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The map label for this gene is argE [H]

Identifier: 187930535

GI number: 187930535

Start: 3626593

End: 3627867

Strand: Reverse

Name: argE [H]

Synonym: Rpic_3470

Alternate gene names: 187930535

Gene position: 3627867-3626593 (Counterclockwise)

Preceding gene: 187930536

Following gene: 187930534

Centisome position: 92.02

GC content: 66.2

Gene sequence:

>1275_bases
ATGACCCAGGCCCAACTTGCTACCCCCGGCATCGATGCGGATATCCGCGCGTTTGTCGAGGCCGCGCACGCGCAGCAGAT
TGAATTCCTGCGCGAGCTGGTGAAGGTGCCGTCGGACAACCCGTCCGGCGATTGCGCTCCGCATGCCGTGCGCGCCAAGG
CGCTGCTGGAGGCGCTGGGCCTGACGGTCGAGGCGCATGCCGTGCCGCAGGCGCAGGTACGTGCCGCCGGCATGGTCAGC
GCCACCAACCTGATCGTGCGGCACACCTTCGGTAGCGGCGGCCCCACGGTTGCCATGAACGCACACGGCGATGTCGTCCC
GCCCGGCCTTGGCTGGACGCACGATCCGTACGGCGGCGAGACCGTCGAGACCGAACACGGCCCCACCATGTTCGGCCGCG
GCGTGGCGGTGTCCAAGTCGGACTTCGCCACGTACACGTGGGCGCTGCTTGCGCTGATCGACGCGGAAAAGCGCGGCGCG
AAGCTCAATGGCACCGTCGAACTCCATTTCACCTACGACGAAGAAACCGGCGGCGATATCGGCCCGAAGTGGCTGCTGGA
TCAGGGCTTAAGCAAGCCCGATTACGCCATCTCCGCCGGCTTTGCCTATGGCATCACTTCGGCGCACAACGGCTGCCTGC
ACGTGCAGGTGACGGTGCGCGGCAAGCAGGCGCACGCTGCCATGCCGCATACGGGCATCGACGCCATCGAGGCAGCCACG
CATATCCTGCAAGCCGTGTATGCCTATCGCGCAGAACTCGCAACGCGCAAATCCGCCGTGCCGGGCATCGACCACGTAAC
GCTCAACGTCGGTTTGATCCAGGGCGGCATCAACACCAACGTGGTGCCCGATCTGGTGACGTTCCGCGTTGACCGCCGGA
TGATTCCTGAAGAAGCCGGGCGCGATGCAGAAGGCGAACTGCGCGCCGTGATCGAGCGCGCGGCGGCAGAACGGCCGGGG
ATCGAGGTTTCAGTCGAACGCATTCTCTTGGCAGAGCCGCTTGCCGAACTGCCGGGCGTGGACGCGCTGATTGGCGCGCT
GCGACGGAATGCGCTGGCGGTGTTTGGTGGCGATGTGCCGGTGCACGGCGTGCCGCTGTATACCGATGCGCGGCATTACA
CGGCGCATGGCGTGCCGACGGTCCTGTATGGCGCGGGGCCGCGCACGTTGATGGAAGCGCGTGGGCACAACACGGATGAG
AACCTGCGGTTGAATGATCTGCGGGGCGCGACTGTGGTGGTGGGGTGCGCTGTGGGGGAGTTGTTGGGCGGATGA

Upstream 100 bases:

>100_bases
CGCTGTAAGCATCGCATCATCGGTGCCGATCCTGAGCCCCCGCACAACGGGGGCTCAGTCACTTTCAATCTCCGTCCCCC
GCAATCAGCGAGACATCGAC

Downstream 100 bases:

>100_bases
TTGATATCGCTTGATGGCATTGTTTTGCGGGGTCGGCTTTGGTCGGCCCTTTTGCTTTTGGGTTTTTTTTTGGGACTTGG
CGGTCCATCCCCCTTTCGGT

Product: peptidase M20

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTQAQLATPGIDADIRAFVEAAHAQQIEFLRELVKVPSDNPSGDCAPHAVRAKALLEALGLTVEAHAVPQAQVRAAGMVS
ATNLIVRHTFGSGGPTVAMNAHGDVVPPGLGWTHDPYGGETVETEHGPTMFGRGVAVSKSDFATYTWALLALIDAEKRGA
KLNGTVELHFTYDEETGGDIGPKWLLDQGLSKPDYAISAGFAYGITSAHNGCLHVQVTVRGKQAHAAMPHTGIDAIEAAT
HILQAVYAYRAELATRKSAVPGIDHVTLNVGLIQGGINTNVVPDLVTFRVDRRMIPEEAGRDAEGELRAVIERAAAERPG
IEVSVERILLAEPLAELPGVDALIGALRRNALAVFGGDVPVHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDE
NLRLNDLRGATVVVGCAVGELLGG

Sequences:

