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The map label for this gene is cpdB [H]

Identifier: 187930624

GI number: 187930624

Start: 3726918

End: 3728972

Strand: Reverse

Name: cpdB [H]

Synonym: Rpic_3560

Alternate gene names: 187930624

Gene position: 3728972-3726918 (Counterclockwise)

Preceding gene: 187930628

Following gene: 187930623

Centisome position: 94.58

GC content: 63.6

Gene sequence:

>2055_bases
ATGCGAGTCCGACCATTGTGTTCGGCGGCGTTGCCGCTTGCTGTTTTCTTGTCGATGTCGCTGGCTGCCTGTGGTGGCAG
CGACGATACTCCGACCACGCCTGCCGCCAGCGCTGCCCCCGCGGGCACCAAGGCCACGCTGGCCGTGCTGGAAACGACCG
ACCTGCACACCAACGTGCTGTCGTACGACTACTTCAAGCTTGCTGCCGACAATTCGCTCGGCTTCGAGCGCGTGGCGACG
CTCATCAATCAGGCGCGCACGCAATTCCCGAATACGCTGCTGCTGGACAACGGCGACACCATCCAGGGCACCGCGCTGTC
GGATTACCAGGCCATGGTGAGCCCCATCACCTGCGACCAGACGCTGGCGATCTACAAGGTAATGAACGCCGCCAAGTACG
ACGGCGGCGGTATCGGGAACCACGAGTTCAACTATGGCCTGCCGTATCTGTCGCAGGTCACGGGCAATACGTTCAACGTC
GATGGCCTGCCCGATCCGGCCACGCAGCAGAAATGCGCAGGCCCGGCCTTCCCGCAGGTGCTGGCCAACGTGGTGAGCGC
GAAGACCAACGCGCCGCTCTTCCAGCCGTACACGATCATCACCAAGACGGTAACGGCCACGGCGCCGGATGGCAGCACGA
TCAGCGCGCCGGTCAAGGTCGGCATCATCAGCTTTACGCCGCCCACCATCACGAGCTGGGACAAGCGCTGGCTCGACGGC
AAGGTCTACACCGTCGGCATCAAGGAAACGGCGGCCAAGTACATCCCCGAGATGCGCGCAAAGGGCGCCGACCTGGTGGT
CGCGATTTCGCACGGTGGGCTGGATAACTCGACGTATTCGCCGACGATGGAAAACGGCAGCTGGTGGCTGTCCACCGTGC
CGGGCATCGACGCCATGTTGATCGGCCACTCGCACCAGCTCTTCCCGGATGCAAAGAGCACGGTCAGCCAGTTCAACCTG
CCGGGTGTGGACAAGGTGGCCGGCACCGTGAACGGCGTGCCGACTGTGATGGCCAACTACTGGGGCAAGCACCTCGGCGT
GATCAAGCTGGGCCTGACGTTCAACGGCACGAACTGGGCCGTGGACAAGACGCAGACCACGGTGGAAGCGCGCTCGATTC
AGAACGCCGACAAGACGTACGTAGCGGCCGACCCGACGGTCTCGGCCGCCATCGCCACCGAACACCAGGCGACGATCAAC
TACGTGAAGACGCCGGTGGGCAGCACCGACTTCAACATGAGCACGTACTTTGCCGACGTGGGCGACCCGGGCGCAATCGA
GATCGTGAACCAGGCGCAGGCCGATTACGTGTCGGCGTACATCCAGGCGAACCTGCCGCAGTACGCGTCGCTGCCGGTGC
TGTCGGTGAGCGCGCCGTTCAAGAGCGGCTTTGGCGGCGGTACGGATTTCACCGATGTTGCAGCCGGCCCGCTGGCGATC
AACAACGCAGCCGACCTGTATCTGTATCCGAACACGGTCTACGCCGTGAAGGTGGCGGGCTCCGACATCAAGAACTGGCT
GGAAACGGCAGCCAAGCGCTTCAACACCATCGACCCGACGCAGGCGACGGTGCAGAAGCTGGTGAGCACGTTCCCAGGCT
ACAACTTCGACATGTTCACCACGCCGGACCTGACGTATGAGATTGACGTCACGCAGCCGGTCGGCAGCCGCATCAAGAAC
CTGATGTACAAGGGCGTGGCGCTCGACCCGGCAGCGCAGTTCATCGTGGCGACCAACAACTACCGCGCAAGCGGCGGCGG
CAACTTCCCGGGCCTGGATGGCAGCAAGACGATCTACGCGTCGCCCGATGCCAACCGCGACGTGCTGATCAGCTACATCA
AGAAGATCGGCAGCGTGAAGCGGGCGACGAACGGCTCGCAGCGCAGTTGGCGCTTCACGAAGCTGGCGAGCTCGGTGGCG
CAGGTGCAGTTCACCTCTGCGCCCAACAAGCTGGCCAACGCCACGGCCGCCGGCATCACCAACGTCACACAGGTGGCTGC
GGATGACGGTTCGGGCAAGGGCTTGGCGGTGTACCAGATCGACCTGACGCAGTAA

Upstream 100 bases:

>100_bases
CCCGGTTTTGCGTGCGCGTCTGCTTGTCATTCGCTTCAGCAGCAATCGCATTCCGCAGTCCGTAGTTCGCATACCAAAAA
TAGACTTCAGGGAGAAGTTC

Downstream 100 bases:

>100_bases
GCAGGAGCCGACGATGCCATCTCTTCGTTCCGCATGGGCGGGTGCACCGGCCATGGAATCTCCGCGACAATCGGTGCCGA
TGCTCACCGTGGCCGCCGCG

Product: 5'-Nucleotidase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MRVRPLCSAALPLAVFLSMSLAACGGSDDTPTTPAASAAPAGTKATLAVLETTDLHTNVLSYDYFKLAADNSLGFERVAT
LINQARTQFPNTLLLDNGDTIQGTALSDYQAMVSPITCDQTLAIYKVMNAAKYDGGGIGNHEFNYGLPYLSQVTGNTFNV
DGLPDPATQQKCAGPAFPQVLANVVSAKTNAPLFQPYTIITKTVTATAPDGSTISAPVKVGIISFTPPTITSWDKRWLDG
KVYTVGIKETAAKYIPEMRAKGADLVVAISHGGLDNSTYSPTMENGSWWLSTVPGIDAMLIGHSHQLFPDAKSTVSQFNL
PGVDKVAGTVNGVPTVMANYWGKHLGVIKLGLTFNGTNWAVDKTQTTVEARSIQNADKTYVAADPTVSAAIATEHQATIN
YVKTPVGSTDFNMSTYFADVGDPGAIEIVNQAQADYVSAYIQANLPQYASLPVLSVSAPFKSGFGGGTDFTDVAAGPLAI
NNAADLYLYPNTVYAVKVAGSDIKNWLETAAKRFNTIDPTQATVQKLVSTFPGYNFDMFTTPDLTYEIDVTQPVGSRIKN
LMYKGVALDPAAQFIVATNNYRASGGGNFPGLDGSKTIYASPDANRDVLISYIKKIGSVKRATNGSQRSWRFTKLASSVA
QVQFTSAPNKLANATAAGITNVTQVAADDGSGKGLAVYQIDLTQ

Sequences:

>Translated_684_residues
MRVRPLCSAALPLAVFLSMSLAACGGSDDTPTTPAASAAPAGTKATLAVLETTDLHTNVLSYDYFKLAADNSLGFERVAT
LINQARTQFPNTLLLDNGDTIQGTALSDYQAMVSPITCDQTLAIYKVMNAAKYDGGGIGNHEFNYGLPYLSQVTGNTFNV
DGLPDPATQQKCAGPAFPQVLANVVSAKTNAPLFQPYTIITKTVTATAPDGSTISAPVKVGIISFTPPTITSWDKRWLDG
KVYTVGIKETAAKYIPEMRAKGADLVVAISHGGLDNSTYSPTMENGSWWLSTVPGIDAMLIGHSHQLFPDAKSTVSQFNL
PGVDKVAGTVNGVPTVMANYWGKHLGVIKLGLTFNGTNWAVDKTQTTVEARSIQNADKTYVAADPTVSAAIATEHQATIN
YVKTPVGSTDFNMSTYFADVGDPGAIEIVNQAQADYVSAYIQANLPQYASLPVLSVSAPFKSGFGGGTDFTDVAAGPLAI
NNAADLYLYPNTVYAVKVAGSDIKNWLETAAKRFNTIDPTQATVQKLVSTFPGYNFDMFTTPDLTYEIDVTQPVGSRIKN
LMYKGVALDPAAQFIVATNNYRASGGGNFPGLDGSKTIYASPDANRDVLISYIKKIGSVKRATNGSQRSWRFTKLASSVA
QVQFTSAPNKLANATAAGITNVTQVAADDGSGKGLAVYQIDLTQ
>Mature_684_residues
MRVRPLCSAALPLAVFLSMSLAACGGSDDTPTTPAASAAPAGTKATLAVLETTDLHTNVLSYDYFKLAADNSLGFERVAT
LINQARTQFPNTLLLDNGDTIQGTALSDYQAMVSPITCDQTLAIYKVMNAAKYDGGGIGNHEFNYGLPYLSQVTGNTFNV
DGLPDPATQQKCAGPAFPQVLANVVSAKTNAPLFQPYTIITKTVTATAPDGSTISAPVKVGIISFTPPTITSWDKRWLDG
KVYTVGIKETAAKYIPEMRAKGADLVVAISHGGLDNSTYSPTMENGSWWLSTVPGIDAMLIGHSHQLFPDAKSTVSQFNL
PGVDKVAGTVNGVPTVMANYWGKHLGVIKLGLTFNGTNWAVDKTQTTVEARSIQNADKTYVAADPTVSAAIATEHQATIN
YVKTPVGSTDFNMSTYFADVGDPGAIEIVNQAQADYVSAYIQANLPQYASLPVLSVSAPFKSGFGGGTDFTDVAAGPLAI
NNAADLYLYPNTVYAVKVAGSDIKNWLETAAKRFNTIDPTQATVQKLVSTFPGYNFDMFTTPDLTYEIDVTQPVGSRIKN
LMYKGVALDPAAQFIVATNNYRASGGGNFPGLDGSKTIYASPDANRDVLISYIKKIGSVKRATNGSQRSWRFTKLASSVA
QVQFTSAPNKLANATAAGITNVTQVAADDGSGKGLAVYQIDLTQ

Specific function: This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Homo sapiens, GI4505467, Length=611, Percent_Identity=21.6039279869067, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790658, Length=664, Percent_Identity=40.3614457831325, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1786687, Length=578, Percent_Identity=22.4913494809689, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR006294
- InterPro:   IPR004843 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.1.3.6; =3.1.4.16 [H]

Molecular weight: Translated: 72412; Mature: 72412

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00786 5_NUCLEOTIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVRPLCSAALPLAVFLSMSLAACGGSDDTPTTPAASAAPAGTKATLAVLETTDLHTNVL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHH
SYDYFKLAADNSLGFERVATLINQARTQFPNTLLLDNGDTIQGTALSDYQAMVSPITCDQ
CCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCHHHHHCCCCCCH
TLAIYKVMNAAKYDGGGIGNHEFNYGLPYLSQVTGNTFNVDGLPDPATQQKCAGPAFPQV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCCCCCCCHHHCCCCCHHHH
LANVVSAKTNAPLFQPYTIITKTVTATAPDGSTISAPVKVGIISFTPPTITSWDKRWLDG
HHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCEEECCEEEEEEEECCCCCCCCHHHHCCC
KVYTVGIKETAAKYIPEMRAKGADLVVAISHGGLDNSTYSPTMENGSWWLSTVPGIDAML
EEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEE
IGHSHQLFPDAKSTVSQFNLPGVDKVAGTVNGVPTVMANYWGKHLGVIKLGLTFNGTNWA
ECCCCCCCCCHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEECCCCEE
VDKTQTTVEARSIQNADKTYVAADPTVSAAIATEHQATINYVKTPVGSTDFNMSTYFADV
ECCCHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHEEHEEECCCCCCCCCCEEEEEEC
GDPGAIEIVNQAQADYVSAYIQANLPQYASLPVLSVSAPFKSGFGGGTDFTDVAAGPLAI
CCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCEEE
NNAADLYLYPNTVYAVKVAGSDIKNWLETAAKRFNTIDPTQATVQKLVSTFPGYNFDMFT
CCCCEEEEECCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEE
TPDLTYEIDVTQPVGSRIKNLMYKGVALDPAAQFIVATNNYRASGGGNFPGLDGSKTIYA
CCCEEEEEECCCHHHHHHHHHHHCCCEECCCCEEEEEECCEECCCCCCCCCCCCCCEEEE
SPDANRDVLISYIKKIGSVKRATNGSQRSWRFTKLASSVAQVQFTSAPNKLANATAAGIT
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHCCC
NVTQVAADDGSGKGLAVYQIDLTQ
HHHEEECCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MRVRPLCSAALPLAVFLSMSLAACGGSDDTPTTPAASAAPAGTKATLAVLETTDLHTNVL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHH
SYDYFKLAADNSLGFERVATLINQARTQFPNTLLLDNGDTIQGTALSDYQAMVSPITCDQ
CCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCHHHHHCCCCCCH
TLAIYKVMNAAKYDGGGIGNHEFNYGLPYLSQVTGNTFNVDGLPDPATQQKCAGPAFPQV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCCCCCCCHHHCCCCCHHHH
LANVVSAKTNAPLFQPYTIITKTVTATAPDGSTISAPVKVGIISFTPPTITSWDKRWLDG
HHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCEEECCEEEEEEEECCCCCCCCHHHHCCC
KVYTVGIKETAAKYIPEMRAKGADLVVAISHGGLDNSTYSPTMENGSWWLSTVPGIDAML
EEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEE
IGHSHQLFPDAKSTVSQFNLPGVDKVAGTVNGVPTVMANYWGKHLGVIKLGLTFNGTNWA
ECCCCCCCCCHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEECCCCEE
VDKTQTTVEARSIQNADKTYVAADPTVSAAIATEHQATINYVKTPVGSTDFNMSTYFADV
ECCCHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHEEHEEECCCCCCCCCCEEEEEEC
GDPGAIEIVNQAQADYVSAYIQANLPQYASLPVLSVSAPFKSGFGGGTDFTDVAAGPLAI
CCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCEEE
NNAADLYLYPNTVYAVKVAGSDIKNWLETAAKRFNTIDPTQATVQKLVSTFPGYNFDMFT
CCCCEEEEECCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEE
TPDLTYEIDVTQPVGSRIKNLMYKGVALDPAAQFIVATNNYRASGGGNFPGLDGSKTIYA
CCCEEEEEECCCHHHHHHHHHHHCCCEECCCCEEEEEECCEECCCCCCCCCCCCCCEEEE
SPDANRDVLISYIKKIGSVKRATNGSQRSWRFTKLASSVAQVQFTSAPNKLANATAAGIT
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHCCC
NVTQVAADDGSGKGLAVYQIDLTQ
HHHEEECCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3005231; 7610040; 9278503; 2172762; 9298646 [H]