEELNEKRINREKVNEKIRYLSKESKGSYNEEKETTEKIYG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VLQKDIDGYEEALEIPYFGRVDFTEKFGFEENIYIGKKGITNNMRGEEVVVDWRAPIADL
HHHHHHCCHHHHHCCCCCCCCCCHHHCCCCCCEEECCCCCCCCCCCCEEEEECCCCHHHH
YYSGTGGEAYYKAPAGLIEGKLLLKRKFLFDDGKIKDIFDDSLNELMINGEEGTELVDEF
EECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHEEECCCCCHHHHHHH
LKINLEESRGKKLKEVVSTIQKEQNEIIRWPKNFPIIVQGSAGSGKTTIALHRLAYLIYR
HHCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
YKDSMKGDDILVLAPNKLFLDYISETLPNLGAEEVKQNTFEELVKSKFKLRGKIYSKDDK
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCHH
LRAIMEEDDDNKRNFIIKSAGFKGSIEFKNMIDKYIALVDSSTREIEDITIDGYIIFEKK
HHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECHH
EIVKLYLKDLKSYAINKRKDEIKRYLSLKIKEKIEVLLYSIDFRWESKIKNIKNTCEDLI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHH
ERRKLLVEEYDKRDEIKNHILKNYKKQFNEYFKSWKGIGVSDIYYRFFTDDLFDFIGPEN
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
ISSELLDFMKEDFLINYENKIIDEDDLAPLLYIRNLLEGIEEKEKFKHIVVDEAQDYSPF
HHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
QIHLINSFSKGNSLTLVGDLAQGIYYYKGLKCWEDITKDLFKDKATYVQLTQSYRSTVEI
EEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IDFAKHTLKAQKLGLKDAKAVLRHGEEPKIIEFDESEKNIYKIIDKIIEKIRELGKISIA
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEE
IITKDSKQAQKVEKILKNNSAYKFQRIKGKEACFLEDNVIIPSYLTKGLEFDCTIIYNPS
EEECCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCEECHHHHHCCCCEEEEEEECCC
KKNYQNNILDQRLLYVMLTRALHYEYILKLDSLTHLIEENN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNELLYEEEVLEEKRSLILEELNEKRINREKVNEKIRYLSKESKGSYNEEKETTEKIYG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VLQKDIDGYEEALEIPYFGRVDFTEKFGFEENIYIGKKGITNNMRGEEVVVDWRAPIADL
HHHHHHCCHHHHHCCCCCCCCCCHHHCCCCCCEEECCCCCCCCCCCCEEEEECCCCHHHH
YYSGTGGEAYYKAPAGLIEGKLLLKRKFLFDDGKIKDIFDDSLNELMINGEEGTELVDEF
EECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHEEECCCCCHHHHHHH
LKINLEESRGKKLKEVVSTIQKEQNEIIRWPKNFPIIVQGSAGSGKTTIALHRLAYLIYR
HHCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
YKDSMKGDDILVLAPNKLFLDYISETLPNLGAEEVKQNTFEELVKSKFKLRGKIYSKDDK
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCHH
LRAIMEEDDDNKRNFIIKSAGFKGSIEFKNMIDKYIALVDSSTREIEDITIDGYIIFEKK
HHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECHH
EIVKLYLKDLKSYAINKRKDEIKRYLSLKIKEKIEVLLYSIDFRWESKIKNIKNTCEDLI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHH
ERRKLLVEEYDKRDEIKNHILKNYKKQFNEYFKSWKGIGVSDIYYRFFTDDLFDFIGPEN
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
ISSELLDFMKEDFLINYENKIIDEDDLAPLLYIRNLLEGIEEKEKFKHIVVDEAQDYSPF
HHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
QIHLINSFSKGNSLTLVGDLAQGIYYYKGLKCWEDITKDLFKDKATYVQLTQSYRSTVEI
EEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IDFAKHTLKAQKLGLKDAKAVLRHGEEPKIIEFDESEKNIYKIIDKIIEKIRELGKISIA
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEE
IITKDSKQAQKVEKILKNNSAYKFQRIKGKEACFLEDNVIIPSYLTKGLEFDCTIIYNPS
EEECCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCEECHHHHHCCCCEEEEEEECCC
KKNYQNNILDQRLLYVMLTRALHYEYILKLDSLTHLIEENN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]