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The map label for this gene is atpA [H]

Identifier: 187930579

GI number: 187930579

Start: 3685776

End: 3687317

Strand: Reverse

Name: atpA [H]

Synonym: Rpic_3514

Alternate gene names: 187930579

Gene position: 3687317-3685776 (Counterclockwise)

Preceding gene: 187930580

Following gene: 187930578

Centisome position: 93.53

GC content: 62.65

Gene sequence:

>1542_bases
ATGCAACTGAACCCCTCCGAGATCAGCGACCTGATCAAGACCCGTATCGAGGGCTTGAAGGCTGGCGCTGACGCAAAGAA
CACCGGCACGGTCATCTCCGTGACGGACGGTATCTGCCGCATTCATGGCCTGTCGGGCGTGATGCAAGGCGAAATGCTGG
AATTCCCGGGCAACACGTTCGGCCTCGCGCTGAACCTCGAGCGCGACTCTGTCGGCGCTGTGGTGCTGGGTGAGTACGAG
CACATTTCCGAAGGCGACGAAGTCAAGTGCACGGGCCGCATTCTGGAAGTGCCGGTTGGCCCGGAACTGCTGGGCCGCGT
GGTCAACGCACTGGGCCAGCCGATCGACGGCAAGGGCCCGATCAACGCCAAGAAGACGGACGTGATCGAAAAGGTCGCTC
CGGGCGTGATCGCGCGTCAGTCGGTGAGCCAGCCGGTGCAGACCGGTCTGAAGTCGATCGACGCAATGGTGCCGATCGGC
CGTGGGCAGCGTGAGCTGATCATTGGCGACCGCCAGACCGGCAAGACCGCCGTGGCAGTCGACGCCATCATCAACCAGAA
GGGCAAGGGCATCTTCTGCGTGTACGTGGCAATCGGCCAGAAGGCTTCGACGATCGCCAACGTGGTGCGCAAGCTCGAAG
AGCACGGCGCGCTGGAATACACGATCGTGGTGGCTGCCGCCGCTTCCGATTCGGCTGCCATGCAGTACCTGTCGGCCTAC
GCCGGCTGCACGATGGGCGAGTACTTCCGCGACCGCGGCGAAGACGCGCTGATCGTGTATGACGATCTGACCAAGCAAGC
TTGGGCGTACCGTCAGGTTTCGCTGCTGCTGCGCCGTCCGCCTGGCCGTGAGGCTTACCCGGGCGACGTGTTCTACCTGC
ACTCGCGTCTGCTGGAGCGTGCTGCGCGTGTGAACGCCGAGCATATCGAGAAGATCACCAACGGTGAAGTCAAGGGCAAG
ACCGGTTCGCTGACCGCACTGCCCGTGATCGAAACGCAGGCCGGCGACGTGTCCGCGTTCGTGCCGACCAACGTGATCTC
GATTACCGACGGCCAGATCTTCCTGGAAACCGACCTGTTCAACGCAGGTGTACGCCCCGCAATCAACGCCGGTATTTCGG
TGTCGCGTGTGGGTGGTGCTGCCCAGACCAAGGTCATCAAGAAGCTGTCCGGCGGTATCCGTACCGACCTGGCCCAGTAC
CGTGAACTGGCTGCGTTCGCGCAGTTTGCTTCCGACCTGGACGAAGCGACCCGCAAGCAGCTCGAGCGCGGCCGCCGCGT
GACCGAACTGCTCAAGCAGCCGCAATACCAGCCGCTGCAGGTGTGGCAGCTGGCCGCGTCGCTCTACGCAGCCAACAACG
GCTTCCTCGACAACGTGGACGTGAAGGACATCCTGGCGTTTGAAAAGGGCCTGCACGACACGCTGAAGACGAAGTACGCC
GACCTCATCAACCGCATCGAAGATACGAAGGATCTGTCGAAGGACGATGAGGCCGCCCTGCGTGCCGCGATCGAGGATTT
CAAGAAGTCCGCCGCGTTCTAA

Upstream 100 bases:

>100_bases
ATGCAGTCTGCGCTGACCGCCGCGTAATGCTGTTTCGCGAGGCGCCGATGCAATCGACGATATCGCGCCCGCAGACAGAT
TGAAGAATTAGGAGCATTCG

Downstream 100 bases:

>100_bases
CCGCGTCATTCCCTGAACTGGTCACGCTTAGCCTGCGTGGCCAGGTCGGAACGGAGAGAGTGAAATGGCCGGAACAAAAG
AAATCCGCACCAAGATCAAG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQLNPSEISDLIKTRIEGLKAGADAKNTGTVISVTDGICRIHGLSGVMQGEMLEFPGNTFGLALNLERDSVGAVVLGEYE
HISEGDEVKCTGRILEVPVGPELLGRVVNALGQPIDGKGPINAKKTDVIEKVAPGVIARQSVSQPVQTGLKSIDAMVPIG
RGQRELIIGDRQTGKTAVAVDAIINQKGKGIFCVYVAIGQKASTIANVVRKLEEHGALEYTIVVAAAASDSAAMQYLSAY
AGCTMGEYFRDRGEDALIVYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNAEHIEKITNGEVKGK
TGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGVRPAINAGISVSRVGGAAQTKVIKKLSGGIRTDLAQY
RELAAFAQFASDLDEATRKQLERGRRVTELLKQPQYQPLQVWQLAASLYAANNGFLDNVDVKDILAFEKGLHDTLKTKYA
DLINRIEDTKDLSKDDEAALRAAIEDFKKSAAF

Sequences:

>Translated_513_residues
MQLNPSEISDLIKTRIEGLKAGADAKNTGTVISVTDGICRIHGLSGVMQGEMLEFPGNTFGLALNLERDSVGAVVLGEYE
HISEGDEVKCTGRILEVPVGPELLGRVVNALGQPIDGKGPINAKKTDVIEKVAPGVIARQSVSQPVQTGLKSIDAMVPIG
RGQRELIIGDRQTGKTAVAVDAIINQKGKGIFCVYVAIGQKASTIANVVRKLEEHGALEYTIVVAAAASDSAAMQYLSAY
AGCTMGEYFRDRGEDALIVYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNAEHIEKITNGEVKGK
TGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGVRPAINAGISVSRVGGAAQTKVIKKLSGGIRTDLAQY
RELAAFAQFASDLDEATRKQLERGRRVTELLKQPQYQPLQVWQLAASLYAANNGFLDNVDVKDILAFEKGLHDTLKTKYA
DLINRIEDTKDLSKDDEAALRAAIEDFKKSAAF
>Mature_513_residues
MQLNPSEISDLIKTRIEGLKAGADAKNTGTVISVTDGICRIHGLSGVMQGEMLEFPGNTFGLALNLERDSVGAVVLGEYE
HISEGDEVKCTGRILEVPVGPELLGRVVNALGQPIDGKGPINAKKTDVIEKVAPGVIARQSVSQPVQTGLKSIDAMVPIG
RGQRELIIGDRQTGKTAVAVDAIINQKGKGIFCVYVAIGQKASTIANVVRKLEEHGALEYTIVVAAAASDSAAMQYLSAY
AGCTMGEYFRDRGEDALIVYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNAEHIEKITNGEVKGK
TGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGVRPAINAGISVSRVGGAAQTKVIKKLSGGIRTDLAQY
RELAAFAQFASDLDEATRKQLERGRRVTELLKQPQYQPLQVWQLAASLYAANNGFLDNVDVKDILAFEKGLHDTLKTKYA
DLINRIEDTKDLSKDDEAALRAAIEDFKKSAAF

