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The map label for this gene is livM [H]

Identifier: 187930599

GI number: 187930599

Start: 3703288

End: 3704292

Strand: Reverse

Name: livM [H]

Synonym: Rpic_3535

Alternate gene names: 187930599

Gene position: 3704292-3703288 (Counterclockwise)

Preceding gene: 187930600

Following gene: 187930597

Centisome position: 93.96

GC content: 63.88

Gene sequence:

>1005_bases
ATGAGCGGCGCGGCCAACATGACCAACTCTTCTTCCCTCAAATACGTGCTGTACGGGCTGCTTCTGGTGGCGCTGATTGC
CGCGCCGCTGGTGGGCGCGTATCCGGTGTTCGTCGCCAAGCTGCTGTGCTTTGCGCTGTTTGCCTCCGCCTTCAACCTGC
TGCTGGGTTACACAGGGCTGCTATCGTTCGGGCATGCGGCGTTCTTTGGCGGCGCGGGCTACGTGGCCGGCTACATGATG
CGCGACCTGCATGTCACGCCGGAGCTTGGCCTGCTGGCGGGCACTGCAGCGGGCGCGTTCATCGGTTTGATCGTCGGCCT
GCTCGCCATCCGTCGTCAGGGGATCTACTTCGCGATGATCACACTGGCGCTGGCACAGATGCTGTATTTCTTCTGCCTTC
AGGTGCCATTCACCGGCGGCGAAGACGGCCTGCAGGGCGTGCCGCGCGGCAAGCTGTTCGGCGTGCTGGATCTGTCGTCC
GACCTCACGCTGTATTACGTCGTGCTCGCTATCGTGGTGCTGGCGTTCCTGCTGATCGTGCGCACGATCCACTCGCCGTT
CGGGCAGATCCTCAAGGCCATCAAGGAGAACGAGCCGCGCGCCACGTCCCTCGGCTACGACACCGATCGTTTCAAGCTGC
TGGCCTTCGTGCTGTCGGCGGCGCTGACGGGCCTGGCCGGTTCGCTCAAGACGCTGGTGCTCGGCTTCGAGACGCTCACC
GACGTGCACTGGTCGATGTCCGGCTCGGTCATCCTGATGACGCTGGTAGGCGGCCTGGGTATCCTGTCTGGCCCGCTGCT
GGGTGCGGCGCTCGTGATCGCGCTGGAAAACAAGCTCGGCGACATCGGCAGTTTCCTCGCTGGCGCCACTGGCATCGACG
GCTTCAATATCCTTGGCGAATCAGTCACCACGGTCACGGGCGCGATCTTCGTGATCTGTGTGCTGACGTTCCGGCGCGGC
ATCATGGGCGAAATTGCGGCGCGTGTGCCCTGGCTGCGACGTTGA

Upstream 100 bases:

>100_bases
TGACCAAGGTGTTTTATCCACAGGCGTCGGCGACCGTGGTGTTCGTGATCATGGTGCTGGTGCTGCTGGTGCGTCCGGCG
GGCCTGTTCGGTAAAGAGAA

Downstream 100 bases:

>100_bases
CGCCACAATGCGCGAAGATGCCGGTAAATTTCACCCGAACGGCTGCACTTGGTGCCTCATGCACCGTAAGGGTTTGCTCT
AGTTGCTGCATTGCGGTGCA

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSGAANMTNSSSLKYVLYGLLLVALIAAPLVGAYPVFVAKLLCFALFASAFNLLLGYTGLLSFGHAAFFGGAGYVAGYMM
RDLHVTPELGLLAGTAAGAFIGLIVGLLAIRRQGIYFAMITLALAQMLYFFCLQVPFTGGEDGLQGVPRGKLFGVLDLSS
DLTLYYVVLAIVVLAFLLIVRTIHSPFGQILKAIKENEPRATSLGYDTDRFKLLAFVLSAALTGLAGSLKTLVLGFETLT
DVHWSMSGSVILMTLVGGLGILSGPLLGAALVIALENKLGDIGSFLAGATGIDGFNILGESVTTVTGAIFVICVLTFRRG
IMGEIAARVPWLRR

Sequences:

>Translated_334_residues
MSGAANMTNSSSLKYVLYGLLLVALIAAPLVGAYPVFVAKLLCFALFASAFNLLLGYTGLLSFGHAAFFGGAGYVAGYMM
RDLHVTPELGLLAGTAAGAFIGLIVGLLAIRRQGIYFAMITLALAQMLYFFCLQVPFTGGEDGLQGVPRGKLFGVLDLSS
DLTLYYVVLAIVVLAFLLIVRTIHSPFGQILKAIKENEPRATSLGYDTDRFKLLAFVLSAALTGLAGSLKTLVLGFETLT
DVHWSMSGSVILMTLVGGLGILSGPLLGAALVIALENKLGDIGSFLAGATGIDGFNILGESVTTVTGAIFVICVLTFRRG
IMGEIAARVPWLRR
>Mature_333_residues
SGAANMTNSSSLKYVLYGLLLVALIAAPLVGAYPVFVAKLLCFALFASAFNLLLGYTGLLSFGHAAFFGGAGYVAGYMMR
DLHVTPELGLLAGTAAGAFIGLIVGLLAIRRQGIYFAMITLALAQMLYFFCLQVPFTGGEDGLQGVPRGKLFGVLDLSSD
LTLYYVVLAIVVLAFLLIVRTIHSPFGQILKAIKENEPRATSLGYDTDRFKLLAFVLSAALTGLAGSLKTLVLGFETLTD
VHWSMSGSVILMTLVGGLGILSGPLLGAALVIALENKLGDIGSFLAGATGIDGFNILGESVTTVTGAIFVICVLTFRRGI
MGEIAARVPWLRR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=263, Percent_Identity=26.615969581749, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 35159; Mature: 35028

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAANMTNSSSLKYVLYGLLLVALIAAPLVGAYPVFVAKLLCFALFASAFNLLLGYTGL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSFGHAAFFGGAGYVAGYMMRDLHVTPELGLLAGTAAGAFIGLIVGLLAIRRQGIYFAMI
HHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
TLALAQMLYFFCLQVPFTGGEDGLQGVPRGKLFGVLDLSSDLTLYYVVLAIVVLAFLLIV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
RTIHSPFGQILKAIKENEPRATSLGYDTDRFKLLAFVLSAALTGLAGSLKTLVLGFETLT
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVHWSMSGSVILMTLVGGLGILSGPLLGAALVIALENKLGDIGSFLAGATGIDGFNILGE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SVTTVTGAIFVICVLTFRRGIMGEIAARVPWLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SGAANMTNSSSLKYVLYGLLLVALIAAPLVGAYPVFVAKLLCFALFASAFNLLLGYTGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSFGHAAFFGGAGYVAGYMMRDLHVTPELGLLAGTAAGAFIGLIVGLLAIRRQGIYFAMI
HHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
TLALAQMLYFFCLQVPFTGGEDGLQGVPRGKLFGVLDLSSDLTLYYVVLAIVVLAFLLIV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
RTIHSPFGQILKAIKENEPRATSLGYDTDRFKLLAFVLSAALTGLAGSLKTLVLGFETLT
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVHWSMSGSVILMTLVGGLGILSGPLLGAALVIALENKLGDIGSFLAGATGIDGFNILGE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SVTTVTGAIFVICVLTFRRGIMGEIAARVPWLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]