>Translated_424_residues
MTQAQLATPGIDADIRAFVEAAHAQQIEFLRELVKVPSDNPSGDCAPHAVRAKALLEALGLTVEAHAVPQAQVRAAGMVS
ATNLIVRHTFGSGGPTVAMNAHGDVVPPGLGWTHDPYGGETVETEHGPTMFGRGVAVSKSDFATYTWALLALIDAEKRGA
KLNGTVELHFTYDEETGGDIGPKWLLDQGLSKPDYAISAGFAYGITSAHNGCLHVQVTVRGKQAHAAMPHTGIDAIEAAT
HILQAVYAYRAELATRKSAVPGIDHVTLNVGLIQGGINTNVVPDLVTFRVDRRMIPEEAGRDAEGELRAVIERAAAERPG
IEVSVERILLAEPLAELPGVDALIGALRRNALAVFGGDVPVHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDE
NLRLNDLRGATVVVGCAVGELLGG
>Mature_423_residues
TQAQLATPGIDADIRAFVEAAHAQQIEFLRELVKVPSDNPSGDCAPHAVRAKALLEALGLTVEAHAVPQAQVRAAGMVSA
TNLIVRHTFGSGGPTVAMNAHGDVVPPGLGWTHDPYGGETVETEHGPTMFGRGVAVSKSDFATYTWALLALIDAEKRGAK
LNGTVELHFTYDEETGGDIGPKWLLDQGLSKPDYAISAGFAYGITSAHNGCLHVQVTVRGKQAHAAMPHTGIDAIEAATH
ILQAVYAYRAELATRKSAVPGIDHVTLNVGLIQGGINTNVVPDLVTFRVDRRMIPEEAGRDAEGELRAVIERAAAERPGI
EVSVERILLAEPLAELPGVDALIGALRRNALAVFGGDVPVHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDEN
LRLNDLRGATVVVGCAVGELLGG

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=334, Percent_Identity=26.9461077844311, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356353, Length=422, Percent_Identity=24.8815165876777, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24649202, Length=402, Percent_Identity=26.3681592039801, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24649204, Length=402, Percent_Identity=26.3681592039801, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24649210, Length=401, Percent_Identity=24.6882793017456, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649206, Length=309, Percent_Identity=23.9482200647249, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 44711; Mature: 44580

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAQLATPGIDADIRAFVEAAHAQQIEFLRELVKVPSDNPSGDCAPHAVRAKALLEALG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHC
LTVEAHAVPQAQVRAAGMVSATNLIVRHTFGSGGPTVAMNAHGDVVPPGLGWTHDPYGGE
CEEEECCCCHHHHHHHCHHHHHEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
TVETEHGPTMFGRGVAVSKSDFATYTWALLALIDAEKRGAKLNGTVELHFTYDEETGGDI
EEECCCCCCEECCCEEECCCCHHHHHHHHHHHHHHHHCCCEECCEEEEEEEECCCCCCCC
GPKWLLDQGLSKPDYAISAGFAYGITSAHNGCLHVQVTVRGKQAHAAMPHTGIDAIEAAT
CHHHHHHCCCCCCCCEEECCHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHH
HILQAVYAYRAELATRKSAVPGIDHVTLNVGLIQGGINTNVVPDLVTFRVDRRMIPEEAG
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHC
RDAEGELRAVIERAAAERPGIEVSVERILLAEPLAELPGVDALIGALRRNALAVFGGDVP
CCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCCC
VHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDENLRLNDLRGATVVVGCAVGE
CCCEEEEECCCCEECCCCCEEEECCCCHHHHHHCCCCCCCCEEEECCCCCEEEEEEHHHH
LLGG
HHCC
>Mature Secondary Structure 
TQAQLATPGIDADIRAFVEAAHAQQIEFLRELVKVPSDNPSGDCAPHAVRAKALLEALG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHC
LTVEAHAVPQAQVRAAGMVSATNLIVRHTFGSGGPTVAMNAHGDVVPPGLGWTHDPYGGE
CEEEECCCCHHHHHHHCHHHHHEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
TVETEHGPTMFGRGVAVSKSDFATYTWALLALIDAEKRGAKLNGTVELHFTYDEETGGDI
EEECCCCCCEECCCEEECCCCHHHHHHHHHHHHHHHHCCCEECCEEEEEEEECCCCCCCC
GPKWLLDQGLSKPDYAISAGFAYGITSAHNGCLHVQVTVRGKQAHAAMPHTGIDAIEAAT
CHHHHHHCCCCCCCCEEECCHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHH
HILQAVYAYRAELATRKSAVPGIDHVTLNVGLIQGGINTNVVPDLVTFRVDRRMIPEEAG
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHC
RDAEGELRAVIERAAAERPGIEVSVERILLAEPLAELPGVDALIGALRRNALAVFGGDVP
CCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCCC
VHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDENLRLNDLRGATVVVGCAVGE
CCCEEEEECCCCEECCCCCEEEECCCCHHHHHHCCCCCCCCEEEECCCCCEEEEEEHHHH
LLGG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9829957 [H]