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=510, Percent_Identity=56.4705882352941, Blast_Score=577, Evalue=1e-164,
Organism=Homo sapiens, GI4757810, Length=510, Percent_Identity=56.4705882352941, Blast_Score=577, Evalue=1e-164,
Organism=Homo sapiens, GI32189394, Length=485, Percent_Identity=25.7731958762887, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI19913428, Length=308, Percent_Identity=27.5974025974026, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI19913426, Length=314, Percent_Identity=27.0700636942675, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI19913424, Length=333, Percent_Identity=26.1261261261261, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790172, Length=513, Percent_Identity=69.3957115009747, Blast_Score=736, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=439, Percent_Identity=24.8291571753986, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788251, Length=281, Percent_Identity=27.7580071174377, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71988063, Length=510, Percent_Identity=56.6666666666667, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI71988080, Length=510, Percent_Identity=56.6666666666667, Blast_Score=574, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI71988074, Length=510, Percent_Identity=52.5490196078431, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI25144756, Length=446, Percent_Identity=24.4394618834081, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17570191, Length=303, Percent_Identity=27.7227722772277, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=382, Percent_Identity=25.130890052356, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17565854, Length=254, Percent_Identity=26.7716535433071, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=54, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988068, Length=85, Percent_Identity=38.8235294117647, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=512, Percent_Identity=55.6640625, Blast_Score=573, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6322581, Length=424, Percent_Identity=25.9433962264151, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319603, Length=308, Percent_Identity=28.8961038961039, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24658560, Length=510, Percent_Identity=56.8627450980392, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=27.5409836065574, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=27.5409836065574, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=27.5409836065574, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24638766, Length=395, Percent_Identity=25.0632911392405, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI28574560, Length=385, Percent_Identity=24.1558441558442, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583992, Length=326, Percent_Identity=25.4601226993865, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583988, Length=255, Percent_Identity=27.0588235294118, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583986, Length=255, Percent_Identity=27.0588235294118, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583984, Length=255, Percent_Identity=27.0588235294118, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129479, Length=348, Percent_Identity=25.5747126436782, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55352; Mature: 55352

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNPSEISDLIKTRIEGLKAGADAKNTGTVISVTDGICRIHGLSGVMQGEMLEFPGNTF
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHCCCHHHCCCEEECCCCEE
GLALNLERDSVGAVVLGEYEHISEGDEVKCTGRILEVPVGPELLGRVVNALGQPIDGKGP
EEEEEECCCCCCEEEEECCHHCCCCCCEEEECEEEECCCCHHHHHHHHHHHCCCCCCCCC
INAKKTDVIEKVAPGVIARQSVSQPVQTGLKSIDAMVPIGRGQRELIIGDRQTGKTAVAV
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DAIINQKGKGIFCVYVAIGQKASTIANVVRKLEEHGALEYTIVVAAAASDSAAMQYLSAY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHH
AGCTMGEYFRDRGEDALIVYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLER
HCCCHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARVNAEHIEKITNGEVKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETDLF
HHHCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCC
NAGVRPAINAGISVSRVGGAAQTKVIKKLSGGIRTDLAQYRELAAFAQFASDLDEATRKQ
CCCCCHHHHCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LERGRRVTELLKQPQYQPLQVWQLAASLYAANNGFLDNVDVKDILAFEKGLHDTLKTKYA
HHHCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DLINRIEDTKDLSKDDEAALRAAIEDFKKSAAF
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLNPSEISDLIKTRIEGLKAGADAKNTGTVISVTDGICRIHGLSGVMQGEMLEFPGNTF
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHCCCHHHCCCEEECCCCEE
GLALNLERDSVGAVVLGEYEHISEGDEVKCTGRILEVPVGPELLGRVVNALGQPIDGKGP
EEEEEECCCCCCEEEEECCHHCCCCCCEEEECEEEECCCCHHHHHHHHHHHCCCCCCCCC
INAKKTDVIEKVAPGVIARQSVSQPVQTGLKSIDAMVPIGRGQRELIIGDRQTGKTAVAV
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHH
DAIINQKGKGIFCVYVAIGQKASTIANVVRKLEEHGALEYTIVVAAAASDSAAMQYLSAY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHH
AGCTMGEYFRDRGEDALIVYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLER
HCCCHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARVNAEHIEKITNGEVKGKTGSLTALPVIETQAGDVSAFVPTNVISITDGQIFLETDLF
HHHCCHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCC
NAGVRPAINAGISVSRVGGAAQTKVIKKLSGGIRTDLAQYRELAAFAQFASDLDEATRKQ
CCCCCHHHHCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LERGRRVTELLKQPQYQPLQVWQLAASLYAANNGFLDNVDVKDILAFEKGLHDTLKTKYA
HHHCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DLINRIEDTKDLSKDDEAALRAAIEDFKKSAAF
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA