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The map label for this gene is groEL [H]

Identifier: 187930493

GI number: 187930493

Start: 3593518

End: 3595140

Strand: Reverse

Name: groEL [H]

Synonym: Rpic_3427

Alternate gene names: 187930493

Gene position: 3595140-3593518 (Counterclockwise)

Preceding gene: 187930494

Following gene: 187930492

Centisome position: 91.19

GC content: 63.65

Gene sequence:

>1623_bases
ATGAGTGCAAAAGACGTCAAGTTCCACGACAGCGCGCGCGTCCGTATCGTCAAGGGCGTGAATGTTCTTGCCGATGCCGT
GAAGGTGACGCTCGGGCCCAAGGGCCGCAACGTGGTCATCGAGCGCAGCTTTGGCGCCCCGACCATCACCAAGGACGGCG
TGTCTGTCGCCAAGGAAATCGAGCTGAAGGATCGCTTCGAAAACATGGGCGCGCAGATGGTCAAGCAGGTCGCATCCAAG
ACTGCGGACATTGCCGGTGACGGCACCACCACCGCCACCGTGCTCGCTCAGGCCATCGTGCAGGAAGGCATGAAGCACGT
GGCCGCCGGCATGAACCCGATGGATCTCAAGCGCGGTATCGACAAGGCCGTGGCCGCCGTGCTCGATGAGCTTCGCAATC
TGTCGAAGCCGATTTCGACCAACCGCGAGATTGCCCAGGTGGGCTCCATTTCGGCCAACTCGGACGAGGCCATCGGCAAG
ATCATTGCCGATGCCATGGAGAAGGTCGGCAAGGAAGGTGTCATTACGGTCGAGGATGGCAAGTCGCTCGACAATGAGCT
GGACGTTGTCGAAGGGATGCAGTTCGACCGCGGCTACGTCAGCCCGTATTTCATCAACGACCCGGAAAAGCAGGCGGCCT
ATCTGGACGACGCGCTGATCCTGCTGCACGACAAGAAGATCTCGAATATCCGCGACCTCCTGCCGATCCTGGAAGCGGCA
TCGAAGGCCGGCAAGCCGCTGCTGATCGTGGCGGAGGATGTCGAGAGCGAAGCGCTGGCCACCCTGGTGGTCAACGCCAT
GCGCGGCATCCTGAAGGTCGCTGCGGTCAAGGCCCCCGGCTTTGGCGATCGCCGCAAGGCCATGCTTGAAGACATCGCCG
TGCTGACCGGCGCAACGGTCATCTCCGAAGAAACCGGTAAGCAGCTCCAGAAGGCTACGTTGGAGGACCTCGGCCGGGCC
AAGCGCGTGGAGGTTCGCAAGGACGACACCATCATCATCGACGGTGCCGGCGACCAGGCCAGCATCGATGCCCGCGTCAA
GTCCATCCGCGTGCAGATCGACGAGGCCACGAGCGACTACGACCGCGAGAAGCTGCAGGAACGCGTGGCGAAGCTTGCCG
GCGGCGTTGCCGTCATCAAGGTGGGCGCGGCGACCGAAGTCGAGATGAAAGAGAAGAAGGACCGTGTCGACGATGCCTTG
CACGCCACCCGCGCGGCTGTGGAAGAGGGCATCGTTCCGGGCGGTGGCGTGGCCTTGCTGCGCGCCCGCTCTGCAGTGCT
CAACCTCAAGGGCGCGAACAGCGATCAGGATGCCGGCATCCGCATCGTGCAGCACGCGCTGGAGGCACCGTTGCGCGCCA
TCGTCGCCAACGCCGGTGAAGAGCCGTCCGTCGTCATTGCGAAGGTCGCCGAAGGCAAGGGCAACTACGGCTACAACGCA
GCCACCGGCGAGTACGGCGACCTCGTGGAAGCAGGCGTCGTCGACCCGACGAAGGTCACGCGTACGGCGCTGCAGAACGC
TGCGTCTGTCGCCGGGCTGATCCTGACCACGGATGCGACCATCGCGGACGCACCGAAGGAAGACAAGCCCGCGCAAGTGC
CGGCCCCTGAGCTGGACTACTGA

Upstream 100 bases:

>100_bases
TGAAGCCTCGAGCCGCTCGCGGACACTGCCGGACAGGACACCGCAAATAGGCCGGTTGTTCGCGACGTGTTGAGTCAACG
ACTTATCCGGAGCAACAAAC

Downstream 100 bases:

>100_bases
ACCACGCAGTTGTGCTGCCATCGACTGGCCGGTTCGCCGGCCGGTGCAACTGCATTCCGGCGCCGCTATCCCCGTTGCGG
TGCCGGCTTTTTGAGGTTCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MSAKDVKFHDSARVRIVKGVNVLADAVKVTLGPKGRNVVIERSFGAPTITKDGVSVAKEIELKDRFENMGAQMVKQVASK
TADIAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGIDKAVAAVLDELRNLSKPISTNREIAQVGSISANSDEAIGK
IIADAMEKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYVSPYFINDPEKQAAYLDDALILLHDKKISNIRDLLPILEAA
SKAGKPLLIVAEDVESEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAVLTGATVISEETGKQLQKATLEDLGRA
KRVEVRKDDTIIIDGAGDQASIDARVKSIRVQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRARSAVLNLKGANSDQDAGIRIVQHALEAPLRAIVANAGEEPSVVIAKVAEGKGNYGYNA
ATGEYGDLVEAGVVDPTKVTRTALQNAASVAGLILTTDATIADAPKEDKPAQVPAPELDY

Sequences:

>Translated_540_residues
MSAKDVKFHDSARVRIVKGVNVLADAVKVTLGPKGRNVVIERSFGAPTITKDGVSVAKEIELKDRFENMGAQMVKQVASK
TADIAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGIDKAVAAVLDELRNLSKPISTNREIAQVGSISANSDEAIGK
IIADAMEKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYVSPYFINDPEKQAAYLDDALILLHDKKISNIRDLLPILEAA
SKAGKPLLIVAEDVESEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAVLTGATVISEETGKQLQKATLEDLGRA
KRVEVRKDDTIIIDGAGDQASIDARVKSIRVQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRARSAVLNLKGANSDQDAGIRIVQHALEAPLRAIVANAGEEPSVVIAKVAEGKGNYGYNA
ATGEYGDLVEAGVVDPTKVTRTALQNAASVAGLILTTDATIADAPKEDKPAQVPAPELDY
>Mature_539_residues
SAKDVKFHDSARVRIVKGVNVLADAVKVTLGPKGRNVVIERSFGAPTITKDGVSVAKEIELKDRFENMGAQMVKQVASKT
ADIAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGIDKAVAAVLDELRNLSKPISTNREIAQVGSISANSDEAIGKI
IADAMEKVGKEGVITVEDGKSLDNELDVVEGMQFDRGYVSPYFINDPEKQAAYLDDALILLHDKKISNIRDLLPILEAAS
KAGKPLLIVAEDVESEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAVLTGATVISEETGKQLQKATLEDLGRAK
RVEVRKDDTIIIDGAGDQASIDARVKSIRVQIDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALH
ATRAAVEEGIVPGGGVALLRARSAVLNLKGANSDQDAGIRIVQHALEAPLRAIVANAGEEPSVVIAKVAEGKGNYGYNAA
TGEYGDLVEAGVVDPTKVTRTALQNAASVAGLILTTDATIADAPKEDKPAQVPAPELDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.219696969697, Blast_Score=555, Evalue=1e-158,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.219696969697, Blast_Score=555, Evalue=1e-158,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=74.0530303030303, Blast_Score=784, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.4971644612476, Blast_Score=566, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=55.4502369668246, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17564182, Length=540, Percent_Identity=24.0740740740741, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.6121673003802, Blast_Score=557, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322524, Length=173, Percent_Identity=27.7456647398844, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=53.5104364326376, Blast_Score=570, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=53.5104364326376, Blast_Score=570, Evalue=1e-162,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=52.9411764705882, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=52.9411764705882, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=52.9411764705882, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=44.9056603773585, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=39.7363465160075, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=39.7363465160075, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57067; Mature: 56936

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKDVKFHDSARVRIVKGVNVLADAVKVTLGPKGRNVVIERSFGAPTITKDGVSVAKEI
CCCCCCEECCCCCEEEEECHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDRFENMGAQMVKQVASKTADIAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAVLDELRNLSKPISTNREIAQVGSISANSDEAIGKIIADAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCC
KSLDNELDVVEGMQFDRGYVSPYFINDPEKQAAYLDDALILLHDKKISNIRDLLPILEAA
CCCCCHHHHHHCCCCCCCCCCCEEECCCHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHH
SKAGKPLLIVAEDVESEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAVLTGATV
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHH
ISEETGKQLQKATLEDLGRAKRVEVRKDDTIIIDGAGDQASIDARVKSIRVQIDEATSDY
HHHHHHHHHHHHHHHHHCCHHEEEEECCCEEEEECCCCCCHHHHHEEEEEEEEECCCCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARSAVLNLKGANSDQDAGIRIVQHALEAPLRAIVANAGEEPSVVIAKVAEGKGNYGYNA
HHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ATGEYGDLVEAGVVDPTKVTRTALQNAASVAGLILTTDATIADAPKEDKPAQVPAPELDY
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAKDVKFHDSARVRIVKGVNVLADAVKVTLGPKGRNVVIERSFGAPTITKDGVSVAKEI
CCCCCEECCCCCEEEEECHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDRFENMGAQMVKQVASKTADIAGDGTTTATVLAQAIVQEGMKHVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAVLDELRNLSKPISTNREIAQVGSISANSDEAIGKIIADAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCC
KSLDNELDVVEGMQFDRGYVSPYFINDPEKQAAYLDDALILLHDKKISNIRDLLPILEAA
CCCCCHHHHHHCCCCCCCCCCCEEECCCHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHH
SKAGKPLLIVAEDVESEALATLVVNAMRGILKVAAVKAPGFGDRRKAMLEDIAVLTGATV
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHH
ISEETGKQLQKATLEDLGRAKRVEVRKDDTIIIDGAGDQASIDARVKSIRVQIDEATSDY
HHHHHHHHHHHHHHHHHCCHHEEEEECCCEEEEECCCCCCHHHHHEEEEEEEEECCCCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARSAVLNLKGANSDQDAGIRIVQHALEAPLRAIVANAGEEPSVVIAKVAEGKGNYGYNA
HHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ATGEYGDLVEAGVVDPTKVTRTALQNAASVAGLILTTDATIADAPKEDKPAQVPAPELDY
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA